SONY 在 DVD 市场上的表现一直都有着出色的表现,在高端机种中出现过像 DVP-S9000ES、DVP-NS999ES 等一代广为人知的一代高级名机,中低端的各种型号更是不计其数,实力无需怀疑。在 DVD 持续增长的中国市场,前几年虽有个别型号推出,但未...SONY 在 DVD 市场上的表现一直都有着出色的表现,在高端机种中出现过像 DVP-S9000ES、DVP-NS999ES 等一代广为人知的一代高级名机,中低端的各种型号更是不计其数,实力无需怀疑。在 DVD 持续增长的中国市场,前几年虽有个别型号推出,但未形成足够的力度,反而让不少品牌走到前面去了,对此,相信 SONY 的一些 FANS 们都心有不甘。不过,我的看法却有不同,SONY 只不过是蓄势待发,一但时机成熟,也就是反攻之日。果然,今年的4月20日,SONY(中国)有限公司发布了新一代的多款 DVD 机,其中最先上市的就是这款 SONY DVP-NS575P。到底该机有何本事可以令到 SONY 在 DVD 机市场上展开反攻呢?下面就让我们一起来看一看这款 DVP-NS575P 吧。展开更多
Zinc-finger proteins play different roles in cancer;however,the function of zinc-finger protein ZNF575 in cancer remains unclear.In the present study,we aimed to determine the function and expression of ZNF575 in colo...Zinc-finger proteins play different roles in cancer;however,the function of zinc-finger protein ZNF575 in cancer remains unclear.In the present study,we aimed to determine the function and expression of ZNF575 in colorectal cancer.Proliferation assay,colony formation assay,and tumor model in mice were used to investigate the function of ZNF575 after ectopic expression of ZNF575 in colorectal cancer(CRC)cells.RNA sequencing,ChIP,and luciferase assays were used to investigate the mechanism behind ZNF575 regulation of CRC cell growth.The expression of ZNF575 was determined by IHC staining in 150 pairs of malignant CRC tissues,followed by prognosis analysis.We indicated that ectopic expression of ZNF575 inhibited CRC cell proliferation,colony formation and promoted cell apoptosis in vitro.Tumor growth in CRC was also impaired by ZNF575 in mice.RNA sequencing,follow-up western blotting,and qPCR results demonstrated the increase of p53,BAK,and PUMA in ZNF575-expressing CRC cells.Further results indicated that ZNF575 directly targeted the p53 promoter and promoted the transcription of p53.Downregulation of ZNF575 was confirmed in malignant tissues,and ZNF575 expression was positively correlated with the prognosis of CRC patients.The present study demonstrated the function,underlying mechanism,expression,and the prognosis-predicting role of ZNF575 in CRC,which indicated that ZNF575 would be a potential prognostic predictor and therapeutic target for CRC and other cancers.展开更多
纵观市面上形形色色的 DVD 播放机中,尽管日本品牌是 DVD 技术的领先者,但国产品牌始终是广大消费者的最爱,为何?答案只有一句话:便宜就是硬道理!其实除了价廉之外,品质也是大家所关心的,当中不乏一些称得上上品的佳作,如万利达在2000...纵观市面上形形色色的 DVD 播放机中,尽管日本品牌是 DVD 技术的领先者,但国产品牌始终是广大消费者的最爱,为何?答案只有一句话:便宜就是硬道理!其实除了价廉之外,品质也是大家所关心的,当中不乏一些称得上上品的佳作,如万利达在2000年12月以开创先河之势推出的逐行扫描 DVD 播放机 DVP-N996,内置美国国家半导体公司的 NDV8501芯片,以其优异的画质和强大的性能获得广大发烧友的青睐;紧接着,创维的1050P 和奇声的4026这两台在国内很难找到的产品(主要是供外销)首创国产 DVD 播放机带 Farouja 公司的DCDi 逐行扫描技术而令吹捧者众,单是一枚 FL2200芯片这一"杀手锏"就令不少发烧友对其苦苦追寻;直至2002年10月,万利达以强势力推巅峰之作(5)占VD 播放机DVP-600,将国产 DVD 播放机的水平推向极致,既叫好又叫座,简直是一时无两,从而也奠定了万利达在业界中的翘楚地位。展开更多
文摘SONY 在 DVD 市场上的表现一直都有着出色的表现,在高端机种中出现过像 DVP-S9000ES、DVP-NS999ES 等一代广为人知的一代高级名机,中低端的各种型号更是不计其数,实力无需怀疑。在 DVD 持续增长的中国市场,前几年虽有个别型号推出,但未形成足够的力度,反而让不少品牌走到前面去了,对此,相信 SONY 的一些 FANS 们都心有不甘。不过,我的看法却有不同,SONY 只不过是蓄势待发,一但时机成熟,也就是反攻之日。果然,今年的4月20日,SONY(中国)有限公司发布了新一代的多款 DVD 机,其中最先上市的就是这款 SONY DVP-NS575P。到底该机有何本事可以令到 SONY 在 DVD 机市场上展开反攻呢?下面就让我们一起来看一看这款 DVP-NS575P 吧。
基金supported by grants from Sichuan Provincial Science and Technology(2022NSFSC0742).
文摘Zinc-finger proteins play different roles in cancer;however,the function of zinc-finger protein ZNF575 in cancer remains unclear.In the present study,we aimed to determine the function and expression of ZNF575 in colorectal cancer.Proliferation assay,colony formation assay,and tumor model in mice were used to investigate the function of ZNF575 after ectopic expression of ZNF575 in colorectal cancer(CRC)cells.RNA sequencing,ChIP,and luciferase assays were used to investigate the mechanism behind ZNF575 regulation of CRC cell growth.The expression of ZNF575 was determined by IHC staining in 150 pairs of malignant CRC tissues,followed by prognosis analysis.We indicated that ectopic expression of ZNF575 inhibited CRC cell proliferation,colony formation and promoted cell apoptosis in vitro.Tumor growth in CRC was also impaired by ZNF575 in mice.RNA sequencing,follow-up western blotting,and qPCR results demonstrated the increase of p53,BAK,and PUMA in ZNF575-expressing CRC cells.Further results indicated that ZNF575 directly targeted the p53 promoter and promoted the transcription of p53.Downregulation of ZNF575 was confirmed in malignant tissues,and ZNF575 expression was positively correlated with the prognosis of CRC patients.The present study demonstrated the function,underlying mechanism,expression,and the prognosis-predicting role of ZNF575 in CRC,which indicated that ZNF575 would be a potential prognostic predictor and therapeutic target for CRC and other cancers.
文摘纵观市面上形形色色的 DVD 播放机中,尽管日本品牌是 DVD 技术的领先者,但国产品牌始终是广大消费者的最爱,为何?答案只有一句话:便宜就是硬道理!其实除了价廉之外,品质也是大家所关心的,当中不乏一些称得上上品的佳作,如万利达在2000年12月以开创先河之势推出的逐行扫描 DVD 播放机 DVP-N996,内置美国国家半导体公司的 NDV8501芯片,以其优异的画质和强大的性能获得广大发烧友的青睐;紧接着,创维的1050P 和奇声的4026这两台在国内很难找到的产品(主要是供外销)首创国产 DVD 播放机带 Farouja 公司的DCDi 逐行扫描技术而令吹捧者众,单是一枚 FL2200芯片这一"杀手锏"就令不少发烧友对其苦苦追寻;直至2002年10月,万利达以强势力推巅峰之作(5)占VD 播放机DVP-600,将国产 DVD 播放机的水平推向极致,既叫好又叫座,简直是一时无两,从而也奠定了万利达在业界中的翘楚地位。
