Objective:To study the effect of Dachengqi Granule (DCQG) on endotoxin level in rats of enterogenous endotoxemia.Methods: Enterogenous endotoxemia model of rats was mad e by peritoneal injection of E.coli. In the tr...Objective:To study the effect of Dachengqi Granule (DCQG) on endotoxin level in rats of enterogenous endotoxemia.Methods: Enterogenous endotoxemia model of rats was mad e by peritoneal injection of E.coli. In the treated groups, the rats were treat ed with different doses of DCQG, cefaclor and DCQG plus cefaclor respectively, starting from 3 days before to 1 day after modeling. Endotoxin levels in plasma, urine and stool were determined and compared. Results: Except for the cefaclor group, the plasma and urine endotoxin levels in the treated groups were lower significantly ( P <0.0 5), while the endotoxin level in stool was obviously higher than that in the unt reated model group.Conclusion:DCQG has the intestinal barrier protective e ffect including anti-bacteria, anti-inflammation and clearing endotoxin.展开更多
Objective: To study the effects of Dachengqi Tang (DCQT) granule on the proliferation of the intestinal epithelial cells in rats with experimental intestinal obstruction. Methods: Experimental intestinal obstruction m...Objective: To study the effects of Dachengqi Tang (DCQT) granule on the proliferation of the intestinal epithelial cells in rats with experimental intestinal obstruction. Methods: Experimental intestinal obstruction models were established in rats and autoradiography with 3 H-TdR was used to determine 3H-TdR labeling counts of intestinal epithelial cells in rats. Results: DCQT granule had no effects on 3H-TdR labeling counts of intestinal epithelial cells in normal rats. DCQT granule obviously increases the rate of renovation in intestinal epithelial cells of the intestinal obstruction rats. Conclusion: DCQT granule could reinforce the intestinal mucosa's defensive function by means of increasing the proliferation of intestinal epithelial cells.展开更多
文摘Objective:To study the effect of Dachengqi Granule (DCQG) on endotoxin level in rats of enterogenous endotoxemia.Methods: Enterogenous endotoxemia model of rats was mad e by peritoneal injection of E.coli. In the treated groups, the rats were treat ed with different doses of DCQG, cefaclor and DCQG plus cefaclor respectively, starting from 3 days before to 1 day after modeling. Endotoxin levels in plasma, urine and stool were determined and compared. Results: Except for the cefaclor group, the plasma and urine endotoxin levels in the treated groups were lower significantly ( P <0.0 5), while the endotoxin level in stool was obviously higher than that in the unt reated model group.Conclusion:DCQG has the intestinal barrier protective e ffect including anti-bacteria, anti-inflammation and clearing endotoxin.
基金This project was supported by the State's Key Projects of the Tenth Five-year Plan (No. 969030105)
文摘Objective: To study the effects of Dachengqi Tang (DCQT) granule on the proliferation of the intestinal epithelial cells in rats with experimental intestinal obstruction. Methods: Experimental intestinal obstruction models were established in rats and autoradiography with 3 H-TdR was used to determine 3H-TdR labeling counts of intestinal epithelial cells in rats. Results: DCQT granule had no effects on 3H-TdR labeling counts of intestinal epithelial cells in normal rats. DCQT granule obviously increases the rate of renovation in intestinal epithelial cells of the intestinal obstruction rats. Conclusion: DCQT granule could reinforce the intestinal mucosa's defensive function by means of increasing the proliferation of intestinal epithelial cells.
