Treatment of rotaviral gastroenteritis with Qiwei Baizhu powder

AIM To observe the effects of Qiwei Baizhu Powder ( QWBZP) on rotaviral gastroenteritis in children and in animal models.``METHODS Enrolled patients were divided into two groups, and one group was treated with oral rehydration solution(ORS) and the other treated with oral liquid of QWBZP. Neonate mice were orally infected with 50 μLrotavirus suspension (4 × l0s PFU/mL) and treated with ORS or oral liquid of QWBZP, respectively.``RESULTS Eighty-three cases of rotaviral gastroenteritis treated with QWBZP revealed a better efficacy than that treated with ORS (x2 - 10.8T, P<0.05). The contents of sodium and glucose as well as number of patients with positive human rotavirus antigen in stool in QWBZP group were all less than that in ORS group. In animal models,QWBZP was found effective in treating rotavirus gastroenteritis in neonate NIH mice, as compared with control groups. In QWBZP group, the mortality of infected mice was decreased by 73.3%, the body weight of infected mice was increased, the contents of sodium and glucose as well as number of mice with positive rotavirus antigen in feces were significantly reduced, and the pathological changes such as damage of small intestinal mucosa and villi were also obviously alleviated.``CONCLUSION QWBZP has effects on improving the absorptive function of small intestine, shortening the duration of diarrhea and rotavirus shedding from stool and alleviating the pathological changes of small intestine induced by rotavirus.

黛矾散治疗肝内胆汁淤积症的临床研究

目的:观察黛矾散治疗肝内胆汁淤积症的临床疗效及安全性。方法:70例肝内胆汁淤积患者按就诊顺序随机分为两组,各35例。治疗组患者以基础治疗加黛矾散(1.5g次/,3次/d)口服;对照组患者以基础治疗加熊去氧胆酸(150mg/次,3次/d)口服。分别检测其血清总胆红素(TB il)、直接胆红素(DB il)、丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)、总胆汁酸(TBA)、γ-谷氨酰转肽酶(GGT),观察各项临床症状变化。结果:治疗组临床治愈率28.57%,总有效率88.57%;对照组分别为14.29%、54.29%。治疗组疗效优于对照组,两组间比较差异有显著性意义(P<0.05)。治疗组临床症状和体征改善情况优于对照组(P<0.05)。治疗后TB i、lDB i、lALT、TBA、ALP、GGT水平治疗组与对照组比较差异有显著性意义(P<0.05)。两组均未发现明显毒副作用。结论:黛矾散治疗肝内胆汁淤积症具有良好的临床疗效及安全性。