Meta-analysis of traditional Chinese medicine dampness-removing therapy in the treatment of psoriasis vulgaris

Objective:To systematically evaluate the clinical effect and safety of dampness-removing therapy in the treatment of psoriasis vulgaris by Meta analysis.Methods:The clinical studies on the treatment of psoriasis with removing dampness therapy in CNKI,Wanfang,VIP,SinoMed,Medline,Embase and Cochrane Library were searched from the establishment of the database to June 2021.After screening,data extraction and bias risk assessment,the retrieved literature was statistically analyzed by Revman5.3 software.Results:A total of 2063 subjects were included in 24 clinical studies.The results of Meta analysis showed that the experimental group was superior to the control group in terms of total effective rate of treatment(OR=3.31,95%CI[2.55,4.31]),reducing PASI score(MD=-2.57,95%CI[-3.08,-2.06])and improving quality of life(MD=-3.23,95%CI[-3.70,-2.76]).The adverse reactions in the experimental group were slighter than those in the control group(OR=0.42,95%CI[0.29,0.61]).Conclusion:The method of removing dampness in traditional Chinese medicine is safe and effective in the treatment of psoriasis vulgaris,but in view of the low overall quality of the included research,larger samples and higher quality clinical trials are still needed to obtain more sufficient evidence.

Research progress of heat-clearing and dampness-removing method to improve the inflammatory microenvironment of gout

Gout is a metabolic bone and joint disease caused by purine metabolism disorder.The disturbance of inflammatory microenvironment caused by monosodium urate(MSU)deposition is an important pathological mechanism of gout occurrence and development.In the understanding of Traditional Chinese medicine(TCM),the interaction of"dampness","heat"and"stasis"is the main pathogenesis of gout,and the method of clearing heat and removing dampness is the main treatment method of TCM for gout.In recent years,studies have found that heat-clearing and dampness-removing method can improve the TCM symptom score of gout patients,especially in the body tiredness,dry mouth and dry throat,short yellow urine,thirsty,etc.,which are the characteristics of dampness and heat syndrome,this may be related to the fact that the TCM heat-clearing and dampness-removing method in the treatment of gout removes the appearance of dampness and heat,improves the inflammatory microenvironment of gout and restores the normal metabolic function of human body.This paper deeply explores the specific mechanism of TCM heat-clearing and dampness-removing method to improve the inflammatory microenvironment of gout,which can provide new ideas for the diagnosis and treatment of clinical gout.

Analysis on application law of dampness-removing traditional Chinese medicines in treatment of coronavirus disease 2019

Objective:Coronavirus Disease 2019(COVID-19)has been diagnosed as an epidemic disease characterized by cold and dampness pathogens in TCM clinic.Due to many Chinese medicines with different functions were used in the treatment of COVID-19,it is very important to find the law of application of dampremoving traditional Chinese medicine with high frequency application,with view to providing a reference for the use and research of Chinese medicine to further control the pandemic.Methods:The publicly released diagnosis and treatment programs issued by the National Health Commission and Health Commission of provinces,autonomous regions and municipalities,and Chinese herbs prescription information in these were collected,a database was established,and Excel and Graphpad 8.0 software were used to analyze the frequency of use of various Chinese medicines,the frequency and property characters including five flavors(bitter,pungent,sweet,sour,and salty)and four natures(warm,hot,cool,and cold)and channel tropisms of Chinese medicine for removing dampness.Results:A total of 137 prescriptions of Chinese medicine for treating COVID-19 were collected,including178 TCMs showing functions of resolving phlegm,relieving cough and asthma,resolving dampness,clearing damp and inducing dieresis,clearing heat,tonifying deficiency,and relieving exterior syndrome,in which the TCMs with the first four functions that we called the dampness-removing TCMs,accounted for 35.78%.Also a number of TCMs in the rest functions showed removing-dampness.The first four functions were divided into subfunctions including aromatic resolving dampness,clearing heat and drying dampness,drying dampness and tonifying spleen qi,drying dampness and removing phlegm,inducing diuresis and relieving swelling,inducing diuresis and relieving exterior syndrome.Among them,the most frequently used TCMs was Ephedrae Herba,followed by Citri Reticulatae Pericarpium,Pogostemonis Herba,Pinelliae Rhizoma,Poria,Scutellariae Radix,and Atractylodis Rhizoma.The property character analysis in the dampness-removing TCMs showed that bitter and pungent were largely present and sour and astringent were absent,warm and hot were dominant;And the lung,spleen,stomach,large intestine,bladder were main channel tropisms.Conclusion:Dampness-removing TCMs are the first important type of traditional Chinese medicine to be considered in the treatment of COVID-19 in Chinese medicine.The application of dampness-removing TCMs in the treatment of COVID-19 needs to be combined with its application law.This study may provide meaningful and useful information on further research to investigate the effective compounds from the dampness-removing Chinese medicine with high frequency application,and also provide a reference for the clinical treatment of COVID-19 accurately against dampness evil with dampness-removing traditional Chinese medicines.