The Pan-1 coal mine located in Huainan municipality, Anhui province, is abundant in coal resources. In order to discover the natural conditions of gas in its coal seams, we inverted the burial history of these coal se...The Pan-1 coal mine located in Huainan municipality, Anhui province, is abundant in coal resources. In order to discover the natural conditions of gas in its coal seams, we inverted the burial history of these coal seams using the software of Easy%Ro method and simulated the development process of gas volumes and pressure of the major coal seams using CBM History Simulation Software. Our analysis shows that the devolution of gas volumes and levels of pressure can be divided into four stages: i.e., a biogas stage (P1-P3), a pyrolysis gas stage (T1-T2), an active gas enrichment stage (T3-K1) and a gas dissipating stage (K2-present). Currently, the average amounts of gas and gas pressure in coal seams Nos. 13-1, 11-2 and 8 of the Pan-1 coal mine are 8.18 m3/t and 2.20 MPa; 3.89 m3/t and 2.47 MPa and 6.35 m3/t and 2.89 MPa, respectively. This agrees very well with current mining data.展开更多
Objective： The aim of this case-control study was to explore whether five tagging single nucleotide poly- morphisms （tSNPs） within the transforming growth factor-ill （TGF-fll） gene were involved in manifestation ...Objective： The aim of this case-control study was to explore whether five tagging single nucleotide poly- morphisms （tSNPs） within the transforming growth factor-ill （TGF-fll） gene were involved in manifestation of inflammatory and fibrotic processes associated with coal workers pneumoconiosis （CWP）. Methods： The study included 508 CWP patients and 526 controls who were underground coal miners from Xuzhou Mining Business Group. Five tSNPs were selected from the HapMap and detected by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method. Results： The single SNP analysis showed that the genotype frequencies of SNP2 （rs1800470, ＋869T/C, extron 1） and SNP5 （rs11466345, intron 5） in CWP cases were significantly different from those in controls. Multivariate logistic regression analysis revealed that SNP2 （rs1800470） CC genotype was associated with decreased risk of CWP （OR = 0.50, 95% CI = 0.32-0.78）, which was evident among subgroups of those never smoke （OR = 0.40, 95%CI = 0.24-0.66）, cases with stage Ⅱ（OR = 0.41, 95%CI = 0.22-0.76） and exposure period （〈 28 y： OR = 0.54, 95%CI = 0.31-0.95; ≥ 28 y： OR = 0.52, 95%CI = 0.32-0.96）. However, the SNP5 （rs11466345） GG genotype was associated with an increased risk of CWP （OR = 2.5, 95%CI = 1.36-4.57）, and further stratification analysis showed that the risk of CWP was increased in both smoking and nonsmoking groups, shorter and longer exposure groups, while the risk of CWP was only increased in patients with stage I and Ⅱ. Conclusion： This study suggests that TGF-β1 polymorphisms may contribute to susceptibility of CWP.展开更多
As a case study of the Panji No.1 Coal Mine in Anhui Province, based on thesite measured and statistical data, summarized the lithologic associations, characteristicsand distribution laws of interlayer-gliding structu...As a case study of the Panji No.1 Coal Mine in Anhui Province, based on thesite measured and statistical data, summarized the lithologic associations, characteristicsand distribution laws of interlayer-gliding structures and tectonic coal in the No.11-2 coalseams.The results show that 9 modes of lithologic association can form interlayer-glidingstructures.It is more easy for rock slip to occur when the lithologic associations are mainroof + coal seam + immediate floor type, compound roof+immediate roof + coal seam +immediate floor type and immediate roof + coal seam + immediate floor type.Lithologicassociations of roof and floor are the precondition to the formation of interlayer-glidingstructures.展开更多
基金Project 2005CB221501 supported by the National Basic Research Program of China
文摘The Pan-1 coal mine located in Huainan municipality, Anhui province, is abundant in coal resources. In order to discover the natural conditions of gas in its coal seams, we inverted the burial history of these coal seams using the software of Easy%Ro method and simulated the development process of gas volumes and pressure of the major coal seams using CBM History Simulation Software. Our analysis shows that the devolution of gas volumes and levels of pressure can be divided into four stages: i.e., a biogas stage (P1-P3), a pyrolysis gas stage (T1-T2), an active gas enrichment stage (T3-K1) and a gas dissipating stage (K2-present). Currently, the average amounts of gas and gas pressure in coal seams Nos. 13-1, 11-2 and 8 of the Pan-1 coal mine are 8.18 m3/t and 2.20 MPa; 3.89 m3/t and 2.47 MPa and 6.35 m3/t and 2.89 MPa, respectively. This agrees very well with current mining data.
基金supported by the National Natural Science Foundation of China(No.30872093)Research Foundation of Health Department of Jiangsu Province(No.H200628)
文摘Objective： The aim of this case-control study was to explore whether five tagging single nucleotide poly- morphisms （tSNPs） within the transforming growth factor-ill （TGF-fll） gene were involved in manifestation of inflammatory and fibrotic processes associated with coal workers pneumoconiosis （CWP）. Methods： The study included 508 CWP patients and 526 controls who were underground coal miners from Xuzhou Mining Business Group. Five tSNPs were selected from the HapMap and detected by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method. Results： The single SNP analysis showed that the genotype frequencies of SNP2 （rs1800470, ＋869T/C, extron 1） and SNP5 （rs11466345, intron 5） in CWP cases were significantly different from those in controls. Multivariate logistic regression analysis revealed that SNP2 （rs1800470） CC genotype was associated with decreased risk of CWP （OR = 0.50, 95% CI = 0.32-0.78）, which was evident among subgroups of those never smoke （OR = 0.40, 95%CI = 0.24-0.66）, cases with stage Ⅱ（OR = 0.41, 95%CI = 0.22-0.76） and exposure period （〈 28 y： OR = 0.54, 95%CI = 0.31-0.95; ≥ 28 y： OR = 0.52, 95%CI = 0.32-0.96）. However, the SNP5 （rs11466345） GG genotype was associated with an increased risk of CWP （OR = 2.5, 95%CI = 1.36-4.57）, and further stratification analysis showed that the risk of CWP was increased in both smoking and nonsmoking groups, shorter and longer exposure groups, while the risk of CWP was only increased in patients with stage I and Ⅱ. Conclusion： This study suggests that TGF-β1 polymorphisms may contribute to susceptibility of CWP.
基金Supported by the National Natural Science Foundation of China(40772092)
文摘As a case study of the Panji No.1 Coal Mine in Anhui Province, based on thesite measured and statistical data, summarized the lithologic associations, characteristicsand distribution laws of interlayer-gliding structures and tectonic coal in the No.11-2 coalseams.The results show that 9 modes of lithologic association can form interlayer-glidingstructures.It is more easy for rock slip to occur when the lithologic associations are mainroof + coal seam + immediate floor type, compound roof+immediate roof + coal seam +immediate floor type and immediate roof + coal seam + immediate floor type.Lithologicassociations of roof and floor are the precondition to the formation of interlayer-glidingstructures.
