Effects of Danqi Yishen Capsule on Blood Lipid Levels and Hemorheological Indicators of Hyperlipidemia Patients

Objective: To explore the effects of Danqi Yishen Capsule (Danqi Capsule for Tonifying Kidney) on blood lipid levels and hemorheological indicators of hyperlipidemia patients. Methods: A total of 96 patients with hyperlipidemia were randomly divided into the control group and observation group of 48 cases respectively. The control group was given by simvastatin in oral administration of 10 mg half an hour after dinner, once a day, while the observation group based on the treatment of the control group, was orally given Danshen Yishen Capsule of three capsules each time, three times a day. The treatment of both groups lasted for two months. Then the comparison focused on blood lipid levels, hemorheological indicators, and adverse reactions between both groups before and after the treatment. Results: There was no significant difference in blood lipid levels and hemorheological indicators between both groups before the treatment (P > 0.05). The symptoms of both groups were significantly improved after the treatment, and the difference before and after the treatment was statistically significant (P < 0.05), and the difference between both groups was also statistically significant (P < 0.05). There was no significant difference in the incidence rate of adverse reactions between both groups (P > 0.05). Conclusion: Danqi Yishen Capsule has a significant value in clinical applications, which can optimize clinical efficacy, improve blood lipid levels and hemorheological indicators of hyperlipidemia patients, as well as reduce the probability of adverse reactions in patients.

丹芪益肾胶囊对糖尿病肾病的疗效及对实验室指标的调控作用研究

目的观察丹芪益肾胶囊用于治疗糖尿病肾病(DN)的临床疗效及对实验室指标的调控作用。方法选择2016年3~12月山西省中医院收治的DN患者70例为研究对象,按照治疗方式不同分为对照组和观察组,每组35例。对照组给予基础治疗,观察组在对照组治疗基础上,给予丹芪益肾胶囊治疗,两组均持续治疗8周。比较两组临床疗效及实验室指标变化。结果观察组较对照组总有效率明显提高(88.57%比62.86%),差异有统计学意义(P<0.05)。治疗后,观察组空腹血糖(FPG)、餐后2h血糖(2hPG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)分别为(5.81±0.75)mmol/L、(7.64±2.12)mmol/L、(4.91±1.03)mmol/L、(1.71±0.46)mmol/L、(2.25±0.69)mmol/L,均明显低于对照组的(6.37±0.92)mmol/L、(8.96±1.97)mmol/L、(4.91±1.03)mmol/L、(2.17±0.52)mmol/L、(3.26±1.05)mmol/L(t=2.791、2.698、3.321、3.920、4.756,均P<0.05);观察组24h尿蛋白排泄率(UAER)、尿β2微球蛋白(β2-MG)、尿白蛋白与肌酐比值(ACR)分别为(104.12±20.61)mg/24h、(256.72±96.43)μg/L、(73.86±33.12),均低于对照组的(139.87±38.45)mg/24h、(431.12±97.84)μg/L、(125.84±38.96)(均P<0.05)。结论丹芪益肾胶囊治疗DN可提高疗效,其作用机制可能与降低血糖、调节血脂、减少尿蛋白有关。