In vitro effects of sodium hyaluronate on the proliferation and the apoptosis in chondrocytes from patients with Kashin-Beck disease and osteoarthritis

Objective：To identify the in vitro effects of sodium hyaluronate（HA） on the proliferation and the apoptosis of chondrocytes from patients with Kashin-Beck disease（KBD） and osteoarthritis（OA）. Methods：Samples of articular cartilages from KBD and OA patients, as well as healthy volunteers（6 subjects in each of the 3 groups） were dissected, digested with collagenase and the cells cultured in monolayers. Chondrocytes from each sample were assigned to an untreated group and two HA-treated groups： H0（no HA）, H100（HA, 0.1 g/L） and H500（HA, 0.5 g/L）. The first passage chondrocytes were used to observe proliferation using the MTT assay, and apoptosis by flow cytometry through Annexin V/PI staining. Results：HA promoted proliferation of chondrocytes in all the three groups, and.in KBD and OA groups, for cells cultured for 4 and 6 days, H500 significantly promoted the cell proliferation. The apoptotic rates of both KBD and OA group chondrocytes were in the order H500 〈 HA100 〈 H0. Conclusion：Sodium hyaluronate administration has a dosedependent in vitro effect to promote proliferation and inhibit apoptosis of chondrocytes from patients with KBD and OA.

Effect of arthroscopic debridement combined with intra-articular sodium hyaluronate injection on the Wnt/β-catenin pathway in joint fluid of patients with knee osteoarthritis

Objective: To investigate the effect of arthroscopic debridement combined with intra-articular sodium hyaluronate injection on the Wnt/β-catenin pathway in joint fluid of patients with knee osteoarthritis. Methods: Patients undergoing arthroscopic debridement for knee osteoarthritis in the hospital between June 2014 and April 2017 were selected as the research subjects and randomly divided into the observation group who accepted arthroscopic debridement combined with intra-articular sodium hyaluronate injection and the control group who accepted arthroscopic debridement alone. The Wnt/β-catenin pathway molecules as well as downstream collagen metabolism molecules and bone metabolism molecules in the joint fluid were measured before surgery and 7 d after surgery. Results: 7 d after surgery, Wnt1, Wnt5a, Wnt7b, β-catenin, MMP1, MMP13, CTX-I, CTX-II, ADAMTS4, ADAMTS5, RANK, RANKL and TRACP5b mRNA expression in joint fluid of both groups of patients were higher than those before surgery whereas OPG and OC contents were lower than those before surgery, and Wnt1, Wnt5a, Wnt7b, β-catenin, MMP1, MMP13, CTX-I, CTX-II, ADAMTS4, ADAMTS5, RANK, RANKL and TRACP5b mRNA expression in joint fluid of observation group were significantly lower than those of control group whereas OPG and OC contents were significantly higher than those of control group. Conclusion: Arthroscopic debridement combined with intra-articular sodium hyaluronate injection can inhibit the collagen metabolism and bone metabolism disorder mediated by Wnt/β-catenin after surgery.

Clinical effect of Rehabmtation Treating combined with Intra-Articular Injection of Sodium Hyaluronate for Exercise induced knee osteoarthritis

Objective: To study the clinical effect of rehabmtation treating combined with intra-articular injection of sodium hyaluronate for exercise induced knee osteoarthritis, and to research the function, biomechanics of knee joint, and inflammatory factor in articular cavity. Method:Selecting 120 patients with exercise induced knee osteoarthritis, then they were randomly divided into control group (n=60) and intervene group (n=60). The patients in the control group were given conventional rehabmtation treating, and the intervene group were given intra-articular injection of sodium hyaluronate on this basic, they were treated 4 weeks. Evaluating the function of knee joint;conduct isokinetic muscle strength test (determination of the angIllar velocity were 60°/S, 180°/S);test the ratio of muscle peak torque and four muscles centripetal centripetal peak torque and peak torque, work load of femoral knee joints after (simultaneous determination of the angular velocity were 60°/S);detect the inflammatory factor in the joint fluid. Results: After the treatment, clinical effect in intervene group was superior to that in control group,but had no statistical significance;after the treatment, the score of function of knee joint in the two groups were higher than before treatment, and had statistical significance, and the score of function of knee joint in the intervene group were higher than control group, and the difference had statistical significance;Angular velocity of 60°/S and 180°/S the two groups peak torque, work load and the H/Q values were significantly increased, the intervene group were higher than control group, and the difference had statistical significance;inflammatory factor in the two groups were significantly decreased, the intervene group were lower than control group, and the difference had statistical significance.Conclusions: On the basic of rehabmtation treating, the treatment of intra-articular injection of sodium hyaluronate can improve the function of knee joint through improving the knee muscle strength, the level of their participation in the activities of the biomechanics of knee joint, and the inflammatory factor in the joint fluid.

Meta-analysis of the traditional Chinese medicine fumigation combined with sodium hyaluronate in the treatment of knee osteoarthritis

Objective:To explore the meta-analysis of traditional Chinese medicine fumigation combined with sodium hyaluronate in the treatment of knee osteoarthritis.Methods: The database was originated from CNKI, Wanfang, Chongqing Weipu database, PubMed and so on. The deadline was April 2017. The database was searched with the keywords of'Chinese herbal fumigation','sodium hyaluronate' and'knee osteoarthritis'. Finally, 13 articles about the treatment of Chinese herbal fumigation combined with sodium hyaluronate were obtained. RCT literatures of knee osteoarthritis identified the outcome indicators as the effective rate and recovery rate. Lysholm's score was observed after treatment in both groups, and all the results were input into Review Manager 5.2 for analysis.Result: A total of 13 RCT literatures about the treatment of knee osteoarthritis with Chinese herbal fumigation and sodium hyaluronate were obtained. The control group was treated with sodium hyaluronate or anti-inflammatory drugs, totaling 619 cases. The study group was treated with sodium hyaluronate and Chinese herbal fumigation, totaling 649 cases. The combined effect of forest map OR=1.82, Z=5.00 (P<0.00001), 95% CI. (1.44, 2.30). Compared with sodium hyaluronate or anti-inflammatory drugs, fumigation with traditional Chinese medicine combined with sodium hyaluronate has obvious advantages in curing knee osteoarthritis. The combined effect of forest chart OR=5.55, Z=7.44 (P<0.00001), 95% CI (3.54, 8.73), indicating that compared with sodium hyaluronate or anti-inflammatory drugs, traditional Chinese medicine is used. Fumigation combined with sodium hyaluronate has obvious advantages in the treatment of knee osteoarthritis;forest map combined effect OR=12.11, Z=5.18 (P<0.00001), 95% CI (7.53, 16.68), indicating that compared with sodium hyaluronate or anti-inflammatory drugs, traditional Chinese medicine fumigation combined with sodium hyaluronate in the treatment of knee osteoarthritis can restore knee joint function. Advantages.Conclusion: Chinese herbal fumigation combined with sodium hyaluronate has obvious advantages in curing and effective rate of knee osteoarthritis, and can better restore knee joint function. Due to the lack of literature and low quality, the exact effect still needs to be confirmed by higher quality RCT literature.

Therapeutic effect of an injectable sustained-release sinomenine hydrochloride and sodium hyaluronate compound in a rabbit model of osteoarthritis

Background While intra-articular injection of sinomenine hydrochloride has a therapeutic effect on osteoarthritis, it has a short half-life, and is thermolabile and photolabile. The aim of this research was to evaluate the sustained-release of sinomenine hydrochloride from an injectable sinomenine hydrochloride and sodium hyaluronate compound （CSSSI） and its therapeutic effect in a rabbit model of osteoarthritis following intra-articular injection. Methods An injectable compound consisting of 1% sodium hyaluronate and 2.5% sinomenine hydrochloride was prepared and kept as the experiment group, and 2.5% sinomenine hydrochloride was prepared and kept as the control group. The cumulative mass release was measured at different time points in each group in vitro. Sixty-five male Zelanian rabbits were randomly divided into five groups： 15 （30 knees） each for the control, sodium hyaluronate, sinomenine hydrochloride, and CSSSI groups respectively, and five （10 knees） for the modeling group. Papain was injected into both knees of each rabbit for model establishment. Subsequently, 0.2 ml of the corresponding drugs was injected into the articular cavities of the remaining experiment groups, while the control group was treated with 0.2 ml normal saline. All groups were treated once a week for 4 weeks. Seven days after the last treatment, knees were anatomized to perl^orm pathological observations and Mankin＇s evaluation of the synovium. Four groups were compared using the SPSS 13.0 software package. Results In the in vitro sustained-release experiments, 90% of the drug was released in the experiment group 360 minutes following the injection. Comparison of the Mankin＇s evaluations of the four groups illustrated statistical discrepancies （P 〈0.05）. In further paired comparisons of the CSSSI group vs. modeling control/sodium hyaluronate/sinomenine hydrochloride groups, statistical significance was uniformly obtained. Moreover, sodium hyaluronate and sinomenine hydrochloride treatments showed significant improvement over the modeling control （P 〈0.05）, whereas sodium hyaluronate vs. sinomenine hydrochloride comparison failed to reach significance （P 〉0.05）. Conclusions CSSSI has a sustained-release effect on sinomenine hydrochloride. Intra-articular injection of CSSSI was significantly better than the sole sodium hyaluronate or sinomenine hydrochloride for the treatment of osteoarthritis in a rabbit model.

The effects of sodium hyaluronate on mRNA expressions of matrix metalloproteinase-1,-3 and tissue inhibitor of metalloproteinase-1 in cartilage and synovium of traumatic osteoarthritis model

Objective: To observe the influence of intra-articular injection of sodium hyaluronate (HA) on the mRNA expressions of matrix metalloproteinase-1,-3 (MMP-1,-3) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in cartilage and synovium of traumatic osteoarthritis (OA).Methods: Sixteen white rabbits underwent unilateral anterior cruciate ligament transection (ACLT) were divided into 2 groups randomly 5 weeks after transection. The experimental group rabbits received 0.3 ml of 1% HA by intra-articular injection once a week. Animals in the control group were treated under the same conditions using physiological saline. Ten weeks following surgery, cartilage and synovium were harvested. The mRNA expressions of MMP-1, MMP-3 and TIMP-1 were analyzed using reverse transcription-polymerase chain reaction (RT-PCR).Results: In synovium, the mRNA expression of MMP-3 was suppressed in the HA injection group. HA treatment had no effect on the MMP-3 expression in cartilage. No significant difference of MMP-1 and TIMP-1 expressions in cartilage and synovium was found between the HA injection group and the control group.Conclusions: One of the mechanisms of the therapeutic effect of HA may be the inhibition of expression of MMP-3 in synovium during early stage of traumatic OA.

Effect of holistic stratification acupotomy on lower limb function,MMP1 and MMP13 in bursal fluid of patients with knee osteoarthritis:A randomized clinical trail

Objective:To observe the differences in clinical effect on knee osteoarthritis(KOA)between the holistic stratification acupotomy and the joint injection with sodium hyaluronate so as to provide a safe and effective treatment for KOA.Methods:A total of 100 KOA patients were randomly divided into an acupotomy group and a sodium hyaluronate group,50 patients in each one.In the acupotomy group,the holistic stratification acupotomy was adopted.In the sodium hyaluronate group,sodium hyaluronate injection was applied in the joints.The index of Western Ontario and McMaster University(WOMAC)and the expressions of MMP1 and MMP13 in bursal fluid of the patients were compared before and after treatment in the patients between two groups before and after treatment,and the clinical therapeutic effect was observed.Results:After treatment,WOMAC score of each dimension and the concentrations of MMP1 and MMP13 in bursal fluid of the patients of either group were all lower than those before treatment(all P<0.05).After treatment,WOMAC score of each dimension and the concentrations of MMP1 and MMP13 in bursal fluid in the acupotomy group were lower than the sodium hyaluronate group(all P<0.05).The total effective rate in the acupotomy group was higher than that of the sodium hyaluronate group(P<0.05).Conclusion:Both the holistic stratification acupotomy and the joint injection with sodium hyaluronate are effective on KOA in this trial.However,the therapeutic effect of holistic stratification acupotomy is remarkable,which is probably related to the improvements in inflammatory response.

人工虎骨粉与玻璃酸钠联合治疗肝肾亏虚型膝骨关节炎的效果分析

目的观察人工虎骨粉与玻璃酸钠联合治疗肝肾亏虚型膝骨关节炎的临床疗效。方法按随机数字表法将120例肝肾亏虚型膝骨关节炎患者分为对照组和治疗组,每组60例。对照组患者每周进行一次玻璃酸钠关节腔内注射治疗,治疗组患者在对照组基础上给予人工虎骨粉口服治疗。持续治疗5周后,比较两组治疗前后Lequesne评分、WOMAC评分、膝关节Lysholm评分、膝骨性关节炎症状分级量化表、中医证候评分,采用ELISA法检测两组治疗前后关节液中MMP-3、TIMP-1、IL-1β及TGF-β1水平。结果治疗组总有效率为86.67%,总满意度91.67%,高于对照组(P<0.05)。治疗后,两组Lequesne评分、WOMAC评分、膝骨性关节炎症状分级量化表评分、中医证候评分及MMP-3、IL-1β表达水平显著降低(P<0.05),且治疗组降低程度低于对照组(P<0.05);治疗后,两组膝关节Lysholm评分,关节液TIMP-1、TGF-β1水平较治疗前升高(P<0.05),且治疗组升高水平明显高于对照组(P<0.05)。结论人工虎骨粉与玻璃酸钠治疗肝肾亏虚型膝骨关节炎可明显改善膝关节活动功能,缓解膝骨关节炎的症状,其机制可能与降低关节液中MMP-3、IL-1β水平,升高TIMP-1、TGF-β1的水平相关。

富血小板血浆注射对膝关节骨性关节炎的观察研究

目的膝关节骨性关节炎(KOA)是一种关节软骨退行性病理改变,患者多见于中老年人群。富血小板血浆(PRP)关节腔内注射可以改善关节疼痛,修复损伤的关节软组织,然而PRP是否可以通过促进成纤维细胞增殖和骨膜增厚,促进滑膜与骨膜修复,促进炎症的吸收,缓解膝关节疼痛,改善膝关节功能,从而达到治疗骨性关节炎目的,有待进一步研究。本研究拟通过关节腔内注射PRP观察对骨性关节炎疼痛影响及膝关节滑膜、骨膜改变和膝关节功能变化。方法收集本院自愿接受治疗的膝关节骨性关节炎患者40例,随机分为两组,治疗组:注射PRP;对照组:注射玻璃酸钠。每隔7 d治疗1次,共3次,分别观察患者治疗前(第0周),第1次注射后1周(第1周)、第2次注射后1周(第2周)、第3次注射后1周(第3周)、注射完毕后12周(第15周),膝关节疼痛NRS评分,骨膜、滑膜变化,膝关节功能改善程度、骨性关节炎分级改变及患者满意度。结果(1)治疗组与对照组治疗后疼痛评分均下降,差异有统计学意义(P<0.05),治疗组第15周NRS评分显著低于对照组,差异有统计学意义(P<0.05);(2)治疗组第15周滑膜数值低于治疗前及对照组,差异有统计学意义(P<0.05);(3)两组治疗后患者膝关节功能关节改善程度数值均低于治疗前,差异有统计学意义(P<0.05),且15周治疗组数值低于对照组,差异有统计学意义(P<0.05)。结论采用PRP治疗膝关节骨性关节炎可有效缓解膝关节疼痛,促进骨膜及滑膜修复,改善膝关节功能。

膝骨关节炎患者SFRP与玻璃酸钠治疗效果的关系

目的探讨膝骨关节炎(knee osteoarthritis,KOA)患者分泌型卷曲相关蛋白(secretory curl related protein,SFRP)水平与玻璃酸钠治疗效果的关系。方法选取2021年5月至2023年6月温州市中医院收治的KOA患者89例纳入观察组,所有患者均采用玻璃酸钠治疗,根据治疗效果分为显效/好转组和效果差组;同期选取67名健康体检者纳入对照组。采用酶联免疫吸附试验测定各组纳入者的SFRP1、SFRP2和SFRP5水平,并对KOA患者玻璃酸钠治疗效果进行多因素Logistic回归分析;绘制受试者操作特征曲线(receiver operating characteristic curve,ROC曲线),分析SFRP水平在KOA患者治疗效果中的评价效能。结果观察组患者的SFRP1、SFRP2及SFRP5水平低于对照组(P<0.05);89例KOA患者经玻璃酸钠治疗后,67例治疗效果良好(75.28%),显效/好转组患者的SFRP1、SFRP2及SFRP5水平高于效果差组(P<0.05);多因素分析结果表明,SFRP1、SFRP2、SFRP5水平及西安大略和麦克马斯特大学骨关节炎指数均为KOA患者治疗效果的影响因素(P<0.05);ROC曲线结果表明,SFRP1、SFRP2联合SFRP5对KOA患者治疗效果评价的敏感度和特异性高于单一指标(P<0.05)。结论SFRP1、SFRP2和SFRP5在KOA患者中呈低表达,其表达水平与患者玻璃酸钠治疗效果存在紧密联系,不同指标联合测定可提高预测的敏感度和特异性。

关节镜手术与透明质酸钠联合治疗老年膝骨关节炎患者的效果分析

目的 分析对老年膝骨关节炎患者开展关节镜手术与透明质酸钠联合治疗的可行性,并探究所获取的治疗效果。方法 84例老年膝骨关节炎患者,通过随机抽签的方式分为研究组及参照组,每组42例。研究组患者开展关节镜手术与透明质酸钠联合治疗,参照组患者采用关节镜手术单独治疗。对比两组疗效,治疗前后的炎症指标[白细胞介素-6 (IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]、代谢指标[软骨寡聚基质蛋白(COMP)、Ⅱ型胶原交联羧基端肽(CTX-Ⅱ)、基质金属蛋白酶(MMP-3)]、各项评分[视觉模拟评分法(VAS)评分、Lyshlom评分],手术和术后指标。结果 研究组治疗总有效率97.62%较参照组的78.57%高,具有统计学差异(P<0.05)。治疗后,研究组患者的TNF-α(1.52±0.99)μg/L、IL-6(87.93±22.54)μg/L、hs-CRP(23.17±11.86)mg/L较参照组的(2.38±1.43)μg/L、(106.48±21.37)μg/L、(34.44±12.75)mg/L低,具有统计学差异(P<0.05)。治疗后,研究组患者的CTX-Ⅱ(419.73±48.40)μg/L、COMP(2.96±0.50)μg/L、MMP-3(2.75±0.53)μg/L较参照组的(507.48±46.74)、(3.82±0.57)、(3.26±0.52)μg/L低,具有统计学差异(P<0.05)。治疗后,研究组的VAS评分(1.44±0.63)分较参照组的(3.77±1.06)分低, Lysholm评分(84.30±8.57)分较参照组的(72.64±8.35)分高,具有统计学差异(P<0.05)。研究组手术用时(56.03±7.25)min长于参照组的(50.13±6.84)min,关节愈合时间(10.34±2.09)周、完全负重功能锻炼时间(12.58±2.37)周、住院天数(8.37±1.26)d短于参照组的(14.17±2.32)周、(16.73±2.52)周、(10.23±1.63)d,具有统计学差异(P<0.05);两组术中出血量对比,无意义(P>0.05)。结论 关节镜手术与透明质酸钠联合治疗老年膝骨关节炎的效果更突出,减轻疼痛程度的同时关节功能、关节功能、炎症指标均得到较大程度的改善,临床应用价值极高,可广泛推行。

透明质酸钠联合关节镜微创手术对老年膝骨关节炎患者膝关节功能及炎性因子水平的影响

目的探讨透明质酸钠联合关节镜微创手术对老年膝骨关节炎(KOA)患者膝关节功能及炎性因子水平的影响。方法选取2019年1月至2021年1月我院收治的158例老年KOA患者作为研究对象,采用随机数字表法将其分为对照组和观察组,各79例。对照组给予关节镜微创手术治疗,观察组在对照组基础上给予透明质酸钠治疗。比较两组的治疗效果。结果观察组的治疗总有效率为96.20%,显著高于对照组的84.81%(P<0.05)。治疗1、3、6个月,观察组的膝关节Lysholm评分高于对照组(P<0.05)。治疗后,观察组的白细胞介素-8(IL-8)、白细胞介素-17(IL-17)、环氧合酶-2(COX-2)水平低于对照组(P<0.05)。治疗后,观察组的总Ⅰ型胶原氨基端延长肽(TPⅠNP)、骨钙素(BGP)、骨保护素(OPG)水平高于对照组(P<0.05)。观察组的并发症总发生率低于对照组(P<0.05)。结论透明质酸钠联合关节镜微创手术治疗老年KOA患者的效果显著,可改善膝关节功能、骨代谢情况,降低炎性因子水平及并发症发生率。

玻璃酸钠联合非甾体抗炎药治疗膝骨关节炎患者的临床疗效分析

分析玻璃酸钠联合非甾体抗炎药的应用价值。选取2021年1月—2023年6月108例膝关节骨性关节炎患者为研究对象,利用随机数字表法将其分为对照组和观察组两组,每组各54例。对照组单用非甾体抗炎药治疗,观察组采用注射玻璃酸钠联合非甾体抗炎药治疗。比较两组患者疗效、不良反应发生情况的差异,以及治疗前后炎症因子水平、疼痛评分、膝关节功能评分变化。研究结果表明,观察组疗效更显著,组间差异有统计学意义(P<0.05);治疗后,观察组炎症因子水平、疼痛评分、膝关节功能评分等相关指标表现更优,组间差异有统计学意义(P<0.05)。两组患者不良反应发生情况对比,无统计学差异(P>0.05)。研究发现,玻璃酸钠联合非甾体抗炎药的疗效与安全性高,能够有效减轻机体炎症反应,缓解患者的疼痛症状,改善其膝关节功能,可推广使用。

膝关节骨性关节炎术后注射关节腔药物对患者膝关节功能和实验室因子表达的影响

目的分析膝关节骨性关节炎患者术后关节腔药物注射的临床效果。方法选取我院2021年1月到2022年8月期间收治的86例经关节镜清理术治疗的膝关节骨性关节炎患者,按简单随机化法进行分组,两组例数相等。其中对照组:术后关节腔注射玻璃酸钠;观察组基于对照组的药物注射上应用罗哌卡因+复方倍他米松混合液进行关节腔注射;对比两组膝关节功能及疼痛情况。结果两组术后膝关节HSS评分增加,NRS评分降低,且观察组术后3、7 d的HSS评分高于对照组,NRS评分低于对照组(P<0.05)。观察组术后7 d白介素(IL)-6、IL-1β及基质金属蛋白酶(MMP)-13低于对照组(P<0.05)。结论关节镜清理术后采用玻璃酸钠联合罗哌卡因+复方倍他米松混合液关节腔注射,可在近期内改善患者膝关节功能,减轻关节疼痛。

中药熏洗联合玻璃酸钠关节腔内注射治疗膝骨关节炎的有效性Meta分析

目的评价中药熏洗结合玻璃酸钠关节腔内注射治疗膝骨关节炎(knee osteoarthritis,KOA)的有效性与安全性。方法检索万方数据库(Wanfang Data)、中国知网(CNKI)、维普网(VIP)、Cochrane Library、Embase以及Pub Med 6个数据库中公开发表的关于中药熏洗联合玻璃酸钠关节腔内注射治疗膝骨关节炎的随机对照试验,检索时限为建库至2022年12月31日,采用Cochrane干预系统评价手册对纳入文献进行质量评价,运用Rev Man 5.3软件对纳入文献进行Meta分析。结果本研究共纳入16篇文献,总计1388例患者。Meta分析结果显示,与单纯使用玻璃酸钠关节腔内注射相比,联合中药熏洗治疗膝骨关节炎的有效率更高(RR=1.16,95%CI 1.11~1.21,P<0.00001),患者疼痛视觉模拟量表(VAS)评分更低(WMD=-0.64,95%CI-0.74~-0.53,P<0.00001),西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分(WMD=-6.81,95%CI-8.03~-5.59,P<0.00001)及Lysholm评分更高(WMD=4.71,95%CI 3.66~5.75,P<0.00001)。结论相比单独使用玻璃酸钠关节腔内注射治疗膝骨关节炎,联合中药熏洗可以提升疗效。

医用臭氧及曲安奈德、玻璃酸钠对膝退行性骨关节炎患者症状改善及镇痛的影响

目的研究医用臭氧与曲安奈德、玻璃酸钠对膝退行性骨关节炎(KDOA)患者的症状和镇痛的效果。方法选择2021年4月至2022年3月收治的90例KDOA患者作为观察对象,随机分为观察组和对照组,每组45例。观察组实施医用臭氧和曲安奈德、玻璃酸钠治疗,对照组予以曲安奈德以及玻璃酸钠,2组均治疗1个月。比较治疗前后的VAS、WOMAC和Lysholmp评分以及临床疗效。结果治疗1周后,2组VAS评分均有所下降(P<0.05),且观察组VAS评分较对照组低(P<0.05)。治疗1个月后,2组VAS和WOMAC评分再次降低(P<0.05),观察组VAS评分同样明显较对照组低(P<0.05)。2组Lysholm评分均有明显提升(P<0.05),且观察组较对照组更显著(P<0.05)。观察组治疗1个月后的总有效率为91.11%,对照组为75.56%,差异有统计学意义(P<0.05)。结论将医用臭氧和玻璃酸钠,以及曲安奈德的综合疗法应用于KDOA患者中的效果显著,尤其是在改善功能状态和疼痛症状等方面有独特优势。

玻璃酸钠联合塞来昔布用于膝骨关节炎射频术后临床评价

目的探讨玻璃酸钠联合塞来昔布用于膝骨关节炎(KOA)患者射频术后的临床疗效。方法选取医院2020年10月至2022年1月收治的行射频术的KOA患者108例,按治疗方案的不同分为对照组和观察组,各54例。两组患者均于射频术后第1天起口服塞来昔布胶囊,观察组患者加予膝眼关节腔内注射玻璃酸钠注射液。两组均连续用药5周,随访6个月。结果观察组总有效率为94.44%,显著高于对照组的79.63%(P<0.05)。治疗后,观察组患者的P物质、β-内啡肽、神经肽Y、5-羟色胺和前列腺素E2水平,以及肿瘤坏死因子-α、类风湿因子和白细胞介素6水平均显著低于对照组(P<0.05);治疗后1个月、3个月、6个月,观察组患者的美国特种外科医院(HSS)评分量表得分均显著高于对照组(P<0.05)。结论玻璃酸钠联合塞来昔布用于KOA患者射频术后,能有效提高临床疗效,降低疼痛介质和炎性因子水平,改善患者的疼痛程度和膝关节功能。

隐神经阻滞结合玻璃酸钠关节腔注射治疗膝关节骨关节炎的临床效果

目的:分析隐神经阻滞结合玻璃酸钠关节腔注射对膝关节骨关节炎(KOA)患者的临床疗效。方法:选取2022年1月—2024年1月北京积水潭医院贵州医院收治的96例KOA患者,随机分成两组,均48例。对照组行玻璃酸钠关节腔注射,观察组加以隐神经阻滞。比较两组治疗效果。结果:观察组治疗总有效率高于对照组;且治疗后1个月的视觉模拟评分法(VAS)评分、西安大略和麦克马斯特大学关节炎指数(WOMAC)评分低于对照组,Lysholm评分、生活质量综合评定问卷(GQOLI-74)内各维度评分高于对照组,差异有统计学意义(P<0.05)。结论:隐神经阻滞结合玻璃酸钠关节腔注射可缓解KOA患者关节疼痛,减轻关节病损程度,有助于尽快恢复膝关节功能,最终改善生活质量。

曲安奈德联合玻璃酸钠注射治疗膝骨关节炎的效果

目的:研究曲安奈德联合玻璃酸钠注射治疗膝骨关节炎(KOA)的效果。方法:选取2020年8月—2023年8月厦门医学院附属第二医院收治的100例KOA患者作为研究对象,依据随机数表法分为两组,各50例。对照组接受玻璃酸钠单药注射治疗,观察组给予曲安奈德联合玻璃酸钠注射治疗,治疗5周。比较两组临床疗效、膝关节功能[西安大略和麦克马斯特大学骨关节炎指数(WOMAC)]、骨代谢状况[骨密度(BMD)、骨钙素(OC)]、机体炎症指标[白细胞介素-1(IL-1)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)]及不良反应发生率。结果:观察组临床总有效率为96.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,观察组疼痛、僵硬、功能障碍评分及总分均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组BMD与OC均高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组IL-1、IL-6及TNF-α均低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:曲安奈德联合玻璃酸钠注射治疗KOA患者的效果显著,可有效促进机体炎症清除,改善患者的膝关节功能及骨代谢状况,且不增加不良反应发生。

针刺疗法联合关节腔注射玻璃酸钠治疗膝骨关节炎对患者疼痛与功能恢复的影响

目的探究针刺疗法联合关节腔注射玻璃酸钠治疗膝骨关节炎(KOA)对患者疼痛与功能恢复的影响。方法选取2019年1月至2020年8月于北京水利医院针灸理疗科门诊接受治疗的80例KOA患者作为研究对象,按照随机数字表法分为注射组与联合组,每组40例。注射组采用单纯关节腔注射玻璃酸钠,联合组在注射组基础上采用针刺治疗。比较两组视觉模拟评分法(VAS)、西大略湖和麦克马斯特大学骨关节指数量表(WOMAC)、生命质量综合评定问卷(GQOL-74)评分。结果治疗后1个月,两组VAS、WOMAC评分比较差异无统计学意义;治疗后6个月,联合组VAS、WOMAC评分均低于注射组,差异有统计学意义(P<0.05)。治疗后6个月,联合组躯体功能、物质功能、社会功能评分均高于注射组,差异有统计学意义(P<0.05);两组心理功能评分比较差异无统计学意义。结论针刺疗法联合关节腔注射玻璃酸钠治疗KOA在近期能改善患者疼痛症状及膝关节功能,提高日常生活能力。