Organisms evolved into different species to adapt to the environment according to the laws of Darwinian evolution. In a single life, prostate cancer cells can also evolve into tumor stem cells to adapt to the microenv...Organisms evolved into different species to adapt to the environment according to the laws of Darwinian evolution. In a single life, prostate cancer cells can also evolve into tumor stem cells to adapt to the microenvironment, such as different chemotherapeutic drugs. These cancer cells become an unrestricted growth group relatively independent of the individual. The present review attempts to establish evidence that prostate cancer cells may survive by hormonotherapy and chemotherapy by gene amplification, mutation, and alternative splicing. Simultaneously, novel treatment strategies have been cited and evaluated, avoiding the resistance mechanisms.展开更多
The neutral theory raised by Motoo Kimura in 1968 asserts that 'the great majority of evolutionary changes at the molecular level, as revealed by comparative studies of protein and DNA sequences. are caused not by...The neutral theory raised by Motoo Kimura in 1968 asserts that 'the great majority of evolutionary changes at the molecular level, as revealed by comparative studies of protein and DNA sequences. are caused not by Darwinian selection but by random drift of selectively neutral or nearly neutral mutants'.展开更多
This paper presents a novel multiple unmanned aerial vehicde(UAV)swarm cotoller based on the fractional alculus theory.This controller i designed baed on fractional order Darwinian pigeon-inepired optimization(F 0DPI0...This paper presents a novel multiple unmanned aerial vehicde(UAV)swarm cotoller based on the fractional alculus theory.This controller i designed baed on fractional order Darwinian pigeon-inepired optimization(F 0DPI0)and PID algorithm.Several comparative simulations are conducted in the paper.The simulation results reveal that FODPIObased muli-UAV formation controller is superior to the basic PIO and dilTerential evolution(DE)method.The fractional oelfcdent in F ODPIO algorithm makes it eflective optimbation with fast convergence rate,small oversboot,and better stability.Therefore,the contnoller propoeed in this paper is fessible and robust.展开更多
There are known cases where a cell sub-population bearing a selective advantage tends to or eventually replaces another cell subpopulation within an organism. This process is supposed to underlie the purging of the mo...There are known cases where a cell sub-population bearing a selective advantage tends to or eventually replaces another cell subpopulation within an organism. This process is supposed to underlie the purging of the most frequent mitochon-drial DNA pathogenic variant from leuko-cytes and other tissues. It is also likely to explain the normal increase of sex chromo-some aneuploidy in human leukocytes with age or under pathological conditions and the expansion of a cell subpopulation after the spontaneous in vivo reversion to normal of an inherited pathogenic variant.展开更多
Three-phase induction motors are becoming increasingly utilized in industrialfield due to their better efficiency and simple manufacture.The speed control of an induction motor is essential in a variety of applications,...Three-phase induction motors are becoming increasingly utilized in industrialfield due to their better efficiency and simple manufacture.The speed control of an induction motor is essential in a variety of applications,but it is dif-ficult to control.This research analyses the three-phase induction motor’s perfor-mance usingfield-oriented control(FOC)and direct torque control(DTC)techniques.The major aim of this work is to provide a critical evaluation of devel-oping a simple speed controller for induction motors with improving the perfor-mance of Induction Motor(IM).For controlling a motor,different optimization approaches are accessible;in this research,a Fuzzy Logic Controller(FLC)with Fractional Order Darwinian Particle Swarm Optimization(FODPSO)algorithm is presented to control the induction motor.The FOC and DTC are controlled using FODPSO,and their performance is compared to the traditional FOC and DTC technique.Each scheme had its own simulation model,and the results were com-pared using hardware experimental and MATLAB-Simulink.In terms of time domain specifications and torque improvement,the proposed technique surpasses the existing method.展开更多
文摘Organisms evolved into different species to adapt to the environment according to the laws of Darwinian evolution. In a single life, prostate cancer cells can also evolve into tumor stem cells to adapt to the microenvironment, such as different chemotherapeutic drugs. These cancer cells become an unrestricted growth group relatively independent of the individual. The present review attempts to establish evidence that prostate cancer cells may survive by hormonotherapy and chemotherapy by gene amplification, mutation, and alternative splicing. Simultaneously, novel treatment strategies have been cited and evaluated, avoiding the resistance mechanisms.
基金Project supported by the National Natural Science Foundation of China.
文摘The neutral theory raised by Motoo Kimura in 1968 asserts that 'the great majority of evolutionary changes at the molecular level, as revealed by comparative studies of protein and DNA sequences. are caused not by Darwinian selection but by random drift of selectively neutral or nearly neutral mutants'.
基金supported by Science and Technology Innovation 2030-Key Project of“New Generation A rtificial Intelligence”under grant#2018A AA0102403National Natural Science Foundation of China under grant#U20B2071,#91948204,#U1913602 and#U19B2033.
文摘This paper presents a novel multiple unmanned aerial vehicde(UAV)swarm cotoller based on the fractional alculus theory.This controller i designed baed on fractional order Darwinian pigeon-inepired optimization(F 0DPI0)and PID algorithm.Several comparative simulations are conducted in the paper.The simulation results reveal that FODPIObased muli-UAV formation controller is superior to the basic PIO and dilTerential evolution(DE)method.The fractional oelfcdent in F ODPIO algorithm makes it eflective optimbation with fast convergence rate,small oversboot,and better stability.Therefore,the contnoller propoeed in this paper is fessible and robust.
文摘There are known cases where a cell sub-population bearing a selective advantage tends to or eventually replaces another cell subpopulation within an organism. This process is supposed to underlie the purging of the most frequent mitochon-drial DNA pathogenic variant from leuko-cytes and other tissues. It is also likely to explain the normal increase of sex chromo-some aneuploidy in human leukocytes with age or under pathological conditions and the expansion of a cell subpopulation after the spontaneous in vivo reversion to normal of an inherited pathogenic variant.
文摘Three-phase induction motors are becoming increasingly utilized in industrialfield due to their better efficiency and simple manufacture.The speed control of an induction motor is essential in a variety of applications,but it is dif-ficult to control.This research analyses the three-phase induction motor’s perfor-mance usingfield-oriented control(FOC)and direct torque control(DTC)techniques.The major aim of this work is to provide a critical evaluation of devel-oping a simple speed controller for induction motors with improving the perfor-mance of Induction Motor(IM).For controlling a motor,different optimization approaches are accessible;in this research,a Fuzzy Logic Controller(FLC)with Fractional Order Darwinian Particle Swarm Optimization(FODPSO)algorithm is presented to control the induction motor.The FOC and DTC are controlled using FODPSO,and their performance is compared to the traditional FOC and DTC technique.Each scheme had its own simulation model,and the results were com-pared using hardware experimental and MATLAB-Simulink.In terms of time domain specifications and torque improvement,the proposed technique surpasses the existing method.
