An OWL-Based Specification of Database Management Systems

In the context of a proliferation of DatabaseManagement Systems(DBMSs),we have envisioned and produced an OWL 2 ontology able to provide a high-level machine-processable description of the DBMSs domain.This conceptualization aims to facilitate a proper execution of various software engineering processes and database-focused administration tasks.Also,it can be used to improve the decision-making process for determining/selecting the appropriate DBMS,subject to specific requirements.The proposed model describes the most important features and aspects regarding the DBMS domain,including the support for various paradigms(relational,graph-based,key-value,tree-like,etc.),query languages,platforms(servers),plus running environments(desktop,Web,cloud),specific contexts—i.e.,focusing on optimizing queries,redundancy,security,performance,schema vs.schema-less approaches,programming languages/paradigms,and others.The process of populating the ontology with significant individuals(actual DBMSs)benefits from the existing knowledge exposed by free and open machine-processable knowledge bases,by using structured data fromWikipedia and related sources.The pragmatic use of our ontology is demonstrated by two educational software solutions based on current practices in Web application development,proving support for learning and experimenting key features of the actual semantic Web technologies and tools.This approach is also an example of using multiple knowledge from database systems,semanticWeb technologies,and software engineering areas.

REDH:A database of RNA editome in hematopoietic differentiation and malignancy

Background:The conversion of adenosine(A)to inosine(I)through deamination is the prevailing form of RNA editing,impacting numerous nuclear and cytoplasmic transcripts across various eukaryotic species.Millions of high-confidence RNA editing sites have been identified and integrated into various RNA databases,providing a convenient platform for the rapid identification of key drivers of cancer and potential therapeutic targets.However,the available database for integration of RNA editing in hematopoietic cells and hematopoietic malignancies is still lacking.Methods:We downloaded RNA sequencing(RNA-seq)data of 29 leukemia patients and 19 healthy donors from National Center for Biotechnology Information(NCBI)Gene Expression Omnibus(GEO)database,and RNA-seq data of 12 mouse hematopoietic cell populations obtained from our previous research were also used.We performed sequence alignment,identified RNA editing sites,and obtained characteristic editing sites related to normal hematopoietic development and abnormal editing sites associated with hematologic diseases.Results:We established a new database,"REDH",represents RNA editome in hematopoietic differentiation and malignancy.REDH is a curated database of associations between RNA editome and hematopoiesis.REDH integrates 30,796 editing sites from 12 murine adult hematopoietic cell populations and systematically characterizes more than 400,000 edited events in malignant hematopoietic samples from 48 cohorts(human).Through the Differentiation,Disease,Enrichment,and knowledge modules,each A-to-I editing site is systematically integrated,including its distribution throughout the genome,its clinical information(human sample),and functional editing sites under physiological and pathological conditions.Furthermore,REDH compares the similarities and differences of editing sites between different hematologic malignancies and healthy control.Conclusions:REDH is accessible at http://www.redhdatabase.com/.This user-friendly database would aid in understanding the mechanisms of RNA editing in hematopoietic differentiation and malignancies.It provides a set of data related to the maintenance of hematopoietic homeostasis and identifying potential therapeutic targets in malignancies.

The Catalog Management Strategy of Distributed Data Base Systems

In this paper the catalog management strategy of the successfully integrating andrunning DDBMS C-POREL is summarized. The new catalog management strategyand its implementation scheme are based on the analysis of the catalog managementmethods of the pioneer DDBMS. The goal of the new strategy is to improve the systemefficiency. Analysis and practice show that this strategy is successful.