Eczema herpeticum vs dermatitis herpetiformis as a clue of dedicator of cytokinesis 8 deficiency diagnosis:A case report

BACKGROUND Dedicator of cytokinesis 8(DOCK 8) deficiency,also known as autosomal recessive hyper immunoglobulin E(IgE) syndrome,is a combined immunodeficiency disease that was first recognized in 2009.It is caused by genetic alterations(mutations or deletions) in the DOCK 8 gene and is characterized by multiple allergies,elevated IgE levels,and susceptibility to viral and bacterial infections.Early diagnosis is critical to optimize the success of stem cell transplantation.CASE SUMMARY This study reports the case of a pediatric patient with DOCK 8 deficiency who had negative genetic testing using multiplex primary immunodeficiency(PID) panel and whole-exome sequencing(WES) with a next-generation sequencing method.He presented with chronic diarrhea and was managed as celiac disease based on previous negative workup for immunodeficiency and duodenal biopsy.He developed a generalized vesicular rash which was thought to be dermatitis herpetiformis associated with celiac disease.However,it turned out to be Eczema herpeticum based on positive herpes simplex virus from blood and lesions.The diagnosis was re-evaluated after the child was found to have multiple viral,bacterial,and parasitic co-infections(herpes simplex virus,cytomegalovirus,Epstein-Barr virus,Salmonella,and cryptosporidiosis).Re-evaluation with target gene testing with copy number variation(CNV) analysis and Multiplex Ligation Probe Amplification(MLPA) showed a large homozygous deletion in the DOCK 8 gene,confirming the diagnosis of DOCK 8 deficiency.CONCLUSION Targeted gene testing with CNV analysis might detect deletions that can be missed by WES for diagnosing patients with PID.

Task Offloading Based on Vehicular Edge Computing for Autonomous Platooning

Autonomous platooning technology is regarded as one of the promising technologies for the future and the research is conducted actively.The autonomous platooning task generally requires highly complex computations so it is difficult to process only with the vehicle’s processing units.To solve this problem,there are many studies on task offloading technique which transfers complex tasks to their neighboring vehicles or computation nodes.However,the existing task offloading techniques which mainly use learning-based algorithms are difficult to respond to the real-time changing road environment due to their complexity.They are also challenging to process computation tasks within 100 ms which is the time limit for driving safety.In this paper,we propose a novel offloading scheme that can support autonomous platooning tasks being processed within the limit and ensure driving safety.The proposed scheme can handle computation tasks by considering the communication bandwidth,delay,and amount of computation.We also conduct simulations in the highway environment to evaluate the existing scheme and the proposed scheme.The result shows that our proposed scheme improves the utilization of nearby computing nodes,and the offloading tasks can be processed within the time for driving safety.

Different in-vitro and Clinical Studies to Evaluate the Improvement of the Eyes Cream Containing the Natural Algal Complex

A natural algal complex is prepared from the brown alga Undaria pinnatifida rich in fucoidan and the red calcareous algal Corallina officinalis. The effect of the algal complex was demonstrated by transcriptomic analysis on normal human fibroblasts through the DNA chip technology from AFFYMETRIX, combined with the following in vitro Elisa test and clinical studies. Clinical studies have been performed with a basic cream containing complex versus placebo on 2 groups of 30 Caucasian women for a period of 28 days. In the present study, the natural algal complex works on the crow’s feet, eye bags, and dark cycle through multiple ways of action, including enhancing natural immune responses, regulating the inflammatory and immunity process, and promoting the extracellular matrix synthesis. As the natural algal complex has excellent improvement on the eye circumference, we have applied it to mageline firming anti-wrinkle eye cream for further research.

CM-MAC:一种基于分簇的多信道车载网MAC协议

车载网VANET是一种应用于智能交通系统的新型无线移动自组织网络(mobile ad hoc network,MANET).随着车辆以及移动ad hoc网络技术的发展,车载网已经成为一个新兴的研究领域.针对VANET中车辆行驶的特征,提出一种拓扑相对稳定的车辆分簇算法.在此算法基础上,根据专用短程通信(dedicated short range communication,DSRC)标准中控制信道(control channel,CCH)和服务信道(service channel,SCH)的分配,考虑车辆间的无线通信干扰和不同应用的QoS需求,提出一种基于分簇的多信道混合型MAC协议,簇内通信采用非竞争的TDMA机制,簇间通信采用基于竞争的CSMA?CA机制,相邻簇采用不同的服务信道.模拟实验表明,提出的MAC协议在同时满足实时应用的延迟需求和非实时应用的吞吐量方面,优于现有协议.

Intelligent Reflecting Surfaces Enabled Cognitive Internet of Things Based on Practical Pathloss Model

In this paper,we aim to unlock the potential of intelligent reflecting surfaces(IRSs)in cognitive internet of things(loT).Considering that the secondary IoT devices send messages to the secondary access point(SAP)by sharing the spectrum with the primary network,the interference is introduced by the IoT devices to the primary access point(PAP)which profits from the IoT devices by pricing the interference power charged by them.A practical path loss model is adopted such that the IRSs deployed between the IoT devices and SAP serve as diffuse scatterers,but each reflected signal can be aligned with its own desired direction.Moreover,two transmission policies of the secondary network are investigated without/with a successive interference cancellation(SIC)technique.The signal-to-interference plus noise ratio(SINR)balancing is considered to overcome the nearfar effect of the IoT devices so as to allocate the resource fairly among them.We propose a Stackelberg game strategy to characterize the interaction between primary and secondary networks.For the proposed game,the Stackelberg equilibrium is analytically derived to optimally obtain the closed-form solution of the power allocation and interference pricing.Numerical results are demonstrated to validate the performance of the theoretical derivations.

Cluster-Based Stable BSM Dissemination System for Safe Autonomous Platooning

Recently,the importance of vehicle safety supporting system has been highlighted as autonomous driving and platooning has attracted the researchers.To ensure driving safety,each vehicle must broadcast a basic safety message(BSM)every 100 ms.However,stable BSM exchange is difficult because of the changing environment and limited bandwidth of vehicular wireless communication.The increasing number of vehicles on the road increases the competition to access wireless networks for BSM exchange;this increases the packet collision rate.An increased packet collision rate impairs the transmission and reception of BSM information,which can easily cause a traffic accident.We propose a solution,the vehicular safety support system(V3S),which exchanges BSMs reliably even when many vehicles are on the road.The V3S uses a clustering scheme to decrease network traffic by reducing the amount of data exchanged between a vehicle and the roadside unit(RSU).In addition,the V3S reduces the collision rate of wireless network packets by broadcasting the vehicle’s BSM in an allocated timeslot using the time division multiple access(TDMA)MAC protocol.The V3S also deals with insufficient bandwidth for dedicated short-range communications(DSRC)by changing DSRC channels according to traffic flow.In evaluating the packet error rate for stable BSM packet delivery,the V3S demonstrates an excellent packet error rate of less than 1%,compared to the 802.11p with its packet error rate of 82%.

Novel integration of extreme learning machine and improved Harris hawks optimization with particle swarm optimization-based mutation for predicting soil consolidation parameter

The study proposes an improved Harris hawks optimization(IHHO) algorithm by integrating the standard Harris hawks optimization(HHO) algorithm and mutation-based search mechanism for developing a high-performance machine learning solution for predicting soil compression index. HHO is a newly introduced meta-heuristic optimization algorithm(MOA) used to solve continuous search problems.Compared to the original HHO, the proposed IHHO can evade trapping in local optima, which in turn raises the search capabilities and enhances the search mechanism relying on mutation. Subsequently, a novel meta-heuristic-based soft computing technique called ELM-IHHO was established by integrating IHHO and extreme learning machine(ELM) to estimate soil compression index. A sum of 688 consolidation test data was collected for this purpose from an ongoing dedicated freight corridor railway project. To evaluate the generalization capability of the proposed ELM-IHHO model, a detailed comparison between ELM-IHHO and other well-established MOAs, such as particle swarm optimization,genetic algorithm, and biogeography-based optimization integrated with ELM, was performed. Based on the outcomes, the ELM-IHHO model exhibits superior performance over the other MOAs in predicting soil compression index.

Big Wave of the Intelligent Connected Vehicles

Internet of things is deemed as the one of the great revolution after the age of Industrial Revolution.With the development of the communication technology,more and more entities are connected to the communication network and become one of the elements in the network.Over recent decades,in the area of intelligent transportation,pedestrian and transport infrastructure are connected to the communication network to improve the driving safety and traffic efficiency which is known as the ICV(Intelligent Connected Vehicle).This paper summarizes the global ICV progresses in the past decades and the latest activities of ICV in China,and introduces various aspects regarding the recent development of the ICV,including industry development,spectrum and standard,at the same time.

中国国家美术馆投标

我认为,她是非常敬业的人,很注意听取业主的意见,绝不会马上承诺、应允,或者拒绝、反驳,而是始终在分析和思考如何去采纳。国家美术馆的方案,要设计师先做概念性方案,选中了的方案,要接着做深化,这两者之间的差别是巨大的。扎哈在这一过程之中,始终注意听我们的意见。

Publication process involving the discovery of artemisinin (qinghaosu) before 1985

All the original references were provided by the Nobel Laureate Youyou Tu. The publication process involving the discovery of artemisinin was collected and sorted by her first Ph D student, Associate Professor Man-Yuan Wang. Through the publication of this article, the journal expects to provide a reference to the scientists who dedicated to the research of artemisinin, especially those who are interested in the discovery process of artemisinin.

Direct peroral cholangioscopy

Peroral cholangioscopy is an important tool for diagnosis and treatment of various biliary disorders. Peroral cholangioscopy can be performed by using a dedicated cholangioscope that is advanced through the accessory channel of a duodenoscope, or by direct insertion of a small-diameter endoscope into the bile duct. Direct peroral cholangioscopy refers to insertion of an ultraslim endoscope directly into the bile duct for visualization of the biliary mucosa and lumen. This approach provides a valuable and economic solution for diagnostic and therapeutic applications in the biliary tree. Compared to ductoscopy using a dedicated cholangioscope, the direct approach has several advantages and disadvantages. In this editorial, I discuss the advantages, disadvantages, and possible future developments pertaining to direct peroral cholangioscopy.

Comparative experimental analysis on various picking types under dedicated and random storage assignments for automated storage and retrieval systems

Product storage policy, single picking volume and picking routing are the three factors of vital importance that affect the efficiency of a crane to pick goods in automated storage and retrieval systems(AS/RS). Comparative experiments on picking efficiency were conducted targeting picking operation with order of 1 to 20. Based on dedicated and random storage policies, 4 picking methods of patching-based, S-type, return-type and optimized-type routes were used and compared in the experiments. The results show that either the dedicated policy or the random policy was applied, crane worked most efficiently with optimizedtype route, followed by S-type path, patching-based path, and return-type path. When the number of orders in a single picking is larger(more than 5), the random storage policy is preferable to the dedicated policy.

Proactive Connection Recovery Strategy with Recovery Time Constraint for Survivable Elastic Optical Networks

This paper presents a halfway signaling exchange shared path protection(HSE-SPP)on the backup route for a fast connection recovery strategy.In the proposed HSE-SPP,a pre-assigned intermediate node on the backup route is chosen for signaling exchange.When connection fails,source and destination nodes simultaneously generate backup connection setup messages to the pre-assigned intermediate node on the reserved backup route.At the intermediate node,signaling process occurs,and acknowledgment is generated for data transmission to the respective end nodes.Consequently,connection recovery time by applying HSE-SPP becomes very low.Simulations are performed for network parameters and results are verified with existing strategies.The average recovery time(RT),bandwidth blocking probability(BBP),bandwidth provisioning ratio(BPR),and resource overbuild(RO)ratio of HSE-SPP for ARPANET is 13.54 ms,0.18,3.02,0.55,and for dedicated path protection(DPP)are 13.20 ms,0.56,6.30,3.75 and for shared path protection(SPP)22.19 ms,0.22,3.23,0.70 respectively.Similarly,average RT,BBP,BPR and RO of HSE-SPP for COST239 are8.33 ms,0.04,1.64,0.26,and for DPP 4.23,0.47,3.50,2.04,and for SPP 11.81,0.08,1.66,0.27 respectively.Hence,results of the proposed strategy are better in terms of RT,BBP,BPR,and RO ratio.

A Coordination-Based Algorithm for Dedicated Destination Vehicle Routing in B2B E-Commerce

This paper proposes a solution to the open vehicle routing problem with time windows(OVRPTW)considering third-party logistics(3PL).For the typical OVRPTW problem,most researchers consider time windows,capacity,routing limitations,vehicle destination,etc.Most researchers who previously investigated this problem assumed the vehicle would not return to the depot,but did not consider its final destination.However,by considering 3PL in the B2B e-commerce,the vehicle is required back to the nearest 3PL location with available space.This paper formulates the problem as a mixed integer linear programming(MILP)model with the objective of minimizing the total travel distance.A coordinate representation particle swarm optimization(CRPSO)algorithm is developed to obtain the best delivery sequencing and the capacity of each vehicle.Results of the computational study show that the proposed method provides solution within a reasonable amount of time.Finally,the result compared to PSO also indicates that the CRPSO is effective.

应用于核电厂安全控制显示装置的QNX操作系统关键特性测试方法研究

在国内使用商业操作系统研发核安全级设备尚未有先例,为了使商用操作系统QNX能应用于安全级设备,国际上通常采用NRC的CGD方法,对关键特性进行验证;其中关键特性测试是最有效的验证方法,但需要确定所做测试的合适范围保证商用软件能够应用于核安全设备产品中。本文在接口函数关键特性基础上提出了增加功能、性能测试的简单易行方法,对使用到的功能、性能、函数接口进行测试,保证了核安全设备所使用到的功能的质量;该方法已在核电厂安全显示装置的开发中应用,效果良好,极大节省了成本,加快了产品开发周期,可以推广到其他核级产品的研发中。

Why We Have to Teach Phonics to Children in China

Good afternoon,teachers,ladies and gentlemen.Thank you very much for coming out today.So nice to see so many dedicated educational professionals.We are all interested in the same thing:How to make English more effective,easier and more interesting for our students to learn.So what we are going to do this afternoon is to talk about Phonics

The Development and Application of Ground Systems and Derived Systems of Space Technology

In this paper,the development ofsatellite ground systems and non-satellite equipments and systems de-rived from satellite technology inthe Chinese Academy of SpaceTechnology is reviewed.Satelliteground systems include those fortracking,monitoring and controlfor the launch and operation ofsatellites as well as transmitting andreceiving system for dedicated andindividual users.Derived systemsand equipment include some ofspinoff from satellite technologies,such as computer measurement andcontrol,attitude control,thermalcontrol,radio electronic technique,vacuum technique and new materi-als.They are related to the eco-nomic and social benefits derivedfrom the development of space tech-nology.

Instructions for Authors

International Journal of Minerals, Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals, Metallurgy and Materials. It is covered by EI Compendex, SCI Expanded, Chemical Abstract, etc. The following components are required for a complete manuscript: Title, Author(s), Author affiliation(s), Abstract, Keywords,Main text, Acknowledgements and References.

THE US TRANSURANIUM AND URANIUM REGISTRIES (USTUR): A FIVE-DECADE FOLLOWUP OF PLUTONIUM AND URANIUM WORKERS

Abstract:Dedication: The research of the US Transuranium and Uranium Registries relies heavily upon postmortem autopsy findings and radiochemical analysis of tissues. The enormous debt owed to those now-deceased registrants who unselfishly voluntarily participated in the US Transuranium and Uranium Registries program through postmortem donation of their tissues and to those stillliving registrants who have volunteered to be future postmortem tissue donors is hereby acknowledged with gratitude. The scientific findings derived from postmortem analysis of these tissues have been instrumental in advancing our understanding of the actinide elements in humans and have led to refinement, validation, and confidence in safety standards for those who work with these elements as well as for the general public. To these generous and anonymous persons who made this ultimate contribution, this paper is dedicated with great thanks and admiration.

A systematic review of dedicated models of care for emergency urological patients

Objective:To systematically evaluate the spectrum of models providing dedicated resources for emergency urological patients(EUPs).Methods:A search of Cochrane,Embase,Medline and grey literature from January 1,2000 to March 26,2019 was performed using methods pre-published on PROSPERO.Reporting followed Preferred Reporting Items for Systematic Review and meta-analysis guidelines.Eligible studies were articles or abstracts published in English describing dedicated models of care for EUPs,which reported at least one secondary outcome.Studies were excluded if they examined pathways dedicated only to single presentations,such as torsion,or outpatient solutions,such as rapid access clinics.The primary outcome was the spectrum of models.Secondary outcomes were time-to-theatre,length of stay,complications and cost.Results:Seven studies were identified,totalling 487 patients.Six studies were conference abstracts,while one study was of full-text length but published in grey literature.Four distinct models were described.These included consultant urologists allocated solely to the care of EUPs(“Acute Urological Unit”)or dedicated registrars or operating theatres(“Hybrid structures”).In some services,EUPs bypassed emergency department assessment and were referred directly to urology(“Urological Assessment Unit”)or were managed by other dedicated means.Allocating services to EUPs was associated with reduced time-to-theatre,length of stay and hospital cost,and improved supervision of junior medical staff.Conclusion:Multiple dedicated models of care exist for EUPs.Low-level evidence suggests these may improve outcomes for patients,staff and hospitals.Higher quality studies are required to explore patient outcomes and minimum requirements to establish these models.