Objective:To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas.Methods:Eighty-one patients with deep burns with different functional jo...Objective:To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas.Methods:Eighty-one patients with deep burns with different functional joint areas from April 2018 to April 2019 were divided into the conventional and rehabilitation groupings.The conventional group(n=40)received routine treatment and rehabilitation while the rehabilitation group(n=41)was given comprehensive rehabilitation treatment.Thereafter,the recovery of joint function in patients with deep burns in different areas,the combined value of clinical long-term treatment,the recovery of joint function and the score of daily living ability were calculated.Results:The total long-term effective rate of treatment,the recovery of the joint function,and the score of daily living ability of the patients with deep burns in the rehabilitation group were more favourable than those of the conventional group as demonstrated by P<0.05,the index data indicating statistical significance.Conclusion:Comprehensive rehabilitation therapy can reduce complications and improve the quality of life in patients with deep burns in different functional joint areas.展开更多
Burn injury is a serious public health problem and scientists are continuously aiming to develop promising biomimetic dressings for effective burn wound management.In this study,a greater efficacy in burn wound healin...Burn injury is a serious public health problem and scientists are continuously aiming to develop promising biomimetic dressings for effective burn wound management.In this study,a greater efficacy in burn wound healing and the associated mechanisms ofα-lactalbumin(ALA)based electrospun nanofibrous scaffolds(ENs)as compared to other regenerative protein scaffolds were established.Bovine serum albumin(BSA),collagen type I(COL),lysozyme(LZM)and ALA were separately blended with poly(ε-caprolactone)(PCL)to fabricate four different composite ENs(LZM/PCL,BSA/PCL,COL/PCL and ALA/PCL ENs).The hydrophilic composite scaffolds exhibited an enhancedwettability and variablemechanical properties.The ALA/PCL ENs demonstrated higher levels of fibroblast proliferation and adhesion than the other composite ENs.As compared to PCL ENs and other composite scaffolds,the ALA/PCL ENs also promoted a better maturity of the regenerative skin tissues and showed a comparable wound healing effect to Collagen sponge^(■)on third-degree burn model.The enhanced wound healing activity of ALA/PCL ENs compared to other ENs could be attributed to their ability to promote serotonin production at wound sites.Collectively,this investigation demonstrated that ALA is a unique protein with a greater potential for burn wound healing as compared to other regenerative proteins when loaded in the nanofibrous scaffolds.展开更多
BACKGROUND Thermal injuries on free transferred or replanted tissues resulting from loss of sensibility are an infrequent occurrence.They require immediate and appropriate management before they progress to an irrever...BACKGROUND Thermal injuries on free transferred or replanted tissues resulting from loss of sensibility are an infrequent occurrence.They require immediate and appropriate management before they progress to an irreversible condition.Although negative pressure wound therapy(NPWT)can prevent wound progression by increasing microcirculation,the inappropriate application of NPWT on complicationthreatened transferred and replanted tissues can induce an adverse effect.CASE SUMMARY A 48-year-old woman who underwent immediate breast reconstruction with a deep inferior epigastric artery perforator free flap.While applying a heating pad directly to the flap site,she sustained a deep second to third-degree contact burn over 30%of the transferred flap on postoperative 7 d.As the necrotic changes had progressed,we applied an NPWT dressing over the burned area after en-bloc debridement of the transferred tissues on postoperative 21 d.After 4 d of NPWT application,the exposed fatty tissues of the flap changed to dry and browncolored necrotic tissues.Upon further debridement,we noted that the wound gradually reached total necrosis with a collapsed vascular pedicle of deep inferior epigastric artery.CONCLUSION Although NPWT has been shown to be successful for treating various wound types,the significant risk of NPWT application in short-lasting reconstructed flap wounds after thermal injury should be reminded.展开更多
Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. Burns can endanger life and are linked to high morbidity and m...Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. Burns can endanger life and are linked to high morbidity and mortalityrates. Effective diagnosis with the help of accurate burn zone and wound depthevaluation is important for clinical efficacy. The following characteristics areassociated with the skin burn wound, such as healing, infection, painand stressand keloid formation. Tissue regeneration also takes a significant amount of timefor formation while considering skin healing after a burn injury. Deep neural networks can automatically assist in the extraction of features from a burn image. Inour approach to burn wound analysis and regeneration of the tissue of the skinburn wound, we use the Faster RCNN (Regional Convolutional Neural Network),which is based on their severity of the burn wound. The success rates of skin curefor burning injuries can be dramatically increased with the use of different skinreplacements. Our objective is to analyze different deep learning techniques thatmay help to analyze and classify burn wounds in a superficial, partial and complete thickness, while treating burn wounds more accurately. The application ofFaster RCNN effectively classifies wound without first degree, second and thirddegree confusion, thus providing a suitable solution to burning wounds. Theadvancement in the field of profound training offers an important path in the fieldof the processing and burning of trauma.展开更多
目的探讨自体富血小板凝胶(APG)结合封闭负压引流(VSD)对深Ⅱ度烧伤患者创面愈合进程及表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年7月—2021年7月在南通大学附属南通第三医院就诊的82例深Ⅱ度烧伤患...目的探讨自体富血小板凝胶(APG)结合封闭负压引流(VSD)对深Ⅱ度烧伤患者创面愈合进程及表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年7月—2021年7月在南通大学附属南通第三医院就诊的82例深Ⅱ度烧伤患者作为研究对象,按随机数字表法分为观察组(APG结合VSD治疗)和对照组(VSD治疗),各41例。比较两组患者的疗效、创面愈合时间、肉芽生长面积、创面愈合率、住院时间、并发症,比较两组患者治疗前后的EGF、bFGF、C反应蛋白(CRP)、白细胞介素6(IL-6)、白细胞计数(WBC)、疼痛视觉模拟评分(VAS)的差值及治疗后1个月、2个月的温哥华瘢痕量表(VSS)评分的差值。结果观察组总有效率高于对照组(P<0.05)。观察组创面愈合时间、住院时间少于对照组,肉芽生长面积大于对照组,创面愈合率高于对照组(P<0.05)。观察组治疗前后EGF、bFGF、CRP、IL-6、WBC的差值高于对照组(P<0.05)。观察组治疗前与治疗后14 d VAS评分及治疗后1个月与2个月VSS评分的差值高于对照组(P<0.05)。两组患者并发症总发生率比较,差异无统计学意义(P>0.05)。结论APG结合VSD治疗深Ⅱ度烧伤可加快患者创面愈合进程,提高EGF、bFGF水平,减轻炎症反应和疼痛,减少瘢痕增生,且并发症少。展开更多
文摘Objective:To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas.Methods:Eighty-one patients with deep burns with different functional joint areas from April 2018 to April 2019 were divided into the conventional and rehabilitation groupings.The conventional group(n=40)received routine treatment and rehabilitation while the rehabilitation group(n=41)was given comprehensive rehabilitation treatment.Thereafter,the recovery of joint function in patients with deep burns in different areas,the combined value of clinical long-term treatment,the recovery of joint function and the score of daily living ability were calculated.Results:The total long-term effective rate of treatment,the recovery of the joint function,and the score of daily living ability of the patients with deep burns in the rehabilitation group were more favourable than those of the conventional group as demonstrated by P<0.05,the index data indicating statistical significance.Conclusion:Comprehensive rehabilitation therapy can reduce complications and improve the quality of life in patients with deep burns in different functional joint areas.
基金supported by the Liaoning Pan Deng Xue Zhe Scholar(No.XLYC2002061)the Overseas Expertise Introduction Project for Discipline Innovation(“111 Project”)(No.D20029)+5 种基金X.G.acknowledges the Educational Department of Liaoning Province(grant No.LJKZ0925),(Youth Project,grant No.LJKQZ2021035)the international postdoctoral exchange fellowship program(grant No.PC2021047)H.B.thanks the financial support from National Natural Science Foundation of China(grant No.82050410448)Fellowship of China Postdoctoral Science Foundation(grant No.2021MD703857)D.Cun acknowledges financial support from Ministry of Education Chunhui Program(2020)VF acknowledges VILLUM FONDEN for supporting the project via the Villum Young Investigator Grant(grant No.19175).
文摘Burn injury is a serious public health problem and scientists are continuously aiming to develop promising biomimetic dressings for effective burn wound management.In this study,a greater efficacy in burn wound healing and the associated mechanisms ofα-lactalbumin(ALA)based electrospun nanofibrous scaffolds(ENs)as compared to other regenerative protein scaffolds were established.Bovine serum albumin(BSA),collagen type I(COL),lysozyme(LZM)and ALA were separately blended with poly(ε-caprolactone)(PCL)to fabricate four different composite ENs(LZM/PCL,BSA/PCL,COL/PCL and ALA/PCL ENs).The hydrophilic composite scaffolds exhibited an enhancedwettability and variablemechanical properties.The ALA/PCL ENs demonstrated higher levels of fibroblast proliferation and adhesion than the other composite ENs.As compared to PCL ENs and other composite scaffolds,the ALA/PCL ENs also promoted a better maturity of the regenerative skin tissues and showed a comparable wound healing effect to Collagen sponge^(■)on third-degree burn model.The enhanced wound healing activity of ALA/PCL ENs compared to other ENs could be attributed to their ability to promote serotonin production at wound sites.Collectively,this investigation demonstrated that ALA is a unique protein with a greater potential for burn wound healing as compared to other regenerative proteins when loaded in the nanofibrous scaffolds.
文摘BACKGROUND Thermal injuries on free transferred or replanted tissues resulting from loss of sensibility are an infrequent occurrence.They require immediate and appropriate management before they progress to an irreversible condition.Although negative pressure wound therapy(NPWT)can prevent wound progression by increasing microcirculation,the inappropriate application of NPWT on complicationthreatened transferred and replanted tissues can induce an adverse effect.CASE SUMMARY A 48-year-old woman who underwent immediate breast reconstruction with a deep inferior epigastric artery perforator free flap.While applying a heating pad directly to the flap site,she sustained a deep second to third-degree contact burn over 30%of the transferred flap on postoperative 7 d.As the necrotic changes had progressed,we applied an NPWT dressing over the burned area after en-bloc debridement of the transferred tissues on postoperative 21 d.After 4 d of NPWT application,the exposed fatty tissues of the flap changed to dry and browncolored necrotic tissues.Upon further debridement,we noted that the wound gradually reached total necrosis with a collapsed vascular pedicle of deep inferior epigastric artery.CONCLUSION Although NPWT has been shown to be successful for treating various wound types,the significant risk of NPWT application in short-lasting reconstructed flap wounds after thermal injury should be reminded.
文摘Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. Burns can endanger life and are linked to high morbidity and mortalityrates. Effective diagnosis with the help of accurate burn zone and wound depthevaluation is important for clinical efficacy. The following characteristics areassociated with the skin burn wound, such as healing, infection, painand stressand keloid formation. Tissue regeneration also takes a significant amount of timefor formation while considering skin healing after a burn injury. Deep neural networks can automatically assist in the extraction of features from a burn image. Inour approach to burn wound analysis and regeneration of the tissue of the skinburn wound, we use the Faster RCNN (Regional Convolutional Neural Network),which is based on their severity of the burn wound. The success rates of skin curefor burning injuries can be dramatically increased with the use of different skinreplacements. Our objective is to analyze different deep learning techniques thatmay help to analyze and classify burn wounds in a superficial, partial and complete thickness, while treating burn wounds more accurately. The application ofFaster RCNN effectively classifies wound without first degree, second and thirddegree confusion, thus providing a suitable solution to burning wounds. Theadvancement in the field of profound training offers an important path in the fieldof the processing and burning of trauma.
文摘目的探讨自体富血小板凝胶(APG)结合封闭负压引流(VSD)对深Ⅱ度烧伤患者创面愈合进程及表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年7月—2021年7月在南通大学附属南通第三医院就诊的82例深Ⅱ度烧伤患者作为研究对象,按随机数字表法分为观察组(APG结合VSD治疗)和对照组(VSD治疗),各41例。比较两组患者的疗效、创面愈合时间、肉芽生长面积、创面愈合率、住院时间、并发症,比较两组患者治疗前后的EGF、bFGF、C反应蛋白(CRP)、白细胞介素6(IL-6)、白细胞计数(WBC)、疼痛视觉模拟评分(VAS)的差值及治疗后1个月、2个月的温哥华瘢痕量表(VSS)评分的差值。结果观察组总有效率高于对照组(P<0.05)。观察组创面愈合时间、住院时间少于对照组,肉芽生长面积大于对照组,创面愈合率高于对照组(P<0.05)。观察组治疗前后EGF、bFGF、CRP、IL-6、WBC的差值高于对照组(P<0.05)。观察组治疗前与治疗后14 d VAS评分及治疗后1个月与2个月VSS评分的差值高于对照组(P<0.05)。两组患者并发症总发生率比较,差异无统计学意义(P>0.05)。结论APG结合VSD治疗深Ⅱ度烧伤可加快患者创面愈合进程,提高EGF、bFGF水平,减轻炎症反应和疼痛,减少瘢痕增生,且并发症少。
