Background： Catheter-directed thrombolysis （CDT） has been a mainstay in treating deep venous thrombosis （DVT）. However, the optimal dosage ofa thrombolytic agent is still controversial. The goal of this study was...Background： Catheter-directed thrombolysis （CDT） has been a mainstay in treating deep venous thrombosis （DVT）. However, the optimal dosage ofa thrombolytic agent is still controversial. The goal of this study was to evaluate the safety and efficacy of low dosage urokinase with CDT for DVT. Methods： A retrospective analysis was perfornaed using data from a total of 427 patients with DVT treated with CDT in our single center between July 2009 and December 2012. Early efficacy of thrombolysis was assessed with a thrombus score based on daily venography. The therapeutic safety was evahmted by adverse events. A venography or duplex ultrasound was performed to assess the outcome at 6 months, 1 year and 2 years postoperatively. Results： The mean total dose of 3.34 （standard deviation [SD] 1.38） million units of urokinase was administered during a mean of 5.18 （SD 2.28） days. Prior to discharge, Grade Ⅲ （complete lysis） was achieved in 154 （36%） patients; Grade II （50-99% lysis） in 222 （52%）： and Grade I （50%~ lysis） in 51 （12%）. The major complications included one intracranial hemorrhage, one henaatochezia, five gross hematuria, and one pulmonary embolism. Moreover, no death occurred in the study. Conclusions： Treatment of low-dose catheter-directed thrombosis is an efficacious and safe therapeutic approach in patients with DVT offering good long-term outcomes and minimal complications.展开更多
Objective: To explore the effect of thrombolysis with anticoagulation treatment for early stage of deep vein thrombosis of lower extremity. Methods: The clinical data of 106 patients at the early stage of deep vein th...Objective: To explore the effect of thrombolysis with anticoagulation treatment for early stage of deep vein thrombosis of lower extremity. Methods: The clinical data of 106 patients at the early stage of deep vein thrombosis (DVT) in the lower extremities treated by thrombolysis with anticoagulation and dispersion drugs were analyzed retrospectively. Results: The thrombolytic effect was significant. After treatment, the deep veins were recanalized without regurgitation in 75.3% of the patients. The total effective rate was 100%. Only three patients had hemorrhagic complication, but none of the patients died. Conclusion: Thrombolysis with anticoagulation treatment is an effective and safe method for DVT at the early stage.展开更多
Objective: To study the pathogenetic mechanism of integrated traditional Chinese and Western medicine in treating lower limb deep venous thrombosis (DVT). Methods: Thrombosis test in vitro of 206 cases with lower limb...Objective: To study the pathogenetic mechanism of integrated traditional Chinese and Western medicine in treating lower limb deep venous thrombosis (DVT). Methods: Thrombosis test in vitro of 206 cases with lower limb DVT was measured. All of them were treated by integrated traditional Chinese and Western medicine. Results: The indexes of thrombosis test in vitro of patients were much higher than those of normal subjects (P < 0. 001 ). The relevent indexes were different in type distribution according to differentiation of symptoms and signs (P < 0. 01 - 0. 001 ) and between pre-treatment and post-treatment (P < 0. 001 ). It showed that hypercoagulability of blood occurred even after DVT took place. Changes of indexes, when after treatment they got lower along with improvement in the state of illness, might be objective parameters for Syndrome Differentiation in traditional Chinese medicine. Conclusions: The therapy of traditional Chinese and Western medicine has good efficacy for DVT.展开更多
目的观察三妙散加减方配合纤溶酶治疗急性下肢深静脉血栓形成(acute deep venous thrombosis,ADVT)的临床效果。方法随机选取ADVT患者80例,以发病时间长短(<7天或7～28天)分为2个时间段,每个时间段40例,每个时间段又分为2组:单纯纤...目的观察三妙散加减方配合纤溶酶治疗急性下肢深静脉血栓形成(acute deep venous thrombosis,ADVT)的临床效果。方法随机选取ADVT患者80例,以发病时间长短(<7天或7～28天)分为2个时间段,每个时间段40例,每个时间段又分为2组:单纯纤溶酶治疗组(A、C组)和内服三妙散加减方配合纤溶酶治疗组(B、D组),每组20例,治疗2周后观察各组治疗效果。结果内服三妙散加减方配合纤溶酶治疗组在减轻肢体肿胀、缓解疼痛等症状,以及降低纤维蛋白原(Fib)上明显优于单纯纤溶酶治疗组;发病时间<7天临床疗效较>7天更好。结论中西医结合治疗ADVT临床效果较好。展开更多
文摘Background： Catheter-directed thrombolysis （CDT） has been a mainstay in treating deep venous thrombosis （DVT）. However, the optimal dosage ofa thrombolytic agent is still controversial. The goal of this study was to evaluate the safety and efficacy of low dosage urokinase with CDT for DVT. Methods： A retrospective analysis was perfornaed using data from a total of 427 patients with DVT treated with CDT in our single center between July 2009 and December 2012. Early efficacy of thrombolysis was assessed with a thrombus score based on daily venography. The therapeutic safety was evahmted by adverse events. A venography or duplex ultrasound was performed to assess the outcome at 6 months, 1 year and 2 years postoperatively. Results： The mean total dose of 3.34 （standard deviation [SD] 1.38） million units of urokinase was administered during a mean of 5.18 （SD 2.28） days. Prior to discharge, Grade Ⅲ （complete lysis） was achieved in 154 （36%） patients; Grade II （50-99% lysis） in 222 （52%）： and Grade I （50%~ lysis） in 51 （12%）. The major complications included one intracranial hemorrhage, one henaatochezia, five gross hematuria, and one pulmonary embolism. Moreover, no death occurred in the study. Conclusions： Treatment of low-dose catheter-directed thrombosis is an efficacious and safe therapeutic approach in patients with DVT offering good long-term outcomes and minimal complications.
文摘Objective: To explore the effect of thrombolysis with anticoagulation treatment for early stage of deep vein thrombosis of lower extremity. Methods: The clinical data of 106 patients at the early stage of deep vein thrombosis (DVT) in the lower extremities treated by thrombolysis with anticoagulation and dispersion drugs were analyzed retrospectively. Results: The thrombolytic effect was significant. After treatment, the deep veins were recanalized without regurgitation in 75.3% of the patients. The total effective rate was 100%. Only three patients had hemorrhagic complication, but none of the patients died. Conclusion: Thrombolysis with anticoagulation treatment is an effective and safe method for DVT at the early stage.
文摘Objective: To study the pathogenetic mechanism of integrated traditional Chinese and Western medicine in treating lower limb deep venous thrombosis (DVT). Methods: Thrombosis test in vitro of 206 cases with lower limb DVT was measured. All of them were treated by integrated traditional Chinese and Western medicine. Results: The indexes of thrombosis test in vitro of patients were much higher than those of normal subjects (P < 0. 001 ). The relevent indexes were different in type distribution according to differentiation of symptoms and signs (P < 0. 01 - 0. 001 ) and between pre-treatment and post-treatment (P < 0. 001 ). It showed that hypercoagulability of blood occurred even after DVT took place. Changes of indexes, when after treatment they got lower along with improvement in the state of illness, might be objective parameters for Syndrome Differentiation in traditional Chinese medicine. Conclusions: The therapy of traditional Chinese and Western medicine has good efficacy for DVT.
文摘目的观察三妙散加减方配合纤溶酶治疗急性下肢深静脉血栓形成(acute deep venous thrombosis,ADVT)的临床效果。方法随机选取ADVT患者80例,以发病时间长短(<7天或7～28天)分为2个时间段,每个时间段40例,每个时间段又分为2组:单纯纤溶酶治疗组(A、C组)和内服三妙散加减方配合纤溶酶治疗组(B、D组),每组20例,治疗2周后观察各组治疗效果。结果内服三妙散加减方配合纤溶酶治疗组在减轻肢体肿胀、缓解疼痛等症状,以及降低纤维蛋白原(Fib)上明显优于单纯纤溶酶治疗组;发病时间<7天临床疗效较>7天更好。结论中西医结合治疗ADVT临床效果较好。
