Nine new compounds,including five natural rarely-occurring 2,3-dihydro-1H-indene derivatives named diaporindenes E−I(1−5),and four new benzophenone analogues named tenellones J−M(6−9)were isolated from the deep-sea se...Nine new compounds,including five natural rarely-occurring 2,3-dihydro-1H-indene derivatives named diaporindenes E−I(1−5),and four new benzophenone analogues named tenellones J−M(6−9)were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508.All the structures for these new compounds were fully characterized on the basis of spectroscopic data,NMR spectra,and ECD calculation and single-crystal X-ray diffraction analysis.The potential anti-tumor activities of compounds 1−9 against four tumor cell lines SF-268,MCF-7,HepG-2,and A549 were evaluated using the SRB method.Compound 7 exhibited cytotoxic activity against the SF-268 cell line with an IC50 value of 11.36μmol·L^(−1).展开更多
基金This work was supported by Guangdong Provincial Special Fund for Marine Economic Development Project(No.GDNRC[2020]042)the National Natural Science Foundation of China(No.41906106)+2 种基金Guangdong Special Support Program(No.2019TQ05Y375)the Team Project of the Natural Science Foundation of Guangdong Province(No.2016A030312014)the GDAS'Project of Science and Technology Development(No.2019GDA-SYL-0103007).
文摘Nine new compounds,including five natural rarely-occurring 2,3-dihydro-1H-indene derivatives named diaporindenes E−I(1−5),and four new benzophenone analogues named tenellones J−M(6−9)were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508.All the structures for these new compounds were fully characterized on the basis of spectroscopic data,NMR spectra,and ECD calculation and single-crystal X-ray diffraction analysis.The potential anti-tumor activities of compounds 1−9 against four tumor cell lines SF-268,MCF-7,HepG-2,and A549 were evaluated using the SRB method.Compound 7 exhibited cytotoxic activity against the SF-268 cell line with an IC50 value of 11.36μmol·L^(−1).
