Clinical Nursing Intervention of Moxibustion on Abdominal Distension Symptoms in Heart Failure (Heart and Kidney Yang Deficiency and Blood Stasis Blocking Collaterals Syndrome)

Objective:To investigate the clinical nursing intervention effect of moxibustion on abdominal distension symptoms in heart failure(heart and kidney yang deficiency and blood stasis blocking collaterals syndrome).Methods:62 patients with heart failure(heart and kidney yang deficiency and blood stasis blocking collaterals syndrome)admitted to our hospital from February 2023 to February 2024 were selected and divided into the observation group(n=31)and the control group(n=31)by using the random numerical table method.The control group adopted conventional nursing interventions,and the observation group received the nursing program of the control group with the addition of moxibustion nursing interventions.The nursing effectiveness,quality of life scores,and nursing satisfaction were compared between the two groups.Results:The nursing effectiveness of the observation group was significantly higher than the control group(P<0.05);the quality of life score of the observation group was significantly higher than the control group(P<0.05);the nursing satisfaction of the observation group was significantly higher than that of the control group(P<0.05).Conclusion:The use of moxibustion nursing intervention in patients with heart failure(heart and kidney yang deficiency and blood stasis blocking collaterals syndrome)can effectively relieve the symptoms of abdominal distension,improve patients'quality of life,and increase nursing satisfaction,which has promotion and application values.

Transcriptomic and metabolomic analysis of the effects of Zhenwu decoction on kidney yang deficiency pattern in chronic kidney disease

Objective:To explore the kidney yang deficiency pattern(KYDP)in a chronic kidney disease(CKD)rat model and the mechanisms underlying the effects of Zhenwu decoction(ZWD)by conducting tran-scriptomic and metabolomic analyses.Methods:Adriamycin(ADR)combined with hydrocortisone(HC)was used to induce CKD with KYDP in rats.ADR was injected into the tail vein twice.HC was injected intramuscularly for 8 weeks.ZWD was administered by gavage for 8 weeks.The general condition was observed,24-h urine protein was detected,serum corticosterone,triiodothyronine,thyroxine,TSH,testosterone,cAMP,and cGMP levels were determined,and pathological analysis was conducted.Transcriptomic and metabolomic analyses were conducted to screen differentially expressed genes(DEGs),differentially expressed metabolites(DEMs),and differentially expressed pathways(DEPs).The core DEMs and DEGs were input to Metab-oanalyst 5.0 to identify the pathways affected by ZWD.Results:In the HC group,KYDP symptoms were observed.Compared with control group,the levels of 24-h urine protein,TSH,and cGMP significantly increased(all P<0.01),and corticosterone,triiodothyronine,thyroxine,and cAMP significantly decreased(all P<0.01)in the HC group.After ZWD intervention,the levels of above-mentioned indicators could be reversed to some extent.Pathological analysis in the HC group revealed kidney lesions.DEGs in the ZWD group were mainly associated with pathways such as nucleotide synthesis and endocrine pathways.In the ZWD group,differences in biosynthesis of unsat-urated fatty acids and butanoate metabolism were observed.The following pathways were significantly affected by ZWD:arachidonic acid metabolism,valine,leucine,and isoleucine biosynthesis,linoleic acid metabolism,and alpha-linolenic acid metabolism.Conclusion:ZWD can be used to treat KYDP in CKD through regulating arachidonic acid metabolism,valine,leucine,and isoleucine biosynthesis,linoleic acid metabolism,and alpha-linolenic acid metabolism.

Proteomics analysis of IBS-D with spleen and kidney yang deficiency

Objective:To investigate the molecular mechanism underlying the development of diarrhea-predominant irritable bowel syndrome (IBS-D) with spleen and kidney yang deficiency (SKYD) using a proteomics approach.Methods:Male Sprague-Dawley rats (n =22) were divided into IBS-D (n =12) and normal control (n =10) groups.SKYD was then modeled in IBS-D rats by a combination of acetic acid enema,bondage,rectal dilation,tail stimulation,and Senna gavage.Colon tissue samples were subsequently collected and examined by Q Exactive mass spectrometry to identify differentially expressed proteins between the two groups.Results:The occurrence of SKYD/IBS-D was associated with ribosomal protein S23 (Rps23),protein phosphatase 2 catalytic subunit alpha (Pp2a),and growth factor receptor-bound protein 2 (Grb2),which are involved in the ribosome,neurotrophin signaling,and Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathways.Conclusion:These data suggest that SKYD/IBS-D pathophysiology likely involves inflammation,cell growth,apoptosis,stress granule formation,immune activation,loss of epithelial cell integrity,and visceral hypersensitivity.

Clinical observation on efficacy of compound of warming yang, descending turbidity and dredging collaterals in the treatment of diabetic kidney disease with Yin-Yang deficiency and blood stasis syndrome

Objective:To observe the clinical efficacy of compound of owarming yang,descending turbidity and dredging collaterals in the treatment of diabetic kidney disease with yin-yang deficiency and blood stasis syndrome.Methods:Seventy-six patients of diabetic kidney disease with yin-yang deficiency and blood stasis syndrome were randomly divided into observation group and control group,thirty-eight cases in each group.The control group was given conventional western medicine treatment,while the observation group took compound of owarming yang,descending turbidity and dredging collaterals orally on the basis of conventional western medicine treatment.The course of treatment covered for one month.Before and after treatment,we observed the scores of traditional Chinese medicine symptoms,indicators of renal function[serum creatinine(Scr),blood urea nitrogen(BUN),microalbuminuria(MALB)],indicators of glucose metabolism[fasting plasma glucose(FPG),2-hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbAlc)],indicators of hemorheology[plasma viscosity(PV),platelet aggregation rate(PAR),fibrinogen(FIB)],Cystatin-C(Cys-C),C-reactive protein(CRP)in the two groups.Results:After treatment,the clinical effect of the observation group was significantly better than the control group(P<0.05).The scores of traditional Chinese medicine symptoms,indicators of renal function(Scr、BUN、UAER),indicators of glucose metabolism(FPG、2hPG、HbAlc),indicators of hemorheology(PV、PAR、FIB),Cys-C and CRP in the two groups were decreased significantly compared with those before treatment(P<0.05),and the decrease in the observation group was superior to that in the control group(P<0.05).Conclusion:Compound of warming yang,descending turbidity and dredging collaterals has remarkable efficacy in treating of diabetic kidney disease patients with yin-yang deficiency and blood stasis syndrome by alleviating clinical symptoms,glucose metabolism,renal function and microcirculatory disturbance,and the mechanism related to alleviation of microinflammation.

Progress of studies on cancer-related anemia in Chinese and Western medicine

Cancer-related anemia is a common complication in patients with a malignant tumor caused by the tumor itself or the tumor's treatment.It can seriously affect the quality of life of patients and even accelerate the progression of the tumor.Western medicine is often given a blood transfusion,erythropoietin,and iron agent in cancer-related anemia treatment,but there are also some problems such as increasing tumor-related mortality.Traditional Chinese medicine believes that cancer-related anemia's occurrence is related to the“Deficiency of Spleen and Kidney and Deficiency of Qi and Blood”,so clinical treatment is mainly to“Tonify Spleen and Kidney and Qi and Blood”.The combination of traditional Chinese and Western medicine is useful in cancer-related anemia's treatment,which provides a new idea and method for cancer-related anemia's clinical treatment.

参杞强精颗粒对慢性疲劳综合征脾肾阳虚证大鼠免疫调节作用研究

目的:探讨参杞强精颗粒对慢性疲劳综合征(CFS)脾肾阳虚证模型大鼠的影响以及免疫调节作用。方法:将50只无特定病原体(SPF)级健康雄性斯泼累格·多雷(SD)大鼠随机分为正常对照组,模型对照组,参杞强精颗粒高剂量组、中剂量组、低剂量组,采用游泳力竭实验造成大鼠体力疲劳,慢性束缚应激造成大鼠心理疲劳,同时给予番泻叶煎煮液灌胃造成脾肾阳虚证候,构建CFS脾肾阳虚证大鼠模型,造模成功后分别按照各组剂量灌胃,连续给药21 d后,测定各组大鼠的胸腺和脾脏指数,酶联免疫吸附试验(ELISA)检测血清免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)浓度以及细胞因子白细胞介素2(IL-2)、白细胞介素6(IL-6)和γ干扰素(IFN-γ)含量,MTT法检测脾脏T、B淋巴细胞增殖能力,流式细胞法检测各组大鼠外周血T淋巴细胞亚群分布情况。结果:行为学结果显示,模型大鼠的体质量增长缓慢,精神萎靡,摄食水量减少,活动减少,便质稀软,力竭游泳时间减少,悬尾静止时间增加。药物干预后,与模型组比较,各给药组大鼠精神状态、体质量、摄食水量均显著改善,力竭游泳时间增加、悬尾静止时间减少(P<0.01或P<0.05);参杞强精颗粒各剂量组能显著提升大鼠胸腺和脾脏指数,提高IgG、Ig M、IgA浓度和IL-2、IL-6、IFN-γ的含量,显著提高脾脏T、B淋巴细胞增殖能力,也能提高CD3+、CD4+T淋巴细胞百分率和CD4+/CD8+T比值,降低CD8+T淋巴细胞百分率,差异有统计学意义(P<0.01或P<0.05)。结论:参杞强精颗粒能显著改善慢性疲劳综合征脾肾阳虚证大鼠免疫功能,缓解疲劳症状,且具有很好的免疫调节作用。

温肾汤治疗慢性肾功能不全脾肾阳虚证的临床疗效及对肾脏纤维化的影响

目的:探究温肾汤治疗慢性肾功能不全脾肾阳虚证的效果及其对肾脏纤维化的影响。方法:选择符合纳入标准的慢性肾功能不全脾肾阳虚证患者96例,依据随机数字表随机分为对照组和观察组。对照组采用常规西药治疗,观察组在对照组基础上口服温肾汤治疗,2周为1个疗程,两组均治疗2个疗程。比较治疗前后两组患者中医症状评分(畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛)、肾功能相关损伤指标(24 h Pro、BUN、Ccr和GFR)及肾纤维化相关指标(CTGF、CIV、PCⅢ和BMP-7)变化情况及临床疗效。结果:对照组临床总有效率为77.1%(37/48),观察组临床总有效率为91.7%(44/48),差异有统计学意义(P<0.05);治疗后两组患者畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛的中医症状评分均较治疗前显著降低(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者24 h Pro、BUN水平均较治疗前显著降低(P<0.05),Ccr、GFR水平显著升高(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者CTGF、CIV及PCⅢ水平较治疗前明显降低(P<0.05),BMP-7水平明显升高(P<0.05),且观察组改善程度优于对照组(P<0.05)。结论:温肾汤可以有效改善慢性肾功能不全脾肾阳虚证患者的肾功能,降低蛋白尿,显著抑制肾脏纤维化。

刘小斌运用麻附细辛汤合甘草干姜汤加减治疗先天性肌无力综合征经验

先天性肌无力综合征(congenital myasthenia syndrome,CMS)为临床罕见的遗传性肌病。CMS患者虽与重症肌无力患者的症状相似,均有肌无力、易疲劳等症,但CMS为先天禀赋不足疾病,以肾元亏损为本,而重症肌无力为后天失养疾病,故在辨治侧重上有所区别。刘小斌教授认为,CMS的中医病机特点为“先天不足,肾元亏损”“脾胃虚损,五脏相关”,属于中医“痿病”范畴;根据患者不易出汗、舌淡红苔白、脉细的病症表现,可辨为脾肾阳虚兼寒邪束表证(少阴太阴兼太阳证);治疗可采用温阳补肾、健脾益损法,常以麻附细辛汤合甘草干姜汤加减,可酌加桑螵蛸、紫河车等益精养血之品,可获显效。

参芪真武汤加味治疗原发性肾病综合征疗效及对患者肾功能、微炎状态、凝血纤溶功能的影响

目的:探讨参芪真武汤加味治疗原发性肾病综合征效果及对患者肾功能、微炎状态、凝血纤溶功能的影响。方法:选取脾肾阳虚证原发性肾病综合征患者110例,根据治疗方案分为两组,观察组和对照组各55例。对照组给予常规对症治疗,观察组在对照组基础上给予参芪真武汤加味治疗,两组均连续治疗8周。比较两组治疗总有效率及不良反应发生情况,同时观察治疗前后中医证候积分、肾功能[24 h尿蛋白定量(24 hTP)、血白蛋白(ALB)、尿素氮(BUN)、血清肌酐(Cr)]、微炎状态[高敏-C反应蛋白(hs-CRP)、白细胞介素-21(IL-21)、白细胞介素-13(IL-13)]、凝血纤溶功能[纤维蛋白原(FIB)、D-二聚体(D-D)]变化情况。结果:观察组临床总有效率为90.91%,高于对照组的76.36%(P<0.05)。经治疗,观察组浮肿、面色白、畏寒肢冷、腰膝酸软、恶寒喜暖各项中医证候积分较对照组低(均P<0.05);观察组ALB水平较对照组高,24 hTP、BUN、Cr较对照组低(均P<0.05);观察组IL-13水平较对照组高,hs-CRP、IL-21水平较对照组低(均P<0.05)。两组FIB、D-D水平低于治疗前,且观察组低于对照组(均P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:参芪真武汤加味治疗原发性肾病综合征脾肾阳虚证可提高临床效果,降低中医证候积分,促进肾功能和凝血纤溶功能改善,减轻机体微炎症状态,且安全性佳。

杨家林教授从调节卵泡论治多囊卵巢综合征经验探微

多囊卵巢综合征(polycystic ovary syndrome,PCOS)为妇科常见内分泌疾病,发病率逐年上升,其所致月经稀发、肥胖、流产、不孕等严重影响到女性生殖健康。杨家林教授从医60余年,认为该病发病责之于脾肾亏虚,痰浊、水湿、瘀血各自或交互为病,导致巢肿卵多,卵滞巢中,排卵无序。杨老在继承古人经方基础上,博采众长,拾遗补漏,创制了治疗PCOS的经验方,临床疗效肯定。本文探微杨家林教授治疗多囊卵巢综合征的临床经验,以飨同道。

Lysine deficiency impaired growth performance and immune response and aggravated inflammatory response of the skin,spleen and head kidney in grown-up grass carp (Ctenopharyngodon idella)

This dissertation was primarily focused on the immune response,inflammatory response and molecular mechanisms in the skin,head kidney and spleen of grown-up grass carp(Ctenopharyngodon idella).Six iso-nitrogen diets differing in lysine concentrations(5.6,8.5,11.6,14.4,17.5 and 20.7 g/kg)were fed to 540 grass carp(164.85±0.79 g)for 60 d.After that,grass carp were challenged by Aeromonas hydrophila for 6 d.This study revealed that lysine deficiency(1)suppressed the growth performa,nce of the fish and decreased their ability to resist skin lesion morbidity,(2)impaired the immune organ s immune response by decreasing the gene expressions of mucin,liver-expressed antimicrobial peptide(LEAP)-2B,β-defensin-1 and LEAP-2A and the production of antibacterial compounds of grown-up grass carp,and(3)aggravated the inflammatory response of immune organs in the fish by increasing the gene expressions of pro-inflammatory cytokines(interferon y2[IFN-γ2],tumor necrosis factorα[TNF-α],interleukin[IL]-15,IL-17D,IL-12p40,IL-6 and IL-8)and down-regulating anti-inflammatory cytokines(IL-11,transforming growth factorβ1[TGF-β1],IL-10 and IL-4/13A),which were tightly correlated with signal transducer and activator of transcription(STAT)1 and STAT3 signaling pathway,respectively.The different phenomenon in the skin,spleen and head kidney of fish may be correlated with the difference in gene subtype.In addition,using quadratic regression analysis of percent weight gain(PWG),skin lesion morbidity,and the lysozyme activities in the spleen and head kidney,the dietary lysine requirements for grown-up grass carp were estimated to be 13.58,13.51,14.56 and 14.18 g/kg,respectively.

升阳泻湿法治疗非酒精性脂肪性肝病初探

非酒精性脂肪性肝病是目前的多发病,为多因素所致,严重影响公共健康,目前对于该病的证治报道较多。该病的临床表现多数不典型,病机证候复杂,笔者汲取李东垣理论思想中升发脾之清气,以及黄元御理论思想中泻湿疏木的治法,把二者进行优化组合,拟定了升阳化湿,培土疏木为治疗大法运用于临床,立足于“湿”,分为“湿浊内蕴”和“脾虚湿困”2个证型,驭繁就简,取得了理想的临床疗效。

肉豆蔻曲代替麸煨肉豆蔻组成方新二神丸的止泻作用研究

目的基于脾肾阳虚泄泻小鼠模型探讨肉豆蔻曲配伍组成新二神丸的止泻作用。方法将KM小鼠随机分为正常组、模型组、二神丸Ⅰ组(盐补骨脂+麸煨肉豆蔻)、二神丸Ⅱ组(盐补骨脂+肉豆蔻曲)、二神丸Ⅲ组(盐补骨脂+肉豆蔻生品)、盐补骨脂组、肉豆蔻曲组,采用“氢化可的松+番泻叶”的复合造模方法建立脾肾阳虚泄泻小鼠模型,观察各组小鼠一般体征、各脏器病理变化,检测小鼠各脏器指数、小肠推进率、胃残留率、血清胃动素(MTL)、胃泌素(GAS)、肾上腺酮(CORT)、促甲状腺激素(TSH)、睾酮(T)、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)水平,对粪便微生物进行16S rDNA测序及信息分析。结果造模后,与正常组相比,模型组小鼠体重减轻,活动量减少,小肠推进率显著升高,胃残留率、各脏器指数均显著降低,血清GAS、CORT、TSH、T水平均显著下降,MTL、TNF-α、IL-β水平均显著上升,肠道菌群物种多样性降低;给药后,各给药组小鼠上述指标和症状均有不同程度改善,且二神丸Ⅱ组整体上优于二神丸Ⅰ组、二神丸Ⅲ组、盐补骨脂组及肉豆蔻曲组。结论肉豆蔻曲与盐补骨脂配伍使用对脾肾阳虚泄泻的作用效果显著,肉豆蔻发酵后能减少其毒性风险,增强其温脾止泻作用,为肉豆蔻曲的开发奠定基础。

Observation on Clinical Effects of Tuina plus Hot Compress for Infantile Diarrhea Due to Spleen-kidney Yang Deficiency

Objective: To observe the clinical effects of tuina plus hot compress for infantile diarrhea due to spleen-kidney yang deficiency. Methods: One hundred cases were randomly divided into a treatment group and a control group, 50 cases in each group. The treatment group was treated with tuina plus hot compress. The control group was treated with oral administration of Live Combined Bifidobacterium, Lactobacillus and Enterococcus powder(Bifico). The clinical effects were observed after 5-day intervention. Results: The total effective rate was 94.0% in the treatment group and was 66.0% in the control group. The difference in the total effective rate between the two groups was statistically significant(P<0.05). The clinical effect was better in the treatment group than that in the control group. Conclusion: Tuina plus hot compress for infantile diarrhea due to spleen-kidney yang deficiency can produce a better clinical effect than oral administration of Bifico.

四神丸治疗溃疡性结肠炎研究进展

四神丸是治疗脾肾泻的经典方剂,具有温肾暖脾、涩肠止泻功效。临床治疗溃疡性结肠炎脾肾阳虚证常以四神丸为基础方加减联合中医其他治法或中西医结合治疗,疗效显著。药理学研究显示,四神丸可能通过调控相关信号通路蛋白表达,调节炎症因子、抑制炎症反应,调节自噬,调节肠道菌群、改善肠黏膜通透性、修复肠黏膜屏障,调节细胞能量代谢,抗氧化应激,调节细胞免疫功能等治疗溃疡性结肠炎。本文对四神丸治疗溃疡性结肠炎研究现状进行整理、归纳,为进一步研究其作用机制及临床应用提供参考。

从脾论治儿童抗生素相关性腹泻

儿童抗生素相关性腹泻(antibiotic-associated diarrhea,AAD)是儿童使用抗菌药后而出现的腹泻,其发病机制与肠道菌群密切相关,抗生素可通过影响肠道菌群的代谢功能及免疫功能导致AAD。中医认为,儿童AAD的病位主要在脾脏,病因不外素体脾胃虚弱、疫毒侵袭、药毒蓄积等,病机以脾虚湿盛、脾气亏虚、脾阳不足为特点。脾虚为小儿AAD发病之本,且脾与肠道菌群具有共通性,故临床治疗小儿AAD可从脾论治。从脾论治儿童ADD以健运脾脏为原则,采用健脾渗湿、健脾益气、健脾温阳等治法,分别以参苓白术散、四君子汤、附子理中丸等为基础方,调理脾脏以达治病求本之目的。

不同剂量腺嘌呤建立脾肾阳虚型慢性肾衰竭大鼠模型的实验研究

目的比较不同剂量腺嘌呤灌胃对模型大鼠一般状态、生化指标及肾脏病理组织的影响,确定腺嘌呤灌胃制备脾肾阳虚型慢性肾衰竭(Chronic kidney disease,CRF)大鼠模型的最佳造模剂量。方法将24只SD雄性大鼠随机分为正常组与模型组,模型组大鼠分为M1组、M2组和M3组,每组6只。正常组给予等量生理盐水灌胃,M1组以腺嘌呤150 mg·kg^(-1)·d^(-1)灌胃、M2组以腺嘌呤200 mg·kg^(-1)·d^(-1)灌胃,M3组以腺嘌呤300 mg·kg^(-1)·d^(-1)灌胃。连续干预3周,造模前及造模后每周检测肌酐(Serum creatinine,Scr)、尿素氮(Blood urea nitrogen,BUN)、24 h尿蛋白定量(24-hour urinary protein quantification,24 h-UTP)水平,3周后取肾脏病理组织采用苏木-伊红(HE)和马松(Masson)染色法对大鼠肾脏组织病理学进行模型评估。结果与正常组大鼠比较,模型组大鼠均出现不同程度的精神萎靡不振,活动度降低,弓背蜷缩,毛发稀疏无光泽,耳缘及脚趾苍白发凉,小便频数,大便稀溏等现象。与正常组大鼠比较,各模型组大鼠体重均有不同程度的减轻(P<0.05),造模第2周,与M1组大鼠体重比较,M2组、M3组大鼠差异均有统计学意义(P<0.05)。与正常组大鼠比较,各模型组大鼠24 h尿量明显增多(P<0.05),Scr、BUN及24 h-UTP水平均升高(P<0.05),且M3组大鼠各指标升高最明显。各模型组大鼠Scr、BUN及24 h-UTP比较差异均有统计学意义(P<0.05)。肾脏病理染色结果显示各模型组大鼠的肾脏组织出现不同程度的改变,镜下见肾小球形态基本完整,部分肾小球结构破坏;部分近肾小管空泡变性严重,上皮萎缩,部分肾小管管腔扩张,管腔内见红染无结构的蛋白管型样物及较多红细胞;随着腺嘌呤灌注剂量增加,肾小球内可见大量黄绿色结晶沉淀物,存在肾间质炎性细胞浸润和纤维组织增生。结论腺嘌呤灌胃可成功建立脾肾阳虚型慢性肾衰竭动物模型,其中200 mg·kg^(-1)·d^(-1)灌胃组更接近临床脾肾阳虚型慢性肾衰竭发展进程,且死亡率较低,符合脾肾阳虚型慢性肾衰竭生理病理学特点。

The Effect of Hormones of the Hypothalamic-pituitary-target Gland Axes in a Kidney-Yang Deficiency Syndrome Model

Kidney-yang deficiency syndrome(KYDS)is a diagnostic pattern in the traditional Chinese medicine.Studies have shown that KYDS is related to the functional disorder of hormones of the hypothalamic-pituitary-target gland axes.The standard procedure used to mimic KYDS is the injection of a high dose of exogenous glucocorticoid(hydrocortisone and corticosterone).Such a model showed symptoms such as exhaustion,body twists,cold limbs,lying crowded together,decreased rectal temperature,sexual dysfunction,decreased reaction speed,reduced spontaneous activity,hair loss,loss of appetite,and weight loss.Moreover,the model manifested an imbalance in mutual control among the hormones of the pituitary-target gland axes,including adrenocorticotrophic hormone,CORT,CRH,thyroid-stimulating hormone,triiodothyronine,thyroxine,T,E2,follicle-stimulating hormone,luteinizing hormone,and 17-OHCS.

巢国俊应用“扶阳消阴,培本通络”法治疗视网膜色素变性经验

介绍巢国俊教授诊治视网膜色素变性临床验案。阳气为人之根本,视网膜色素变性患者本质为脾肾阳虚,阳虚气化不足导致阴邪内生,阴盛则寒,内生阴邪加之外寒之邪,寒性凝滞,进而影响阳气的通达及气血的运行,气血不能到达、濡养视网膜周边,故有夜盲之象。临床诊治视网膜色素变性应当以阴阳为纲,补虚扶本,兼顾气血,遵循“病在阳者,扶阳抑阴”,先温补脾肾之阳,固守先后天之本,扶阳消阴,散邪通络,阳气通达,阴实消散,气血畅通,则视物夜盲改善。

基于“中气下陷”理论探析膜性肾病的病机及诊治思路

基于中气下陷理论探讨膜性肾病的病机,提出“湿蕴脾肾,中气下陷”的病机理论,其中以风邪外侵,中土亏损为发病先导,中气不足,脾肾亏虚为发病基础,气机凝滞,湿瘀阻络为病机核心,毒损脾肾,中气下陷为病情进展,大气虚散,脏腑衰惫为病重结局,中气亏虚贯穿膜性肾病发病始终。论治当取升阳举陷大法,强调早期调补脾肾,御风于外,中期祛湿化瘀解毒,升阳通络,晚期升阳益胃排毒,兼顾心肾虚损。