Taking the Qi and Yin deficiency syndrome as an example,the research method of pharmacology of syndrome management system was proposed.By means of text mining,systematic pharmacology and target analysis,to attempt to ...Taking the Qi and Yin deficiency syndrome as an example,the research method of pharmacology of syndrome management system was proposed.By means of text mining,systematic pharmacology and target analysis,to attempt to reveal the essence of the corresponding syndrome by studying the drugs and targets of Qi and Yin deficiency.Fourteen Chinese herbs treating Qi and Yin deficiency were retrieved and used more than 30 times,and 9,317 related targets were predicted.The common targets of action were 85.Topological analysis was carried out by using degree centrality,closeness centrality and betweenness centrality to confirm that estrogen receptor(ESR1),tumor necrosis factor(TNF),D(2)dopamine receptor(DRD2),vitamin D3 receptor(VDR),glucocorticoid receptor(NR3C1),acetylcholinesterase(ACHE)and endothelin-1(EDN1)were highly correlated with Qi and Yin deficiency syndrome.Through the target to find Qi and Yin deficiency syndrome corresponding to 17 categories of diseases.A new idea was provided for studying the biological essence of TCM clinical syndrome differentiation.展开更多
Objective:To investigate the characteristics of TCM syndromes in elderly patients with acute myeloid leukemia(AML)at the onset,and to analyze the main syndrome types and their correlation with age,percentage of bone m...Objective:To investigate the characteristics of TCM syndromes in elderly patients with acute myeloid leukemia(AML)at the onset,and to analyze the main syndrome types and their correlation with age,percentage of bone marrow blasts,and genetic prognostic stratification.Methods:A retrospective analysis was performed on 159 AML patients aged over 60 years who were diagnosed and treated in our hospital,and the clinical data were collected and analyzed statistically.Results:In 159 elderly AML patients,the main clinical symptoms were fatigue,poor appetite,conscious fever,and various hemorrhages.The main syndromes were Ying(42.01%),Wei(31.25%),Essential(14.81%)and Blood(11.69%);the syndromes are divided into Qi and Yin deficiency(32.70%),Qi and blood deficiency(30.19%),true Yin deficiency(28.03%)and Qi heat and blood(8.81%).The age difference between the two groups was statistically significant(P<0.001),and the multiple comparison results showed that the age of the Qi-blood deficiency group was younger than the true-Yin deficiency group and the Qi-Yin deficiency group;the percentage of bone marrow blasts was statistically significant in the three groups at the initial diagnosis(P<0.05),multiple comparison results showed that the percentage of bone marrow blasts in the true Yin deficiency group was higher than that in the Qi-blood deficiency group and the Qi-Yin deficiency group;the genetic prognostic stratification of the three groups was statistically significant(P<0.05),multiple comparisons.The results showed that the genetic prognosis of the true Yin deficiency group was poorer than that of the Qi and blood deficiency group and the Qi and Yin deficiency group.Conclusion:The most common clinical symptoms of elderly AML patients are fatigue,the disease is located in the bone marrow,and the disease is Ying,Wei,essence,and blood.With the increase in the patient's age,the TCM syndrome types tend to be more insufficiency of true Yin and deficiency of both Qi and Yin,and the prognosis of patients with insufficiency of true Yin is poor.It provides a directional scientific basis for the treatment of senile AML with integrated traditional Chinese and Western medicine.展开更多
目的探讨益气甘露方治疗2型糖尿病气阴两虚证的临床疗效及其对血清代谢产物的影响。方法将80例2型糖尿病气阴两虚证患者随机分为对照组、试验组,每组40例,同时选取了40名与糖尿病患者年龄、性别相匹配的健康人作为健康对照组。西药对照...目的探讨益气甘露方治疗2型糖尿病气阴两虚证的临床疗效及其对血清代谢产物的影响。方法将80例2型糖尿病气阴两虚证患者随机分为对照组、试验组,每组40例,同时选取了40名与糖尿病患者年龄、性别相匹配的健康人作为健康对照组。西药对照组予二甲双胍治疗,中药试验组予益气甘露方治疗,对比治疗前后两组的临床疗效、生化指标、炎症因子、中医症状积分及血清代谢产物的变化。结果治疗前,两组患者的血糖及血脂指标比较差异无统计学意义(P>0.05);治疗后,两组患者的FPG、2 h PG、HbAlc、INS、INS120′、TC、TG、LDL-C、TNF-α、IL-6、hs-CRP水平与治疗前比较差异均具有统计学意义(P<0.05),且中药试验组疗效不低于西药对照组。2型糖尿病气阴两虚证与健康人的差异性代谢物主要有溶血磷脂酸、磷脂酰乙醇胺、心磷脂、二氢生物蝶呤等,所参与的代谢途径主要涉及脂类代谢和氨基酸代谢。结论益气甘露方可以降低血糖、血脂及炎症水平,调节脂质与氨基酸代谢,改善临床症状。展开更多
文摘Taking the Qi and Yin deficiency syndrome as an example,the research method of pharmacology of syndrome management system was proposed.By means of text mining,systematic pharmacology and target analysis,to attempt to reveal the essence of the corresponding syndrome by studying the drugs and targets of Qi and Yin deficiency.Fourteen Chinese herbs treating Qi and Yin deficiency were retrieved and used more than 30 times,and 9,317 related targets were predicted.The common targets of action were 85.Topological analysis was carried out by using degree centrality,closeness centrality and betweenness centrality to confirm that estrogen receptor(ESR1),tumor necrosis factor(TNF),D(2)dopamine receptor(DRD2),vitamin D3 receptor(VDR),glucocorticoid receptor(NR3C1),acetylcholinesterase(ACHE)and endothelin-1(EDN1)were highly correlated with Qi and Yin deficiency syndrome.Through the target to find Qi and Yin deficiency syndrome corresponding to 17 categories of diseases.A new idea was provided for studying the biological essence of TCM clinical syndrome differentiation.
文摘Objective:To investigate the characteristics of TCM syndromes in elderly patients with acute myeloid leukemia(AML)at the onset,and to analyze the main syndrome types and their correlation with age,percentage of bone marrow blasts,and genetic prognostic stratification.Methods:A retrospective analysis was performed on 159 AML patients aged over 60 years who were diagnosed and treated in our hospital,and the clinical data were collected and analyzed statistically.Results:In 159 elderly AML patients,the main clinical symptoms were fatigue,poor appetite,conscious fever,and various hemorrhages.The main syndromes were Ying(42.01%),Wei(31.25%),Essential(14.81%)and Blood(11.69%);the syndromes are divided into Qi and Yin deficiency(32.70%),Qi and blood deficiency(30.19%),true Yin deficiency(28.03%)and Qi heat and blood(8.81%).The age difference between the two groups was statistically significant(P<0.001),and the multiple comparison results showed that the age of the Qi-blood deficiency group was younger than the true-Yin deficiency group and the Qi-Yin deficiency group;the percentage of bone marrow blasts was statistically significant in the three groups at the initial diagnosis(P<0.05),multiple comparison results showed that the percentage of bone marrow blasts in the true Yin deficiency group was higher than that in the Qi-blood deficiency group and the Qi-Yin deficiency group;the genetic prognostic stratification of the three groups was statistically significant(P<0.05),multiple comparisons.The results showed that the genetic prognosis of the true Yin deficiency group was poorer than that of the Qi and blood deficiency group and the Qi and Yin deficiency group.Conclusion:The most common clinical symptoms of elderly AML patients are fatigue,the disease is located in the bone marrow,and the disease is Ying,Wei,essence,and blood.With the increase in the patient's age,the TCM syndrome types tend to be more insufficiency of true Yin and deficiency of both Qi and Yin,and the prognosis of patients with insufficiency of true Yin is poor.It provides a directional scientific basis for the treatment of senile AML with integrated traditional Chinese and Western medicine.
文摘目的探讨益气甘露方治疗2型糖尿病气阴两虚证的临床疗效及其对血清代谢产物的影响。方法将80例2型糖尿病气阴两虚证患者随机分为对照组、试验组,每组40例,同时选取了40名与糖尿病患者年龄、性别相匹配的健康人作为健康对照组。西药对照组予二甲双胍治疗,中药试验组予益气甘露方治疗,对比治疗前后两组的临床疗效、生化指标、炎症因子、中医症状积分及血清代谢产物的变化。结果治疗前,两组患者的血糖及血脂指标比较差异无统计学意义(P>0.05);治疗后,两组患者的FPG、2 h PG、HbAlc、INS、INS120′、TC、TG、LDL-C、TNF-α、IL-6、hs-CRP水平与治疗前比较差异均具有统计学意义(P<0.05),且中药试验组疗效不低于西药对照组。2型糖尿病气阴两虚证与健康人的差异性代谢物主要有溶血磷脂酸、磷脂酰乙醇胺、心磷脂、二氢生物蝶呤等,所参与的代谢途径主要涉及脂类代谢和氨基酸代谢。结论益气甘露方可以降低血糖、血脂及炎症水平,调节脂质与氨基酸代谢,改善临床症状。
