Diffuse axonal injury （DAI） is one of the devastating mechanisms of traumatic brain injury （TBI） and shows extensive sub- cortical lesions due to shearing forces induced by rapid acceleration-deceleration and rota...Diffuse axonal injury （DAI） is one of the devastating mechanisms of traumatic brain injury （TBI） and shows extensive sub- cortical lesions due to shearing forces induced by rapid acceleration-deceleration and rotation of the brain （Adams et al., 1982; Meythaler et al., 2001）. As a result, conventional brain imaging techniques including brain MRI have been limited in demon- strating neuronal degeneration in patients with DAI. However, diffusion tensor tractography （DTT）, which is derived from diffusion tensor imaging （DTI） has enabled three-dimensional reconstruction of the neural tracts （Jang and Seo, 2014）. Since the introduction of DTI, several studies have demonstrated neuronal degeneration after TBI （Tomaiuolo et al., 2005; Hong and lang, 2010; Kwon and Jang, 2014）. However, little is known about delayed neuronal degeneration in patients with TBI.展开更多
基金supported by the Medical Research Center Program(2015R1A5A2009124)through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and Future Planning
文摘Diffuse axonal injury （DAI） is one of the devastating mechanisms of traumatic brain injury （TBI） and shows extensive sub- cortical lesions due to shearing forces induced by rapid acceleration-deceleration and rotation of the brain （Adams et al., 1982; Meythaler et al., 2001）. As a result, conventional brain imaging techniques including brain MRI have been limited in demon- strating neuronal degeneration in patients with DAI. However, diffusion tensor tractography （DTT）, which is derived from diffusion tensor imaging （DTI） has enabled three-dimensional reconstruction of the neural tracts （Jang and Seo, 2014）. Since the introduction of DTI, several studies have demonstrated neuronal degeneration after TBI （Tomaiuolo et al., 2005; Hong and lang, 2010; Kwon and Jang, 2014）. However, little is known about delayed neuronal degeneration in patients with TBI.
