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Investigation of the cell composition and gene expression in the delayed-type hypersensitivity tuberculin skin test
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作者 Hui-Juan Duan Hong-Qian Chu +4 位作者 Ting-Ming Cao Guang-Ming Dai Na Tian Gang Sheng Zhao-Gang Sun 《Military Medical Research》 SCIE CAS CSCD 2024年第1期148-151,共4页
Dear Editor,The tuberculin skin test(TST)reagents have continuously improved,with the ESAT6-CFP10(EC)test having recently been introduced,but are seldom based on the direction of the delayed-type hypersensitivity(DTH)... Dear Editor,The tuberculin skin test(TST)reagents have continuously improved,with the ESAT6-CFP10(EC)test having recently been introduced,but are seldom based on the direction of the delayed-type hypersensitivity(DTH)mechanism.Previous studies only partially showed the infiltration and activation of immune cells and the production of cytokines of the skin induration[1,2],and lack the detailed measurements of cell proportions and gene expression in the DTH response.Therefore,in this study,we revealed the comprehensive characteristics of DTH by single-cell RNA sequencing(scRNA-seq)in the guinea pig tuberculosis(TB)model[Experimental Animal Welfare Ethics Committee,Beijing Tuberculosis and Thoracic Tumor Research Institute(2021-064)]. 展开更多
关键词 Tuberculin skin test delayed-type hypersensitivity Single-cell RNA sequencing
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Analysis of T-lymphocyte subtypes of the peripheral blood and skindelayed-type hypersensitivity in patients with hyper-IgE syndrome
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作者 XiaobingLei ShengshunTan WeihuiZeng JunminWang PanjianZhang YuanYuan 《Journal of Nanjing Medical University》 2005年第2期99-101,共3页
Objective: To study the function of ce ll ular immunity in patients with hyper-IgE syndrome (HIE). Methods: T-lymphocyte subtypes of the peripheral blood and cutaneous delayed-typ e hypersensitivity (DTH) response ... Objective: To study the function of ce ll ular immunity in patients with hyper-IgE syndrome (HIE). Methods: T-lymphocyte subtypes of the peripheral blood and cutaneous delayed-typ e hypersensitivity (DTH) response to two recall antigens, tetanus toxoid (TT) an d purified protein derivative(PPD), were measured in five patients with HIE and 15 healthy controls, respectively. Results: The CD4+ cell cou nts in HIE group were significantly lower than those in control group (P<0. 01). In contrast, CD8+ cells were significantly higher than those in the contro l (P<0.01). The induration sizes of DTH response to two recall antigens wer e smaller in HIE group than those in the control group (P<0.01). Co nclusion: There was an immunologic dysfunction of T lymphocytes in the p atients with HIE. 展开更多
关键词 Hyper-IgE Syndrome T-lymphocyte subtypes delayed-type hypersensitivity
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Intermittent Fasting Ameliorates Delayed-Type Hypersensitivity in NC/Nga Mice
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作者 Hirao Kohno Katsuyasu Kouda +5 位作者 Hiroyasu Ishihara Nobuhiro Nishio Yutaka Sasaki Harunobu Nakamura Masayuki Iki Yoshiaki Sonoda 《Food and Nutrition Sciences》 2011年第4期287-293,共7页
It is well documented that dietary restriction can prevent many different diseases and extend the life spans of different rodent species. In the previous study, we reported that intermittent fasting (IF) as well as mo... It is well documented that dietary restriction can prevent many different diseases and extend the life spans of different rodent species. In the previous study, we reported that intermittent fasting (IF) as well as moderate dietary restriction ameliorated the allergic dermatitis in ICR mice. In the present study, we demonstrated the ameliorative effects of IF on allergic dermatitis in NC/Nga mice, a strain known as a model for atopic dermatitis. Interestingly, the total number of CD4+CD8+ double positive thymocyte in mice after IF significantly decreased in comparison to that in mice fed ad libitum. Although it was reported that an immunosuppressive compound inhibited the contact allergic response by inducing the CD4+CD25+ regulatory T-cells, IF did not affect regulatory T cells in the present study. These results suggested that CD4+CD8+ double positive thymocytes play an important role in the regulation of allergy by IF in NC/Nga mice. 展开更多
关键词 INTERMITTENT FASTING delayed-type hypersensitIVITY Contact DERMATITIS THYMOCYTE
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Identif ication of a hypersensitive response core peptide of HrpZ and its role in increasing grape downy mildew resistance
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作者 Zongbao Fan Xueqiang Guan +4 位作者 Zhichang Zhang Yushuai Sun Fei Wang Huiru Chi Yuxin Yao 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第5期1112-1120,共9页
Harpins play a key role in inducing disease resistance in crops,and identifying their core functional regions and establishing a system for their efficient expression would be very valuable.In this study,large amounts... Harpins play a key role in inducing disease resistance in crops,and identifying their core functional regions and establishing a system for their efficient expression would be very valuable.In this study,large amounts of soluble fusion proteins of harpin HrpZ and its subpeptides were obtained via the optimized induction conditions(28℃ with 0.5 mmol·L^(-1) IPTG for 6 h)in Escherichia coli BL21(DE3).Hypersensitive response(HR)assays demonstrated that the C-terminal 66 aa of HrpZ(HrpZ_C_2_2)elicited a strong HR in tobacco(Nicotiana benthamiana)and grape(Flame Seedless)leaves.Additionally,treatment with HrpZ,and particularly HrpZ_C_2_2,significantly reduced the disease incidence and severity index of field vine leaves and those inoculated with downy mildew.The determination of the physiological parameters indicated that HrpZ,and especially HrpZ_C_2_2,improved the photosynthesis-and chlorophyll fluorescence-related parameters,enhanced the activity of defense-related enzymes,including SOD,POD,CAT and PAL,and increased the H_(2)O_(2) level.Collectively,we efficiently expressed a core peptide of HrpZ and elucidated its strong ability to elicit a HR and resistance to downy mildew.This research provides insight into understanding the structure and function of HrpZ and will advance the application of HrpZ_C_2_2 to increase the resistance of grapevine to downy mildew. 展开更多
关键词 GRAPEVINE Harpin HrpZ Prokaryotic expression Downy mildew hypersensitive response
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A Selective‑Response Hypersensitive Bio‑Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through‑Slits Structures
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作者 Qun Wang Zhongwen Yao +8 位作者 Changchao Zhang Honglie Song Hanliang Ding Bo Li Shichao Niu Xinguan Huang Chuanhai Chen Zhiwu Han Luquan Ren 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第2期139-153,共15页
Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced fields.However,the effective integration of hypersensitivity and highly selective response into... Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced fields.However,the effective integration of hypersensitivity and highly selective response into one flexible strain sensor remains a huge challenge.Herein,inspired by the hysteresis strategy of the scorpion slit receptor,a bio-inspired flexible strain sensor(BFSS)with parallel through-slit arrays is designed and fabricated.Specifically,BFSS consists of conductive monolayer graphene and viscoelastic styrene–isoprene–styrene block copolymer.Under the synergistic effect of the bio-inspired slit structures and flexible viscoelastic materials,BFSS can achieve both hypersensitivity and highly selective frequency response.Remarkably,the BFSS exhibits a high gage factor of 657.36,and a precise identification of vibration frequencies at a resolution of 0.2 Hz through undergoing different morphological changes to high-frequency vibration and low-frequency vibration.Moreover,the BFSS possesses a wide frequency detection range(103 Hz)and stable durability(1000 cycles).It can sense and recognize vibration signals with different characteristics,including the frequency,amplitude,and waveform.This work,which turns the hysteresis effect into a"treasure,"can provide new design ideas for sensors for potential applications including human–computer interaction and health monitoring of mechanical equipment. 展开更多
关键词 Bio-inspired strain sensors Hysteresis effect hypersensitIVITY Selective frequency response Health monitoring applications
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Evaluation of Recombinant <i>Mycobacterium tuberculosis</i>Antigens MPT64, CFP10, and ESAT6 for Delayed-Type Hypersensitivity Responses in Guinea Pigs
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作者 Wandee Yindeeyoungyeon Kamolchanok Rukseree +1 位作者 Siriporn Tungsudjai Tasanee Panichakul 《Advances in Microbiology》 2015年第8期586-598,共13页
The tuberculin Purified Protein Derivative (PPD) skin test is widely used;however, the results are often inaccurate. Positive results can be observed in patients with active tuberculosis (TB) as well as in BCG-vaccina... The tuberculin Purified Protein Derivative (PPD) skin test is widely used;however, the results are often inaccurate. Positive results can be observed in patients with active tuberculosis (TB) as well as in BCG-vaccinated persons and individuals who are infected with mycobacteria but have not developed the disease. MPT64, an antigen secreted from actively growing Mycobacterium tuberculosis and some strains of M. bovis BCG such as BCG Tokyo and BCG Russia, is immunogenic and elicits delayed-type hypersensitivity (DTH) in guinea pigs and humans. This antigen has been used to develop a new skin test for the diagnosis of active TB infection. Two of the antigens encoded by the M. tuberculosis-specific region of difference 1 (RD1, deleted in M. bovis BCG strains), CFP10 (culture filtrate protein 10) and ESAT6 (early secreted antigenic target-6), also induce M. tuberculosis-specific DTH responses. The aim of this study was to investigate the DTH responses in guinea pigs infected with M. tuberculosis or M. bovis BCG Tokyo elicited by three purified recombinant proteins (rMPT64, rCFP10 and rESAT6) compared to those elicited by PPD. In this study genes encoding MPT64, CFP10, and ESAT6 were cloned and expressed as recombinant proteins with the addition of a C-terminal His6 tag for ease of purification by Immobilized Metal ion Affinity Chromatography (IMAC). The recombinant proteins (rMPT64, rCFP10, and rESAT6) were purified to homogeneity and were used to elicit DTH responses in guinea pigs infected with M. tuberculosis or M. bovis BCG Tokyo. The results showed that rMPT64 elicits a DTH response comparable to that of PPD in M. bovis BCG Tokyo-vaccinated animals. However, M. tuberculosis-infected animals show less reactivity to rMPT64 than they do to PPD. Although single rCFP10 or rESAT6 did not readily elicit a DTH response in M. tuberculosis-infected animals, combining these antigens with rMPT64 led to an increased DTH response, thus enabling the detection of TB infection. 展开更多
关键词 M. tuberculosis M. BOVIS BCG Tokyo delayed-type hypersensitivity DTH MPT64 CFP10 ESAT6
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The Beneficial Effect of 3-Month-Induction Therapy with Corticosteroids and Mycophenolate Mofetil Followed by Maintenance Therapy with Yearly Rituximab Infusions as Sole Maintenance Therapy in Cryptogenic Chronic Hypersensitivity Pneumonitis
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作者 Kamel El-Reshaid Abdulmohsen Al-Bader +1 位作者 Sana S. Almutairi Sayed H. M. Mohamad 《International Journal of Clinical Medicine》 2023年第8期338-346,共17页
Background: The available data on cryptogenic chronic hypersensitivity pneumonitis (ccHP) indicate an inherited predisposition to disease with triggering autoimmune phenomena. Hence, we evaluated prospectively the rol... Background: The available data on cryptogenic chronic hypersensitivity pneumonitis (ccHP) indicate an inherited predisposition to disease with triggering autoimmune phenomena. Hence, we evaluated prospectively the role of a new autoimmune regimen in treatment of its severe and progressive disease. Patients and Methods: A total of 9 patients were included in the study. They had criteria for ccHP viz. 1) clinical features of cryptogenic progressive restrictive lung disease, 2) high-resolution computed tomographic pulmonary abnormalities, and 3) bronchoalveolar lavage lymphocytosis (>30%). The regimen consisted of an initial induction phase of 3-month Solumedrol 1 g IV daily for 3 days followed by 1 month of Prednisone (P) 60 mg/day to tapered down to discontinuation by 3rd month. They also had received Mycophenolate mofetil (MMF) 1 g twice daily for 3 months. This stage was followed by a maintenance phase of yearly Rituximab infusions (1 g followed by 1 g 2 weeks later). Results: compared to their previous 6 months deterioration;all patients showed significant improvement in their forced vital volume, diffusion capacity for carbon monoxide, 6-minutes-walk after the induction phase (at 3 months) which improved further at 15 months with Rituximab therapy. Conclusion: After 3-month induction therapy with P and MMF;yearly R treatment is a safe, practical and effective long-term therapy for ccHP. 展开更多
关键词 hypersensitivity Pneumonitis Mycophenolate Mofetil RITUXIMAB SPIROMETRY HRCT BAL
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腹部推拿对内脏高敏感腹泻型肠易激综合征大鼠肠道肥大细胞、TRPV1的影响 被引量:2
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作者 李华南 王毓岩 +4 位作者 张小凡 张玮 马菲 董桦 王金贵 《辽宁中医杂志》 CAS 北大核心 2024年第3期191-195,I0008,共6页
目的观察腹部推拿对内脏高敏感腹泻型肠易激综合征(diarrhea-type irritable bowel syndrome,IBS-D)模型大鼠肠道肥大细胞(mastcell,MC)及TRPV1表达水平的影响,探讨腹部推拿调控内脏高敏感IBS-D作用机制。方法40只SD雄性大鼠随机分为空... 目的观察腹部推拿对内脏高敏感腹泻型肠易激综合征(diarrhea-type irritable bowel syndrome,IBS-D)模型大鼠肠道肥大细胞(mastcell,MC)及TRPV1表达水平的影响,探讨腹部推拿调控内脏高敏感IBS-D作用机制。方法40只SD雄性大鼠随机分为空白组、模型组、腹部推拿组、MC阻断剂组,每组10只。采用母婴分离法+慢性应激法制备IBS-D大鼠模型。应用粪便性状(Bristol)评分、旷场试验评价干预效果,透射电镜观察结肠组织MC变化,定量PCR检测TRPV1 mRNA表达,免疫荧光法检测瞬时感受器电位香草酸亚型1(transient receptor potential vanilloid subfamily 1,TRPV1)阳性细胞数。结果(1)Bristol评分:与空白组比较,模型组Bristol评分增加(P<0.05);与模型组比较,腹部推拿组、MC阻断剂组评分降低(P<0.01)。(2)旷场试验:与空白组比较,模型组穿行方格次数、中央停留次数、中央停留时间和站立次数均显著减少(P<0.01);与模型组比较,腹部推拿组、MC阻断剂组各评分升高(P<0.05,P<0.01);与MC阻断剂组比较,腹部推拿组在站立次数方面低于MC阻断剂组(P<0.01)。(3)透射电镜:与空白组比较,模型组肠道MC微绒毛形态不规则,呈脱颗粒状态;腹部推拿组较模型组MC形态规整,脱颗粒程度不明显。MC阻断剂组形态规则与空白组近似。(4)TRPV1 mRNA表达:与空白组比较,模型组表达量明显升高(P<0.01);与模型组比较,腹部推拿组和MC阻断剂组表达量明显降低(P<0.01);与MC阻断剂组比较,腹部推拿组TRPV1 mRNA的表达略高(P<0.05)。(5)免疫荧光检测:与空白组比较,模型组TRPV1阳性细胞数显著增多,且荧光强度明显增高;与模型组比较,腹部推拿组和MC阻断剂组模型组TRPV1阳性细胞数显著减少,且荧光强度明显降低。结论腹部推拿可能借助调控肠道MC脱颗粒,降低TRPV1表达,从而对内脏高敏感IBS-D大鼠起到干预作用。 展开更多
关键词 腹部推拿 腹泻型肠易激综合征 内脏高敏感 作用机制
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Hypersensitivity Reaction Caused by Intravenous Gadolinium-based MRI Contrast Agents
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作者 Lai Jing Qin Liangyi +2 位作者 Qin Yane Lan Xiaobu Zhang Qi 《Asian Journal of Social Pharmacy》 2023年第3期296-298,共3页
Objective To present a rare case of skin allergic reaction to gadobutrol,a magnetic resonance imaging(MRI)contrast agent,in a 37-year-old man.Methods The adverse reactions of gadobutrol were analyzed combined with the... Objective To present a rare case of skin allergic reaction to gadobutrol,a magnetic resonance imaging(MRI)contrast agent,in a 37-year-old man.Methods The adverse reactions of gadobutrol were analyzed combined with the instructions and related literatures.Results and Conclusion The presence of this patient is consistent with the adverse reactions in the instructions of gadobutrol.The incidence of ADR in gadobutrol is considered to be low,although sometimes patients report a hypersensitivity reaction when undergoing MRI.There are only a few cases of immediate adverse reactions to gadobutrol.However,we should improve the ability of medical staff to use drugs safely and take preventive measures. 展开更多
关键词 GADOBUTROL magnetic resonance imaging(MRI) hypersensitivity reaction ALLERGY safety
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药物超敏反应综合征并人类免疫缺陷病毒感染1例及文献复习
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作者 张静 李军友 +1 位作者 黄蓉 骆志成 《安徽医药》 CAS 2024年第3期628-630,共3页
目的 提高临床医师对药物超敏反应综合征和人类免疫缺陷病毒(HIV)感染者/艾滋病病人药疹的认识,减少误诊。方法回顾性分析2021年11月于兰州大学第二医院住院的1例药物超敏反应综合征伴HIV感染者的临床资料,并行文献复习。结果 病人因“... 目的 提高临床医师对药物超敏反应综合征和人类免疫缺陷病毒(HIV)感染者/艾滋病病人药疹的认识,减少误诊。方法回顾性分析2021年11月于兰州大学第二医院住院的1例药物超敏反应综合征伴HIV感染者的临床资料,并行文献复习。结果 病人因“全身出红斑伴痒20 d”入院,入院前有复杂的用药史,入院后反复发热,查体面部水肿、淋巴结肿大、脾大,辅助检查提示嗜酸性粒细胞明显升高、HIV抗体筛查阳性,明确诊断为药物超敏反应综合征,予以糖皮质激素联合人免疫球蛋白为主的治疗,病情缓解。结论 药物超敏反应综合征是一种病毒激活相关的重症药疹,典型特征为发热、皮疹、面部水肿、嗜酸性粒细胞升高、淋巴结肿大、肝酶异常和病情反复,系统使用糖皮质激素联合人免疫球蛋白治疗有效。HIV感染可参与该病的发生发展。 展开更多
关键词 超敏反应 迟发型 药物超敏反应综合征 嗜酸粒细胞增多 人类免疫缺陷病毒感染 艾滋病 糖皮质激素类
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利妥昔单抗快速脱敏治疗 病例报告/病例系列的系统评价
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作者 陈默 马雪 +2 位作者 李超 邱悦 陈娅 《医药导报》 CAS 北大核心 2024年第8期1259-1269,共11页
目的系统评价利妥昔单抗快速脱敏治疗的有效性和安全性。方法检索PubMed、Embase、Cochrane、Web of Science、Scopus、中国知识基础设施工程网(CNKI)、万方数据库数字化期刊和重庆维普中文科技期刊数据库,检索时限均为建库至2023年2月... 目的系统评价利妥昔单抗快速脱敏治疗的有效性和安全性。方法检索PubMed、Embase、Cochrane、Web of Science、Scopus、中国知识基础设施工程网(CNKI)、万方数据库数字化期刊和重庆维普中文科技期刊数据库,检索时限均为建库至2023年2月。由2位评价员独立筛选文献、提取数据,并评价纳入文献的质量,对结果数据进行描述性分析或统计性分析。系统评价方案已在PROSPERO注册(CRD:42022306557)。结果纳入25项研究(11个病例报告和14个病例系列),共计138例患者进行脱敏治疗,129例脱敏成功(即至少完成一次目标剂量给药)。脱敏前预处理方案为H1、H2受体拮抗剂,糖皮质激素,镇静剂,NSAIDs和对乙酰氨基酚等药物中2种或以上联合,88%的研究预处理分别包含H1受体拮抗剂或糖皮质激素。16项(64.0%)研究报告患者脱敏前皮试情况,皮肤点刺试验(n=16)和皮内试验(n=59)阳性率分别为12.50%、49.15%。17项研究(68.0%)采用3袋-12步法快速脱敏方案,其余为4袋-16步或2袋-8步等多种方法;利妥昔单抗初始给药浓度(即第一袋脱敏药液浓度)为1/10 X-1/10000 X,第一步输注速率基本为1.5~5 mL·min^(-1),单次脱敏总时长4~10.5 h。23项(92%)研究报告患者脱敏过程中变态反应发生情况,其中5项研究未发生变态反应、18项研究中大部分患者在给予对症处理或修改脱敏方案后完成脱敏治疗。结论当前证据表明,利妥昔单抗快速脱敏治疗具有一定的有效性和安全性,但目前缺乏具体的操作性强的高质量证据或执行标准,有待更多大样本、多中心的研究在脱敏前皮试、预处理、个体化脱敏步骤和脱敏过程中过敏反应处理等方面进一步探索。 展开更多
关键词 利妥昔单抗 药物超敏反应 快速脱敏治疗
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加味芎蝎散对咳嗽高敏综合征大鼠神经源性炎症的影响
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作者 孙洮玉 杨斌 +3 位作者 任军华 樊茂蓉 徐春英 郭慧娟 《现代中西医结合杂志》 CAS 2024年第5期619-626,共8页
目的探讨加味芎蝎散对咳嗽高敏综合征大鼠咳嗽及神经源性炎症的影响。方法取雄性SD大鼠36只,随机选取6只作为正常组,剩余大鼠采用密室烟熏法建立咳嗽高敏综合征模型。将造模成功大鼠随机分成5组,每组6只。加味芎蝎散高、中、低剂量组分... 目的探讨加味芎蝎散对咳嗽高敏综合征大鼠咳嗽及神经源性炎症的影响。方法取雄性SD大鼠36只,随机选取6只作为正常组,剩余大鼠采用密室烟熏法建立咳嗽高敏综合征模型。将造模成功大鼠随机分成5组,每组6只。加味芎蝎散高、中、低剂量组分别给予加味芎蝎散12 g/(kg·d)、6 g/(kg·d)、3 g/(kg·d)灌胃,磷酸可待因组给予磷酸可待因10 mg/(kg·d)灌胃,正常组及模型组给予等量蒸馏水灌胃,均连续灌胃3周。分别在灌胃1周、2周、3周末进行咳嗽反应检测,记录3 min内的咳嗽次数;灌胃3周后,HE染色观察肺组织病理形态,尼氏染色观察大脑皮质神经元尼氏体,免疫组化法检测支气管组织中P物质(SP)、降钙素基因相关肽(CGRP)、瞬态电压感受器阳离子通道(TRPV1)蛋白和大脑皮质中白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)表达情况。结果与正常组比较,模型组大鼠咳嗽次数明显增多(P<0.05);支气管黏膜上皮变性,平滑肌层排列紊乱、增生,管壁大量炎性细胞浸润;神经元细胞形态不规则,尼氏体减少;支气管组织中SP、CGRP、TRPV1蛋白表达积分光密度值和大脑皮质中IL-6、IL-1β表达积分光密度值均明显升高(P均<0.05)。与模型组比较,加味芎蝎散高、中剂量组大鼠咳嗽次数明显减少(P均<0.05),病理变化均有不同程度的减轻,支气管组织中SP、CGRP、TRPV1蛋白表达积分光密度值和大脑皮质中IL-6、IL-1β表达积分光密度值均明显降低(P均<0.05)。结论加味芎蝎散可以明显减轻咳嗽高敏综合征大鼠气道上皮及大脑皮质神经元病变,抑制咳嗽反射,机制可能与抑制神经源性炎症有关。 展开更多
关键词 咳嗽高敏综合征 加味芎蝎散 神经源性炎症 大鼠
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生物活性材料治疗修复中常见的牙本质敏感症的效果研究
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作者 李丹 刘侠 王淑英 《口腔颌面修复学杂志》 2024年第3期198-203,共6页
目的:牙本质敏感症(dentin hypersensitivity,DH)作为口腔中常见的一种症状和疾病,可能对患者的生活质量产生较大影响,本研究通过体外实验比较Regesi生物活性材料、Gluma脱敏剂和可乐丽菲露Clearfil SE Bond两步法粘接剂对牙本质小管封... 目的:牙本质敏感症(dentin hypersensitivity,DH)作为口腔中常见的一种症状和疾病,可能对患者的生活质量产生较大影响,本研究通过体外实验比较Regesi生物活性材料、Gluma脱敏剂和可乐丽菲露Clearfil SE Bond两步法粘接剂对牙本质小管封闭程度及耐久性的差异,为其用于牙本质敏感症的治疗提供数据支持。方法:体外实验中,用离体牙制作牙本质敏感模型,根据脱敏材料的不同进行随机分组(对照组:人工唾液组;A组:Regesi组;B组:Gluma组;C组:Clearfil SEBond组),通过SEM观察脱敏剂作用后,4组牙本质敏感模型的形貌及牙本质小管封闭效果,分析对比其脱敏效果的差异,并通过耐磨性实验,分析材料间脱敏效果持久性之间的差异及表面硬度的差异。结果:SEM观察可见A、B、C组的牙本质小管封闭效果均优于对照组,结果有统计学差异,其中A组封闭效果最好,较其他两组有统计学差异。耐磨性实验前后,A组的表面硬度均高于其他三组,结果有统计学差异。结论:Regesi生物活性材料较Gluma脱敏剂和Clearfil SE Bond两步法粘接剂对牙本质小管的封闭程度及耐久性能更佳,能更好地治疗牙本质敏感症。 展开更多
关键词 牙本质敏感症 生物活性材料 脱敏剂
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右美托咪定对孕产妇椎管内麻醉期间寒战及血流动力学的影响
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作者 朱咏仪 温博伦 +2 位作者 吴青霖 梁少玲 宗银东 《天津医药》 CAS 2024年第4期387-391,共5页
目的 探讨右美托咪定对孕产妇行椎管内麻醉期间寒战及血流动力学的影响。方法 纳入384例术中发生寒战的剖宫产产妇并随机分为观察组和对照组,各192例。对照组采用哌替啶对寒战进行治疗,观察组采用右美托咪定。比较2组麻醉效果、寒战治... 目的 探讨右美托咪定对孕产妇行椎管内麻醉期间寒战及血流动力学的影响。方法 纳入384例术中发生寒战的剖宫产产妇并随机分为观察组和对照组,各192例。对照组采用哌替啶对寒战进行治疗,观察组采用右美托咪定。比较2组麻醉效果、寒战治疗的疗效、血流动力学指标及血清中超敏C反应蛋白(hs-CRP)、前列腺素E2(PGE2)、皮质醇(Cor)水平。结果 相较于对照组,观察组的寒战停止时间较短,寒战控制情况较好(P<0.05);2组舒张压、收缩压、心率、血氧饱和度均发生改变,但观察组波动幅度显著小于对照组(P<0.05);2组应激指标均升高,但观察组hs-CRP、PGE2、Cor水平较对照组升高幅度小(P<0.05);观察组不良反应总发生率低于对照组(P<0.05)。结论 临床应用右美托咪定对剖宫产产妇进行椎管内麻醉治疗寒战的效果较好,可稳定机体血流动力学水平,临床应用价值较高。 展开更多
关键词 剖宫产术 右美托咪定 寒战 血流动力学 超敏C反应蛋白
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多重微球流式免疫荧光技术对肺癌患者外周血IL-1β、IL-6、IFN-γ水平测定及与hs-CRP的相关性分析
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作者 王芳 刘莲芳 +3 位作者 王蕾 徐国新 何丽 周勤峰 《国际检验医学杂志》 CAS 2024年第21期2561-2565,共5页
目的探讨多重微球流式免疫荧光技术在肺癌患者外周血白细胞介素(IL)-1β、IL-6和干扰素γ(IFN-γ)细胞因子的表达情况及与超敏C反应蛋白(hs-CRP)相关性分析。方法采用回顾性研究的方法,选择张家港市中医医院(下称该院)肿瘤科和肺病科收... 目的探讨多重微球流式免疫荧光技术在肺癌患者外周血白细胞介素(IL)-1β、IL-6和干扰素γ(IFN-γ)细胞因子的表达情况及与超敏C反应蛋白(hs-CRP)相关性分析。方法采用回顾性研究的方法,选择张家港市中医医院(下称该院)肿瘤科和肺病科收治的30例肺癌患者作为肺癌组,另选择同期该院收治的30例肺炎患者作为肺炎组,同时选取同期该院体检健康者30例作为对照组,通过多重微球流式免疫荧光技术检测血清中IL-1β、IL-6和IFN-γ水平,同时利用乳胶增强免疫散射比浊法测定外周血全血中hs-CRP水平。结果肺癌组与对照组比较,IL-1β、IL-6和hs-CRP水平显著升高,差异有统计学意义(P<0.001),而IFN-γ水平差异无统计学意义(P>0.05);肺炎组与对照组比较,IL-1β、IL-6、IFN-γ、hs-CRP水平均显著升高,差异有统计学意义(P<0.001);肺癌组与肺炎组比较,IL-6、IFN-γ、hs-CRP水平明显降低且IL-1β水平升高,差异均有统计学意义(P<0.05);肺癌组、肺炎组IL-6和hs-CRP水平分别进行Pearson相关性分析,均无明显的相关性。结论IL-1β、IL-6、IFN-γ可以作为有效评估肺癌患者免疫功能的辅助指标,多重微球流式免疫荧光技术的应用对于肺癌的诊断及监测具有潜在的临床应用价值。 展开更多
关键词 肺癌 肺炎 多重微球流式免疫荧光技术 细胞因子 超敏C反应蛋白
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慢性避水应激法建立大鼠肠易激综合征模型及其评价
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作者 刘婷婷 张擎宇 +6 位作者 赵香顺 石运来 于燕南 王正文 陈少宗 冯楚文 杨添淞 《吉林大学学报(医学版)》 CAS CSCD 北大核心 2024年第3期840-846,共7页
目的:探讨慢性避水应激(WAS)法建立肠易激综合征(IBS)大鼠模型的方法,并评价其可行性。方法:30只雄性清洁型Wistar大鼠,随机分为对照组(n=10)和模型组(n=20),模型组大鼠每日采用WAS法诱导1 h,连续干预造模10 d;对照组大鼠不进行任何干... 目的:探讨慢性避水应激(WAS)法建立肠易激综合征(IBS)大鼠模型的方法,并评价其可行性。方法:30只雄性清洁型Wistar大鼠,随机分为对照组(n=10)和模型组(n=20),模型组大鼠每日采用WAS法诱导1 h,连续干预造模10 d;对照组大鼠不进行任何干预。造模结束后,观察并记录2组大鼠一般情况和体质量,采用高架十字迷宫(EPM)实验检测2组大鼠进入开放臂次数(OE)百分率和进入开放臂时间(OT)百分率,腹壁撤回反射(AWR)实验检测2组大鼠内脏敏感性,心电图检查2组大鼠心率变异性(HRV),腹外斜肌肌电图(EMG)检测2组大鼠结直肠痛敏阈值,多通道生理信号记录仪检测2组大鼠结肠慢波频率。结果:2组大鼠在整个造模期间均无死亡情况,造模结束后,模型组大鼠均伴有精神状态欠佳、自主活动减少、少动、皮毛散乱且无光泽、易激惹和肛门口不净等情况;对照组大鼠精神状态、自主活动、皮毛和肛周无明显变化。与对照组比较,模型组大鼠体质量明显降低(P<0.05)。EPM实验,与对照组比较,模型组大鼠OE百分率和OT百分率均明显降低(P<0.01)。AWR实验,模型组中AWR半定量评分≥3分大鼠共12只,内脏痛大鼠模型造模成功率为60%。与对照组比较,模型组大鼠低频信号(LF)和LF/高频信号(HF)比值均明显升高(P<0.01),HF明显降低(P<0.05)。EMG法,与对照组比较,模型组大鼠结肠痛敏阈值明显降低(P<0.01),结肠慢波频率明显升高(P<0.01)。结论:采用WAS法建立IBS大鼠模型,大鼠行为及精神情绪改变、内脏敏感性升高、结肠慢波频率加快和自主神经系统平衡性紊乱,WAS法可作为一种有效的造模方式,用于观察和评价IBS治疗的相关药物及干预方法。 展开更多
关键词 肠易激综合征 行为学 内脏高敏感性 结肠功能 自主神经系统平衡性
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母女同患紫癜性肾炎合并Alport综合征1家系报道
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作者 张宏文 杨武 王利霞 《临床肾脏病杂志》 2024年第1期81-84,共4页
过敏性紫癜(henoch-schonlein purpura,HSP)又称IgA血管炎,是儿童常见的系统性血管炎疾病之一,本病多为自限性疾病、预后相对较好。HSP累及肾脏即为紫癜性肾炎(henoch schonlein purpura nephritis,HSPN),又称IgA血管炎肾炎,是儿科临床... 过敏性紫癜(henoch-schonlein purpura,HSP)又称IgA血管炎,是儿童常见的系统性血管炎疾病之一,本病多为自限性疾病、预后相对较好。HSP累及肾脏即为紫癜性肾炎(henoch schonlein purpura nephritis,HSPN),又称IgA血管炎肾炎,是儿科临床肾脏专业常见的继发性肾小球疾病之一[1-4]。 展开更多
关键词 过敏性紫癜性肾炎 ALPORT综合征 免疫球蛋白A
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药物超敏反应综合征发病及预后的相关进展
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作者 曹嘉力 邢昕竹 +1 位作者 范洁 何焱玲 《实用皮肤病学杂志》 2024年第2期93-96,106,共5页
药物超敏反应综合征(DIHS)又称为伴嗜酸粒细胞增多和系统症状的药疹,是一种特殊类型的重症药疹。临床表现以皮损、发热、淋巴结增大、血液学异常及多脏器受损为主,同时可伴有人疱疹病毒6(HHV-6)的重新激活。目前认为DIHS的发病机制是疱... 药物超敏反应综合征(DIHS)又称为伴嗜酸粒细胞增多和系统症状的药疹,是一种特殊类型的重症药疹。临床表现以皮损、发热、淋巴结增大、血液学异常及多脏器受损为主,同时可伴有人疱疹病毒6(HHV-6)的重新激活。目前认为DIHS的发病机制是疱疹病毒和机体免疫反应之间复杂相互作用的结果,并与个体基因易感性等因素有关,趋化因子在发病过程中也起到重要作用。兹对DIHS发病机制及临床治疗、预后的相关进展进行综述。 展开更多
关键词 药物超敏反应综合征 基因 趋化因子 治疗 预后
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左氧氟沙星氯化钠致以短暂意识丧失为临床表现的速发型药物超敏反应1例
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作者 郑造乾 骆瑾瑜 余荣亮 《中国药物应用与监测》 CAS 2024年第1期90-93,共4页
1例53岁男性患者,因上呼吸道感染于2022年12月23日给予盐酸氨溴索注射液化痰+左氧氟沙星氯化钠注射液(0.5 g:100 mL,即刻,静脉滴注)抗感染治疗。在静脉滴注左氧氟沙星氯化钠注射液约17 min(约25 mL)时,患者出现胸闷心慌,呼吸急促,皮肤瘙... 1例53岁男性患者,因上呼吸道感染于2022年12月23日给予盐酸氨溴索注射液化痰+左氧氟沙星氯化钠注射液(0.5 g:100 mL,即刻,静脉滴注)抗感染治疗。在静脉滴注左氧氟沙星氯化钠注射液约17 min(约25 mL)时,患者出现胸闷心慌,呼吸急促,皮肤瘙痒,随后出现短暂意识丧失,呼之不应,小便失禁,以及全身皮疹、皮肤潮红、肿胀等皮肤反应。立即停止输液并更换输液器,予急诊内科护理常规,特级护理,心电监护,2 L·min^(-1)吸氧、卧床休息、开通静脉通路等处理,肌内注射盐酸异丙嗪注射液25mg,并送入抢救室,途中患者意识恢复,持续3min左右。经过治疗后明显好转。经诺氏评估量表评分为7分,考虑为左氧氟沙星氯化钠注射液所致的以短暂意识丧失为临床表现的速发型药物超敏反应。 展开更多
关键词 速发型药物超敏反应 左氧氟沙星 短暂意识丧失 小便失禁
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血清降钙素原联合超敏C反应蛋白对大叶性肺炎患儿预后的预测价值
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作者 王耀邦 沙宁 张逸娴 《中国医学创新》 CAS 2024年第2期142-145,共4页
目的:探讨降钙素原(PCT)联合超敏C反应蛋白(hs-CRP)对大叶性肺炎患儿预后的预测价值。方法:选择2019年1月—2022年1月于淮安市第二人民医院儿科病房住院的103例大叶性肺炎患儿为研究对象。检测所有患儿血清PCT、hs-CRP水平,根据患儿的... 目的:探讨降钙素原(PCT)联合超敏C反应蛋白(hs-CRP)对大叶性肺炎患儿预后的预测价值。方法:选择2019年1月—2022年1月于淮安市第二人民医院儿科病房住院的103例大叶性肺炎患儿为研究对象。检测所有患儿血清PCT、hs-CRP水平,根据患儿的预后情况分为治疗不佳组(n=10)与治愈组(n=93),收集患儿的临床资料,以多因素logistic回归分析大叶性肺炎的危险因素,制作受试者操作特征(ROC)曲线,以曲线下面积(AUC)评估血清PCT、hs-CRP对大叶性肺炎预后的预测价值。结果:两组患儿年龄、性别、身高、体重、白细胞计数对比,差异均无统计学意义(P>0.05);治疗不佳组hs-CRP、PCT水平均明显高于治愈组(P<0.05)。多因素logistic回归分析显示,血清PCT、hs-CRP均为大叶性肺炎治疗不佳的危险因素(P<0.05)。血清PCT、hs-CRP单一及联合预测大叶性肺炎治疗不佳的AUC分别为0.805、0.810、0.921,联合预测AUC高于单一预测(P<0.05)。结论:大叶性肺炎患儿血清PCT、hs-CRP水平明显升高,与大叶性肺炎治疗不佳密切相关,且两者在预测大叶性肺炎预后中具有重要价值,PCT、hs-CRP联合预测大叶性肺炎治疗不佳价值更高。 展开更多
关键词 血清降钙素原 超敏C反应蛋白 大叶性肺炎 治疗不佳
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