Runx3 might participate in regulating dendriti cell function in patients with irritable bowel syndrome

Objective:To evaluate the expression levels and correlations among the expressions of transforming growth factor-β1（TGF-β1）,Kunx3 and CD83 in colonic mucosal specimens from IBS patients.Methods:A total of 40 patients were selected,who were confirmed as IBS by Rome III standard and 40 healthy volunteers served as control.Colonic mucosal specimens of each subject were collected from colon sigmoideum with biopsy forceps.Runx3,TGF-β1?and CD83(the marker for immunecompetent mature dendritic cells（DCs）mRNA in the sigmoid colon tissue were measured by real-time fluorescence quantitative PCR.Results:Compared with the control group,CD83 mRNA expressions were higher in patients with IBS than in healthy controls（P【0.05）and were associated with runt-related transcription factor 3（Runx3）mRNA levels（r=-0.361,P【0.05）.Meanwhile,Runx3 mRNA levels were associated with TGF-β1,mRNA expressions in irritable bowel syndrome（IBS）patients（r=0.402,P【0.05）.However,there was no correlation between the mRNA expressions of TGF-β1 and CD83（P】0.05）.Conclusions:The increase of abnormal dendritic cells might influence the occurrence and development of IBS.TGF-β1 signal pathway might not be involved in Runx 3-regulated maturation of dendritic cells in IBS.

Interface modulation of twinned Pt Fe nanoplates branched 3D architecture for oxygen reduction catalysis

Highly-branched dendritic Pt-based nanocrystals possess great potential in catalyzing the oxygen reduction reaction(ORR),but encounter performance ceiling due to their poor thermal and electrochemical stability.Here,we present a novel Pt Fe nanodendrites(NDs)branched with two-dimensional(2 D)twinned nanoplates rather than conventional 1 D nanowires,which breaks the ORR performance ceiling of dendritic catalysts by inducing the unique Pt-skin configuration via rationally thermal treatment.By further hybridizing the Pt-skin Pt Fe NDs/C with amino-functionalized ionic liquids(ILs),we achieve an unprecedented mass activity of 3.15 A/mgPtat 0.9 V versus reversible hydrogen electrode(RHE)in the Pt Fe-based ORR electrocatalytic system.They also show excellent electrocatalytic durability for ORR with negligible activity decay and no apparent structural change after 20,000 cycles,in sharp contrast to the nanowires branched Pt Fe NDs counterpart.The remarkable catalytic performance is attributed to a combination of several structural features,including 2 D morphology,twin boundary,partially ordered phase and strong coordination with amino group.This work highlights the significance of stabilizing electrocatalytic structures via morphology tuning,which thus enables further surface and interface modification for performance breakthrough in ORR electrocatalysis.