Dental Treatment and Quantum Mechanics

In clinical practice, dentists sometimes encounter phenomena that cannot be explained by common medical concepts;for example, patients’ bodily symptoms immediately improved after adjusting a denture that was not even inside their mouth, by extracting an infected tooth, and by bringing medicine close to the body. Although it seems difficult to completely elucidate the mechanism through modern medicine, it can be explained using quantum mechanics if it is assumed that symptoms appear because of the pathological waves emitted by the afflicted area of the body. The quantum, the smallest unit of matter composition, exhibits wave-particle duality. The fact that symptoms can be improved simply by bringing dentures or medicines closer to the body indicates that the waves emitted by dentures or medicine interfere with the pathological waves. Thus, the pathological waves are deformed and lead to a change in symptoms. In this way, quantum theory can explain phenomena that are difficult to elucidate in conventional medicine, which are encountered in daily clinical practice. Using biological reactions, unsolved problems in quantum mechanics, such as measurement problems, can be solved.

Objective and Subjective Dental Treatment Needs among Nursing Home Residents

Objective: The aim of the study was to analyze oral, dental and denture hygiene, and the current treatment needs in nursing home residents. Design: Cross-sectional design. Setting: Nursing homes in Saxony, Germany. Participants and Intervention: Participating dentists recorded the frequency of oral, dental and denture care, dental treatment needs, and the request for treatment in 11,144 nursing home residents by using standardized checklists. Results: Mean age of the residents was 82.5 years, and 74.6% were females. For 54.0% of those examined, nursing staff did care for oral, dental, and denture hygiene. 77.5% of the residents performed oral hygiene more frequently than once daily, 19.8% only once a day, and 2.6% performed oral hygiene less frequent. A need for dental treatment was identified in 64.1% of the residents, of which 34.5% were missing dentures, and 29.7% suffered from dental diseases. 58.3% of the residents not requesting treatment had a clinical need for dental therapy. Objective and subjective need for treatment correlated positively (p < 0.001). Conclusion: Nursing home staff should be aware of the poor oral hygiene and health care conditions in residents. In addition to regular dental check-ups, nursing home residents should be given advice on dental care. Furthermore, dentists and health insurances should develop an action plan to improve oral health of nursing home residents, and to reduce additional costs due to lack of dental care.

Two Cases of Parkinson’s Disease for Which Dental Treatment Was Effective

The purpose of this study is to document the improvement observed in two cases of Parkinson’s disease (PD) after dental treatment. The first subject is a man in his 60s with severe Parkinson’s disease;medication has not been very effective in this case. Prior to treatment, he was unable to stand without support due to?rigidity. Just after removing as much of the dental infection as possible, he was able to walk, albeit slowly, and as a result of continuing treatment, one month later, the symptoms had significantly improved. The second subject?is a woman in her 40s, who became aware of joint stiffness seven years ago, and was later diagnosed with PD independently at three hospitals. Her main symptoms were rigidity, knee pain, and speech disorder. The dopamine medication worked well against rigidity, but the symptoms reappeared after the medication stopped working. Her condition was significantly improved just after one tooth with an apical lesion was extracted. Although the underlying mechanism has not been clarified, I hypothesize that, at least in these cases, negative signals that passed through the trigeminal nerve to the midbrain affected predominantly the dopaminergic neurons in the substantia nigra of the midbrain. Removal of the harmful signals from the oral area resulted in normalization of the substantia nigra. Further research should be promoted with dental and medical cooperation.

Dental Treatment for Dizziness and Joint Mobility Disorder Caused by Harmful Electromagnetic Waves

With the development of an IT (Information Technology) society, the opportunity to use electronic devices, such as cell phones and personal computers, has increased. These electronic devices pro-vide many benefits to society. However, there have been a number of reports of electromagnetic hypersensitivity (EHS) related to the use of electronic devices. The symptoms of EHS may include headaches, fatigue, tinnitus, dizziness, memory loss, irregular heartbeat, and skin trouble. Since the pathogenic mechanism of such conditions is not yet clear, further research is required. This report shows how a subject’s dizziness and joint mobility disorder, caused by electromagnetic waves emitted by electronic devices, were cured by removing an onlay from the patient’s mouth and replacing it with a gold alloy onlay. The result indicates that the subject’s symptoms were caused by EHS. Although the symptoms were improved after the dental treatment, the underlying mechanism of the symptoms and the reason why this treatment is successful remain unclear. Further research is required to clarify these issues.

Dental Treatment with 30% Trichloroacetic Acid in a Patient with Moderate Hemophilia A

We present the case of a 51-year-old moderate hemophiliac with gingival bleeding due to papillary inflammation and adherence in the molar area 47. After dental diagnosis a calculus was removed and 30% trichloroacetic acid was placed by a pressurized applicator for five seconds;the procedure was repeated until the bleeding stopped, then tranexamic acid was placed by a gauze. The patient chewed the gauze for 30 minutes and was discharged after repeating the same procedure for 30 minutes more. We observed how local treatment with trichloroacetic acid combined to tranexamic acid placed on the hemorrhagic site was able to stop the bleeding.

Awareness of Patients toward Dental Implants as an Alternative Treatment to Replace Missing Teeth in Kinshasa, D. R. Congo

Background: Dental implant is an artificial root inserted in the jawbone, which restores a lost tooth so that it looks, feels, and is fit like a natural tooth. It is considered to be the best treatment option for single or multiple missing teeth. The aim of this study was to assess the awareness of patients about dental implants as an alternative treatment in Congolese patients. Materials and Methods: A cross-sectional study was conducted in two institutions namely, CBCO Bandal and Ngaliema Clinic, from August to December 2017. A total of 450 respondents have participated in the survey. A printed questionnaire comprised of 20 questions in order to evaluate patients dental awareness was used. Gender, level of education, awareness of dental implant and dental implants therapy, sources of information and the expectation about the sources of information were assessed. The collected data were entered in Microsoft Excel 2010 and analyzed by SPSS (IBM SPSS 20.0, Chicago, IL, USA) software. Results: Out of 450 participants, 14.4% were aware of dental implants. The main disadvantage of dental implant was the high cost. When asked about the anchorage, 86% didn’t know where the dental implant was anchored. Ninety-two percent didn’t know for how long an implant last, 6% thought that dental implant last for a lifetime. When patients were asked about the sources of information, the dentist (5%) and media (5.5%) were the main sources of information. The majority of patients (88.4%) would like to get information about dental implants from their dentist. Conclusion: Dentists should be more involved in the promotion of information about dental implants as a treatment modality to replace missing teeth.

Non-Thermal Atmospheric Plasma:Can it Be Taken as a Common Solution for the Surface Treatment of Dental Materials?

This study aimed to evaluate the surface roughness and wetting properties of various dental prosthetic materials after different durations of non-thermal atmospheric plasma（NTAP）treatment.One hundred and sixty discs of titanium（Ti）（n：40）,cobalt chromium（Co-Cr）（n：40）,yttrium stabilized tetragonal zirconia polycrystals（Y-TZP）（n：40）and polymethylmethacrylate（PMMA）（n：40）materials were machined and smoothed with silicon carbide papers.The surface roughness was evaluated in a control group and in groups with different plasma exposure times [1-3-5 s].The average surface roughness（Ra）and contact angle（CA）measurements were recorded via an atomic force microscope（AFM）and tensiometer,respectively.Surface changes were examined with a scanning electron microscope（SEM）.Data were analyzed with two-way analysis of variance（ANOVA）and the Tukey HSD test α=0.05）.According to the results,the NTAP surface treatment significantly affected the roughness and wettability properties（P 〈 0.05）.SEM images reveal that more grooves were present in the NTAP groups.With an increase in the NTAP application time,an apparent increment was observed for Ra,except in the PMMA group,and a remarkable reduction in CA was observed in all groups.It is concluded that the NTAP technology could enhance the roughening and wetting performance of various dental materials.

牙科全麻技术在不同阶段低龄儿童牙科治疗中的应用

目的:分析婴幼儿及学龄前两个阶段牙科全麻技术(DGA)应用的临床效果。方法:收集牙科治疗中需要进行全身麻醉的儿童647例,按照年龄段分为两组。婴幼儿组(3岁以下)135例,学龄前组(3~6岁)512例,分析其性别、年龄、合并疾病、就诊原因、治疗牙数、治疗内容、治疗时间、麻醉效果及术后并发症情况。结果:总中位数年龄47(38~56)月,并发其他疾病者占比32.25%,两组间比较无统计学差异(P>0.05)。就诊原因主要为疼痛和猛性龋,组间比较有统计学差异(均P<0.05)。治疗牙数中位数14(12~16)颗,治疗时间中位数110(95~130)min,婴幼儿组均低于学龄前组(均P<0.05)。治疗内容包括窝沟封闭、拔牙、充填治疗和牙髓治疗,组间比较有统计学差异(均P<0.05)。麻醉效果评价为优者占比96.91%,组间比较无统计学差异(P>0.05)。术后婴幼儿组烦躁比例高于学龄前组(P<0.05),但口渴、进食困难发生率低于对照组(均P<0.05)。结论:3岁以下婴幼儿较3~6岁学龄前儿童DGA下治疗牙数量更少,时间更短,虽然术后烦躁发生率较高,但是疼痛、口渴和进食困难发生率更低。对于3岁以下婴幼儿牙科疾病,DGA技术是较为安全、高效的解决办法。

Root Canal Treatment Outcome and Restorative Condition of Teeth Treated by Undergraduates—A Clinical and Radiographic Evaluation

Background: The aim was to evaluate the nonsurgical Root Canal Treatment (nRCT) outcome, the restorative condition and the relationship between the coronal restoration quality and the outcome of teeth endodontic treated by undergraduates at the University of Caxias do Sul School of Dentistry (UCS-SD), Brazil, between 2019 and 2021. Materials and Methods: Data from the endodontically treated cases were retrieved, and the patients were recalled for a follow-up appointment at the university. The endodontic diagnosis, radiographs, and the presence of definitive restorations were analyzed in the clinical records. During the follow-up appointment, endodontically treated teeth were classified as present or absent. The nRCT was classified as successful (complete or incomplete healing) or failure (uncertain or unsatisfactory healing). Coronal restoration was classified as absent or present. When it was present, it was classified as permanent or temporary, and its quality as adequate or inadequate restoration. The results were presented as percentages. Results: A total of 257 teeth were endodontically treated. The most prevalent diagnosis was Chronic Apical Periodontitis (33.33%) and the most commonly treated teeth were premolars (46.15%). A total of 52 (21%) treated teeth were clinically and radiographically reexamined. The success rate for the nRCT was 98.08%. About 61.54% of this sample had a definitive composite resin restoration. Conclusion: The nRCT success rate was high. Special attention should be given to the presence and quality of the definitive restoration. Clinical Implications: There was no statistically significant impact between the coronal restoration and the nRCT success (P > 0.05).

一例哈利犬牙结石的诊治分析

牙结石是成年犬门诊较为常见的一种口腔疾病,它是由牙菌斑和牙垢钙化后沉积在牙齿表面引起。牙结石是龋齿、牙周炎、溃疡性口炎、牙龈炎和齿髓炎等多种口腔疾病的主要诱因。本文通过对一例哈利犬的牙结石病例的诊治分析及经验总结,以期为宠物门诊常见疾病之牙结石的临床诊断、治疗和预防提供参考。

口腔临床诊疗中数字牙片影像技术的应用价值

目的探讨口腔临床诊疗中数字牙片影像技术的应用价值。方法选择2022年1月至2023年5月期间在本院口腔科就诊且需要拔牙治疗的50例正畸患者作为研究对象。患者在治疗前,完成数字化牙片摄影和传统牙片摄影。记录投照上、下颌牙齿X线倾斜的垂直平均角度,并统计牙齿根尖片的曝光时间,对比两种摄影技术对牙齿长度的测量结果。结果传统牙片摄影时,上颌和下颌切牙位、单尖牙、双尖牙位、第一磨牙位、第二及三磨牙位(足侧倾斜)选择投射角度低于数字化牙片摄影(P<0.05)。数字化牙片摄影投照上颌和下颌切牙位、单尖牙位、双尖牙位、第三磨牙位及第一、二磨牙位牙齿根尖片的曝光时间低于传统牙片摄影(P<0.05)。数字化牙片摄影对待拔除牙齿单根、双根颊和双根腭测量结果与游标卡尺测量结果相比,差异无统计学意义(P>0.05);传统牙片摄影对待拔除牙齿单根、双根颊和双根腭测量结果低于游标卡尺测量结果,差异具有统计学意义(P<0.05);以游标卡尺测量结果为依据,数字化牙片摄影和传统牙片摄影对待拔除牙齿单根、双根颊和双根腭测量结果相比,差异具有统计学意义(P<0.05)。结论数字牙片影像技术投照条件宽容度相对较大,投射时曝光时间短,对牙齿根尖的测量准确度较高,便于细致观察牙齿,应用于口腔临床诊疗的价值较高。

2种不同消毒方法对口腔综合诊疗室空气消毒效果的对比研究

目的研究等离子体立体消毒与紫外线平面消毒法在口腔综合诊疗室的空气消毒效果,探讨有效、适宜的空气消毒方法。方法对360名就诊者进行超声波洁治术,洁治后即刻用2种不同消毒方法消毒口腔综合诊疗室并布采样点研究,120例布采样点于遮挡物前面,对照组1为紫外线平面消毒,实验组1为等离子体立体消毒,2组各60例;120例随机布采样点(存在采样点位于遮挡物背面的可能),对照组2为紫外线平面消毒,实验组2为等离子体立体消毒,2组各60例;120例布采样点于遮挡物背面,对照组3为紫外线平面消毒,实验组3为等离子体立体消毒,2组各60例。结果对照组1、实验组1实验前后菌落总数差值中位数分别为1.85、1.90,实验组1空气菌落数下降与对照组1相比,差异无统计学意义(P>0.05)。实验组2、对照组2实验前后菌落总数差值中位数分别为2.80、1.70(P<0.05),实验组2空气菌落数下降高于对照组2。实验组3、对照组3实验前后菌落总数差值中位数分别为2.25、0.30(P<0.05),实验组3空气菌落数下降高于对照组3。结论等离子体立体消毒法对于口腔综合诊疗室空气消毒的有效性优于紫外线平面消毒法,值得临床推广运用。

三种不同消毒剂对口腔综合治疗台水路消毒效果的比较

目的比较3种不同消毒剂对口腔综合治疗台水路(DUWLs)的消毒效果。方法选取本院2019年装修后待开诊前7台采用独立水源的综合治疗台,分为4组(3组实验组+1组对照组),实验组分别采用500 mg/L含氯消毒剂(A组2台综合治疗椅)、3%过氧化氢(B组2台综合治疗椅)、60 g/L过氧化氢银离子消毒剂(C组2台综合治疗椅)和净化后市政用水纯水(D组对照组1台综合治疗椅),通过3种不同的消毒剂对DUWLs进行消毒,然后收集各组三用枪和高速手机水样进行细菌培养,比较各组DUWLs消毒前及消毒后即刻、1d、3d、7d细菌菌落总数。结果消毒前DU⁃WLs各组细菌菌落总数均严重超标(均>4500 cfu/mL)。3种消毒剂消毒后即刻和消毒后1 d细菌菌落总数明显下降,低于消毒前及对照组。消毒后3 d,除实验C组外,实验A、B两组细菌菌落总数均超过北京市《口腔综合治疗台水路消毒技术规范(DB11/T 1703-2019)》规定的口腔医疗卫生用水标准。消毒后7 d,A、B、C三组细菌菌落总数均接近或超过消毒前水平。结论500 mg/L含氯消毒剂和3%过氧化氢消毒剂对水路消毒效果维持时间短,长期使用对管路内壁造成不可修复的危害。60g/L过氧化氢银离子消毒剂在控制口腔牙椅水路(DU⁃WLs)细菌落数总数和抑制细菌生长时间方面效果最优。

麻花丝流动树脂固定术在牙外伤固定治疗中的应用效果

目的:探讨麻花丝流动树脂固定术在牙外伤固定治疗中的临床应用效果。方法:选择2021年4月—2023年8月潮州市中心医院口腔科门急诊收治的46例需行固定的前牙牙外伤患者作为研究对象。采取随机数表法分为观察组和对照组,各23例。对照组给予牙弓夹板钢丝固定,观察组给予麻花丝流动树脂固定术。比较两组治疗前后牙周指数[牙龈指数(GI)、菌斑指数(PLI)、牙周袋深度(PD)]、龈沟液相关因子水平[缺氧诱导因子(HIF-1α)、白细胞介素-8(IL-8)、趋化因子(CX3CL1)]、手术时间、临床疗效及并发症发生情况。结果:治疗后,两组GI、PLI、PD、龈沟液IL-8、HIF-1α水平均低于治疗前,CX3CL1水平高于治疗前,且观察组GI、PLI、PD、龈沟液IL-8、HIF-1α、CX3CL1水平均低于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,但两组间比较,差异无统计学意义(P>0.05)。观察组手术时间短于对照组,差异有统计学意义(t=10.183,P<0.001)。观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论:麻花丝流动树脂固定术有效减轻牙外伤炎症反应,临床疗效高,卫生方便且操作效率高,在牙外伤固定治疗中应用效果较好。

基于环境听觉管理的舒适化口腔治疗应用于儿童牙科畏惧症的效果观察

目的:探讨基于环境听觉管理的舒适化口腔治疗应用于儿童牙科畏惧症的效果。方法:选取2021年1月-2022年7月医院收治的122例儿童牙科畏惧症患儿作为研究对象,随机分为对照组与观察组,各61例。对照组实施常规口腔治疗,观察组实施基于环境听觉管理的舒适化口腔治疗。比较两组患儿治疗前后生理应激水平、牙科畏惧症状、临床焦虑水平及舒适度变化。结果:观察组患儿治疗后舒张压、心率低于对照组,收缩压高于对照组(P<0.05);观察组患儿治疗后“害怕牙医”“让不认识的人碰”“医生钻牙”“想象钻牙的场景”“医生把工具放到嘴巴里”及总分低于对照组(P<0.05);观察组患儿临床焦虑水平轻于对照组(P<0.05);观察组患儿治疗后舒适度各维度评分、总分均高于对照组(P<0.05)。结论:基于环境听觉管理的舒适化口腔治疗应用于儿童牙科畏惧症中可促使生理应激水平保持稳定,提高舒适度,减轻患儿畏惧症状及焦虑水平。

1例重度牙周炎患者牙周种植联合治疗5年观察

Ⅳ期C级牙周炎是临床上分期分级最严重的牙周炎类型,这类患者常伴有牙列缺损与软硬组织缺损,需要联合多学科针对病情设计个性化治疗方案。本文报道1例广泛型Ⅳ期C级牙周炎患者的序列治疗全过程,包括病情分析、治疗的个性化设计、多学科联合手术过程、支持治疗以及5年随访观察。

Dental management of a patient with Moebius syndrome:A case report

BACKGROUND Moebius syndrome(MBS)is a nonprogressive and rare congenital neuromuscular disorder involving the facial nerve and abductor nerve;it mainly manifests as facial paralysis and eye strabismus paralytic symptoms.Tissues in the oral cavity are also compromised,characterized by microstomia,micrognathia,tongue malformation,cleft lip,high arched palate or cleft palate,bifid uvula,and dental malocclusion.Therefore,dentistry plays a fundamental and crucial role in caring for these individuals.However,there is limited available data on MBS treatment,particularly regarding dental management.CASE SUMMARY This case report presents dental treatment of a 21-year-old man with MBS and discusses crucial interactions among oral complications of MBS.In this case,the patient was clinically characterized by congenital neuromuscular disorder,occlusal disorders,and tooth and gum problems.It is noteworthy that the patient presented early eruption of deciduous teeth 2 mo after birth,which has not been reported in other MBS cases and suggests a potentially new clinical manifestation of this syndrome.It is important to note that MBS cannot be cured,and oral manifestations of this syndrome can be managed by a multidisciplinary health care team that helps the patient maintain oral hygiene and dental health.After a series of oral treatments,no obvious poor oral hygiene,swollen gums,or abnormal imaging results were observed after 2 years of follow-up.CONCLUSION This case addressed the oral clinical manifestations of MBS and difficulties experienced during dental management,and suggested early tooth eruption as a potentially new clinical manifestation of this syndrome.Knowledge of the loopmediated association among oral complications of this syndrome is essential to perfecting treatments.

成人骨型Ⅲ类矫治前后前牙区变化的临床研究

目的探讨成人骨型Ⅲ类患者矫治前后上下前牙区牙槽高度和宽度变化以及前牙区牙根位置变化。方法选取2020年5月—2022年11月在中山市小榄人民医院口腔科正畸掩饰治疗的成人骨型Ⅲ类患者50例,比较正畸治疗前后患者上下颌前牙牙槽骨厚度和高度,其中包括上前牙槽骨厚度(upper anterior alveolar bonethickness,UA)、上后牙槽骨厚度(upper posterior alveolar bone thickness,UP)、上牙槽骨总厚度(upper alveolar bone width,UW)、下前牙槽骨厚度(lower anterior alveolar bone thickness,LA)、下后牙槽骨厚度(lower posterior alveolar bone thickness,LP)、下牙槽骨总厚度(lower alveolar bone width,LW)、根中水平上前牙槽骨厚度(upper anterior alveolar bone thickness at the mid-root level,UA-m)、根中水平上后牙槽骨厚度(upper posterior alveolar bone thickness at the mid-root level,UP-m)、根中水平上牙槽骨总厚度(upper alveolar bone thickness at the mid-root level,UW-m)、根中水平下前牙槽骨厚度(lower anterior alveolar bone thickness at the mid-root level,LA-m)、根中水平下后牙槽骨厚度(lower posterior alveolar bone thickness at the mid-root level,LP-m)、根中水平下牙槽骨总厚度(lower alveolar bone thickness at the mid-root level,LW-m)以及上前牙槽骨高度(upper anterior alveolar bone height,UAH)和下前牙槽骨高度(lower anterior alveolarbone height,LAH)。结果正畸治疗前后患者UA、UP-m测量值比较,差异无统计学意义(P>0.05)。与正畸治疗前比较,正畸治疗后患者UP、UW、UA-m、UW-m测量值均显著降低(P<0.05)。正畸治疗后患者LP、LA-m测量值与正畸治疗前比较,差异无统计学意义(P>0.05)。与正畸治疗前比较,正畸治疗后患者LA、LW、LP-m、LW-m测量值均降低(P<0.05)。与正畸治疗前比较,正畸治疗后患者UAH、LAH测量值均显著降低(P<0.05)。正畸治疗后,患者上下颌前牙解剖牙根长度分别为(10.62±0.57)mm、(9.65±0.48)mm,正畸治疗前患者上下颌前牙解剖牙根长度分别为(11.01±0.58)mm、(10.37±0.48)mm,与正畸治疗前比较,患者上下颌前牙解剖牙根长度明显减小(P<0.05)。结论成人骨型Ⅲ类患者进行正畸掩饰治疗后,牙槽形态会发生相应改变,患者上下前牙牙槽骨厚度和高度会一定程度地减少。因此,在矫治过程中应当对患者牙槽形态的变化给予密切关注,尽量避免上下前牙发生代偿性移动,从而降低不良反应情况发生的风险。

近代牙科知识的传播与话语建构

牙齿作为人体重要器官,其健康状况有着重要意义。明清以来,在医学理论方面,人们对牙齿问题论述比较详尽,但在日常实践中,普通民众对牙齿的关注却不尽如人意。19世纪下半叶,西方牙科学传入中国,与以往不同的近代牙科知识逐渐进入人们的视野。在社会和国家的双重推动下,近代牙科知识的传播手段不断丰富,传播范围也愈加广泛,通过大众传媒、讲座展览会、学校教育和国家宣传等传播方式,提示民众关注牙齿健康、重塑卫生观念。与此同时,近代牙科知识在传播中也逐渐被构建成科学、健康、资本和政治的综合性话语。

口腔种植术后疼痛机制及治疗的研究进展

随着口腔种植技术的快速发展,在牙列缺损或牙列缺失患者中,口腔种植修复已逐渐成为一种常规的修复方式。然而,口腔种植术作为“侵入性”治疗,即使经过准确的术前评估和规范的外科手术,患者也可能出现术后疼痛。术后疼痛会影响患者的语言交流、咀嚼及吞咽等,使患者的生活质量降低,甚至可引起医疗事故。随着种植手术的普及,未来可能会有更多的患者遭受种植术后疼痛,尤其是种植术后神经病理性疼痛,其治疗难度仍较大,且治疗药物的疗效往往不确切,并与各种不良反应有关。本文介绍了种植术后疼痛的相关机制,对种植术后疼痛的治疗进行概括,并结合当前研究热点提出未来治疗种植术后神经病理性疼痛的潜在靶点,旨在为开展相关临床工作提供新思路。