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Progress on Transition Metal Ions Dissolution Suppression Strategies in Prussian Blue Analogs for Aqueous Sodium-/Potassium-Ion Batteries 被引量:1
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作者 Wenli Shu Junxian Li +3 位作者 Guangwan Zhang Jiashen Meng Xuanpeng Wang Liqiang Mai 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第7期142-168,共27页
Aqueous sodium-ion batteries(ASIBs)and aqueous potassium-ion batteries(APIBs)present significant potential for large-scale energy storage due to their cost-effectiveness,safety,and environmental compatibility.Nonethel... Aqueous sodium-ion batteries(ASIBs)and aqueous potassium-ion batteries(APIBs)present significant potential for large-scale energy storage due to their cost-effectiveness,safety,and environmental compatibility.Nonetheless,the intricate energy storage mechanisms in aqueous electrolytes place stringent require-ments on the host materials.Prussian blue analogs(PBAs),with their open three-dimensional framework and facile synthesis,stand out as leading candidates for aqueous energy storage.However,PBAs possess a swift capacity fade and limited cycle longevity,for their structural integrity is compromised by the pronounced dis-solution of transition metal(TM)ions in the aqueous milieu.This manuscript provides an exhaustive review of the recent advancements concerning PBAs in ASIBs and APIBs.The dissolution mechanisms of TM ions in PBAs,informed by their structural attributes and redox processes,are thoroughly examined.Moreover,this study delves into innovative design tactics to alleviate the dissolution issue of TM ions.In conclusion,the paper consolidates various strategies for suppressing the dissolution of TM ions in PBAs and posits avenues for prospective exploration of high-safety aqueous sodium-/potassium-ion batteries. 展开更多
关键词 Prussian blue analogs Transition metal ions dissolution Suppression strategies Aqueous sodium-ion batteries Aqueous potassium-ion batteries
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Oilfield analogy and productivity prediction based on machine learning: Field cases in PL oilfield, China
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作者 Wen-Peng Bai Shi-Qing Cheng +3 位作者 Xin-Yang Guo Yang Wang Qiao Guo Chao-Dong Tan 《Petroleum Science》 SCIE EI CAS CSCD 2024年第4期2554-2570,共17页
In the early time of oilfield development, insufficient production data and unclear understanding of oil production presented a challenge to reservoir engineers in devising effective development plans. To address this... In the early time of oilfield development, insufficient production data and unclear understanding of oil production presented a challenge to reservoir engineers in devising effective development plans. To address this challenge, this study proposes a method using data mining technology to search for similar oil fields and predict well productivity. A query system of 135 analogy parameters is established based on geological and reservoir engineering research, and the weight values of these parameters are calculated using a data algorithm to establish an analogy system. The fuzzy matter-element algorithm is then used to calculate the similarity between oil fields, with fields having similarity greater than 70% identified as similar oil fields. Using similar oil fields as sample data, 8 important factors affecting well productivity are identified using the Pearson coefficient and mean decrease impurity(MDI) method. To establish productivity prediction models, linear regression(LR), random forest regression(RF), support vector regression(SVR), backpropagation(BP), extreme gradient boosting(XGBoost), and light gradient boosting machine(Light GBM) algorithms are used. Their performance is evaluated using the coefficient of determination(R^(2)), explained variance score(EV), mean squared error(MSE), and mean absolute error(MAE) metrics. The Light GBM model is selected to predict the productivity of 30 wells in the PL field with an average error of only 6.31%, which significantly improves the accuracy of the productivity prediction and meets the application requirements in the field. Finally, a software platform integrating data query,oil field analogy, productivity prediction, and knowledge base is established to identify patterns in massive reservoir development data and provide valuable technical references for new reservoir development. 展开更多
关键词 Data mining technique analogy parameters Oilfield analogy Productivity prediction Software platform
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The Analogy between the Immune System and Human Life
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作者 Gassem Gohal 《Open Journal of Immunology》 2024年第3期47-59,共13页
The immune system operates as a complex organization with distinct roles and functions. Excitingly we recognized the similarities between the cellular dynamics of the immune system and our lives, activities, and behav... The immune system operates as a complex organization with distinct roles and functions. Excitingly we recognized the similarities between the cellular dynamics of the immune system and our lives, activities, and behaviors. Observing the immune system can guide how to respond to various daily situations, including when to react, tolerate, or ignore. Recognizing this analogy between our lives and the immune system should motivate us to adopt a wisdom-based approach when investigating the mechanisms and future discoveries related to this system and to deepen our understanding of this complex system with newfound respect. In this context, the present review examines several integral biological processes of the immune system by drawing parallels between them and human life, activities, and behaviors to learn how we must behave based on the insights offered by this complex organization. The literature search was conducted in international databases such as PubMed/MEDLINE and Google Scholar search engine using English equivalent keywords from 1998 up to April 2023. The search strategy used the following subject heading terms: Immune system, analogy, human life, cellular dynamics, memory, tolerance, and ignorance. In conclusion, the immune system is a complex organization comprising various cells interacting within specific sites and networks, communicating, drawing experiences, and learning how to tolerate certain conditions that make it share certain similarities with human life. 展开更多
关键词 Immune System analogY MEMORY TOLERANCE IGNORANCE
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Discovery of a geomorphological analog to Martian araneiforms in the Qaidam Basin, Tibetan Plateau
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作者 Shengxing Zhang Yiliang Li Wei Leng 《中国科学技术大学学报》 CAS CSCD 北大核心 2024年第5期1-9,I0006,共10页
Araneiforms are spider-like ground patterns that are widespread in the southern polar regions of Mars.A gas erosion process driven by the seasonal sublimation of CO_(2) ice was proposed as an explanation for their for... Araneiforms are spider-like ground patterns that are widespread in the southern polar regions of Mars.A gas erosion process driven by the seasonal sublimation of CO_(2) ice was proposed as an explanation for their formation,which cannot occur on Earth due to the high climatic temperature.In this study,we propose an alternative mechanism that attrib-utes the araneiform formation to the erosion of upwelling salt water from the subsurface,relying on the identification of the first terrestrial analog found in a playa of the Qaidam Basin on the northern Tibetan Plateau.Morphological analysis indicates that the structures in the Qaidam Basin have fractal features comparable to araneiforms on Mars.A numerical model is developed to investigate the araneiform formation driven by the water-diffusion mechanism.The simulation res-ults indicate that the water-diffusion process,under varying ground conditions,may be responsible for the diverse aranei-form morphologies observed on both Earth and Mars.Our numerical simulations also demonstrate that the orientations of the saltwater diffusion networks are controlled by pre-existing polygonal cracks,which is consistent with observations of araneiforms on Mars and Earth.Our study thus suggests that a saltwater-related origin of the araneiform is possible and has significant implications for water searches on Mars. 展开更多
关键词 araneiform landform subsurface water Qaidam Basin Mars analog fractal simulations
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Experimental and computational optimization of Prussian blue analogues as high-performance cathodes for sodium-ion batteries:A review
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作者 Gwangeon Oh Junghoon Kim +4 位作者 Shivam Kansara Hyokyeong Kang Hun-Gi Jung Yang-Kook Sun Jang-Yeon Hwang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第6期627-662,I0015,共37页
In this review,we discuss the electrochemical properties of Prussian blue(PB)for Na^(+)storage by combining structural engineering and electrolyte modifications.We integrated experimental data and density functional t... In this review,we discuss the electrochemical properties of Prussian blue(PB)for Na^(+)storage by combining structural engineering and electrolyte modifications.We integrated experimental data and density functional theory(DFT)in sodium-ion battery(SIB)research to refine the atomic arrangements and crystal lattices and introduce substitutions and dopants.These changes affect the lattice stability,intercalation,electronic and ionic conductivities,and electrochemical performance.We unraveled the intricate structure-electrochemical behavior relationship by combining experimental data with computational models,including first-principles calculations.This holistic approach identified techniques for optimizing PB and Prussian blue analog(PBA)structu ral properties for SIBs.We also discuss the tuning of electrolytes by systematically adjusting their composition,concentration,and additives using a combination of molecular dynamics(MD)simulations and DFT computations.Our review offers a comprehensive assessment of strategies for enhancing the electrochemical properties of PB and PBAs through structural engineering and electrolyte modifications,combining experimental insights with advanced computational simulations,and paving the way for next-generation energy storage systems. 展开更多
关键词 Prussian blue analogs(PBAs) Sodium ion batteries(SIBs) Structural engineering Electrolyte modifications Experiments Density functional theory(DFT)
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An Adaptive Control Strategy for Energy Storage Interface Converter Based on Analogous Virtual Synchronous Generator
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作者 Feng Zhao Jinshuo Zhang +1 位作者 Xiaoqiang Chen Ying Wang 《Energy Engineering》 EI 2024年第2期339-358,共20页
In the DC microgrid,the lack of inertia and damping in power electronic converters results in poor stability of DC bus voltage and low inertia of the DC microgrid during fluctuations in load and photovoltaic power.To ... In the DC microgrid,the lack of inertia and damping in power electronic converters results in poor stability of DC bus voltage and low inertia of the DC microgrid during fluctuations in load and photovoltaic power.To address this issue,the application of a virtual synchronous generator(VSG)in grid-connected inverters control is referenced and proposes a control strategy called the analogous virtual synchronous generator(AVSG)control strategy for the interface DC/DC converter of the battery in the microgrid.Besides,a flexible parameter adaptive control method is introduced to further enhance the inertial behavior of the AVSG control.Firstly,a theoretical analysis is conducted on the various components of the DC microgrid,the structure of analogous virtual synchronous generator,and the control structure’s main parameters related to the DC microgrid’s inertial behavior.Secondly,the voltage change rate tracking coefficient is introduced to adjust the change of the virtual capacitance and damping coefficient flexibility,which further strengthens the inertia trend of the DC microgrid.Additionally,a small-signal modeling approach is used to analyze the approximate range of the AVSG’s main parameters ensuring system stability.Finally,conduct a simulation analysis by building the model of the DC microgrid system with photovoltaic(PV)and battery energy storage(BES)in MATLAB/Simulink.Simulation results from different scenarios have verified that the AVSG control introduces fixed inertia and damping into the droop control of the battery,resulting in a certain level of inertia enhancement.Furthermore,the additional adaptive control strategy built upon the AVSG control provides better and flexible inertial support for the DC microgrid,further enhances the stability of the DC bus voltage,and has a more positive impact on the battery performance. 展开更多
关键词 Adaptive control analogous virtual synchronous generator DC/DC converter inertia of DC microgrid DC microgrid with PV and BES BATTERY DC bus voltage
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5-aza-2’deoxycytidine联合trichostatin A抑制乳腺癌细胞增殖能力的研究 被引量:4
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作者 范江 陆劲松 +6 位作者 王磊 吴炅 侯意枫 李大强 狄根红 沈镇宙 邵志敏 《中国癌症杂志》 CAS CSCD 2006年第5期329-332,共4页
背景与目的:晚近报道应用DNA甲基转移酶抑制剂5-aza-2’deoxycytid ine(AZA)联合组蛋白去乙酰化酶抑制剂trichostatin A(TSA)作用于多种肿瘤,可以达到治疗肿瘤的目的。本文在此探讨通过AZA联合TSA作用,抑制乳腺癌细胞株增殖能力。方法:... 背景与目的:晚近报道应用DNA甲基转移酶抑制剂5-aza-2’deoxycytid ine(AZA)联合组蛋白去乙酰化酶抑制剂trichostatin A(TSA)作用于多种肿瘤,可以达到治疗肿瘤的目的。本文在此探讨通过AZA联合TSA作用,抑制乳腺癌细胞株增殖能力。方法:联合应用两种药物作用于肿瘤细胞,应用RT-PCR的方法检测MDA-MB-435细胞株p21和p27的mRNA转录水平的改变。通过W ST方法来检测乳腺癌细胞的增殖能力变化,将MDA-MB-435细胞根据药物处理共分四组:①对照组;②AZA+TSA组;③AZA+TSA+4-OH TAM组;④4-OH TAM组。并且采用流式细胞仪来分析肿瘤细胞周期分布的改变,将MDA-MB-435分成另外四组:①对照组;②AZA+TSA组;③AZA+TSA+E2组;④AZA+TSA+E2+4-OH TAM组。结果:TSA以及AZA联合应用能使肿瘤细胞MDA-MB-435的p27的mRNA水平增加,而p21mRNA水平略减弱。增殖分析的四个组中:AZA+TSA组细胞增殖能力减弱(P<0.01),同时出现细胞阻滞于S期,加入雌激素后细胞阻滞稍减弱。AZA+TSA+4-OH TAM组增殖能力进一步减弱(P<0.01)。4-OH TAM组增殖能力没有改变。细胞周期分析的四个组中:AZA+TSA组出现细胞阻滞于S期,AZA+TSA+E2组细胞阻滞稍减弱。AZA+TSA+E2+4-OH TAM组细胞阻滞再次提高。结论:两种药物联合应用能使得乳腺癌肿瘤细胞增殖能力下降,对于肿瘤细胞有一定抑制作用。 展开更多
关键词 乳腺肿瘤 5-aza-2’deoxycytidine TRICHOSTATIN A 培养 肿瘤细胞 增殖能力
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Synthesis of Phenylpropanoid Glycoside Analogs 被引量:1
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作者 李树春 周静 李中军 《Journal of Chinese Pharmaceutical Sciences》 CAS 2004年第1期14-18,共5页
The regioselective acylation of unprotected phenylethyl glucoside withcinnamoyl chloride leads to 6-OH cin-namoylated glucoside. In this manner, thirteen phenylpropanoidglycoside analogs were designed and prepared. Th... The regioselective acylation of unprotected phenylethyl glucoside withcinnamoyl chloride leads to 6-OH cin-namoylated glucoside. In this manner, thirteen phenylpropanoidglycoside analogs were designed and prepared. Their structure was confirmed by ~1H NMR and ^(13)CNMR spectra. 展开更多
关键词 medicinal chemistry regioselective acylation phenylpropanoid glycoside glycoside analogs chemical synthesis
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5-aza-2’-deoxycytidine重新激活MDA-MB-231乳腺癌细胞雌激素受体基因的表达 被引量:2
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作者 李林蔚 王瑞 +3 位作者 王瑞林 王留兴 樊青霞 赵培荣 《河南肿瘤学杂志》 2005年第1期6-7,F002,共3页
目的 探讨 5 AZA CdR重新激活MDA MB 2 3 1乳腺癌细胞雌激素受体基因的表达。方法 采用免疫组织化学的方法 ,对用浓度为 2mg/L的 5 AZA CdR处理MDA MB 2 3 1乳腺癌细胞前后和阳性对照MCF 7乳腺癌细胞雌激素受体基因的表达情况进行... 目的 探讨 5 AZA CdR重新激活MDA MB 2 3 1乳腺癌细胞雌激素受体基因的表达。方法 采用免疫组织化学的方法 ,对用浓度为 2mg/L的 5 AZA CdR处理MDA MB 2 3 1乳腺癌细胞前后和阳性对照MCF 7乳腺癌细胞雌激素受体基因的表达情况进行检测分析。结果  5 AZA CdR处理过的MDA MB 2 3 1乳腺癌细胞ER的阳性表达率明显增高 (P <0 .0 5 )。结论  5 AZA CdR可以重新激活MDA MB 2 3 展开更多
关键词 乳腺癌 雌激素受体 5-aza-2'-deoxycytidine 免疫组织化学
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Treatment of central precocious puberty by GnRH analogs: long-term outcome in men 被引量:13
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作者 Silvano Bertelloni Dick Mul 《Asian Journal of Andrology》 SCIE CAS CSCD 2008年第4期525-534,共10页
In boys, central precocious puberty (CPP) is the appearance of secondary sex characteristics driven by pituitary gonadotropin secretion before the age of 9 years. In the last years, relevant improvements in the trea... In boys, central precocious puberty (CPP) is the appearance of secondary sex characteristics driven by pituitary gonadotropin secretion before the age of 9 years. In the last years, relevant improvements in the treatment of CPP have been achieved. Because CPP is rare in boys, the majority of papers on this issue focus on girls and do not address specific features of male patients regarding end results and safety. In the present paper, recent advances of CPP management with GnRH analogs in men are summarized. End results in untreated and treated patients are also reviewed by an analysis of the recently published literature on treatment of CPP in men. The available data indicate that therapy with GnRH analogs can improve final height into the range of target height without significant adverse short-term and long-term effects, but longer follow-up of larger series of patients is still required to draw definitive conclusions. 展开更多
关键词 ADOLESCENT MALE central precocious puberty gonadotropin-releasing hormone analog treatment gonadotropin-releasing hormone analog safety long-term outcome adult height
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Studies on the Synthesis of a Natural Product-Piceatannol and its Analogs 被引量:4
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作者 Zhi Song PIAO Lin WANG +1 位作者 Ya Bin FENG Zhi Zhong ZHAO 《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第6期521-524,共4页
Piceatannol, (E)-3, 3, 4, 5-tetrahydroxy stilbene, a natural polyhydroxy stilbene, possesses many biological activities, its synthesis has been reported. We designed another route of its synthesis, which can be contr... Piceatannol, (E)-3, 3, 4, 5-tetrahydroxy stilbene, a natural polyhydroxy stilbene, possesses many biological activities, its synthesis has been reported. We designed another route of its synthesis, which can be controlled more easily. The synthetic product was characterized by elemental analysis, IR, MS and 1H-NMR. Its analogs were synthesized by the similar method. 展开更多
关键词 Total synthesis PICEATANNOL analogs.
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Isomerization of n-pentane catalyzed by amide-AlCl3-based ionic liquid analogs with various additives 被引量:3
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作者 Pengcheng Hu Jingwei Zheng +2 位作者 Wei Jiang Lijuan Zhong Shufeng Zhou 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2020年第1期152-157,共6页
The isomerization of n-pentane to generate high-quality blending components for clean gasoline was catalyzed by several amide-AlCl3-based ionic liquid(IL) analogs with various amides as donor molecules. The catalytic ... The isomerization of n-pentane to generate high-quality blending components for clean gasoline was catalyzed by several amide-AlCl3-based ionic liquid(IL) analogs with various amides as donor molecules. The catalytic performance of these IL analogs was evaluated in a magnetic agitated autoclave operated in batch mode.IL analog based n-methylacetamide(NMA)-AlCl3 with the amide/AlCl3 molar ratio of 0.65 showed excellent performance toward n-pentane isomerization because 0.65 NMA-1.0 AlCl3 had a low viscosity and bidentate coordination structure. The influences of reaction time, reaction temperature, and stirring speed on the catalytic performance were also investigated. Optimal reaction conditions comprised the reaction time of 1 h, the reaction temperature of 40 °C, and the stirring speed of 1500 r·min-1. Under optimal condition, the n-C5 conversion,research octane number(RON) increment, total liquids yield, and isoparaffin yield in isomerized oil were56.80%, 13.51, 89.90 wt%, and 44.32 wt%, respectively. A new mathematical model was constructed to predict the relationships among RON increment, RON increment/n-C5 conversion ratio, and n-C5 conversion. The new model indicated that an appropriate conversion per pass of n-C5 did not exceed 50%–55%. Various cycloparaffin additives were used to improve the catalytic performance of 0.65 NMA-1.0 AlCl3. The n-C5 conversion increased from 56.80% to 67.32%. The RON increment, total liquids yield, and isoparaffin yield reached 17.83, 97.36 wt%,and 63.74 wt%, respectively. 展开更多
关键词 ISOMERIZATION Ionic liquid analogs N-PENTANE Mathematical model ADDITIVES
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Isolation of Resistance Gene Analogs from Wheat Based on Conserved Domains of Resistance Genes 被引量:1
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作者 秦跟基 陈佩度 +2 位作者 顾红雅 冯祎高 牛吉山 《Acta Botanica Sinica》 CSCD 2003年第3期340-345,共6页
Two pairs of degenerate primers were designed based on nucleotide-binding site (NBS) and serine/threonine kinase domain. PCR was performed with the primers and cDNA from the Triticum aestivum-Haynaldia villosa translo... Two pairs of degenerate primers were designed based on nucleotide-binding site (NBS) and serine/threonine kinase domain. PCR was performed with the primers and cDNA from the Triticum aestivum-Haynaldia villosa translocation line 6VS/6AL. Amplified products were cloned and sequenced. Nine clones with NBS and one with serine/threonine kinase domain were obtained. The NBS clones were classified to six groups according to their nucleotide sequence identities (90% or higher). These resistance gene analogs (RGAs) all have open reading frames (ORF), and their amino acid sequences show high similarity to Yr10 in wheat, Mla1 and Mla6 in barley, RPS2 in Arabidopsis and other resistance (R) genes with conserved motifs. They were preliminarily mapped on the chromosomes of homoeologous groups 1, 2 and 5 of common wheat by nulli-tetrasomic analysis. The 5'-end sequence of an RGA N5 was obtained by 5'-RACE PCR. It encodes six leucine zipper (LZ) and has high sequence similarity to RPS2. 展开更多
关键词 resistance gene analogs nucleotide-binding site PCR Triticum aestivum-Haynaldia villosa translocation line
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Determination of structure-activity relationships between fentanyl analogs and human μ-opioid receptors based on active binding site models 被引量:3
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作者 Ming Liu Xiaoli Liu +2 位作者 Ping Wan Qiangsan Wu Wenxiang Hu 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第4期267-276,共10页
Fentanyl is a potent and widely used clinical narcotic analgesic, as well as a highly selective IJ-opioid agonist. The present study established a homologous model of the human μ-opioid receptor; an intercomparison o... Fentanyl is a potent and widely used clinical narcotic analgesic, as well as a highly selective IJ-opioid agonist. The present study established a homologous model of the human μ-opioid receptor; an intercomparison of three types of μ-opioid receptor protein sequence homologous rates was made. The secondary receptor structure was predicted, the model reliability was assessed and verified using the Ramachandran plot and ProTab analysis. The predictive ability of the CoMFA model was further validated using an external test set. Using the Surflex-Dock program, a series of fentanyl analog molecules were docked to the receptor, the calculation results from Biopolymer/SitelD showed that the receptor had a deep binding area situated in the extracellular side of the transmembrane domains (TM) among TM3, TM5, TM6, and TMT. Results suggested that there might be 5 active areas in the receptor. The important residues were Asp147, Tyr148, and Tyr149 in TM3, Trp293, and His297 in TM6, and Trp318, His319, Ile322, and Tyr326 in TM7, which were located at the 5 active areas. The best fentanyl docking orientation position was the piperidine ring, which was nearly perpendicular to the membrane surface in the 7 TM domains. Molecular dynamic simulations were applied to evaluate potential relationships between ligand conformation and fentanyl substitution. 展开更多
关键词 μ-opioid receptor fentanyl analogs AGONIST active site structure-activity relationship
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Studies on the Synthesis of Pyridine Analogs of the Natural Product3,5,4'-Trimethoxystilbene 被引量:2
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作者 Zhi Song PIAO Lin WANG Zhi Zhong ZHAO 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第11期1119-1122,共4页
Five pyridine analogs of the natural product, 3, 5, 4'-trimethoxystilbene, were synthesized. The final compounds were characterized by 1H-NMR.
关键词 SYNTHESIS pyridine analogs of 3 5 4'-trimethoxystilbene .
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THE PREPARATION AND BIOACTIVITIES OF OPTICALANALOGS OF BAOGONGTENG A 被引量:2
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作者 杨丽敏 王惠宁 严忠红 《Medical Bulletin of Shanghai Jiaotong University》 CAS 1999年第1期51-53,共3页
objective We prepared optical analogs of Baogongteng A and investigated their bioactivities soas to find new effective hypotoxic drugs at M- receptors. Methods Racemic analogs of Baogongteng A wereresolved with chiral... objective We prepared optical analogs of Baogongteng A and investigated their bioactivities soas to find new effective hypotoxic drugs at M- receptors. Methods Racemic analogs of Baogongteng A wereresolved with chiral acid. Results Six chiral analogs of Baogongteng A were prepared. In mydriatic tests inrabbits, (+) - 32 - benzoyloxy - 6β - acetoxytropane and (+) - 32 - parachloro benzoyloxy- 6β- acetoxytropanepossess anticholinergic activities. Conclusion The configuration of enantiomers has significant influence on thebioactivity of analogs of Baogongteng A. 展开更多
关键词 analogs of Baogongteng A CHIRAL MEDICINE ANTICHOLINERGIC ACTIVITY
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Synthesis and Antibacterial Activity of Novel Oxazolidinone Analogs Containing Substituted Thiazole/Fused-Bicyclic Groups 被引量:1
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作者 ZHAI Xin ZHAO Yan-fang WANG Jia HONG Wei HUANG Liang GONG Ping 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2006年第4期459-464,共6页
Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic(imidazo[ 1,2-b] pyridazine/ imidazo[2,1-b] thiazole) groups were designed and synthesized. A new method for the preparation of the k... Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic(imidazo[ 1,2-b] pyridazine/ imidazo[2,1-b] thiazole) groups were designed and synthesized. A new method for the preparation of the key intermediate compound 11 was proposed. The structures of the target compounds were confirmed by ^1H NMR, IR and MS, and their in vitro antibacterial activities against staphylococcus aureus were evaluated. Among them, compound 16a displays a promising antibacterial activity comparable to that of linezolid. 展开更多
关键词 Oxazolidinone analog SYNTHESIS Antibacterial activity
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Effect of 5-Aza-2’-deoxycytidine on immune-associated proteins in exosomes from hepatoma 被引量:10
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作者 Gao-Wa Sanren 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第19期2371-2377,共7页
AIM: To study the effect of 5-Aza-2’-deoxycytidine (5-Aza-CdR) on heat shock protein 70 (HSP70), human leucocyte antigen-Ⅰ (HLA-Ⅰ) and NY-ESO-1 proteins in exosomes produced by hepatoma cells, HepG2 and Hep3B. METH... AIM: To study the effect of 5-Aza-2’-deoxycytidine (5-Aza-CdR) on heat shock protein 70 (HSP70), human leucocyte antigen-Ⅰ (HLA-Ⅰ) and NY-ESO-1 proteins in exosomes produced by hepatoma cells, HepG2 and Hep3B. METHODS: Exosomes derived from HepG2 and Hep3B cells treated with or without 5-aza-CdR were isolated and purified by ultrafiltration centrifugation and sucrose gradient ultracentrifugation. The number of exosomes was counted under electron microscope. Concentration of proteins in exosomes was measured by bicinchoninic acid protein assay. Expression of HSP70, HLA-Ⅰ and NY-ESO-1 proteins in exosomes was detected by Western blotting and immunoelectron microscopy. mRNA expression of p53 gene was detected by reverse transcription polymerase chain reaction.RESULTS: The mRNA expression of p53 gene was increased in both hepatoma cell lines after treatment with 5-Aza-CdR. The number of exosomes and the concentration of total proteins in exosomes were increased signifi cantly after treatment with 5-aza-CdR (P < 0.05). After treatment with 5-Aza-CdR, immunoelectron microscopy and Western blotting showed that the HSP70, HLA-Ⅰ and NY-ESO-1 proteins were increased in exosomes produced by both hepatoma cell lines. CONCLUSION: 5-aza-CdR, an inhibitor of DNA methyltransferase, can increase exosomes produced by hepatoma cells and immune-associated protein component of exosomes, which may be mediated by p53 gene upregulation and 5-Aza-CdR demethylation. 展开更多
关键词 5-Aza-2’-deoxycytidine EXOSOME Immu-nomolecule Hepatoma cell
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Synthesis and antibacterial activity of 4″-O-carbamoyl analogs of clarithromycin 被引量:3
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作者 Xue Cui Shen Bo Jiao Shu Tao Ma 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第3期257-260,共4页
A series of novel 4'-O-carbamoyl analogs of clarithromycin were synthesized and evaluated for their in vitro antibacterial activity. All of the desired compounds showed excellent activity against erythromycin-susc... A series of novel 4'-O-carbamoyl analogs of clarithromycin were synthesized and evaluated for their in vitro antibacterial activity. All of the desired compounds showed excellent activity against erythromycin-susceptible S.pneumoniae.Particularly,4-fluorobenzyl carbamate 7a demonstrated potent activity against erythromycin-resistant S.pneumoniae encoded by the mef gene,and remarkably improved activity against erythromycin-resistant S.pneumoniae encoded by the erm gene,and the erm and mef genes. 展开更多
关键词 Clarithromycin analogs 4″-O-carbamate SYNTHESIS Antibacterial activity Resistant bacteria
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Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus 被引量:1
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作者 Vladislav A Zykov Taisiia P Tuchina +6 位作者 Denis A Lebedev Irina B Krylova Alina Y Babenko Elvira V Kuleshova Elena N Grineva Alekber A Bayramov Michael M Galagudza 《World Journal of Diabetes》 SCIE CAS 2018年第9期149-156,共8页
AIM To evaluate the effects of glucagon-like peptide-1 analogs(GLP-1 a) combined with insulin on myocardial ischemiareperfusion injury in diabetic rats.METHODS Type 2 diabetes mellitus(T2 DM) was induced in maleWistar... AIM To evaluate the effects of glucagon-like peptide-1 analogs(GLP-1 a) combined with insulin on myocardial ischemiareperfusion injury in diabetic rats.METHODS Type 2 diabetes mellitus(T2 DM) was induced in maleWistar rats with streptozotocin(65 mg/kg) and verified using an oral glucose tolerance test. After anesthesia, the left coronary artery was occluded for 40 min followed by 80 min reperfusion. Blood glucose level was measured during surgery. Rats were randomized into six groups as follows:(1) control rats;(2) insulin(0.1 U/kg) treated rats prior to ischemia;(3) insulin(0.1 U/kg) treated rats at reperfusion;(4) GLP-1 a(140 mg/kg) treated rats prior to ischemia;(5) GLP-1 a(140 mg/kg) treated rats at reperfusion; and(6) rats treated with GLP-1 a(140 mg/kg) prior to ischemia plus insulin(0.1 U/kg) at reperfusion. Myocardial area at risk and infarct size was measured planimetrically using Evans blue and triphenyltetrazolium chloride staining, respectively.RESULTS There was no significant difference in the myocardial area at risk among groups. Insulin treatment before ischemia resulted in a significant increase in infarct size(34.7% ± 3.4% vs 18.6% ± 3.1% in the control rats, P < 0.05). Post-ischemic administration of insulin or GLP-1 a had no effect on infarct size. However, pre-ischemic administration of GLP-1 a reduced infarct size to 12% ± 2.2%(P < 0.05). The maximal infarct size reduction was observed in the group treated with GLP-1 a prior to ischemia and insulin at reperfusion(8% ± 1.6%, P < 0.05 vs the control and GLP-1 a alone treated groups).CONCLUSION GLP-1 a pre-administration results in myocardial infarct size reduction in rats with T2 DM. These effects are maximal in rats treated with GLP-1 a pre-ischemia plus insulin at reperfusion. 展开更多
关键词 Glucagon-like peptide-1 analog INSULIN Myocardial ISCHEMIA-REPERFUSION injury INFARCT size Type 2 diabetes mellitus RATS Experimental research
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