Lipofuscin-like pigments (LFPs) are highly oxidized cross-linked aggregates of oxidized protein and lipids which are formed under oxidative state conditions by free radicals produced. The present study aimed to evalua...Lipofuscin-like pigments (LFPs) are highly oxidized cross-linked aggregates of oxidized protein and lipids which are formed under oxidative state conditions by free radicals produced. The present study aimed to evaluate the probable ameliorative effects of some of the Mn-salens namely EUKs 8, 134, 15, 115, 122 and 132 (compounds 1-6) and vitamin C against carbon tetrachloride (CCl4)-induced acute damage on rats’ livers and brains. Exposure to CCl4 is believed to induce oxidative stress and cause tissue damage due to the formation of trichloromethyl (·CCl3) and peroxy trichloromethyl (·OOCCl3) radicals. In this study, 54 rats were randomly divided into 9 groups of six each: normal group received only vehicle (olive oil;2 ml/kg b.w.) for 6 consecutive days;CCl4- intoxicated group received the vehicle and CCl4 (50% solution of CCl4 in olive oil, 2 ml/kg b.w.) on the first and second days and the vehicle on the third to sixth days;test rats received Mn-salens or vitamin C (20 mg/kg b.w.) and CCl4 (2 ml/kg b.w.) on the first and second days and Mn-salens or vitamin C (20 mg/kg b.w.) on the third to sixth days. Mn-salens administration ameliorated the effects of CCl4 by decreasing the levels of ROS, lipid and protein oxidations and LFPs formation on liver and brain as well as cholesterol and triglycerides, aminotransferases and alkaline phosphatase contents in sera of rats whereas increased the activities of catalase, superoxide dismutase,glutathione reductase, glutathione peroxidase and reduced glutathione in liver and brain tissues. Histopathological studies confirmed the toxic effects of CCl4 and ameliorative action of Mn-salens on tissues. These results suggest that the evaluated EUKs were able to attenuate LFPs accumulation and morphological changes caused by CCl4 in rats and thus, confirming the ameliorative role of Mn-salens against CCl4-induced oxidative damage and age-related diseases.展开更多
The hose pulse testing bench generally uses electro-hydraulic servo system. It occupies little space, tracks signals fast and has simple structure, and therefore it is widely used in industrial control field. However,...The hose pulse testing bench generally uses electro-hydraulic servo system. It occupies little space, tracks signals fast and has simple structure, and therefore it is widely used in industrial control field. However, there are lots of problems such as little accuracy and instability caused by slow response of hydraulic and various interference factors. Simple proportional integra- tion derivatiation （PID） control method of traditional pulse bench is simple in principle, but it is difficult in parameter adjust- ment. According to the special requirements of the control system, a PID method based on fuzzy control is proposed in the pa- per. This method not only retains the advantages of the conventional control system, but also ameliorates the drawbacks of parameter uncertainty, instability and lag. It has been testified that the method is practicable and can improve the precision and adaptation.展开更多
文摘Lipofuscin-like pigments (LFPs) are highly oxidized cross-linked aggregates of oxidized protein and lipids which are formed under oxidative state conditions by free radicals produced. The present study aimed to evaluate the probable ameliorative effects of some of the Mn-salens namely EUKs 8, 134, 15, 115, 122 and 132 (compounds 1-6) and vitamin C against carbon tetrachloride (CCl4)-induced acute damage on rats’ livers and brains. Exposure to CCl4 is believed to induce oxidative stress and cause tissue damage due to the formation of trichloromethyl (·CCl3) and peroxy trichloromethyl (·OOCCl3) radicals. In this study, 54 rats were randomly divided into 9 groups of six each: normal group received only vehicle (olive oil;2 ml/kg b.w.) for 6 consecutive days;CCl4- intoxicated group received the vehicle and CCl4 (50% solution of CCl4 in olive oil, 2 ml/kg b.w.) on the first and second days and the vehicle on the third to sixth days;test rats received Mn-salens or vitamin C (20 mg/kg b.w.) and CCl4 (2 ml/kg b.w.) on the first and second days and Mn-salens or vitamin C (20 mg/kg b.w.) on the third to sixth days. Mn-salens administration ameliorated the effects of CCl4 by decreasing the levels of ROS, lipid and protein oxidations and LFPs formation on liver and brain as well as cholesterol and triglycerides, aminotransferases and alkaline phosphatase contents in sera of rats whereas increased the activities of catalase, superoxide dismutase,glutathione reductase, glutathione peroxidase and reduced glutathione in liver and brain tissues. Histopathological studies confirmed the toxic effects of CCl4 and ameliorative action of Mn-salens on tissues. These results suggest that the evaluated EUKs were able to attenuate LFPs accumulation and morphological changes caused by CCl4 in rats and thus, confirming the ameliorative role of Mn-salens against CCl4-induced oxidative damage and age-related diseases.
基金High Level Talented Person Funded Project of Hebei Province(No.C2013005003)Excellent Experts for Going Abroad Training Program of Hebei Province(No.10215601D)
文摘The hose pulse testing bench generally uses electro-hydraulic servo system. It occupies little space, tracks signals fast and has simple structure, and therefore it is widely used in industrial control field. However, there are lots of problems such as little accuracy and instability caused by slow response of hydraulic and various interference factors. Simple proportional integra- tion derivatiation （PID） control method of traditional pulse bench is simple in principle, but it is difficult in parameter adjust- ment. According to the special requirements of the control system, a PID method based on fuzzy control is proposed in the pa- per. This method not only retains the advantages of the conventional control system, but also ameliorates the drawbacks of parameter uncertainty, instability and lag. It has been testified that the method is practicable and can improve the precision and adaptation.
