Objective:To compare the therapeutic effects of three different external wet compress methods on facial hormone dependent dermatitis(FCAD),and to provide reference for clinical treatment of FCAD.Methods:From June 2016...Objective:To compare the therapeutic effects of three different external wet compress methods on facial hormone dependent dermatitis(FCAD),and to provide reference for clinical treatment of FCAD.Methods:From June 2016 to June 2019,160 FCAD patients in our dermatology clinic were selected and divided into three groups according to random number table:the first group was treated with Compound Cortex Phellodendri liquid coating,the second group was treated with collagen paste dressing,and the third group was treated with 0.9%sodium chloride injection solution.Apply 8 layers of gauze or cold compress directly to the skin lesions for 4 weeks in each group.Results:After 4 weeks of treatment,no adverse reactions were found.The effective rates of the first group,the second group,and the third group were 72.22%,62.26%and 41.51%,respectively.Compared with the third group,the effective rate of the first group and the second group was significantly higher,and there was statistical significance between the groups(x2=10.294,x2=4.573,P<0.05);but there was no significant statistical difference between the first group and the second group(x2=1.205,P>0.05).Conclusion:Compound Cortex Phellodendri coating is suitable for FCAD patients with severe inflammation,collagen paste dressing is suitable for FCAD patients with mild to moderate inflammatory reaction and pigmentation,and 0.9%sodium chloride injection is suitable for patients with mild facial flushing and swelling.Clinical treatment should be selected according to the patient's condition and rash characteristics.展开更多
Introduction: Topical corticosteroids are commonly prescribed for children with atopic dermatitis. Although generally well tolerated, long term unsupervised use can lead to ocular damage, including glaucoma. Much of t...Introduction: Topical corticosteroids are commonly prescribed for children with atopic dermatitis. Although generally well tolerated, long term unsupervised use can lead to ocular damage, including glaucoma. Much of the current literature focuses on the periorbital use in older patients. We present a case of an adolescent who suffered glaucomatous damage secondary to long term topical steroid use on her extremities. Methods: This is a case report of a child with extensive work-up for glaucoma suspect. Results: A 7-year-old African American female was found to have glaucomatous damage after using 2.5% hydrocortisone cream on her arms, legs, and back of neck twice daily continuously for 2 years. There were no other mechanisms that could have produced a secondary glaucoma. Congenital anomalous disk is a remote possibility. Discussion: Steroid cream use for atopic dermatitis is relatively common. The side effect profile of topical corticosteroids has been well documented and includes glaucoma. These patients may not have any visual symptoms, and can present at an advanced stage, with irreversible vision loss. Children with atopic dermatitis are especially susceptible to the systemic effects of steroids because of the damaged epithelial layer and also the body surface area to volume, both of which increase the bioavailability of the medication. Conclusion: Because topical steroids are commonly used, especially in children, patients need to be aware of the potentially dangerous side effects, including vision loss from glaucoma.展开更多
文摘Objective:To compare the therapeutic effects of three different external wet compress methods on facial hormone dependent dermatitis(FCAD),and to provide reference for clinical treatment of FCAD.Methods:From June 2016 to June 2019,160 FCAD patients in our dermatology clinic were selected and divided into three groups according to random number table:the first group was treated with Compound Cortex Phellodendri liquid coating,the second group was treated with collagen paste dressing,and the third group was treated with 0.9%sodium chloride injection solution.Apply 8 layers of gauze or cold compress directly to the skin lesions for 4 weeks in each group.Results:After 4 weeks of treatment,no adverse reactions were found.The effective rates of the first group,the second group,and the third group were 72.22%,62.26%and 41.51%,respectively.Compared with the third group,the effective rate of the first group and the second group was significantly higher,and there was statistical significance between the groups(x2=10.294,x2=4.573,P<0.05);but there was no significant statistical difference between the first group and the second group(x2=1.205,P>0.05).Conclusion:Compound Cortex Phellodendri coating is suitable for FCAD patients with severe inflammation,collagen paste dressing is suitable for FCAD patients with mild to moderate inflammatory reaction and pigmentation,and 0.9%sodium chloride injection is suitable for patients with mild facial flushing and swelling.Clinical treatment should be selected according to the patient's condition and rash characteristics.
文摘Introduction: Topical corticosteroids are commonly prescribed for children with atopic dermatitis. Although generally well tolerated, long term unsupervised use can lead to ocular damage, including glaucoma. Much of the current literature focuses on the periorbital use in older patients. We present a case of an adolescent who suffered glaucomatous damage secondary to long term topical steroid use on her extremities. Methods: This is a case report of a child with extensive work-up for glaucoma suspect. Results: A 7-year-old African American female was found to have glaucomatous damage after using 2.5% hydrocortisone cream on her arms, legs, and back of neck twice daily continuously for 2 years. There were no other mechanisms that could have produced a secondary glaucoma. Congenital anomalous disk is a remote possibility. Discussion: Steroid cream use for atopic dermatitis is relatively common. The side effect profile of topical corticosteroids has been well documented and includes glaucoma. These patients may not have any visual symptoms, and can present at an advanced stage, with irreversible vision loss. Children with atopic dermatitis are especially susceptible to the systemic effects of steroids because of the damaged epithelial layer and also the body surface area to volume, both of which increase the bioavailability of the medication. Conclusion: Because topical steroids are commonly used, especially in children, patients need to be aware of the potentially dangerous side effects, including vision loss from glaucoma.
文摘目的:探讨荆防方加减联合红黄光及重组牛碱性成纤维细胞生长因子(rb-bFGF)凝胶治疗面部糖皮质激素依赖性皮炎(Facial corticosteroid addictive dermatitis,FCAD)的效果。方法:根据治疗方法不同将2022年2月-2023年8月笔者医院的90例FCAD患者分为对照组和观察组,各45例。对照组使用红黄光照射治疗,观察组同时使用荆防方治疗。对比两组的临床疗效、症状评分、皮肤屏障功能、血清炎症因子水平、不良反应。结果:观察组的有效率(91.11%)高于对照组(73.33%)(P<0.05),观察组治疗后潮红、瘙痒、干燥脱屑、灼热疼痛的症状评分均低于对照组(P<0.05),观察组治疗后的皮脂含量、皮肤角质层含水量(Cuticle water conten,WCSC)高于对照组,经皮肤水分流失量(Transcutaneous water loss,TEWL)低于对照组(P<0.05),观察组治疗后的干扰素-γ(INF-γ)、免疫球蛋白-E(IgE)、白细胞介素-4(IL-4)水平均低于对照组(P<0.05),两组不良反应比较,差异无统计学意义(P>0.05)。结论:荆防方加减联合红黄光及rb-bFGF凝胶治疗FCAD的效果显著,能够减轻患者的症状,提高皮肤屏障功能,改善炎症状态。
