The ozonation of hydroxyl compounds （e.g., sugars and alcohols） gives a broad range of products such as alcohols, aldehydes, ketones, and carboxylic adds. This study developed and optimized a two-step derivatization...The ozonation of hydroxyl compounds （e.g., sugars and alcohols） gives a broad range of products such as alcohols, aldehydes, ketones, and carboxylic adds. This study developed and optimized a two-step derivatization procedure for analyzing polar products of aldehydes and carboxylic acids from the ozonation of diethylene glycol （DEG） in a non-aqueous environment using gas chromatography-mass spectrometry. Experiments based on Central Composite Design with response surface methodology were carried out to evaluate the effects of derivatization variables and their interactions on the analysis. The most desirable derivati- zation conditions were reported, i.e., oximation was performed at room temperature overnight with the o-（2,3,4,5,6-pentafluorobenzyl） hydroxyl amine to analyte molar ratio of 6, silylation reaction temperature of 70℃, reaction duration of 70 min, and N,O-bis（trimethylsilyl）- trifluoroacetamide volume of 12.5 μL. The applicability of this optimized procedure was verified by analyzing DEG ozonation products in an ultrafine condensation particle counter simulation system.展开更多
基金supported by the National Natural Science Foundation of China(nos.21422703 and 41227805)the National Key Basic Research and Development Program of China(no.2013CB228505)
文摘The ozonation of hydroxyl compounds （e.g., sugars and alcohols） gives a broad range of products such as alcohols, aldehydes, ketones, and carboxylic adds. This study developed and optimized a two-step derivatization procedure for analyzing polar products of aldehydes and carboxylic acids from the ozonation of diethylene glycol （DEG） in a non-aqueous environment using gas chromatography-mass spectrometry. Experiments based on Central Composite Design with response surface methodology were carried out to evaluate the effects of derivatization variables and their interactions on the analysis. The most desirable derivati- zation conditions were reported, i.e., oximation was performed at room temperature overnight with the o-（2,3,4,5,6-pentafluorobenzyl） hydroxyl amine to analyte molar ratio of 6, silylation reaction temperature of 70℃, reaction duration of 70 min, and N,O-bis（trimethylsilyl）- trifluoroacetamide volume of 12.5 μL. The applicability of this optimized procedure was verified by analyzing DEG ozonation products in an ultrafine condensation particle counter simulation system.
