Heavy-payload forging manipulators are mainly characterized by large load output and large capacitive-load input.The relationship between outputs and inputs,which will greatly influence the control and the reliability...Heavy-payload forging manipulators are mainly characterized by large load output and large capacitive-load input.The relationship between outputs and inputs,which will greatly influence the control and the reliability,is the key issue in type design for heavy-payload forging manipulators.In this paper,a type design method by considering the incidence relationship between output characteristics and actuator inputs is presented and used to design the mechanism for forging manipulators.The concept of modeling method based on the outputs tasks is defined and investigated.The principle of type design from the viewpoints of the relationship between output characteristics and actuator inputs is discussed.An idea of establishing the incidence relationship between output characteristics and actuator inputs is proposed.The incidence relationship matrix between outputs and inputs is also given.The design flow is obtained,and the incidence relationship between outputs and inputs for heavy-payload forging manipulators is divided into three parts after detailed understanding of the functional properties.Four types of mechanisms for heavy-payload forging manipulators are given,and the corresponding spatial mechanical sketches are also drawn,some new designed mechanisms have been adopted by company or used as prototype.These novel forging manipulators which satisfy certain functional requirements provide an effective help for the design of forging manipulators and patent application.展开更多
Production of petrochemical catalysts accounts for one of the largest shares of platinum group metals(PGMs) consumption;thus,recycling of spent petrochemical catalysts holds great economic value.Conventionally,PGMs ar...Production of petrochemical catalysts accounts for one of the largest shares of platinum group metals(PGMs) consumption;thus,recycling of spent petrochemical catalysts holds great economic value.Conventionally,PGMs are recovered through hydrometallurgical processes which have a low recovery efficiency and produce a large amount of waste.In this regard,this paper proposed a method to use iron-capturing PGMs based on CaO-Al_(2)O_(3)-Na_(2)O slag.This method avoided the formation of Fe-Si alloy and achieved efficient enrichment of PGMs.The droplet force model showed that the recovery efficiency of PGMs could be improved if the slag had low density and low viscosity.Based on this result,FactSage software optimized the composition of slag.Furthermore,the effect of B_(2)O_(3) on the 1400 ℃ liquidus of CaO-Al_(2)O_(3)-Na_(2)O_(3)-B_(2)O_(3) phase diagram was revealed.Moreover,it was found that the recovery efficiency of PGMs exceeded 99% under the following optimized conditions:basicity of 1.0,20 wt%Na_(2)O,15 wt% B_(2)O_(3),15 wt% Fe,3 wt% C and a temperature range of 1400-1500℃.The thermodynamic model revealed the mechanism of iron capture.Different chemical bonds prevented the formation of bonds between the alloy and slag,resulting in the separation of the slag from the alloy.PGMs particles and iron microspheres had significant surface Gibbs free energy.Only when iron microspheres and PGMs particles collided and fused with each other to reduce their surface area could the Gibbs free energy of the system be reduced.展开更多
Dipeptidyl peptidase Ⅳ(DPP4) inhibitors are proven in the treatment of type 2 diabetes.We designed and synthesized a series of novel indole compounds that selectively inhibit the activity of DPP4 over dipeptidyl pe...Dipeptidyl peptidase Ⅳ(DPP4) inhibitors are proven in the treatment of type 2 diabetes.We designed and synthesized a series of novel indole compounds that selectively inhibit the activity of DPP4 over dipeptidyl peptidase 9(DPP9)(〉200 fold).We further co-crystallized DPP4 with indole sulfonamide(compound 1) to confirm a proposed binding mode.Good metabolic stability of the indole compounds represents another positive attribute for further development.展开更多
基金supported by National Key Basic Research Program of China (973 Program,Grant No. 2006CB705402)Important National Science & Technology Specific Projects (Grant No. 2009ZX04002-061)National Hi-tech Research and Development Program of China (863Program,Grant No. 2008AA04XK1478950)
文摘Heavy-payload forging manipulators are mainly characterized by large load output and large capacitive-load input.The relationship between outputs and inputs,which will greatly influence the control and the reliability,is the key issue in type design for heavy-payload forging manipulators.In this paper,a type design method by considering the incidence relationship between output characteristics and actuator inputs is presented and used to design the mechanism for forging manipulators.The concept of modeling method based on the outputs tasks is defined and investigated.The principle of type design from the viewpoints of the relationship between output characteristics and actuator inputs is discussed.An idea of establishing the incidence relationship between output characteristics and actuator inputs is proposed.The incidence relationship matrix between outputs and inputs is also given.The design flow is obtained,and the incidence relationship between outputs and inputs for heavy-payload forging manipulators is divided into three parts after detailed understanding of the functional properties.Four types of mechanisms for heavy-payload forging manipulators are given,and the corresponding spatial mechanical sketches are also drawn,some new designed mechanisms have been adopted by company or used as prototype.These novel forging manipulators which satisfy certain functional requirements provide an effective help for the design of forging manipulators and patent application.
基金financially supported by the National Natural Science Foundation of China (Nos.U2002212 and 52204412)the National Key R&D Program of China (Nos. 2019YFC1907101,2019YFC1907103 and 2021YFC1910504)+3 种基金Key R&D Program of Ningxia Hui Autonomous Region (No. 2020BCE01001)Guangdong Basic and Applied Basic Research Foundation (No.2020A1515110408)Foshan Science and Technology Innovation Special Foundation (No.BK21BE002)the Fundamental Research Funds for the Central Universities (No.FRF-TP20-031A1)。
文摘Production of petrochemical catalysts accounts for one of the largest shares of platinum group metals(PGMs) consumption;thus,recycling of spent petrochemical catalysts holds great economic value.Conventionally,PGMs are recovered through hydrometallurgical processes which have a low recovery efficiency and produce a large amount of waste.In this regard,this paper proposed a method to use iron-capturing PGMs based on CaO-Al_(2)O_(3)-Na_(2)O slag.This method avoided the formation of Fe-Si alloy and achieved efficient enrichment of PGMs.The droplet force model showed that the recovery efficiency of PGMs could be improved if the slag had low density and low viscosity.Based on this result,FactSage software optimized the composition of slag.Furthermore,the effect of B_(2)O_(3) on the 1400 ℃ liquidus of CaO-Al_(2)O_(3)-Na_(2)O_(3)-B_(2)O_(3) phase diagram was revealed.Moreover,it was found that the recovery efficiency of PGMs exceeded 99% under the following optimized conditions:basicity of 1.0,20 wt%Na_(2)O,15 wt% B_(2)O_(3),15 wt% Fe,3 wt% C and a temperature range of 1400-1500℃.The thermodynamic model revealed the mechanism of iron capture.Different chemical bonds prevented the formation of bonds between the alloy and slag,resulting in the separation of the slag from the alloy.PGMs particles and iron microspheres had significant surface Gibbs free energy.Only when iron microspheres and PGMs particles collided and fused with each other to reduce their surface area could the Gibbs free energy of the system be reduced.
基金supported in part by funds from the Ministry of Science and Technology (No. 2014CB910300)the Natural Science Foundation of Zhejiang Province (No. R2100439)the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20110101110122)
文摘Dipeptidyl peptidase Ⅳ(DPP4) inhibitors are proven in the treatment of type 2 diabetes.We designed and synthesized a series of novel indole compounds that selectively inhibit the activity of DPP4 over dipeptidyl peptidase 9(DPP9)(〉200 fold).We further co-crystallized DPP4 with indole sulfonamide(compound 1) to confirm a proposed binding mode.Good metabolic stability of the indole compounds represents another positive attribute for further development.