Objective To explore the effects of steroid hormone contraceptives (SHCs), such as Mercilon, Chinese No. 1 pill, Post coital pill, Mesigyna, and Cyclofem, on lipid metabolism in Chinese women during the last decade...Objective To explore the effects of steroid hormone contraceptives (SHCs), such as Mercilon, Chinese No. 1 pill, Post coital pill, Mesigyna, and Cyclofem, on lipid metabolism in Chinese women during the last decade Materials & Methods A total of 122 healthy volunteers who requested contraception were recruited in the study and one of the above mentioned SHCs was administered.Fasting serum samples were taken from each subject before, during and after treatments. Triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL c), low density lipoprotein cholesterol (LDL c), Apolipoprotein A I, A II and B were measured. The changes in the ratios of TC/HDL c, Apo A I/Apo B were also observed. Results Although the levels of lipid were either increased or decreased by any one of the 5 contraceptives, these changes recovered after withdrawal of the drug administration. No significant changes were detected in the ratios of TC/HDL c, Apo A I/Apo B during treatments. Conclusion The results suggest that there is no obvious impact on lipid profile induced by any of the 5 contraceptives within one year. The induced effects on lipid metabolism could be reduced by alternate use of 2 contraceptives with different biological activities.展开更多
总结7种含有不同生物活性的常用甾体激素避孕药(Marvelon,Microgynon,中国Ⅰ号片,Mercilon,LNG事后药,Mesigyna,Cyclofem)对中国妇女脂代谢的影响。191例需要避孕的健康志愿者分别服用以上不同的避孕药,并依次在用药前、用药期间及停药...总结7种含有不同生物活性的常用甾体激素避孕药(Marvelon,Microgynon,中国Ⅰ号片,Mercilon,LNG事后药,Mesigyna,Cyclofem)对中国妇女脂代谢的影响。191例需要避孕的健康志愿者分别服用以上不同的避孕药,并依次在用药前、用药期间及停药后采空腹静脉血,观察血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白A Ⅰ(apo A Ⅰ)、载脂蛋白AⅡ(apo AⅡ)、载脂蛋白B(apo B)水平变化及TC/HDL-C、apo A Ⅰ/apo B比值改变。共观察1665个周期。结果显示,以上7种避孕药均有升高或降低某些脂质水平的作用,但停药后均能恢复,而且无论在用药期间或停药后,以上两项比值无显著改变。结果提示短期服用以上7种避孕药(一年内),对脂代谢无不良影响,并发现由于各种甾体激素类避孕药的配伍各异,因而产生的生物活性不同,对人体脂代谢的影响亦不一致。因此建议如能交替使用不同种类的避孕药,也许可减少长期服药者副作用的发生。展开更多
文摘Objective To explore the effects of steroid hormone contraceptives (SHCs), such as Mercilon, Chinese No. 1 pill, Post coital pill, Mesigyna, and Cyclofem, on lipid metabolism in Chinese women during the last decade Materials & Methods A total of 122 healthy volunteers who requested contraception were recruited in the study and one of the above mentioned SHCs was administered.Fasting serum samples were taken from each subject before, during and after treatments. Triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL c), low density lipoprotein cholesterol (LDL c), Apolipoprotein A I, A II and B were measured. The changes in the ratios of TC/HDL c, Apo A I/Apo B were also observed. Results Although the levels of lipid were either increased or decreased by any one of the 5 contraceptives, these changes recovered after withdrawal of the drug administration. No significant changes were detected in the ratios of TC/HDL c, Apo A I/Apo B during treatments. Conclusion The results suggest that there is no obvious impact on lipid profile induced by any of the 5 contraceptives within one year. The induced effects on lipid metabolism could be reduced by alternate use of 2 contraceptives with different biological activities.
文摘总结7种含有不同生物活性的常用甾体激素避孕药(Marvelon,Microgynon,中国Ⅰ号片,Mercilon,LNG事后药,Mesigyna,Cyclofem)对中国妇女脂代谢的影响。191例需要避孕的健康志愿者分别服用以上不同的避孕药,并依次在用药前、用药期间及停药后采空腹静脉血,观察血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白A Ⅰ(apo A Ⅰ)、载脂蛋白AⅡ(apo AⅡ)、载脂蛋白B(apo B)水平变化及TC/HDL-C、apo A Ⅰ/apo B比值改变。共观察1665个周期。结果显示,以上7种避孕药均有升高或降低某些脂质水平的作用,但停药后均能恢复,而且无论在用药期间或停药后,以上两项比值无显著改变。结果提示短期服用以上7种避孕药(一年内),对脂代谢无不良影响,并发现由于各种甾体激素类避孕药的配伍各异,因而产生的生物活性不同,对人体脂代谢的影响亦不一致。因此建议如能交替使用不同种类的避孕药,也许可减少长期服药者副作用的发生。
