Real-world utility of serological tests in patients with suspected scrub typhus in the Republic of Korea:A single-center,retrospective,observational study

Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are evident.This study aims to assess their practical value in clinical settings.Methods:We analyzed the data of adult patients with suspected scrub typhus who visited a tertiary care hospital in the Republic of Korea from September to December from 2019 to 2021.The included patients had an acute fever and at least one of the following ten secondary findings:myalgia,skin rash,eschar,headache,thrombocytopenia,increased liver enzyme levels,lymphadenopathy,hepatomegaly,splenomegaly,and pleural effusion.The diagnoses were grouped as scrub typhus or other diseases by two infectious disease physicians.Results:Among 136 patients who met the eligibility criteria,109 had scrub typhus and 27 had different diseases.Single and paired total antibodies using immunofluorescence assay(IFA),and total antibodies using immunochromatography-based rapid diagnostic testing(ICT)were measured in 98%,22%,and 75%of all patients,respectively.Confirmation using paired samples for scrub typhus was established at a median of 11[interquartile range(IQR)10-16]days following the first visit.Among the 82 admitted patients,the median admission time was 9(IQR 7-13)days.According to IFA,58(55%)patients with scrub typhus had total immunoglobulin titers≥1:320,while 23(85%)patients with other disease had titers<1:320.Positive ICT results were observed in 64(74%)patients with scrub typhus and 10(67%)patients with other diseases showed negative ICT results.Conclusions:Serological testing for scrub typhus is currently insufficient for decision-making in clinical practice.

Discussion on Test and Detection Technology of Highway Asphalt Pavement

The road traffic industry in China has been developing rapidly in recent years.Asphalt has become the main material in road construction because of its seamless connection and short construction period,and it has an important impact on the overall quality of highway construction.Therefore,it is necessary to conduct scientific and reasonable tests and detections for highway asphalt pavement.This paper presents a discussion on the test and detection technology of highway asphalt pavement for future reference.

NHPP-based software reliability model considering testing effort and multivariate fault detection rate

In recent decades,many software reliability growth models（SRGMs） have been proposed for the engineers and testers in measuring the software reliability precisely.Most of them is established based on the non-homogeneous Poisson process（NHPP）,and it is proved that the prediction accuracy of such models could be improved by adding the describing of characterization of testing effort.However,some research work indicates that the fault detection rate（FDR） is another key factor affects final software quality.Most early NHPPbased models deal with the FDR as constant or piecewise function,which does not fit the different testing stages well.Thus,this paper first incorporates a multivariate function of FDR,which is bathtub-shaped,into the NHPP-based SRGMs considering testing effort in order to further improve performance.A new model framework is proposed,and a stepwise method is used to apply the framework with real data sets to find the optimal model.Experimental studies show that the obtained new model can provide better performance of fitting and prediction compared with other traditional SRGMs.

Wigner-Matrix-Based Normality Test and Application to Weak Signal Detection in SISO/SIMO Systems

Based on the asymptotic spectral distribution of Wigner matrices, a new normality test method is proposed via reforming the white noise sequence. In this work, the asymptotic cumulative distribution function （CDF） of eigenvalues of the Wigner matrix is deduced. A numerical Kullback-Leibler divergence of the empiric-d spectral CDF based on test samples from the deduced asymptotic CDF is established, which is treated as the test statistic. For validating the superiority of our proposed normality test, we apply the method to weak SIPSK signal detection in the single-input single-output （SISO） system and the single-input multiple-output （SIMO） system. By comparing with other common normality tests and the existing signal detection methods, simulation results show that the proposed method is superior and robust.

Strategies for Strengthening Highway Construction Testing and Quality Control

In recent years,the scale of China’s highway projects have been expanding.However,in real life,road construction projects in some places have not passed professional and rigorous inspections,resulting in various quality problems,and seriously affecting the safety of drivers and pedestrians.This paper analyzes the current situation of highway engineering test and detection,expounds the application of new technologies for highway engineering test and detection.In this paper,a case study was carried out on ground penetrating radar(GPR),which aims to improve highway engineering test and detection and provide reference for reducing highway safety risks.

Application Strategy of CBR Test in Highway Engineering

California Bearing Ratio(CBR)test is highly professional and requires a high level of skills.In order to improve the accuracy of the test results,the relevant staff will not only need to understand the rules and procedures involved in the test,they would also need to be meticulous in their work to avoid human errors,provide good data support for highway engineering,and improve the overall quality of the project.Therefore,this paper presents an analysis of the application of CBR test in highway engineering,which can provide reference for engineering and promote the development of the highway industry.

TEST STUDY OF DETECTING OIL AND GAS BY USING REMOTE SENSING TECHNIQUE

Ⅰ The Indexes of Detecting Oil and Gas Resources The deeply buried reservoir which in a dynamic equilibrium state has a great pressure inside, and between it and earth surface there is a great difference of pressure. Therefore the hydrocarbon must spread and move vertically to the surface along the pressure gradient orientation. Hydrocarbons in the reservoir along some small rifts, cracks, joints and cleavages penetrate the overlying strata and seepage onto the surface. Thus the hydrocarbons become unvisble oil and gas signs. This process is called the phenomena of hydrocarbon microseepage of reservoir. Hydrocarbons microseepage in the process

Durbin test with enhanced detection performance to mismatched signal

This paper deals with the problem of detecting a signal whose amplitude is a scaling factor in the presence of homogeneous Gaussian noise with unknown covariance matrix.Since no uniformly most powerful test exists for the problem at hand,we devise and assess a detection strategy based on the well-known Durbin test design criteria.The closed-form expressions for the probabilities of false alarm and detection of the Durbin test are derived,which show that it bears a constant false alarm rate property against the noise covariance matrix.At the analysis stage,the performance of the new receiver is assessed,also in comparison with some classical adaptive detectors,both in matched and in mismatched signal cases.The results show that the proposed detector achieves a visible performance improvement in the presence of severe steering vector mismatch,while maintaining an acceptable detection loss for matched signal.

Immune fluorescence test strips based on quantum dots for rapid and quantitative detection of carcino-embryonic antigen

At present,many researchers focused on the point-of-care testing（POCT）,a method of disease markers detection without large-scale instruments and specialized persons.However,most POCT diagnostic methods were suffered from poor detection sensitivity or inefficiency in quantitative detection.Herein,we developed a newly QD-immune fluorescence test strips（QD-IFTS） based on quantum dots（QDs） as the fluorescence nanocarrier to prepare the immune fluorescence probes in the classical immunochromatography detection system for sensing carcino-embryonic antigen（CEA）,a kind of glycoprotein produced by intestinal tissue and a broad spectrum of tumor marker for cancer diagnosis.And we designed a homemade strips fluorescence reader for detection of fluorescence intensity of QDs on the QD-IFTS.Under the optimized reaction conditions,chromatographic time of the newly QD-IFTS was only25 min,sample volume of the newly QD-IFTS was only 40 m L and the LOD of the newly QD-IFTS was 0.72 ng/m L.In addition,the efficiency and robustness of the newly QD-IFTS were confirmed by successfully application in 300 clinical serum samples,and the results revealed great potential in clinical POCT of other biomarkers.

Efficient Activation Method of Hardware Trojan Based on Greedy Algorithm

To generate test vector sets that can efficiently activate hardware Trojans and improve probability of the hardware Trojan activation,an efficient hardware Trojan activation method is proposed based on greedy algorithm for combinatorial hardware Trojans. Based on the greedy algorithm and the recursive construction method in the combination test,the method formulates appropriate and useful greedy strategy and generates test vector sets with different combinatorial correlation coefficients to activate hardware Trojans in target circuits. The experiment was carried out based on advanced encryption standard（ AES） hardware encryption circuit,different combinatorial hardware Trojans were implanted in AES as target circuits,the experiment of detecting hardware Trojans in target circuits was performed by applying the proposed method and different combinatorial hardware Trojans in target circuits were activated successfully many times in the experiment. The experimental results showthat the test vector sets generated using the proposed method could effectively activate combinatorial hardware Trojans,improve the probability of the hardware Trojan being activated,and also be applied to practice.

Physical design of superconducting magnet for ADS injection Ⅰ

A superconducting solenoid prototype magnet for Accelerator Driven Snbcritical System（ADS） Injection I has been designed and fabricated,which has also been tested in a liquid Helium state inside a vertical Dewar in the Haerbin institute of Technology in November 2012.The design current was 210 A.when the test current reached400 A no quench occurred so the solenoid magnet was forced to quench by the embedded heaters.The integral field strength,leakage held at the nearby upstream and downstream superconducting spoke cavities all meet the design requirements.At the same time,it also checked the reliability of the vertical test Dewar and the quenched detection system.The superconducting prototype magnet has accumulated valuable experiences for the coming batch magnets production and cryogenic test.