Dominating factors on well productivity and development strategies optimization in Weiyuan shale gas play, Sichuan Basin, SW China

Weiyuan shale gas play is characterized by thin high-quality reservoir thickness,big horizontal stress difference,and big productivity differences between wells.Based on integrated evaluation of shale gas reservoir geology and well logging interpretation of more than 20 appraisal wells,a correlation was built between the single well test production rate and the high-quality reservoir length drilled in the horizontal wells,high-quality reservoir thickness and the stimulation treatment parameters in over 100 horizontal wells,the dominating factors on horizontal well productivity were found out,and optimized development strategies were proposed.The results show that the deployed reserves of high-quality reservoir are the dominating factors on horizontal well productivity.In other words,the shale gas well productivity is controlled by the thickness of the high-quality reservoir,the high-quality reservoir drilling length and the effectiveness of stimulation.Based on the above understanding,the development strategies in Weiyuan shale gas play are optimized as follows:(1)The target of horizontal wells is located in the middle and lower parts of Longyi 11(Wei202 area)and Longyi 11(Wei204 area).(2)Producing wells are drilled in priority in the surrounding areas of Weiyuan county with thick high-quality reservoir.(3)A medium to high intensity stimulation is adopted.After the implementation of these strategies,both the production rate and the estimated ultimate recovery(EUR)of individual shale gas wells have increased substantially.

Optimize the Environment for Human Rights Development and Boost Sustainable Human Rights Development

Human rights are not isolated; rather, they are human rights situated in the soci- ety, the network interwoven with economy, politics, society, culture and so on, and human rights protection has to depend upon certain interior and exterior environments and institutional arrangement. As early as in 1948, the Universal Declaration of Human Rights has pointed out, ＂Everyone is entitled to a social and international order in which the rights and freedoms set forth in this Declaration can be fully realized.＂ The realization of human rights not only involves the claim to rights themselves,

A comprehensive review of recent advancements and developments in heat exchanger network synthesis techniques

The rapid development of computational technology and the increasing energy demand have improved heat exchanger network(HEN)synthesis.The HEN synthesis involves several optimizations of matches,distributions of heat loads,and stream splitting of heat units.Thus,obtaining good results at high efficiency has been the main standard for evaluating the techniques in the research area of HEN synthesis.This paper first summarizes and analyzes the main contributions of the existing HEN synthesis techniques.To compare related data quantitively,information on ten typical cases is presented in this paper.Furthermore,recently improved solutions for commonly encountered existing literature cases demonstrate the evolution and competition trends in the field of HEN synthesis.The comparison data presented in this paper not only provide a useful reference for future research but also present the optimization directions.Based on the findings of this study,it is noted that there is still a large room for improvement,and current approaches are incapable of dealing with all HEN cases.Moreover,it is still difficult to escape a local optimum and overcome structural constraints when seeking the global optimum.As a follow-up to the current work,the parallel computing mode and adaptively coordinating the ratio of global and local searching abilities are major development trends for future investigation.

Developing high-efficiency base editors by combining optimized synergistic core components with new types of nuclear localization signal peptide

The clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein(Cas) system has been widely used for genome editing. In this system, the cytosine base editor(CBE) and adenine base editor(ABE) allow generating precise and irreversible base mutations in a programmable manner and have been used in many different types of cells and organisms. However, their applications are limited by low editing efficiency at certain genomic target sites or at specific target cytosine(C) or adenine(A) residues. Using a strategy of combining optimized synergistic core components, we developed a new multiplex super-assembled ABE(sABE) in rice that showed higher base-editing efficiency than previously developed ABEs. We also designed a new type of nuclear localization signal(NLS) comprising a FLAG epitope tag with four copies of a codon-optimized NLS(F4NLS^(r2)) to generate another ABE named F4NLS-sABE. This new NLS increased editing efficiency or edited additional A at several target sites. A new multiplex super-assembled CBE(sCBE) and F4NLS^(r2) involved F4NLS-sCBE were also created using the same strategy. F4NLS-sCBE was proven to be much more efficient than sCBE in rice. These optimized base editors will serve as powerful genome-editing tools for basic research or molecular breeding in rice and will provide a reference for the development of superior editing tools for other plants or animals.

Computer-assisted optimization of mobile phase compositions and development distance selectivity in gradient two-step development high-performance thin-layer chromatography

A computer-assisted method is presented for optimization of mobile phase compositions and development distance in gradient two-step development HPTLC. The method is based on a system which can predict the final R(f) values for gradient two-step development from values measured using five preliminary runs. The statistical scanning method is then used for optimization, using R(f) difference as the selection criterion. The method was evaluated using a mixture of eight components. Excellent agreement was obtained between predicted and experimental results.

Sense of Family Coherence in Parents of(Sub)Optimally Developing Children

The theoretical basis of the paper is Aron Antonovsky’s salutogenetic model of health,which is based on the salutogenic orientation and the sense of coherence understood as the central concept and the most important resource.The primary aim of the study is to determine the strength of the sense of family coherence in parents of optimally developing children and in parents of suboptimally developing children and their correlation with:family satisfaction and family orientation to crisis situations.The study was done using parents(N=394)sampled from the population of the Republic of Serbia.Questionnaire for Obtaining Basic Data,The Family Sense of Coherence Scale,The Family Adaptation Scale and Family Crisis-oriented Scales were used for the purposes of this study.The findings of the study showed that parents of optimally developing children have a more heightened sense of family coherence than parents of suboptimally developing children.Also,the findings showed positive correlation with:family satisfaction and family orientation to crisis,and family sense of coherence.More precisely,the sense of family coherence in the parents who participated in the research correlates positively with satisfaction with one’s own family and family orientation to crisis.

Optimal Intelligent Reconfiguration of Distribution Network in the Presence of Distributed Generation and Storage System

In the present paper,the distribution feeder reconfiguration in the presence of distributed generation resources(DGR)and energy storage systems(ESS)is solved in the dynamic form.Since studies on the reconfiguration problem have ignored the grid security and reliability,the non-distributed energy index along with the energy loss and voltage stability indices has been assumed as the objective functions of the given problem.To achieve the mentioned benefits,there are several practical plans in the distribution network.One of these applications is the network rearrangement plan,which is the simplest and least expensive way to add equipment to the network.Besides,by adding the DGRs to the distribution grid,the radial mode of the grid and the one-sided passage of power are eliminated,and the ordinary and simple grid is replaced with a complex grid.In this paper,an improved particle clustering algorithm is used to solve the distribution network rearrangement problem with the presence of distributed generation sources.The PQ model and the PV model are both considered,and for this purpose,a model based on the compensation technique is used to model the PV busbars.The proposed developed model has particularly improved the local and global search of this algorithm.The reconfiguration problem is discussed and investigated considering different scenarios in a standard 33-bus grid as a well-known power system in different scenarios in the presence and absence of the DGRs.Then,the obtained results are compared.

Current Situation and Thinking of Introduction,Cultivation and Use of High-level Talents in Agricultural Research Institutes under the New Era:A Case Study of Hebei Academy of Agriculture and Forestry Sciences

Current situation of introduction,cultivation and use of high-level talents in agricultural research institutes are analyzed,and the optimized development strategy of further strengthening the construction,introduction,cultivation and use of high-level talent team is thought.It plays a positive role in provincial agricultural research institutes discovering,cultivating and gathering a number of high-quality talents and high-level innovation teams.

Optimizing Export Commodities Mix and Developing Complete Equipment Export

Founded in 1978, the Zhejiang Machinery Equipment Import & Export Corporation is an industrial and trading company engaged in the import and export business of machinery, electronics and instruments. Since 1980, when is was granted self-operational rights, the company has increased year by year in terms of export volume, with its management improving and economic returns steadily rising. In 1995, its import and export volume hit US$119.