Development and validation of a screening instrument for cognitive fluctuation in patientswith neurocognitive disorder with Lewy bodies(NCDLB):the Mayo Fluctuations Scale-Thai version

Background Prevalence of neurocognitive disorder with Lewy bodies （NCDLB） is low in Asian populations, which may partially refect its diagnostic diffculty. The Mayo Fluctuations Scale, a short questionnaire that evaluates cognitive fuctuation, has been shown to signifcantly differentiate NCDLB from Alzheimer＇s disease.Aim This study aimed to develop the Mayo Fluctuations Scale-Thai version and assess its validity to screen NCDLB in an elderly population.Methods The Mayo Fluctuations Scale was translated into Thai. The process involved back-translation, cross-cultural adaptation, feld testing of the prefnal version, as well as fnal adjustments. From all patients attending the Psychiatric and Memory Clinic at Ramathibodi Hospital, 135 patients accompanied by their primary caregivers were included. Caregivers were interviewed by research assistants using a four-item scale, and psychiatrists determined patients＇ diagnosis based on the diagnostic and statistical manual of mental disorders （DSM）-5 criteria. Evaluations performed by psychiatrists and research assistants were blinded.Results Seventeen participants had been diagnosed with major NCDLB. At a cut-off score of 2 or over, the Mayo Fluctuations Scale exhibited excellent performance to differentiate major NCDLB from other major neurocognitive disorders （NCDs）, with a sensitivity of 94.1% and a specifcity of 71.4%, and acceptable performance to differentiate mild NCDLB from other mild NCDs, with a sensitivity of 60% and a specifcity of 93.1%.Conclusion The Mayo Fluctuations Scale-Thai version is an excellent screening tool for major NCDLB and an acceptable tool that may be used with other additional tests for mild NCDLB. The tool is practical for use in memory and psychiatric clinics. Further validation studies in participants with other specifc clinical conditions are required.

Progress in the development and application of plant-based antiviral agents

Plant virus disease is one of the major causes of biological disasters in agriculture worldwide. Given the complexity of transmission media and plant disease infection mechanisms, the prevention and control of plant viral diseases is a great challenge, and an efficient green pesticide is urgently needed. For this reason, when developing candidate drug leads to regulate plant viruses, pesticide experts have focused on characteristics such as low pesticide resistance, eco-friendliness, and novel mechanism. Researchers have also theoretically investigated the molecular targets of viruses infecting agricultural crops. Antiviral screening models have been constructed based on these molecular targets, and the mechanisms of commercial drugs and high-activity compounds have been extensively investigated. After screening, some compounds have been applied in the field and found to have good commercial prospects; these drugs may be used to create new green antiviral pesticides to control plant viruses. This paper reviews the screening, mode of action, development and application of recently used plant-based antiviral agents.

Early Childhood Development (0 - 6 Years Old) from Healthy to Pathologic: A Review of the Literature

Early childhood development involves an appropriate global intervention concerning the different areas of development such as: physical, cognitive, language and socio-emotional [1]. Especially during the first six years of life in an adequate environment rich in exchange and interaction. We will present in this article a review of the literature concerning normal early childhood development, focus firstly in normal development’s steps, the importance of first experiences and first aid with a stable and caring attachment figure. second, we will describe the various developmental disorders, occurring during this age group which extends from birth to 6 years and based on the DSM5 classification, namely that developmental delay may concern only one aspect of development (e.g. language delay or motor delay specifically) or concern the different aspects of development (overall development delay). The dynamics of development is also important to clarify because schematically we contrast the pathologies fixed to progressive pathologies (where we find the concepts of stagnation or regression in the development of the child). We will discuss in the third chapter, the interest of early detection as well as the multiple clinical and psychometric diagnostic tools, which aim to detect any delay or disorder in order to initiate appropriate care and minimize the long-term consequences.

Development of a risk score to guide targeted hepatitis C testing among human immunodeficiency virus patients in Cambodia

BACKGROUND The World Health Organization recommends testing all human immunodeficiency virus(HIV)patients for hepatitis C virus(HCV).In resource-constrained contexts with low-to-intermediate HCV prevalence among HIV patients,as in Cambodia,targeted testing is,in the short-term,potentially more feasible and cost-effective.AIM To develop a clinical prediction score(CPS)to risk-stratify HIV patients for HCV coinfection(HCV RNA detected),and derive a decision rule to guide prioritization of HCV testing in settings where‘testing all’is not feasible or unaffordable in the short term.METHODS We used data of a cross-sectional HCV diagnostic study in the HIV cohort of Sihanouk Hospital Center of Hope in Phnom Penh.Key populations were very rare in this cohort.Score development relied on the Spiegelhalter and Knill-Jones method.Predictors with an adjusted likelihood ratio≥1.5 or≤0.67 were retained,transformed to natural logarithms,and rounded to integers as score items.CPS performance was evaluated by the area-under-the-ROC curve(AUROC)with 95% confidence intervals(CI),and diagnostic accuracy at the different cut-offs.For the decision rule,HCV coinfection probability≥1% was agreed as test-threshold.RESULTS Among the 3045 enrolled HIV patients,106 had an HCV coinfection.Of the 11 candidate predictors(from history-taking,laboratory testing),seven had an adjusted likelihood ratio≥1.5 or≤0.67:≥50 years(+1 point),diabetes mellitus(+1),partner/household member with liver disease(+1),generalized pruritus(+1),platelets<200×10^(9)/L(+1),aspartate transaminase(AST)<30 IU/L(-1),AST-to-platelet ratio index(APRI)≥0.45(+1),and APRI<0.45(-1).The AUROC was 0.84(95%CI:0.80-0.89),indicating good discrimination of HCV/HIV coinfection and HIV mono-infection.The CPS result≥0 best fits the test-threshold(negative predictive value:99.2%,95%CI:98.8-99.6).Applying this threshold,30%(n=926)would be tested.Sixteen coinfections(15%)would have been missed,none with advanced fibrosis.CONCLUSION The CPS performed well in the derivation cohort,and bears potential for other contexts of low-to-intermediate prevalence and little onward risk of transmission(i.e.cohorts without major risk factors as injecting drug use,men having sex with men),and where available resources do not allow to test all HIV patients as recommended by WHO.However,the score requires external validation in other patient cohorts before any wider use can be considered.

Pregnancy and child developmental outcomes after preimplantation genetic screening: a meta-analytic and systematic review

Background In in vitro fertilization (IVF) treatment, preimplantation genetic diagnosis/screening (PGD/S) attempts to detect chromosomal abnormalities in embryos before implantation. Using the meta-analytic and qualitative review approaches, this study aims to evaluate the effect of PGD/S on clinical pregnancy, live births, and childhood outcomes. Methods We conducted a literature search using 1) PubMed and other search engines, and 2) an ancestry search by track-ing references cited in prior work. After screening the studies, we extracted information pertinent to the meta-analysis. We calculated the effect sizes for clinical pregnancy and live birth rates, and performed a moderation analysis by maternal age, type of genetic screening, and timing of the biopsy. For childhood outcomes, we conducted a systematic review of studies reporting the anthropometric, psychomotor, cognitive, behavioral, and family functioning of PGD/S children. Results We included 26 studies for clinical pregnancy and live births, and 18 studies for childhood outcomes. Results indi-cated that women who underwent comprehensive chromosome screening-based PGD/S had significantly higher clinical pregnancy rates (rr 1.207, 95% CI 1.017–1.431) and live birth rates (rr 1.362, 95% CI 1.057–1.755) than those whose IVF treatment did not include PGD/S. Early childhood outcomes of PGD/S children did not differ from those of non-PGD/S children. Conclusions Comprehensive chromosome screening-based PGD/S can improve clinical pregnancy and live birth rates without adversely affecting functioning in childhood at least up to age 9. Results are discussed in the context of bioethical, financial, legal, and psychological issues surrounding PGD/S.

3D bioprinting of in vitro porous hepatoma models:establishment,evaluation,and anticancer drug testing

Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted drugs.To address this,this study describes the use of threedimensional(3D)bioprinting technology to construct a 3D model with human hepatocarcinoma SMMC-7721 cells(3DP-7721)by combining gelatin methacrylate(GelMA)and poly(ethylene oxide)(PEO)as two immiscible aqueous phases to form a bioink and innovatively applying fluorescent carbon quantum dots for long-term tracking of cells.The GelMA(10%,mass fraction)and PEO(1.6%,mass fraction)hydrogel with 3:1 volume ratio offered distinct pore-forming characteristics,satisfactorymechanical properties,and biocompatibility for the creation of the 3DP-7721 model.Immunofluorescence analysis and quantitative real-time fluorescence polymerase chain reaction(PCR)were used to evaluate the biological properties of the model.Compared with the two-dimensional culture cell model(2D-7721)and the 3D mixed culture cell model(3DM-7721),3DP-7721 significantly improved the proliferation of cells and expression of tumor-related proteins and genes.Moreover,we evaluated the differences between the three culture models and the effectiveness of antitumor drugs in the three models and discovered that the efficacy of antitumor drugs varied because of significant differences in resistance proteins and genes between the three models.In addition,the comparison of tumor formation in the three models found that the cells cultured by the 3DP-7721 model had strong tumorigenicity in nude mice.Immunohistochemical evaluation of the levels of biochemical indicators related to the formation of solid tumors showed that the 3DP-7721 model group exhibited pathological characteristics of malignant tumors,the generated solid tumors were similar to actual tumors,and the deterioration was higher.This research therefore acts as a foundation for the application of 3DP-7721 models in drug development research.

Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

BACKGROUND Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical research.Despite over a decade of development and increasing research achievements in this field,a systematic and comprehensive analysis of the research hotspots and future trends is lacking.AIM To address this problem by employing bibliometric tools to explore the publication years,countries/regions,institutions,journals,authors,keywords,and references in this field.METHODS The literature was collected from Web of Science databases.CiteSpace-6.2R4,a widely used bibliometric analysis software package,was used for institutional analysis and reference burst analysis.VOSviewer 1.6.19 was used for journal cocitation analysis,author co-authorship and co-citation analysis.The‘online platform for bibliometric analysis(https://bibliometric.com/app)’was used to assess the total number of publications and the cooperation relationships between countries.Finally,we employed the bibliometric R software package(version R.4.3.1)in R-studio,for a comprehensive scientific analysis of the literature.RESULTS Our analysis included a total of 1466 publications,revealing a significant yearly increase in articles on the study of gastrointestinal tumor organoids.The United States(n=393)and Helmholtz Association(n=93)have emerged as the leading countries and institutions,respectively,in this field,with Hans Clevers and Toshiro Sato being the most contributing authors.The most influential journal in this field is Gastroenterology.The most impactful reference is"Long term expansion of epithelial organs from human colon,adenoma,adenocarcinoma,and Barrett's epithelium".Keywords analysis and citation burst analysis indicate that precision medicine,disease modeling,drug development and screening,and regenerative medicine are the most cutting-edge directions.These focal points were further detailed based on the literature.CONCLUSION This bibliometric study offers an objective and quantitative analysis of the research in this field,which can be considered as an important guide for next scientific research.

基于Easy Screen工具的SINUMERIK828D HMI开发

西门子SINUMERIK828D数控系统具有良好的对人机界面(HMI)进行二次开发的能力,常用的工具之一是Easy Screen。本文对这种开发工具做了解析,并以实际项目为例,整体性地介绍了基于Easy Screen工具的使用和文件结构。

DDST用于维族婴幼儿筛查效度的探索性研究

目的:研究丹佛发育筛查测验(DDST)用于维族婴幼儿的筛查效度。方法:80名未见躯体疾病的维族婴幼儿纳入研究。以格塞尔发育诊断量表(Gesell)为效标,进行Gesell和DDST的个别测试。效度评价采用灵敏度、特异度、假阳性率、假阴性率、符合率和工作特征曲线下面积(AUC)。结果:DDST迟缓筛查率为17.50%,语言能区迟缓率最高,占比达56.00%。以Gesell发育商DQ≤75分为切点时,DDST筛查的灵敏度、特异度、假阳性率、假阴性率和符合率分别为100.00%、85.71%、14.29%、0.00和86.25%,AUC为0.93(P<0.01)。以Gesell发育商DQ<85分为切点时,DDST的灵敏度、特异度、假阳性率、假阴性率和符合率分别为69.23%、92.54%、7.46%、30.77%和88.75%,AUC为0.80(P<0.01)。结论:用于筛查Gesell异常诊断的维族婴幼儿时,DDST具有较高筛查价值;用于筛查Gesell可疑诊断的婴幼儿时,DDST筛查能力中等。语言可能影响了DDST的筛查效度,可考虑建立维族常模。

0～3岁婴幼儿发育状况的调查分析

目的 通过应用丹佛智能筛查表（DST）了解沭阳农村0-3岁儿童智力发育情况,分析影响儿童发育的因素,促进农村家长重视家庭教育。方法 采用DST量表对江苏沭阳0-3岁婴幼儿共401人测试并为家长提供指导意见。结果 401例儿童中,检出“正常”328例,“可疑”47例,“异常”26例,检查结果无明显性别差别。结论 重视农村0-3岁儿童智能发育情况,在早期主动筛查和干预有利于及时发现异常和可疑病例,同时宣教家庭教育重要性,促进农村儿童保健工作,提高人口素质。

发育筛查量表的评价者间信度和共聚效度分析

目的分析发育筛查量表(DST)在婴幼儿发育评估中的可靠性和有效性。方法选取2016年4月1日~2017年3月31日在贵州省人民医院儿科康复门诊就诊的0~6岁婴幼儿。两名经过严格培训的专业评估师对纳入研究对象进行DST评估,分析其评价者间的信度。纳入研究对象同时进行Peabody运动发育量表评估,该工具作为金标准评估工具,分析DST的共聚效度。结果共有174患儿(男99例,56.9%)纳入本次研究,年龄为(10.23±9.43)个月。DST中发育商(DQ)得分为(67.83±19.63)分,智商(MI)得分为(61.94±15.90)分,女孩DQ和MI得分均高于男孩,差异有统计学意义(P<0.05)。DST各维度得分的组内相关系数(ICC值)为0.76~0.89,提示评估师评分之间具有较好的相关性。Peabody中的粗大运动商(GMQ)、精细运动商(FMQ)、总运动商(TMQ)得分与DST的DQ和MI得分之间的相关系数分别为0.59 vs.0.57、0.62 vs.0.68、0.63 vs.0.64。Peabody中粗大运动中反射、姿势和移动得分与DQ和MI的相关系数分别为0.42 vs.0.36、0.54 vs.0.50、0.56 vs.0.58;精细运动中抓握和视觉运动整合的分与DQ和MI得分的相关系数分别为0.65 vs.0.70、0.62 vs.0.68,DST各维度与Peabody精细运动维度相关性最好,与粗大运动维度相关性稍低。结论 DST发育筛查测试量表具有较好的评价者间信度和共聚效度,提示该量表在中国儿童人群中是一个可靠和有效的运动发育筛查工具。

DenverⅡ发育筛查量表的上海标准化及其相关因素研究

目的研制新的上海市DenverⅡ发育常模,使儿童保健监测手段能适应社会发展的需要。方法采用定额样本,整群分层随机抽取0～6.5岁的上海市常住户口的正常健康儿童进行发育测定,以及问卷调查。完成人数2826名,分布于75个年龄组,男女分别为1414名和1412名。结果用SAS软件包进行Logistic回归,依次对125个项目逐条求解其回归方程,建立相应的拟合曲线,确定25%、50%、75%和90%的通过年龄,对问卷内容采用逐步回归分析对每条项目的影响,相关因素分析显示具有显著意义的因素主要集中在母亲孕期接触电脑、母亲孕期患病、性别、儿童患病情况、儿童的集散居情况等。结论①制定上海丹佛Ⅱ儿童发育量表;②上海与丹佛儿童发育比较中,揭示种族差异、社会文化背景、养育方法、经济状况的不同导致两国儿童发育上存在着明显的差异。

彩色多普勒超声检查在DDH多种高危因素新生儿髋关节发育筛查中的应用

本文选择因伴DDH多种高危因素接受髋关节发育筛查的新生儿115例作为研究组,另选择同期于本院接受儿童保健检查的100例正常新生儿作为对照组。观察两组新生儿的彩色多普勒超声检查髋关节α角、β角,并经Graf髋关节病理分型分析彩超筛查结果。本文经彩超Graf法检查发现,研究组新生儿的髋关节α角显著低于对照组,但髋关节β角显著高于对照组(P<0.05)。彩色多普勒超声检查在DDH多种高危因素新生儿髋关节发育筛查中的应用价值高,能准确评价DDH发病类型,并能显示不同DDH高危因素中新生儿DDH发生的差异性,可尽早为新生儿提供有效诊断和治疗。

婴幼儿智能发育筛查分析

目的：了解0~6岁婴幼儿智能发育状况及影响其发育的因素。方法：0~6岁发育筛查测验（简称DST）对就诊婴幼儿1165名进行测评。结果：高危儿216名中MI和（或）DQ异常172名（异常发生率79.6%），可疑28名（13.1%），正常16名（7.5%）；非高危儿949名中MI和（或）DQ异常416名（异常发生率43.8%），可疑260名（27.3%），正常273名（28.7%）。城市婴幼儿总人数521名，农村儿童总人数644名。城市婴幼儿按父母学历和职业，依次：初中工人，初中个体，高中工人，高中个体，大学个体，大学教师公务员建筑师，其MI异常发生率为：42.3%,38.7%,19.5%,13.7%,8.9%,15.7%；DQ异常发生率为42.3%,41.5%,14.6%,13.7%,11.1%,22.2%。农村婴幼儿按父母学历和职业，依次：小学农民，初中农民，高中农民，高中个体，其MI异常发生率为：85.3%,67.4%,36.1%,46.7%；DQ异常发生率为：91.4%,72.8%,36.1%,45.1%。结论：本测试智能水平城市婴幼儿优于农村，智能发育与父母亲从事的职业、文化程度、以及各种高危因素如难产、早产、低出生体重、出生窒息、高胆红素血症等密切相关。提高人口素质，重视早期教育，定期检查，早发现、早干预，以最大限度提高智力、运动、社会、适应行为发育的水平程度。

彩色多普勒超声检查在发育性髋关节发育不良多种高危因素新生儿髋关节发育筛查中的应用研究

目的研究彩色多普勒超声检查在发育性髋关节发育不良(DDH)多种高危因素新生儿髋关节发育筛查中的应用效果。方法选取2013年1月-2015年12月该院行髋关节发育筛查的224例存在DDH高危因素新生儿为研究对象,研究对象均接受髋关节彩色多普勒超声检查,并应用Graf髋关节病理分型对超声筛查结果进行分析,并对比DDH不同高危因素新生儿不成熟髋关节和DDH检出率。结果经检查,224例患者448个髋关节,其中,不成熟髋关节检出13个,检出率为2.90%;DDH检出33个,检出率为7.37%[其中,Ⅱb型检出率为0.00%(0/448)、Ⅱc型检出率为2.68%(12/448)、Ⅱd型检出率为1.12%(5/448)、Ⅲ型检出率为2.01%(9/448)和Ⅳ型检出率为1.56%(7/448)]。各种高危因素中,因下肢不等长导致新生儿不成熟髋关节、DDH 6例,检出率为54.55%(6/11);因存在家族史导致新生儿不成熟髋关节、DDH 4例,检出率为10.00%(4/40);因胎位为臀位导致新生儿不成熟髋关节、DDH 5例,检出率为7.81%(5/64);因髋外展受限导致新生儿不成熟髋关节、DDH 4例,检出率为3.77%(4/106);因臀纹不对称导致新生儿不成熟髋关节、DDH 11例,检出率为11.22%(11/98);因大腿纹不对称导致新生儿不成熟髋关节、DDH 3例,检出率为2.33%(3/129)。以上结果均与最终确诊结果完全相符。结论彩色多普勒超声检查在DDH多种高危因素新生儿髋关节发育筛查中应用效果显著,可对其发病类型进行准确评价,且可对比不同高危因素新生儿之间DDH发病率的差异性,以根据高危因素尽早进行诊断治疗。

缺氧缺血性脑病新生儿的行为神经测定与发育筛查

目的探讨对新生儿缺氧缺血性脑病进行新生儿行为神经测定及发育筛查的临床意义。方法对 60例缺氧缺血性脑病新生儿在出生后 12— 14天进行新生儿行为神经测定 ,生后 6个月进行发育筛查。结果中重度缺氧缺血性脑病新生儿及行为神经测定评分低者预后不良。结论新生儿行为神经测定及发育筛查可为新生儿缺氧缺血性脑病的早期干预提供依据。

窒息合并肾损伤新生儿的神经预后追踪及意义

目的:探讨窒息合并肾损伤新生儿的神经预后追踪结果及其临床意义。方法:选择39例窒息新生儿,按是否出现肾功能异常分为窒息组33例、窒息合并肾损伤组6例;同时选取20例单纯肾功能异常的新生儿作为对照组(单纯肾损伤组)。所有患儿在3、6、12月龄时测定头围值、行丹佛智能测评(DDST)。结果:3组患儿生后3、6、12个月头围值和DDST发育商水平比较,差异有统计学意义(均P<0.05);患儿头围发育过程中,时间与肾功能差异存在交互效应(F=0.66;P=0.00),但在发育商水平变化过程中,时间与肾功能差异间无交互效应(F=2.84;P=0.61)。结论:早期评估肾损伤情况,同时加强干预,可改善窒息合并肾损伤患儿神经预后。

学龄前儿童发育相关影响因素的临床研究

目的探究学龄前儿童发育的相关影响因素。方法回顾性分析2017年5月1日至2018年5月1日就诊于解放军总医院第四医学中心的445例拟进行全身麻醉手术的学龄前儿童的临床资料,根据丹佛发育筛查试验(Denver developmental screening test,DDST)筛查结果分为正常组(409例)和阳性组(36例)。445例学龄前儿童中120例有手术麻醉史,根据DDST筛查结果进一步将120例学龄前儿童分为对照组(DDST筛查正常,105例)和观察组(DDST筛查阳性,15例)。分析学龄前儿童发育的相关影响因素。结果阳性组的体重指数(body mass index,BMI)、手术麻醉史比例、租住房屋比例、剖宫产比例均显著高于正常组(P<0.05),父母文化程度、父母从事脑力劳动比例、独生子女比例均显著低于正常组(P<0.05)。多因素logistic回归分析结果显示,母亲职业为脑力劳动者是学龄前儿童DDST筛查阳性的独立保护因素(P<0.05),而高BMI、租住房屋、剖宫产是学龄前儿童DDST筛查阳性的独立危险因素(P<0.05)。观察组的既往手术麻醉时长≥3h和剖宫产比例显著高于对照组(P<0.05),父母文化程度、母亲从事脑力劳动比例显著低于对照组(P<0.05)。多因素logistic回归分析结果显示,母亲文化程度为本科及以上、母亲职业为脑力劳动者是经历手术麻醉的学龄前儿童DDST筛查阳性的独立保护因素(P<0.05),既往手术麻醉时长≥3h、剖宫产是经历手术麻醉的学龄前儿童DDST筛查阳性的独立危险因素(P<0.05)。结论BMI、租住房屋、剖宫产、母亲职业是学龄前儿童发育的影响因素,对于经历手术麻醉的学龄前儿童,其发育受既往手术麻醉时长影响。

早期感觉统合训练高危婴儿的效果研究

目的了解早期感觉统合训练对高危婴儿运动能力和发育筛查测验(DST)评定结果的干预效果。方法将2009年1月至2011年6月在常州市妇幼保健院门诊常规42天体检的早产儿、剖宫产儿随机分成训练组和对照组,训练组婴儿置于大笼球上给予按摩及被动操,加之摇晃和缓慢倒立转动为感觉统合训练,训练时间为每天1次,每次10~15分钟,7天后手把手教会家长转入家庭训练,训练疗程持续至5月龄。于3、6、9、12月龄时对大运动能力进行评估,12月龄同时进行DST效果评定。对照组作相应评估。结果训练组与对照组在3、6、9、12月龄时大运动能力比较差异均有统计学意义(x^2值分别为72.64、68.27、52.24、4.04,均P<0.05)。训练组和对照组在婴儿12月龄时的智力指数(MI)不同得分发生率比较差异无统计学意义(P>0.05),而发育商(DQ)比较差异有统计学意义(x^2=55.38,P<0.05)。结论感觉统合训练高危婴儿,早期从感知、本体觉及运动综合方面进行干预,可提高大运动协调能力,减少感觉统合失调儿童的发生率,促进儿童智能发展。

深圳市福田区婴幼儿神经发育筛查结果分析

目的探讨5884例婴幼儿的神经发育状况，进行针对性的早期教育，促进其智能发育。方法采用上海医科大学儿科医院编制的《0-6岁儿童发育筛查测验》（DST）对5884例婴幼儿进行运动、社会适应、智力三大能区检测，利用SPSS软件对发育商（OQ）、智力指数（MI）及各年龄段发育落后项目进行统计分析。结果5884例婴幼儿DQ为95．11±17．40，MI为100．26016．42，均符合正态分布。DQ正常率77．4％，可疑率17．0％，异常率5．6％。正常儿运动、社会适应、智力三个能区中至少1项未通过率分别为20．7％、9．8％、17．1％，经，检验，均P〈0．01，显示运动能区未通过率最高，其次是智力能区，社会适应的未通过率最低。未通过的关键项目有：手膝爬行、按令再见、听铃声转头等。结论通过DST筛查可以早期发现发育落后的儿童，针对不同的发育落后项目制定适宜的早教计划。