We investigated the radiologic developmental process of the arcuate fasciculus（AF） using subcomponent diffusion tensor imaging（DTI） analysis in typically developing volunteers. DTI data were acquired from 96 conse...We investigated the radiologic developmental process of the arcuate fasciculus（AF） using subcomponent diffusion tensor imaging（DTI） analysis in typically developing volunteers. DTI data were acquired from 96 consecutive typically developing children, aged 0–14 years. AF subcomponents, including the posterior, anterior, and direct AF tracts were analyzed. Success rates of analysis（AR） and fractional anisotropy（FA） values of each subcomponent tract were measured and compared. AR of all subcomponent tracts, except the posterior, showed a significant increase with aging（P 〈 0.05）. Subcomponent tracts had a specific developmental sequence： First, the posterior AF tract, second, the anterior AF tract, and last, the direct AF tract in identical hemispheres. FA values of all subcomponent tracts, except right direct AF tract, showed correlation with subject＇s age（P 〈 0.05）. Increased AR and FA values were observed in female subjects in young age（0–2 years） group compared with males（P 〈 0.05）. The direct AF tract showed leftward hemispheric asymmetry and this tendency showed greater consolidation in older age（3–14 years） groups（P 〈 0.05）. These findings demonstrated the radiologic developmental patterns of the AF from infancy to adolescence using subcomponent DTI analysis. The AF showed a specific developmental sequence, sex difference in younger age, and hemispheric asymmetry in older age.展开更多
Few would doubt that understanding the developmental landscape from which a mature neuron is derived is essential to understand its biology.The temporal and spatial position of a cell from the very earliest stages of ...Few would doubt that understanding the developmental landscape from which a mature neuron is derived is essential to understand its biology.The temporal and spatial position of a cell from the very earliest stages of development predicts the unique combinations of growth factors it will subsequently be exposed to.展开更多
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science and Technology,No.2012-013997
文摘We investigated the radiologic developmental process of the arcuate fasciculus（AF） using subcomponent diffusion tensor imaging（DTI） analysis in typically developing volunteers. DTI data were acquired from 96 consecutive typically developing children, aged 0–14 years. AF subcomponents, including the posterior, anterior, and direct AF tracts were analyzed. Success rates of analysis（AR） and fractional anisotropy（FA） values of each subcomponent tract were measured and compared. AR of all subcomponent tracts, except the posterior, showed a significant increase with aging（P 〈 0.05）. Subcomponent tracts had a specific developmental sequence： First, the posterior AF tract, second, the anterior AF tract, and last, the direct AF tract in identical hemispheres. FA values of all subcomponent tracts, except right direct AF tract, showed correlation with subject＇s age（P 〈 0.05）. Increased AR and FA values were observed in female subjects in young age（0–2 years） group compared with males（P 〈 0.05）. The direct AF tract showed leftward hemispheric asymmetry and this tendency showed greater consolidation in older age（3–14 years） groups（P 〈 0.05）. These findings demonstrated the radiologic developmental patterns of the AF from infancy to adolescence using subcomponent DTI analysis. The AF showed a specific developmental sequence, sex difference in younger age, and hemispheric asymmetry in older age.
基金Raine Foundation Priming GrantAustralian Research Council Discovery Project Grant(DP772899)Cancer Council WA Suzanne Cavanagh Early Career Research Grant
文摘Few would doubt that understanding the developmental landscape from which a mature neuron is derived is essential to understand its biology.The temporal and spatial position of a cell from the very earliest stages of development predicts the unique combinations of growth factors it will subsequently be exposed to.
