The objective of the work is to determine the influence of the PLA melting temperature during 3D printing on the dimensional accuracy of the model parts. Two modular drilling devices were also made using PLA model par...The objective of the work is to determine the influence of the PLA melting temperature during 3D printing on the dimensional accuracy of the model parts. Two modular drilling devices were also made using PLA model parts. The model parts were 3D printed using FDM technology and the ZMorph 2.0 hybrid 3D printer. The accuracy of 3D printing of the model part influences the realization of modular devices. In recent years, technology has evolved a lot, and the need to have the most efficient manufacturing equipment has increased. This is the reason for the development of 3D printers using FDM technology for plastic parts. The software used by these 3D printers used in FDM technology is very sophisticated, as they allow the manufacture of very precise 3D prototypes, identical to the designed 3D model, through modern additive manufacturing techniques. The quality and mechanical strength of the prototypes obtained using 3D printers is very good. The materials used by the 3D printers manufactured by FDM are cheap and accessible. These 3D printers are used to make three-dimensional objects (gears, flanges, bearings, covers, casings, mechanisms, figurines, interior and exterior design elements, architectural models, medical models).展开更多
Device to Device (D2D) communication is expected to be anessential part of 5G cellular networks. D2D communication enables closeproximitydevices to establish a direct communication session. D2D communicationoffers man...Device to Device (D2D) communication is expected to be anessential part of 5G cellular networks. D2D communication enables closeproximitydevices to establish a direct communication session. D2D communicationoffers many advantages, such as reduced latency, high data rates,range extension, and cellular offloading. The first step to establishing a D2Dsession is device discovery;an efficient device discovery will lead to efficientD2D communication. D2D device further needs to manage its mode of communication,perform resource allocation, manage its interference and mostimportantly control its power to improve the battery life of the device. Thiswork has developed six distinct scenarios in which D2D communication canbe initiated, considering their merits, demerits, limitations, and optimizationparameters. D2D communication procedures for the considered scenarioshave been formulated, based upon the signal flow, containing device discovery,resource allocation, and session teardown. Finally, latency for each scenariohas been evaluated, based on propagation and processing delays.展开更多
To enhance encoding efficiency, an unequal error protection (UEP) broadcast scheme based on one additional feedback is proposed. Different from the equal probability selection for source packets in traditional fount...To enhance encoding efficiency, an unequal error protection (UEP) broadcast scheme based on one additional feedback is proposed. Different from the equal probability selection for source packets in traditional fountain encoding, the proposed scheme calculates the packet loss ratio (PLR) according to the feedback results in systematic broadcast phase (SBP) and then optimizes the selection probability for source packets to guarantee higher level error protection for those source packets with larger PLRs. Thus the amount of unnecessarily redundant encoded packets during encoding broadcast phase (EBP) is decreased significantly. Numerical results show that the proposed scheme can recover 60% more packets than the traditional non-feedback broadcast scheme at the ex- pense of tolerably only one feedback procedure.展开更多
Device to device(D2D) communications may generate interference to the existing cellular networks.An interference suppression(IS) scheme is proposed in this paper.With this scheme,the threshold of D2D-pairs(D2D-Ps) com...Device to device(D2D) communications may generate interference to the existing cellular networks.An interference suppression(IS) scheme is proposed in this paper.With this scheme,the threshold of D2D-pairs(D2D-Ps) communication was designed to reject the D2D-Ps which were not satisfied the threshold constraint,ensuring that the cellular users(CUs) had priority to use the spectrum resources.Then the interference from D2D-Ps at the receiver of CUs was eliminated first by precoding at the D2D transmitter and decoding at the CU's receiver.Next,the interference between D2D-Ps was suppressed by using interference alignment(IA).Performance analysis shows that the priority of CUs using the spectrum resources has been guaranteed;the interference generated on the cellular links is well eliminated;the interference between D2D-Ps can also be suppressed.展开更多
With a large number of researches being conducted on two?dimen?sional(2D) materials, their unique properties in optics, electrics, mechanics, and magnetics have attracted increasing attention. Accordingly, the idea of...With a large number of researches being conducted on two?dimen?sional(2D) materials, their unique properties in optics, electrics, mechanics, and magnetics have attracted increasing attention. Accordingly, the idea of combining distinct functional 2D materials into heterostructures naturally emerged that pro?vides unprecedented platforms for exploring new physics that are not accessible in a single 2D material or 3D heterostructures. Along with the rapid development of controllable, scalable, and programmed synthesis techniques of high?quality 2D heterostructures, various heterostructure devices with extraordinary performance have been designed and fabricated, including tunneling transistors, photodetectors, and spintronic devices. In this review, we present a summary of the latest progresses in fabrications, properties, and applications of di erent types of 2D heterostruc?tures, followed by the discussions on present challenges and perspectives of further investigations.展开更多
Immobilization devices may be a valuable aid to ensure the improved effectiveness of radiotherapy treatments where constraining the movements of specific anatomical segments is crucial. This need is also present in ot...Immobilization devices may be a valuable aid to ensure the improved effectiveness of radiotherapy treatments where constraining the movements of specific anatomical segments is crucial. This need is also present in other situations, specifically when the superposition of various medical images is required for fine identification and characterization of some pathologies. Because of their structural characteristics, existing head immobilization systems may be claustrophobic and very uncomfortable for patients, during both the modeling and usage stages. Because of this, it is important to minimize all the discomforts related to the mask to alleviate patients’ distress and to simultaneously guarantee and maximize the restraint effectiveness of the mask. In the present work, various head immobilization mask models are proposed based on geometrical information extracted from computerized tomography images and from 3D laser scanning point clouds. These models also consider the corresponding connection to a radiotherapy table, as this connection is easily altered to accommodate various manufacturers’ solutions. A set of materials used in the radiotherapy field is considered to allow the assessment of the stiffness and strength of the masks when submitted to typical loadings.展开更多
In the last decade, the rise of two-dimensional (2D) materials has attracted a tremendous amount of interest for the entire field of photonics and opto-electronics. The mechanism of light-matter interaction in 2D ma...In the last decade, the rise of two-dimensional (2D) materials has attracted a tremendous amount of interest for the entire field of photonics and opto-electronics. The mechanism of light-matter interaction in 2D materials challenges the knowledge of materials physics, which drives the rapid development of materials synthesis and device applications. 2D materials coupled with plasmonic effects show impressive optical characteristics, involving efficient charge transfer, plas- monic hot electrons doping, enhanced light-emitting, and ultrasensitive photodetection. Here, we briefly review the recent remarkable progress of 2D materials, mainly on graphene and transition metal dichalcogenides, focusing on their tunable optical properties and improved opto-electronic devices with plasmonic effects. The mechanism of plasmon enhanced light-matter interaction in 2D materials is elaborated in detail, and the state-of-the-art of device applications is compre- hensively described. In the future, the field of 2D materials holds great promise as an important platform for materials science and opto-electronic engineering, enabling an emerging interdisciplinary research field spanning from clean energy to information technology.展开更多
Black phosphorus(BP)has attracted significant attention owing to its unique structure and preeminent photoelectric properties,which can be utilized to create novel junctions.Based on different BP-based junctions,versa...Black phosphorus(BP)has attracted significant attention owing to its unique structure and preeminent photoelectric properties,which can be utilized to create novel junctions.Based on different BP-based junctions,versatile optoelectronic devices have been fabricated and investigated in recent years,providing a fertile library for the characteristics of BP-based junctions and their optoelectronic applications.This review summarizes diverse BP-based junctions and their optoelectronic device applications.We firstly introduce the structure and properties of BP.Then,we emphatically describe the formation,properties,and optoelectronic device applications of the BP-based junctions including heterojunctions of BP and other two-dimensional(2D)semiconductors,BP p–n homojunctions,and BP/metal Schottky junctions.Finally,the challenge and prospect of the development and application of BP-based junctions are discussed.This timely review gives a snapshot of recent research breakthroughs in BP-based junctions and optoelectronic devices based on them,which is expected to provide a comprehensive vision for the potential of BP in the optoelectronic field.展开更多
Device to device(D2 D) multi-hop communication in multicast networks solves the contradiction between high speed requirements and limited bandwidth in regional data sharing communication services. However, most networ...Device to device(D2 D) multi-hop communication in multicast networks solves the contradiction between high speed requirements and limited bandwidth in regional data sharing communication services. However, most networking models demand a large control overhead in eNodeB. Moreover, the topology should be calculated again due to the mobility of terminals, which causes the long delay. In this work, we model multicast network construction in D2 D communication through a fuzzy mathematics and game theory based algorithm. In resource allocation, we assume that user equipment(UE) can detect the available frequency and the fuzzy mathematics is introduced to describe an uncertain relationship between the resource and UE distributedly, which diminishes the time delay. For forming structure, a distributed myopic best response dynamics formation algorithm derived from a novel concept from the coalitional game theory is proposed, in which every UE can self-organize into stable structure without the control from eNodeB to improve its utilities in terms of rate and bit error rate(BER) while accounting for a link maintenance cost, and adapt this topology to environmental changes such as mobility while converging to a Nash equilibrium fast. Simulation results show that the proposed architecture converges to a tree network quickly and presents significant gains in terms of average rate utility reaching up to 50% compared to the star topology where all of the UE is directly connected to eNodeB.展开更多
Retina nociceptor,as a key sensory receptor,not only enables the transport of warning signals to the human central nervous system upon its exposure to noxious stimuli,but also triggers the motor response that minimize...Retina nociceptor,as a key sensory receptor,not only enables the transport of warning signals to the human central nervous system upon its exposure to noxious stimuli,but also triggers the motor response that minimizes potential sensitization.In this study,the capability of two-dimensional all-oxide-heterostructured artificial nociceptor as a single device with tunable properties was confirmed.Newly designed nociceptors utilize ultra-thin sub-stoichiometric TiO2–Ga2O3 heterostructures,where the thermally annealed Ga2O3 films play the role of charge transfer controlling component.It is discovered that the phase transformation in Ga2O3 is accompanied by substantial jump in conductivity,induced by thermally assisted internal redox reaction of Ga2O3 nanostructure during annealing.It is also experimentally confirmed that the charge transfer in alloxide heterostructures can be tuned and controlled by the heterointerfaces manipulation.Results demonstrate that the engineering of heterointerfaces of two-dimensional(2D)films enables the fabrication of either high-sensitive TiO2–Ga2O3(Ar)or high-threshold TiO2–Ga2O3(N2)nociceptors.The hypersensitive nociceptor mimics the functionalities of corneal nociceptors of human eye,whereas the delayed reaction of nociceptor is similar to high-threshold nociceptive characteristics of human sensory system.The long-term stability of 2D nociceptors demonstrates the capability of heterointerfaces engineering for e ective control of charge transfer at 2D heterostructured devices.展开更多
Animal models have been extensively used in cancer pathology studies and drug discovery.These models,however,fail to reflect the complex human tumor microenvironment and do not allow for high-throughput drug screening...Animal models have been extensively used in cancer pathology studies and drug discovery.These models,however,fail to reflect the complex human tumor microenvironment and do not allow for high-throughput drug screening in more human-like physiological conditions.Three-dimensional(3D)cancer models present an alternative to automated high-throughput cancer drug discovery and oncology.In this review,we highlight recent technology innovations in building 3D tumor models that simulate the complex human tumor microenvironment and responses of patients to treatment.We discussed various biofabrication technologies,including 3D bioprinting techniques developed for characterizing tumor progression,metastasis,and response to treatment.展开更多
This paper describes the recent research and development of an endo surgical/biomedical instrument in surgical suture applications for minimally invasive therapy procedure. The newly developed instruments can not only...This paper describes the recent research and development of an endo surgical/biomedical instrument in surgical suture applications for minimally invasive therapy procedure. The newly developed instruments can not only protect the wound during the surgical procedure but also actively help the healing process. The new mechanism design of the surgical instrument aids in better ergonomic design, reliable functionality, and continuous cost reduction in product manufacturing. 3-D modeling technique, functionality analysis, kinematical simulation and computer aided solution have been applied to the instrument design, development and future improvement to meet the specific requirements of minimally invasive surgery procedure. The improved new endo surgical/biomedical instrument can prevent patient’s vessels and tissues from being damaging because the distal move of clips are well controlled without clip drop-off incident. Plus the operational force to form the clip is lower than regular surgical/biomedical instruments due to this special new mechanism design. In addition to the above, the manufacturing and product cost can be decreased because the dimensional tolerance of components, such as clip channel and jaw guide track, can be loose due to this new instrument design. The prototypes of this new endo surgical/biomedical instrument design are analyzed through computer aided modeling and simulation, in order to prove its feasible functionality, reliable performance, and mechanical advantage. All these improved features have also been tested and verified through the prototypes.展开更多
Recently,fundamental properties and practical applications of two-dimensional(2D)materials have attracted tremendous interest.Micro/nanostructures and functional devices in 2D materials have been fabricated by various...Recently,fundamental properties and practical applications of two-dimensional(2D)materials have attracted tremendous interest.Micro/nanostructures and functional devices in 2D materials have been fabricated by various methods.Ultrafast direct laser writing(DLW)with the advantages of rich light-matter interactions;unique three-dimensional processing capability;arbitrary-shape design flexibility;and minimized thermal effect,which enables high fabrication accuracy resolution,has been widely applied in the fabrication of 2D materials for multifunctional devices.This timely review summarizes the laser interactions with 2D materials and the advances in diverse functional photonics devices by DLW.The perspectives and challenges in designing and improving laser-fabricated 2D material photonic devices are also discussed.展开更多
Doping of semiconductors,i.e.,accurately modulating the charge carrier type and concentration in a controllable manner,is a key technology foundation for modern electronics and optoelectronics.However,the conventional...Doping of semiconductors,i.e.,accurately modulating the charge carrier type and concentration in a controllable manner,is a key technology foundation for modern electronics and optoelectronics.However,the conventional doping technologies widely utilized in silicon industry,such as ion implantation and thermal diffusion,always fail when applied to two-dimensional(2D)materials with atomically-thin nature.Surface charge transfer doping(SCTD)is emerging as an effective and non-destructive doping technique to provide reliable doping capability for 2D materials,in particular 2D semiconductors.Herein,we summarize the recent advances and developments on the SCTD of 2D semiconductors and its application in electronic and optoelectronic devices.The underlying mechanism of STCD processes on 2D semiconductors is briefly introduced.Its impact on tuning the fundamental properties of various 2D systems is highlighted.We particularly emphasize on the SCTD-enabled high-performance 2D functional devices.Finally,the challenges and opportunities for the future development of SCTD are discussed.展开更多
文摘The objective of the work is to determine the influence of the PLA melting temperature during 3D printing on the dimensional accuracy of the model parts. Two modular drilling devices were also made using PLA model parts. The model parts were 3D printed using FDM technology and the ZMorph 2.0 hybrid 3D printer. The accuracy of 3D printing of the model part influences the realization of modular devices. In recent years, technology has evolved a lot, and the need to have the most efficient manufacturing equipment has increased. This is the reason for the development of 3D printers using FDM technology for plastic parts. The software used by these 3D printers used in FDM technology is very sophisticated, as they allow the manufacture of very precise 3D prototypes, identical to the designed 3D model, through modern additive manufacturing techniques. The quality and mechanical strength of the prototypes obtained using 3D printers is very good. The materials used by the 3D printers manufactured by FDM are cheap and accessible. These 3D printers are used to make three-dimensional objects (gears, flanges, bearings, covers, casings, mechanisms, figurines, interior and exterior design elements, architectural models, medical models).
基金supported in part by Basic Science Research Program through the National Research Foundation of Korea (NRF)funded by the Ministry of Education (NRF-2021R1A6A1A03039493)in part by the NRF grant funded by the Korea government (MSIT) (NRF-2022R1A2C1004401).
文摘Device to Device (D2D) communication is expected to be anessential part of 5G cellular networks. D2D communication enables closeproximitydevices to establish a direct communication session. D2D communicationoffers many advantages, such as reduced latency, high data rates,range extension, and cellular offloading. The first step to establishing a D2Dsession is device discovery;an efficient device discovery will lead to efficientD2D communication. D2D device further needs to manage its mode of communication,perform resource allocation, manage its interference and mostimportantly control its power to improve the battery life of the device. Thiswork has developed six distinct scenarios in which D2D communication canbe initiated, considering their merits, demerits, limitations, and optimizationparameters. D2D communication procedures for the considered scenarioshave been formulated, based upon the signal flow, containing device discovery,resource allocation, and session teardown. Finally, latency for each scenariohas been evaluated, based on propagation and processing delays.
基金Supported by China National S&T Major Project(2013ZX03003002003)the National Natural Science Foundation of China(61371075)"111"Project of China(B14010)
文摘To enhance encoding efficiency, an unequal error protection (UEP) broadcast scheme based on one additional feedback is proposed. Different from the equal probability selection for source packets in traditional fountain encoding, the proposed scheme calculates the packet loss ratio (PLR) according to the feedback results in systematic broadcast phase (SBP) and then optimizes the selection probability for source packets to guarantee higher level error protection for those source packets with larger PLRs. Thus the amount of unnecessarily redundant encoded packets during encoding broadcast phase (EBP) is decreased significantly. Numerical results show that the proposed scheme can recover 60% more packets than the traditional non-feedback broadcast scheme at the ex- pense of tolerably only one feedback procedure.
基金National Natural Science Foundation of China(No.61503251)
文摘Device to device(D2D) communications may generate interference to the existing cellular networks.An interference suppression(IS) scheme is proposed in this paper.With this scheme,the threshold of D2D-pairs(D2D-Ps) communication was designed to reject the D2D-Ps which were not satisfied the threshold constraint,ensuring that the cellular users(CUs) had priority to use the spectrum resources.Then the interference from D2D-Ps at the receiver of CUs was eliminated first by precoding at the D2D transmitter and decoding at the CU's receiver.Next,the interference between D2D-Ps was suppressed by using interference alignment(IA).Performance analysis shows that the priority of CUs using the spectrum resources has been guaranteed;the interference generated on the cellular links is well eliminated;the interference between D2D-Ps can also be suppressed.
基金supported by NSF of China (Grant No. 61775241)partly by the Innovation-driven Project (Grant No. 2017CX019)the funding support from the Australian Research Council (ARC Discovery Projects, DP180102976)
文摘With a large number of researches being conducted on two?dimen?sional(2D) materials, their unique properties in optics, electrics, mechanics, and magnetics have attracted increasing attention. Accordingly, the idea of combining distinct functional 2D materials into heterostructures naturally emerged that pro?vides unprecedented platforms for exploring new physics that are not accessible in a single 2D material or 3D heterostructures. Along with the rapid development of controllable, scalable, and programmed synthesis techniques of high?quality 2D heterostructures, various heterostructure devices with extraordinary performance have been designed and fabricated, including tunneling transistors, photodetectors, and spintronic devices. In this review, we present a summary of the latest progresses in fabrications, properties, and applications of di erent types of 2D heterostruc?tures, followed by the discussions on present challenges and perspectives of further investigations.
基金supported by the Project IPL/2016/Soft Imob/ISEL and Project LAETA—UID/EMS/50022/2019
文摘Immobilization devices may be a valuable aid to ensure the improved effectiveness of radiotherapy treatments where constraining the movements of specific anatomical segments is crucial. This need is also present in other situations, specifically when the superposition of various medical images is required for fine identification and characterization of some pathologies. Because of their structural characteristics, existing head immobilization systems may be claustrophobic and very uncomfortable for patients, during both the modeling and usage stages. Because of this, it is important to minimize all the discomforts related to the mask to alleviate patients’ distress and to simultaneously guarantee and maximize the restraint effectiveness of the mask. In the present work, various head immobilization mask models are proposed based on geometrical information extracted from computerized tomography images and from 3D laser scanning point clouds. These models also consider the corresponding connection to a radiotherapy table, as this connection is easily altered to accommodate various manufacturers’ solutions. A set of materials used in the radiotherapy field is considered to allow the assessment of the stiffness and strength of the masks when submitted to typical loadings.
基金Project supported by the National Basic Research Program of China(Grant No.2015CB932403)the National Natural Science Foundation of China(Grant Nos.61422501,11674012,11374023,and 61521004)+2 种基金Beijing Natural Science Foundation,China(Grant No.L140007)Foundation for the Author of National Excellent Doctoral Dissertation of China(Grant No.201420)National Program for Support of Top-notch Young Professionals,China
文摘In the last decade, the rise of two-dimensional (2D) materials has attracted a tremendous amount of interest for the entire field of photonics and opto-electronics. The mechanism of light-matter interaction in 2D materials challenges the knowledge of materials physics, which drives the rapid development of materials synthesis and device applications. 2D materials coupled with plasmonic effects show impressive optical characteristics, involving efficient charge transfer, plas- monic hot electrons doping, enhanced light-emitting, and ultrasensitive photodetection. Here, we briefly review the recent remarkable progress of 2D materials, mainly on graphene and transition metal dichalcogenides, focusing on their tunable optical properties and improved opto-electronic devices with plasmonic effects. The mechanism of plasmon enhanced light-matter interaction in 2D materials is elaborated in detail, and the state-of-the-art of device applications is compre- hensively described. In the future, the field of 2D materials holds great promise as an important platform for materials science and opto-electronic engineering, enabling an emerging interdisciplinary research field spanning from clean energy to information technology.
基金This work was supported by the National Natural Science Foundation of China for Excellent Young Scholars(No.61622404)the National Natural Science Foundation of China(No.62074098)Chang Jiang(Cheung Kong)Scholars Program of Ministry of Education of China(No.Q2017081).
文摘Black phosphorus(BP)has attracted significant attention owing to its unique structure and preeminent photoelectric properties,which can be utilized to create novel junctions.Based on different BP-based junctions,versatile optoelectronic devices have been fabricated and investigated in recent years,providing a fertile library for the characteristics of BP-based junctions and their optoelectronic applications.This review summarizes diverse BP-based junctions and their optoelectronic device applications.We firstly introduce the structure and properties of BP.Then,we emphatically describe the formation,properties,and optoelectronic device applications of the BP-based junctions including heterojunctions of BP and other two-dimensional(2D)semiconductors,BP p–n homojunctions,and BP/metal Schottky junctions.Finally,the challenge and prospect of the development and application of BP-based junctions are discussed.This timely review gives a snapshot of recent research breakthroughs in BP-based junctions and optoelectronic devices based on them,which is expected to provide a comprehensive vision for the potential of BP in the optoelectronic field.
基金supported by the National Science and Technology Major Project of China(2013ZX03005007-004)the National Natural Science Foundation of China(6120101361671179)
文摘Device to device(D2 D) multi-hop communication in multicast networks solves the contradiction between high speed requirements and limited bandwidth in regional data sharing communication services. However, most networking models demand a large control overhead in eNodeB. Moreover, the topology should be calculated again due to the mobility of terminals, which causes the long delay. In this work, we model multicast network construction in D2 D communication through a fuzzy mathematics and game theory based algorithm. In resource allocation, we assume that user equipment(UE) can detect the available frequency and the fuzzy mathematics is introduced to describe an uncertain relationship between the resource and UE distributedly, which diminishes the time delay. For forming structure, a distributed myopic best response dynamics formation algorithm derived from a novel concept from the coalitional game theory is proposed, in which every UE can self-organize into stable structure without the control from eNodeB to improve its utilities in terms of rate and bit error rate(BER) while accounting for a link maintenance cost, and adapt this topology to environmental changes such as mobility while converging to a Nash equilibrium fast. Simulation results show that the proposed architecture converges to a tree network quickly and presents significant gains in terms of average rate utility reaching up to 50% compared to the star topology where all of the UE is directly connected to eNodeB.
基金supported by Research and Development Program of the Ghent University Global Campus,South Korea.
文摘Retina nociceptor,as a key sensory receptor,not only enables the transport of warning signals to the human central nervous system upon its exposure to noxious stimuli,but also triggers the motor response that minimizes potential sensitization.In this study,the capability of two-dimensional all-oxide-heterostructured artificial nociceptor as a single device with tunable properties was confirmed.Newly designed nociceptors utilize ultra-thin sub-stoichiometric TiO2–Ga2O3 heterostructures,where the thermally annealed Ga2O3 films play the role of charge transfer controlling component.It is discovered that the phase transformation in Ga2O3 is accompanied by substantial jump in conductivity,induced by thermally assisted internal redox reaction of Ga2O3 nanostructure during annealing.It is also experimentally confirmed that the charge transfer in alloxide heterostructures can be tuned and controlled by the heterointerfaces manipulation.Results demonstrate that the engineering of heterointerfaces of two-dimensional(2D)films enables the fabrication of either high-sensitive TiO2–Ga2O3(Ar)or high-threshold TiO2–Ga2O3(N2)nociceptors.The hypersensitive nociceptor mimics the functionalities of corneal nociceptors of human eye,whereas the delayed reaction of nociceptor is similar to high-threshold nociceptive characteristics of human sensory system.The long-term stability of 2D nociceptors demonstrates the capability of heterointerfaces engineering for e ective control of charge transfer at 2D heterostructured devices.
文摘Animal models have been extensively used in cancer pathology studies and drug discovery.These models,however,fail to reflect the complex human tumor microenvironment and do not allow for high-throughput drug screening in more human-like physiological conditions.Three-dimensional(3D)cancer models present an alternative to automated high-throughput cancer drug discovery and oncology.In this review,we highlight recent technology innovations in building 3D tumor models that simulate the complex human tumor microenvironment and responses of patients to treatment.We discussed various biofabrication technologies,including 3D bioprinting techniques developed for characterizing tumor progression,metastasis,and response to treatment.
文摘This paper describes the recent research and development of an endo surgical/biomedical instrument in surgical suture applications for minimally invasive therapy procedure. The newly developed instruments can not only protect the wound during the surgical procedure but also actively help the healing process. The new mechanism design of the surgical instrument aids in better ergonomic design, reliable functionality, and continuous cost reduction in product manufacturing. 3-D modeling technique, functionality analysis, kinematical simulation and computer aided solution have been applied to the instrument design, development and future improvement to meet the specific requirements of minimally invasive surgery procedure. The improved new endo surgical/biomedical instrument can prevent patient’s vessels and tissues from being damaging because the distal move of clips are well controlled without clip drop-off incident. Plus the operational force to form the clip is lower than regular surgical/biomedical instruments due to this special new mechanism design. In addition to the above, the manufacturing and product cost can be decreased because the dimensional tolerance of components, such as clip channel and jaw guide track, can be loose due to this new instrument design. The prototypes of this new endo surgical/biomedical instrument design are analyzed through computer aided modeling and simulation, in order to prove its feasible functionality, reliable performance, and mechanical advantage. All these improved features have also been tested and verified through the prototypes.
基金the Australia Research Council through the Discovery Project scheme(No.DP190103186)the Industrial Transformation Training Centres scheme(No.IC180100005).
文摘Recently,fundamental properties and practical applications of two-dimensional(2D)materials have attracted tremendous interest.Micro/nanostructures and functional devices in 2D materials have been fabricated by various methods.Ultrafast direct laser writing(DLW)with the advantages of rich light-matter interactions;unique three-dimensional processing capability;arbitrary-shape design flexibility;and minimized thermal effect,which enables high fabrication accuracy resolution,has been widely applied in the fabrication of 2D materials for multifunctional devices.This timely review summarizes the laser interactions with 2D materials and the advances in diverse functional photonics devices by DLW.The perspectives and challenges in designing and improving laser-fabricated 2D material photonic devices are also discussed.
基金the financial support from Natural Science Foundation of Jiangsu Province(No.BK20170005)the National Natural Science Foundation of China(No.21872100)+1 种基金Singapore MOE Grants MOE2019-T2-1-002 and R143-000-A43-114,Fundamental Research Foundation of Shenzhen(Nos.JCYJ20190808152607389 and JCYJ20170817100405375)Shenzhen Peacock Plan(No.KQTD2016053112042971).
文摘Doping of semiconductors,i.e.,accurately modulating the charge carrier type and concentration in a controllable manner,is a key technology foundation for modern electronics and optoelectronics.However,the conventional doping technologies widely utilized in silicon industry,such as ion implantation and thermal diffusion,always fail when applied to two-dimensional(2D)materials with atomically-thin nature.Surface charge transfer doping(SCTD)is emerging as an effective and non-destructive doping technique to provide reliable doping capability for 2D materials,in particular 2D semiconductors.Herein,we summarize the recent advances and developments on the SCTD of 2D semiconductors and its application in electronic and optoelectronic devices.The underlying mechanism of STCD processes on 2D semiconductors is briefly introduced.Its impact on tuning the fundamental properties of various 2D systems is highlighted.We particularly emphasize on the SCTD-enabled high-performance 2D functional devices.Finally,the challenges and opportunities for the future development of SCTD are discussed.