Ascorbic acid alleviates reproductive toxicity of di-(2-ethyl hexyl) phthalate in female Wistar rats

Objective:To investigate the potential of ascorbic acid in mitigating reproductive toxicity induced by di-(2-ethyl hexyl)phthalate(DEHP)in female Wistar rats,focusing on oxidative stress,hormone levels,and gonadotropin receptors expression.Methods:Forty female Wistar rats[30 days old,weighing(60±10)g]were randomly divided into five groups(n=8 per group).Group 1 received corn oil(control).Groups 2 and 3 were administered DEHP at 10 and 100 mg/kg body weight(b.wt.),respectively.Groups 4 and 5 received DEHP at 10 and 100 mg/kg b.wt.,respectively,plus ascorbic acid 100 mg/kg b.wt..All treatments were given orally for 30 days.Blood and ovarian tissues were collected to assess serum reproductive hormones,gonadotropin receptor gene expression,oxidative stress markers,and apoptosis.Results:DEHP,particularly at the higher dose,significantly decreased hormone levels(follicle-stimulating hormone,luteinizing hormone,estradiol)and gonadotropin receptor gene expression(FSHR,LHR),while increasing oxidative stress and apoptosis.Co-treatment with ascorbic acid significantly improved these parameters,reducing oxidative stress and apoptosis,and restoring hormone levels and gonadotropin receptor expression.Histopathology revealed fewer atretic follicles and less disruption in ovarian structure in DEHP and ascorbic acid-treated groups compared to those treated with DEHP alone.Conclusions:Ascorbic acid demonstrates protective effects against DEHP-induced reproductive toxicity in female rats,likely through mitigating oxidative stress and normalizing hormone levels and ovarian function.

Correlation of periodontal inflamed surface area with glycated hemoglobin,interleukin-6 and lipoprotein(a)in type 2 diabetes with retinopathy

BACKGROUND The two-way relationship between periodontitis and type 2 diabetes mellitus(T2DM)is well established.Prolonged hyperglycemia contributes to increased periodontal destruction and severe periodontitis,accentuating diabetic complications.An inflammatory link exists between diabetic retinopathy(DR)and periodontitis,but the studies regarding this association and the role of lipoprotein(a)[Lp(a)]and interleukin-6(IL-6)in these conditions are scarce in the literature.AIM To determine the correlation of periodontal inflamed surface area(PISA)with glycated Hb(HbA1c),serum IL-6 and Lp(a)in T2DM subjects with retinopathy.METHODS This cross-sectional study comprised 40 T2DM subjects with DR and 40 T2DM subjects without DR.All subjects were assessed for periodontal parameters[bleeding on probing(BOP),probing pocket depth,clinical attachment loss(CAL),oral hygiene index-simplified,plaque index(PI)and PISA],and systemic parameters[HbA1c,fasting plasma glucose and postprandial plasma glucose,fasting lipid profile,serum IL-6 and serum Lp(a)].RESULTS The proportion of periodontitis in T2DM with and without DR was 47.5%and 27.5%respectively.Severity of periodontitis,CAL,PISA,IL-6 and Lp(a)were higher in T2DM with DR group compared to T2DM without DR group.Significant difference was observed in the mean percentage of sites with BOP between T2DM with DR(69%)and T2DM without DR(41%),but there was no significant difference in PI(P>0.05).HbA1c was positively correlated with CAL(r=0.351,P=0.001),and PISA(r=0.393,P≤0.001)in study subjects.A positive correlation was found between PISA and IL-6(r=0.651,P<0.0001);PISA and Lp(a)(r=0.59,P<0.001);CAL and IL-6(r=0.527,P<0.0001)and CAL and Lp(a)(r=0.631,P<0.001)among study subjects.CONCLUSION Despite both groups having poor glycemic control and comparable plaque scores,the periodontal parameters were higher in DR as compared to T2DM without DR.Since a bidirectional link exists between periodontitis and DM,the presence of DR may have contributed to the severity of periodontal destruction and periodontitis may have influenced the progression of DR.

N-acetylcysteine and zinc sulphate abate di-2-ethylhexyl phthalate-mediated reproductive dysfunction in rats:Focus on oxidative and sex hormone receptors mechanisms

Objective:To investigate the potential of N-acetylcysteine(NAC)and zinc sulphate(ZnSO_(4))in mitigating reproductive dysfunction caused by di-2-ethylhexyl phthalate(DEHP)in rats and to understand the underlying mechanisms,specifically oxidative stress and sex hormone receptor activity.Methods:Thirty-five male Wistar rats were randomly divided into five equal groups(n=7 per group).Group 1 was administered 0.5 mL of distilled water and served as the control group.Group 2 was given only DEHP(750 mg/kg/day),while group 3,4 and 5 were given DEHP(750 mg/kg/day)plus NAC(100 mg/kg/day),DEHP(750 mg/kg/day)plus ZnSO_(4)(0.5 mg/kg/day),and DEHP(750 mg/kg/day)plus NAC(100 mg/kg/day)as well as ZnSO_(4)(0.5 mg/kg/day),respectively.All treatments lasted for 21 days.Samples were obtained after the rats were sacrificed,and hormones levels in the serum and markers of oxidative stress in the testicles were analyzed using the enzyme-linked immunosorbent assay.The amount of androgen receptors in the testicles was determined by immunohistochemistry,and the susceptibility of testosterone and DEHP to bind to androgen receptor and 5α-reductase was determined by molecular docking studies.Results:DEHP decreased reproductive hormones,testicular antioxidant enzymes,increased malondialdehyde levels,and negatively impacted histology of the pituitary and testes.NAC or ZnSO_(4) treatment showed a marked improvement in testicular antioxidant status and hormone levels,as well as a positive effect on the histology of the pituitary and testes.The combination of both treatments appeared to be more effective.The affinity of DEHP to bind to androgen receptors may lead to disruption of androgen receptor signaling,which can further result in dysfunction of hormones related to androgen.However,NAC is more likely to form stronger binding interactions with follicle stimulating hormone and luteinizing hormone receptors,as well as gonadotropin-releasing hormone receptors,when compared to DEHP.Conclusions:The possibility that NAC and ZnSO_(4) could downregulate DEHP-induced sex hormone changes is suggested by their potential to reduce toxicity.

Acetylacetone-TiO_(2) Promoted Large Area Compatible Cascade Electron Transport Bilayer for Efficient Perovskite Solar Cells

In designing efficient perovskite solar cells(PSCs),the selection of suitable electron transport layers(ETLs)is critical to the final device performance as they determine the driving force for selective charge extraction.SnO_(2)nanoparticles(NPs)based ETLs have been a popular choice for PSCs due to superior electron mobility,but their relatively deep-lying conduction band energy levels(ECB)result in substantial potential loss.Meanwhile,TiO_(2)NPs establish favorable band alignment owing to shallower ECB,but their low intrinsic mobility and abundant surface trap sites impede the final performance.For this reason,constructing a cascaded bilayer ETL is highly desirable for efficient PSCs,as it can rearrange energy levels and exploit on advantages of an individual ETL.In this study,we prepare SnO_(2)NPs and acetylacetone-modified TiO_(2)(Acac-TiO_(2))NPs and implement them as bilayer SnO_(2)/Acac-TiO_(2)(BST)ETL,to assemble cascaded energy band structure.SnO_(2)contributes to rapid charge carrier transport from high electron mobility while Acac-TiO_(2)minimizes band-offset and effectively suppresses interfacial recombination.Accordingly,the optimized BST ETL generates synergistic influence and delivers power conversion efficiency(PCE)as high as 23.14%with open-circuit voltage(V_(oc))reaching 1.14 V.Furthermore,the BST ETL is transferred to a large scale and the corresponding mini module demonstrates peak performance of 18.39%PCE from 25 cm^(2)aperture area.Finally,the BST-based mini module exhibit excellent stability,maintaining 83.1%of its initial efficiency after 1000 h under simultaneous 1 Sun light-soaking and damp heat(85℃/RH 85%)environment.

A Multi-Center Randomized Controlled Study UsingΔP_(CO2)/Ca-v_(O2)as the Target to Guide Early Tissue Hypoperfusion in Sepsis in Plateau Areas

Objective:To explore the value of using the venous-arterial carbon dioxide partial pressure difference and the arterial-venous oxygen content difference ratio(ΔP_(CO2)/Ca-v_(O2))as targets to guide early tissue hypoperfusion in sepsis in plateau areas.Methods:90 sepsis patients admitted to the Third People’s Hospital of Xining and Golmud People’s Hospital from June 2017 to December 2022 were selected as the research subjects,and they were divided into the Scv_(O2)(central venous oxygen saturation)group and theΔP_(CO2)/Ca-v_(O2)group,with 45 cases in each group.The two groups were treated with early shock resuscitation according to different protocols.The hemodynamic characteristics of the two groups of patients before and after resuscitation were observed,and the volume responsiveness was evaluated.The ROC(receiver operating characteristic)curve was used to analyze the significance ofΔP_(CO2)/Ca-v_(O2),Scv_(O2),lactate,lactate clearance,and urine output in evaluating patient prognosis and the correlation betweenΔP_(CO2)/Ca-v_(O2)and the above indicators was explored.Results:Compared with before resuscitation,after fluid resuscitation,the heart rate(HR),mean arterial pressure(MAP),central venous pressure(CVP),cardiac index(CI),lactate,lactate clearance rate,and urine output of the two groups of patients were significantly improved(P<0.05);in terms of therapeutic effect,the 28-day mortality rate,6-hour fluid balance,and lactic acid clearance of theΔP_(CO2)/Ca-v_(O2)group were better than the Scv_(O2)group.The ROC characteristic curve showed that theΔP_(CO2)/Ca-v_(O2)value can effectively predict the prognosis of patients(AUC=0.907,sensitivity was 97%,specificity was 72.4%,and critical value was 1.84).ΔP_(CO2)/Ca-v_(O2)significantly correlated with Scv_(O2),lactic acid,and lactic acid clearance rate.Conclusion:TheΔP_(CO2)/Ca-v_(O2)value can be used to guide fluid resuscitation in early hypoperfusion in sepsis in plateau areas,improve patients’hemodynamics,reduce lactate indicators,and increase urine output.ΔP_(CO2)/Ca-v_(O2)level>1.84 can effectively improve patient prognosis.

Analysis of the Correlation Between Visceral Fat Area and Insulin Resistance in Patients with Type 2 Diabetes and Abdominal Obesity

Objective: To analyze the correlation between visceral fat area and insulin resistance index (HOMA-IR) in patients with type 2 diabetes mellitus (T2DM) and abdominal obesity and to provide a reference for screening and related research of such patients. Methods: Two hundred patients with T2DM admitted to Guandu People’s Hospital of Kunming were included. The study was carried out from October 2022 to December 2023. The patients were divided into three groups according to different abdominal visceral fat areas (VFA): Group A (n = 65) was less than 75cm2, Group B (n = 75) was 75-100 cm2, and Group C (n = 60) was greater than 100 cm2. The subjects in the three groups were all tested for glycated hemoglobin (HbA1c), fasting insulin (FINS), and fasting blood glucose (FPG). Height and weight were measured to calculate body mass index (BMI). The HOMA-IR and TYG (fasting triglyceride and glycemic index) were also calculated. Changes in the BMI, VFA, HOMA-IR, and TYG levels were observed in the three groups. Results: The VFA, BMI, HbA1c, FPG, FINS, HOMA-IR, and TYG of the patients all increased, with a more significant increase in the BMI, FINS, HOMA-IR, and TYG levels (P < 0.01). Multiple linear stepwise regression analyses used visceral fat area (VFA) as the dependent variable. The results showed that VFA was closely related to BMI, FINS, HOMA-IR, and TYG. Conclusion: Early reduction of VFA to reduce insulin resistance may be a better treatment and effective method for T2DM, providing powerful measures and new strategies for effective blood sugar control and early prevention in the treatment of metabolic diseases.

长裙竹荪多糖Di-S2P的分离纯化和鉴定

长裙竹荪 (Dictyophoraindusiata)子实体经 ρ(Na2 CO3 ) =2 %溶液提取 ,用蛋白酶法和Sevag法相结合除去蛋白 ,乙醇分级沉淀 ,级分 2经DEAE -SephadexA -2 5柱层析纯化得到长裙竹荪多糖Di-S2P .经测定该多糖为均一组分 ,分子量约为 8 7× 10 5,红外光谱呈现出典型的多糖吸收峰 ,紫外扫描无核酸和蛋白质的特征吸收峰 .纸层析和气相层析分析得知Di -S2P含有D -葡萄糖、D-半乳糖、D -甘露糖和D -木糖 ,其摩尔比为 1 6 2∶1 87∶1 0 0∶0 93。

基于哨兵-2数据的白岗岩型铀矿构造蚀变特征研究——以纳米比亚罗辛矿区为例

白岗岩型铀矿是重要的铀矿资源,但针对该类铀矿典型矿床遥感特征的研究还十分薄弱。文章以纳米比亚罗辛铀矿区为研究对象,获取了该矿区哨兵-2遥感影像,总结了矿区典型蚀变矿物的光谱吸收特征,建立了针对矿区地质体的增强与构造解译方法。在此基础上,对获取的遥感影像进行了大气校正与几何校正,并应用主成分分析、波段比值等方法,提取了铁染、羟基和碳酸盐化蚀变信息。结果表明,罗辛铀矿中碳酸盐化蚀变在空间上与卡里毕比组的分布较为一致。通过选取合理的阈值,识别出与铀成矿相关的含大理岩地层。同时,对图像进行增强,并利用建立的构造解译方法,对罗辛铀矿的构造进行了识别。经野外查证,发现遥感识别构造、蚀变与野外查证结果一致,说明利用哨兵-2数据可以对白岗岩型铀矿的成矿条件与控矿要素进行识别,进而为铀矿勘查提供参考。

中深层稠油水平井前置CO_(2)蓄能压裂技术

利用准噶尔盆地西北缘乌夏地区中深层稠油油藏参数,对水平井前置CO_(2)蓄能压裂技术的开发机理、关键操作参数及开发效果进行了详细研究。研究结果表明:①伴随压裂—焖井—生产等开发阶段的延伸,前置CO_(2)蓄能压裂后的油井逐步显现出增能改造、扩散降黏、膨胀补能、释压成泡沫油流等特性,井底流压提高了2~4MPa,CO_(2)扩散至油藏的1/3,原油黏度降至500mPa·s以下,泡沫油流明显;②研究区最优压裂段间距为60m、裂缝半长为90m、裂缝导流能力为10t/m,CO_(2)最佳注入强度为1.5m3/m,注入速度为1.8m3/min,油井焖井时间为30d,油藏采收率提高了2%~3%;③通过与常规压裂生产效果进行对比,前置CO_(2)蓄能压裂技术可使产油量提高5.2t/d,预测CO_(2)换油率达2.45,开发效果显著提升。

基于Sentinel-2的青铜峡灌区水稻和玉米种植分布早期识别

及时准确地掌握灌区内作物种植分布对于灌溉水资源高效配置、农田精准管理具有重要指导意义。以宁夏青铜峡灌区为研究对象,利用多时相Sentinel-2卫星数据,通过水稻和玉米早期特征分析,提取关键的“水淹”信号和“植被”信号,构建时序归一化差异水体指数(MNDWI)和归一化植被指数(NDVI)特征值数据集,并通过样本分析关键特征阈值,构建水稻和玉米早期种植分布决策树模型,提取2022年宁夏青铜峡灌区水稻和玉米种植的空间分布。结果表明(:1)玉米和水稻苗期的后半段5月15—31日,水淹信号和植被信号是区分二者关键时期。(2)基于早期作物物候特征的方法,在5月16—31日获取的水稻和玉米图像制图精度高于90%,用户精度超过91%,总体精度超过90%,Kappa系数高于0.88,明显高于同时期随机森林方法的分类精度。(3)本研究提出的方法在早期水稻和玉米种植分布提取方面具有较强的适用性,并且能够在时空尺度上以较少的实地样本进行延展,同时在时间上也更有优势。因此,该方法为青铜峡灌区水稻和玉米种植分布早期调查提供了重要的方法支撑。

季冻区纳米SiO_(2)改性SAP路面混凝土的耐磨性

为解决季冻区高吸水性树脂(SAP)路面混凝土耐磨性下降的问题,通过耐磨性试验探索了纳米SiO_(2)(NS)对季冻区SAP路面混凝土磨损量的影响;采用压汞仪(MIP)和扫描电镜(SEM)研究了冻融前后NS改性SAP路面混凝土孔结构和微观形貌的变化,从细微观角度阐述其耐磨性的提升机理;并对其微观结构与耐磨性进行相关性分析。研究结果表明,经150次冻融循环之后,掺有3%NS的改性SAP路面混凝土在200 N磨耗负荷下的磨损量较基准下降30.92%,20~50nm的孔占比上升,50~200nm的孔占比下降,总孔隙量和孔隙率减少,界面区裂缝数量和尺寸大幅降低,内部密实性程度显著提高,耐磨性明显增强。

中低分辨率卫星蓝藻水华监测面积校正研究:以GOCI-2为例

面对中低分辨率影像因监测尺度较低而导致其估算湖泊蓝藻水华面积精度较差这一问题,文章以GK 2B卫星上搭载的多光谱成像设备GOCI-2为例,选取太湖研究区,分析了GOCI-2与Sentinel-2卫星遥感影像水华面积提取结果的差异,研究了GOCI-2混合像元中NDVI值与水华面积占比的关系,并进行回归分析;以此为基础构建了面向GOCI-2的水华面积校正模型,并对该模型进行精度验证和比对分析。试验结果表明:混合像元中水华面积占比与NDVI值非线性正相关,直接用NDVI阈值法提取的蓝藻水华面积比实际值偏大;经模型校正后GOCI-2水华面积监测平均精度由67.8%提升到90.0%,且校正模型对NDVI阈值设定不敏感;与EVI、AFAI水华提取算法相比,NDVI能更好的反映出水华在混合像元中的占比。文章的研究成果可为GOCI-2影像在水华监测领域的应用提供一定参考。

Synergistic extraction of rare earth by mixtures of 2-ethylhexyl phosphoric acid mono-2-ethylhexyl ester and di-(2-ethylhexyl) phosphoric acid from sulfuric acid medium

The extraction of Nd^3＋ and Sm^3＋, including the extraction and stripping capability as well as the separation effect of Nd^3＋ or Sm^3＋, from a sulfuric acid medium, by mixtures of di-（2-ethylhexyl） phosphoric acid （HDEHP, H2A2（0）） and 2-ethylhexyl phosphoric acid mono-2-ethylhexyl ester （HEH/EHP, H2L2（0）） were studied. The distribution ratios and synergistic coefficients of Nd^3＋ and Sm^3＋ in different acidities were also determined. A synergistic extractive effect was found when HDEHP and HEH/EHP were used as mixed extractants for Sm^3＋ or Nd^3＋. The chemical compositions of the extracted complex were determined as Nd.（HA2）2-HL2 and Sm.（HA2）2-HL2. The extraction equilibrium constants, enthalpy change, and entropy change of the extraction reaction were also determined.

GJB2 mutation spectrum in deaf population in a typical southeastern area of China

Mutations in GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment. However, the spectrum and prevalence of mutations in this gene vary among different ethnic groups. In China, 30,000 infants are born with congenital hearing impairment annually. In order to provide appropriate genetic testing and counseling to the families, we investigated the molecular etiology of nonsyndromic deafness in 103 unrelated school children attending Nantong School for the Deaf and Mute in Jiangsu Province, China. The coding exon of the GJB2 gene was PCR amplified and sequenced. Sixty two GJB2 mutant alleles were identified in 35.9% (37/103) of the patients. Twenty five patients carried two pathogenic mutations and 12 patients carried one mutant allele. The 235delC was the most common mutation accounting for 69.4% (43/62) of GJB2 mutant alleles. The GJB2 mutant alleles accounted for 30.1% (62/206) of all chromosomes responsible for nonsyndromic hearing impairment. Testing of the 3 most prevalent deleterious frame shift mutations in this cohort detected 100% of all GJB2 mutant alleles. These results demonstrate that an effective genetic testing of GJB2 gene for patients and families with nonsyndromic hearing impairment is possible.

Nitrogen and sulfur dual-doped high-surface-area hollow carbon nanospheres for efficient CO2 reduction

The electrochemical reduction of CO2(CO2 RR) can substantially contribute to the production of useful chemicals and reduction of global CO2 emissions. Herein, we presented N and S dual-doped high-surface-area carbon materials(SZ-HCN) as CO2 RR catalysts. N and S were doped by one-step pyrolysis of a N-containing polymer and S powder. ZnCl2 was applied as a volatile porogen to prepare porous SZ-HCN. SZ-HCN with a high specific surface area(1510 m2 g–1) exhibited efficient electrocatalytic activity and selectivity for CO2 RR. Electrochemical measurements demonstrated that SZ-HCN showed excellent catalytic performance for CO2-to-CO reduction with a high CO Faradaic efficiency(~93%) at-0.6 V. Furthermore, SZ-HCN offered a stable current density and high CO selectivity over at least 20 h continuous operation, revealing remarkable electrocatalytic durability. The experimental results and density functional theory calculations indicated that N and S dual-doped carbon materials required lower Gibbs free energy to form the COOH* intermediate than that for single-N-doped carbon for CO2-to-CO reduction, thereby enhancing CO2 RR activity.

A two-year(2020–2021)observation of marine phycotoxins in phytoplankton in typical mariculture areas of East China Sea

To learn the marine phycotoxins(MPTs)contamination status in mariculture areas in the East China Sea(ECS),from May 2020 to October 2021,80 net-concentrated phytoplankton samples were collected from 12 stations in three typical areas with high incidence of red tides,namely,Gouqi Island,Sandu’ao-Lianjiang,and Zhangzhou-Dongshan Island in ECS,and MPTs of the samples were detected.Six types of toxins were detected in 24 samples from 9 stations.Lipophilic marine toxins(LMTs)were more common and diverse in these areas.Pectenotoxin 2(PTX2)was the main lipophilic marine toxin(LMT)in the concentrated phytoplankton samples and the occurrence showed seasonal differences from north to south.According to the potential risks of pectenotoxin(PTXs)to seafood safety,it is suggested to execute regular monitoring on PTXs in ECS and a mandatory standard should be formulated based on the comprehensive analysis of in-situ monitoring and lab research.Meanwhile,contamination risks of cyclic imine toxins in the north and domoic acid(DA)in the south of ECS should also be paid with attention to.Only 2 paralytic shellfish toxins(PSTs),N-sulfocarbamoyl toxin C2(C2),and decarbamoyl gonyatoxin 3(dcGTX3),were found from spring samples in the north of ECS.As the biggest mussel culture county of China,Gouqi Island showed higher toxin diversity and the toxin detection rate was higher than the other two areas.In Gouqi Island area,PSTs were a serious potential threat in spring,and LMTs instead of PSTs became the main risk in summer-autumn seasons.To ensure the safety of seafood and marine environmental health,it is recommended to conduct long-term targeted tracking and monitoring of MPTs in this and similar mariculture areas.

目标范围内时间和sdLDL-C水平与2型糖尿病患者发生冠心病的相关性分析

目的 分析葡萄糖目标范围内时间(TIR)和小而密低密度脂蛋白胆固醇(sd LDL-C)水平与2型糖尿病患者发生冠心病的相关性。方法 本研究为回顾性研究,收集2020年12月至2022年1月河北省邢台市人民医院2型糖尿病患者73例作为2型糖尿病组,收集同期2型糖尿病伴冠心病患者54例作为2型糖尿病伴冠心病组。比较2组患者临床资料、sdLDL-C、胆固醇(TC)、甘油三酯(TG)及TIR的差异。采用多因素Logistic回归分析2型糖尿病患者发生冠心病的危险因素。采用受试者工作特征(ROC)曲线评估TIR和sdLDL-C水平对2型糖尿病患者发生冠心病的预测价值。结果 与2型糖尿病患者相比,2型糖尿病伴冠心病组患者年龄、高血压患病率、TG、sdLDL-C明显升高(P <0.05),TIR明显降低(P <0.05)。多因素Logistic回归分析显示sdLDL-C是2型糖尿病患者发生冠心病的独立危险因素。ROC曲线分析显示,TIR和sdLDL-C对2型糖尿病患者发生冠心病的预测曲线下面积(AUC)分别为0.62(95%CI:0.52~0.72,P=0.021),0.649(95%CI:0.555~0.744,P=0.004),两者联合检测,AUC为0.681(95%CI:0.589~0.773,P=0.001)。结论 2型糖尿病伴冠心病患者TIR明显低于2型糖尿病患者,血清sdLDL-C水平明显高于2型糖尿病患者,sdLDL-C是2型糖尿病患者发生冠心病的独立危险因素,TIR联合sdLDL-C对2型糖尿病发生冠心病的预测能力更高。

中老年男性2型糖尿病患者糖化血红蛋白控制水平与性腺激素相关性的分析

目的:探讨中老年男性2型糖尿病患者糖化血红蛋白控制水平对性腺激素、体重指数、血脂、内脏脂肪面积的影响,并对影响睾酮的相关因素进行分析。方法:选择90例中老年2型糖尿病男性患者,收集30例糖化血红蛋白<7%、30例糖化血红蛋白7%~9%、30例糖化血红蛋白>9%,分别收集患者年龄、体重指数、血脂、内脏脂肪面积、性腺激素,对三组数据进行统计学分析;再根据睾酮大于中位数(>4.08 ng/mL)及小于等于中位数(≤4.08 ng/mL)分为两组,对两组之间体重指数、内脏脂肪面积、糖化血红蛋白、血脂等数据进行统计分析。结果:糖化血红蛋白水平与高密度脂蛋白、睾酮呈负相关(P<0.05),而与甘油三酯、总胆固醇、低密度脂蛋白、体重指数、内脏脂肪面积、雌二醇呈正相关(P<0.05),与促卵泡生成素、促黄体生成素、泌乳素水平无关(P>0.05)。睾酮与体重指数、内脏脂肪面积、糖化血红蛋白、甘油三酯,总胆固醇,低密度脂蛋白水平呈负相关(P<0.05),与高密度脂蛋白呈正相关(P<0.05)。Logistic回归分析显示:糖化血红蛋白水平,内脏脂肪面积、体重指数、血脂异常是睾酮减少的危险因素。结论:良好的血糖控制可有效减少男性睾酮下降,促进机体脂质代谢;较高的睾酮水平对血糖、血脂代谢亦起到积极作用;糖化血红蛋白、内脏脂肪面积、体重指数、血脂异常是睾酮减少的危险因素。

Sequence of densification and hydrocarbon charging of Xu2 reservoir in Anyue–Hechuan area,Sichuan Basin,China

The sequence of the densification and hydrocarbon charging of the Xu2 reservoir in the Anyue–Hechuan area of Central Sichuan Basin is discussed.The diagenetic sequence is considered a time line to determine the historical relationship between the densification process and the hydrocarbon charging of the Xu2 reservoir in the study area:Early diagenetic stage B(the first stage of hydrocarbon charging,which was about 200–160 Ma ago,with a porosity of about 20%,consolidated and not tight)→middle diagenetic stage A(the second stage of hydrocarbon charging,which was about 140–120 Ma ago,with a porosity of 10%–20%and relatively tight)→middle diagenetic stage B(the third stage of hydrocarbon charging,which was about 20–5 Ma ago,with a porosity of 6%–10%and tight;However,fractures have developed).The study results prove that large-scale hydrocarbon charging and accumulation completed before the densification of the Xu2 reservoir,showing that the Upper Triassic Xujiahe Fm unconventional tight reservoir in the Sichuan Basin is prospective for exploration.

Correlation of periodontal inflamed surface area with glycemic status in controlled and uncontrolled type 2 diabetes mellitus

BACKGROUND The bidirectional link between periodontitis and diabetes mellitus(DM)has been established.Periodontitis causes systemic inflammatory burden through inflammatory mediators.The currently utilized tools[clinical attachment loss(CAL)and probing pocket depth(PPD)]are linear measurements,that do not exactly quantify the inflammatory burden of periodontitis.Periodontal inflamed surface area(PISA)quantifies the surface area of bleeding pocket epithelium and estimates the inflammatory burden.Studies relating to the periodontal status of diabetic patients with and without microvascular complications are scarce.This study assessed the proportion of periodontitis and correlation of PISA with glycemic status in controlled,uncontrolled type 2 DM(T2DM)with and without microvascular complications.AIM To assess the proportion of periodontitis and correlation of PISA with glycemic status in controlled,and uncontrolled T2DM with and without microvascular complications.METHODS This study comprised 180 T2DM patients.Based on glycated hemoglobin(HbA1c)levels,they were grouped into:(1)Controlled T2DMgroup:(HbA1c≤7%);(2)Uncontrolled T2DM group:(HbA1c>7%)without microvascular complications;and(3)Uncontrolled T2DM group:(HbA1c>7%)with microvascular complications.Each group comprised 60 patients.All patients were assessed for periodontal parameters(Bleeding on Probing,PPD,CAL,Oral hygiene index simplified and PISA),and systemic parameters(HbA1c,fasting plasma glucose and post prandial plasma glucose).RESULTS The proportion of periodontitis among controlled T2DM group,uncontrolled T2DM group without microvascular complications,uncontrolled T2DM group with micro-vascular complications was 75%,93.4%and 96.6%respectively.Extent and severity of periodontitis were high in the uncontrolled T2DM group.A significant positive correlation was found between PISA and HbA1c among all patients(r=0.393,P<0.001).The dose–response relationship between PISA and HbA1c was observed.An increase of PISA with 168 mm^(2) was associated with a 1.0%increase of HbA1c.CONCLUSION High proportion and severity of periodontitis,and increased inflamed surface area in uncontrolled T2DM may have contributed to the poor glycemic control and microvascular complications.