Objective To evaluate the possible relationship between insulin like growth factor 1 (IGF 1) and diabetic neuropathy (DNP). Methods Sixty nine patients with Type 2 non insulin dependent diabetes (54 with peri...Objective To evaluate the possible relationship between insulin like growth factor 1 (IGF 1) and diabetic neuropathy (DNP). Methods Sixty nine patients with Type 2 non insulin dependent diabetes (54 with peripheral neuropathy and 15 without neuropathy) were observed. Normal controls were 34 non diabetic persons. Diabetic peripheral neuropathy diagnosis was carried out taking into account results of NS, ND, NC and AF. After an overnight fast, blood was taken for IGF 1, glucose, hemoglobin Alc, C peptide, and insulin. Plasma IGF 1 was measured by radioimmunoassay (RIA) method. Results The neuropathic group had significantly lower levels for IGF 1 (86.43 ng/ml ±45.18 ng/ml) compared to normal controls (119.68 ng/ml ±89.42 ng/ml) (P<0.05), and to diabetic patients without neuropathy (113.75 ng/ml ±66.58 ng/ml) (P< 0.05). No significant difference was found between diabetic non neuropathic group and normal control subjects (P>0.05). In diabetic subjects there was a positive correlation (γ=0.27, P<0.05) between IGF 1 and beat to variation in heart rate. There were negative correlation bwteen IGF 1 and postprandial blood glucose (γ=-0.3, P< 0.05), and aspartic acid translocase (γ=-0.27, P<0.05). Conclusion In diabetic patients with peripheral neuropathy there are abnormalities of IGF 1 that may contribute to the pathogeneses of diabetic neuropathy.展开更多
文摘Objective To evaluate the possible relationship between insulin like growth factor 1 (IGF 1) and diabetic neuropathy (DNP). Methods Sixty nine patients with Type 2 non insulin dependent diabetes (54 with peripheral neuropathy and 15 without neuropathy) were observed. Normal controls were 34 non diabetic persons. Diabetic peripheral neuropathy diagnosis was carried out taking into account results of NS, ND, NC and AF. After an overnight fast, blood was taken for IGF 1, glucose, hemoglobin Alc, C peptide, and insulin. Plasma IGF 1 was measured by radioimmunoassay (RIA) method. Results The neuropathic group had significantly lower levels for IGF 1 (86.43 ng/ml ±45.18 ng/ml) compared to normal controls (119.68 ng/ml ±89.42 ng/ml) (P<0.05), and to diabetic patients without neuropathy (113.75 ng/ml ±66.58 ng/ml) (P< 0.05). No significant difference was found between diabetic non neuropathic group and normal control subjects (P>0.05). In diabetic subjects there was a positive correlation (γ=0.27, P<0.05) between IGF 1 and beat to variation in heart rate. There were negative correlation bwteen IGF 1 and postprandial blood glucose (γ=-0.3, P< 0.05), and aspartic acid translocase (γ=-0.27, P<0.05). Conclusion In diabetic patients with peripheral neuropathy there are abnormalities of IGF 1 that may contribute to the pathogeneses of diabetic neuropathy.
