Objective:To systematically evaluate the risk factors for multidrug-resistant organisms(MDROs)infection in patients with diabetic foot ulcer(DFU).Methods:The quality assessment of outcome measures was performed by sea...Objective:To systematically evaluate the risk factors for multidrug-resistant organisms(MDROs)infection in patients with diabetic foot ulcer(DFU).Methods:The quality assessment of outcome measures was performed by searching the Web of Science,Embase library,PubMed,Cochrane Library databases and screening the literature on the risk factors of MDROs infection in DFU patients according to the inclusion and exclusion criteria,and meta-analysis was performed using revman5.3 analysis software.Results:13 literature was retrieved,involving in 1715 patients.A total of 15 risk factors were included in the analysis and the meta-analysis showed that Previous hospitalization(OR=2.61,95%CI[1.51,4.52],P=0.0006),Previous antibiotic use(OR=2.17,95%CI[1.24-3.78],P<0.01),Type of diabetes(OR=2.44,95%CI[1.29-4.63],P<0.01),Nature of ulcer(OR=2.16,95%CI[1.06-4.40],P=0.03),Size of ulcer(OR=2.56,95%CI[1.53-4.28],P<0.01),Osteomyelitis(OR=3.50,95%CI[2.37-5.17],P<0.01),Peripheral vascular disease(OR=2.37,95%CI[1.41-3.99],P<0.01),and Surgical treatment(OR=4.81,95%CI[2.95-7.84],P<0.01)were closely associated with MDROs infection in DFU patients.Conclusions:The risk factors of MDROs infection in patients with DFU were previous hospitalization,previous antibiotic use,type of diabetes,nature of ulcer,size of ulcer,osteomyelitis,peripheral vascular disease,and surgical treatment.This study is conducive to early detection of MDROs infection in high-risk groups and timely comprehensive treatment to delay the development of the disease.展开更多
目的:系统评价糖尿病足溃疡患者感染多重耐药菌(MDROs)的危险因素。方法:检索Web of Science、Embase图书馆、PubMed、Cochrane图书馆数据库,根据纳入和排除标准筛选出有关糖尿病足溃疡患者感染MDROs危险因素的文献,对结局指标进行质量...目的:系统评价糖尿病足溃疡患者感染多重耐药菌(MDROs)的危险因素。方法:检索Web of Science、Embase图书馆、PubMed、Cochrane图书馆数据库,根据纳入和排除标准筛选出有关糖尿病足溃疡患者感染MDROs危险因素的文献,对结局指标进行质量评估,并采用Revman5.3分析软件进行meta分析。结果:检索出13篇满足条件的文献,一共纳入1715例患者。纳入分析的危险因素共15个。Meta分析结果显示:入院前住院记录[OR=2.61,95%CI(1.51,4.52),P=0.0006]、入院前抗生素的使用[OR=2.17,95%CI(1.24,3.78),P<0.01]、糖尿病类别[OR=2.44,95%CI(1.29,4.63),P<0.01]、溃疡类型[OR=3.01,95%CI(1.58,5.72),P<0.05]、溃疡大小[OR=1.86,95%CI(1.56,2.22),P<0.01]、骨髓炎[OR=3.50,95%CI(2.37,5.17),P<0.01]、血管病变[OR=2.37,95%CI(1.41,3.99),P<0.01]和外科治疗[OR=4.81,95%CI(2.95,7.84),P<0.01]被确定为糖尿病足部溃疡患者MDROs感染的危险因素。结论:糖尿病足部溃疡患者MDROs感染的危险因素有入院前住院记录、入院前抗生素的使用、糖尿病类别、溃疡类型、溃疡大小、骨髓炎、血管病变和外科治疗。这项研究有利于早期发现MDROs感染高危人群并及时采取相关综合性治疗,延缓疾病的发展。展开更多
基金National Natural Science Foundation of China(81973614)。
文摘Objective:To systematically evaluate the risk factors for multidrug-resistant organisms(MDROs)infection in patients with diabetic foot ulcer(DFU).Methods:The quality assessment of outcome measures was performed by searching the Web of Science,Embase library,PubMed,Cochrane Library databases and screening the literature on the risk factors of MDROs infection in DFU patients according to the inclusion and exclusion criteria,and meta-analysis was performed using revman5.3 analysis software.Results:13 literature was retrieved,involving in 1715 patients.A total of 15 risk factors were included in the analysis and the meta-analysis showed that Previous hospitalization(OR=2.61,95%CI[1.51,4.52],P=0.0006),Previous antibiotic use(OR=2.17,95%CI[1.24-3.78],P<0.01),Type of diabetes(OR=2.44,95%CI[1.29-4.63],P<0.01),Nature of ulcer(OR=2.16,95%CI[1.06-4.40],P=0.03),Size of ulcer(OR=2.56,95%CI[1.53-4.28],P<0.01),Osteomyelitis(OR=3.50,95%CI[2.37-5.17],P<0.01),Peripheral vascular disease(OR=2.37,95%CI[1.41-3.99],P<0.01),and Surgical treatment(OR=4.81,95%CI[2.95-7.84],P<0.01)were closely associated with MDROs infection in DFU patients.Conclusions:The risk factors of MDROs infection in patients with DFU were previous hospitalization,previous antibiotic use,type of diabetes,nature of ulcer,size of ulcer,osteomyelitis,peripheral vascular disease,and surgical treatment.This study is conducive to early detection of MDROs infection in high-risk groups and timely comprehensive treatment to delay the development of the disease.
文摘目的:系统评价糖尿病足溃疡患者感染多重耐药菌(MDROs)的危险因素。方法:检索Web of Science、Embase图书馆、PubMed、Cochrane图书馆数据库,根据纳入和排除标准筛选出有关糖尿病足溃疡患者感染MDROs危险因素的文献,对结局指标进行质量评估,并采用Revman5.3分析软件进行meta分析。结果:检索出13篇满足条件的文献,一共纳入1715例患者。纳入分析的危险因素共15个。Meta分析结果显示:入院前住院记录[OR=2.61,95%CI(1.51,4.52),P=0.0006]、入院前抗生素的使用[OR=2.17,95%CI(1.24,3.78),P<0.01]、糖尿病类别[OR=2.44,95%CI(1.29,4.63),P<0.01]、溃疡类型[OR=3.01,95%CI(1.58,5.72),P<0.05]、溃疡大小[OR=1.86,95%CI(1.56,2.22),P<0.01]、骨髓炎[OR=3.50,95%CI(2.37,5.17),P<0.01]、血管病变[OR=2.37,95%CI(1.41,3.99),P<0.01]和外科治疗[OR=4.81,95%CI(2.95,7.84),P<0.01]被确定为糖尿病足部溃疡患者MDROs感染的危险因素。结论:糖尿病足部溃疡患者MDROs感染的危险因素有入院前住院记录、入院前抗生素的使用、糖尿病类别、溃疡类型、溃疡大小、骨髓炎、血管病变和外科治疗。这项研究有利于早期发现MDROs感染高危人群并及时采取相关综合性治疗,延缓疾病的发展。
