Objective:To evaluate the antihyperglycemic activity of Tecomaria aipensis(T.capensis) Thunb. (Bignoniaceae) methanolic leaves extract(TCLE) using blood glucose level in normal fasted rats, glucose tolerance test and ...Objective:To evaluate the antihyperglycemic activity of Tecomaria aipensis(T.capensis) Thunb. (Bignoniaceae) methanolic leaves extract(TCLE) using blood glucose level in normal fasted rats, glucose tolerance test and alloxan induced hyperglycemia models.Methods:TCLE(100,300, 1 000 and 2 000 mg/kg body wt.) was given to rats orally to observe acute toxicity,and observed for 14 d.TCLE 200 and 400 mg/kg,and glibenclamide 0.6 mg/kg were given orally in all models. Results:Results demonstrated that the no mortality was reported even after 14 d.This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight.TCLE(200 and 400 mg/kg p.o.) exhibited remarkable blood glucose lowering effect in blood glucose level in normal fasted rats,glucose tolerance and alloxan induced hyperglycemia model.Cholesterol and triglyceride also decreased in alloxan induced hyperglycemia model.Condosions:The results of this study exhibites that methanol extract of T.capensis possesses antihypergycemic activity and it may prove to be effective for the treatment of hyperglycemia.展开更多
文摘Objective:To evaluate the antihyperglycemic activity of Tecomaria aipensis(T.capensis) Thunb. (Bignoniaceae) methanolic leaves extract(TCLE) using blood glucose level in normal fasted rats, glucose tolerance test and alloxan induced hyperglycemia models.Methods:TCLE(100,300, 1 000 and 2 000 mg/kg body wt.) was given to rats orally to observe acute toxicity,and observed for 14 d.TCLE 200 and 400 mg/kg,and glibenclamide 0.6 mg/kg were given orally in all models. Results:Results demonstrated that the no mortality was reported even after 14 d.This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight.TCLE(200 and 400 mg/kg p.o.) exhibited remarkable blood glucose lowering effect in blood glucose level in normal fasted rats,glucose tolerance and alloxan induced hyperglycemia model.Cholesterol and triglyceride also decreased in alloxan induced hyperglycemia model.Condosions:The results of this study exhibites that methanol extract of T.capensis possesses antihypergycemic activity and it may prove to be effective for the treatment of hyperglycemia.
