Monoclonal antibodies against colon and pancreatic cancer, CL-2, CL-3, PS-9, PS-10, were used to detect the associated antigens in feces of patients with gastrointestinal carcinoma and non-cancer diseases. Binding inh...Monoclonal antibodies against colon and pancreatic cancer, CL-2, CL-3, PS-9, PS-10, were used to detect the associated antigens in feces of patients with gastrointestinal carcinoma and non-cancer diseases. Binding inhibition test by SABC-ELISA method were performed for the measurement of the antigen level. Results showed that the associated antigen detected in feces of patients with colon cancer were significantly higher than that of non-cancer disease or normal subjects. The positive rates were 61.1% as detected with CL-2; 53.4% with CL-3; 55.0%, PS-9; and 53.3% PS-10 in cancer patients while that in normal subjects were 7%; 9%; 8%; and 8% respectively. When 'cocktail' of CL-2, PS-9 and PS-10 were used, the positive rates were 92.5% in colon cancer and 14% in normal subjects. In seven out of the sixty patients with colon cancer studied who were graded as Dukes A, the results were all positive. The results seem superior to the serologic detection and may provide a promising new approach in the early diagnosis of colon cancer.展开更多
Destruction of the lung parenchyma may result in the forma- tion of cysts, cavities and bullae. Definition of the type of destructive lesion is best achieved by high-resolution computed tomography （HRCT） scans of th...Destruction of the lung parenchyma may result in the forma- tion of cysts, cavities and bullae. Definition of the type of destructive lesion is best achieved by high-resolution computed tomography （HRCT） scans of the chest （Trotman- Dickenson, 2014）. The loss of lung parenchyma may result in respiratory compromise and pneumothoraces. In the case of cystic lung destruction, multiple causes have been identified, with the cysts being a manifestation of inherited and non- inherited diseases （Sahn and Heffner, 2000）. Compared with sporadic cases, familial lung cysts/spontaneous pneumothorax are rare and are manifestation of some Mendelian genetic diseases.展开更多
文摘Monoclonal antibodies against colon and pancreatic cancer, CL-2, CL-3, PS-9, PS-10, were used to detect the associated antigens in feces of patients with gastrointestinal carcinoma and non-cancer diseases. Binding inhibition test by SABC-ELISA method were performed for the measurement of the antigen level. Results showed that the associated antigen detected in feces of patients with colon cancer were significantly higher than that of non-cancer disease or normal subjects. The positive rates were 61.1% as detected with CL-2; 53.4% with CL-3; 55.0%, PS-9; and 53.3% PS-10 in cancer patients while that in normal subjects were 7%; 9%; 8%; and 8% respectively. When 'cocktail' of CL-2, PS-9 and PS-10 were used, the positive rates were 92.5% in colon cancer and 14% in normal subjects. In seven out of the sixty patients with colon cancer studied who were graded as Dukes A, the results were all positive. The results seem superior to the serologic detection and may provide a promising new approach in the early diagnosis of colon cancer.
基金supported by the National High Technology Research and Development Program of China (863 Program) (No. 2012AA02A201)supported by the Intramural Research Program,National Institutes of Health, National Heart, Lung and Blood Institute,USA
文摘Destruction of the lung parenchyma may result in the forma- tion of cysts, cavities and bullae. Definition of the type of destructive lesion is best achieved by high-resolution computed tomography （HRCT） scans of the chest （Trotman- Dickenson, 2014）. The loss of lung parenchyma may result in respiratory compromise and pneumothoraces. In the case of cystic lung destruction, multiple causes have been identified, with the cysts being a manifestation of inherited and non- inherited diseases （Sahn and Heffner, 2000）. Compared with sporadic cases, familial lung cysts/spontaneous pneumothorax are rare and are manifestation of some Mendelian genetic diseases.
