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Assessment of seismic hazard of roller compacted concrete dam site in Gilgit-Baltistan of northern Pakistan
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作者 Shahzada Khurram Perveiz Khalid +1 位作者 Jahanzeb Qureshi Zia Ud Din 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2021年第3期621-630,共10页
The proposed site of the Diamer Bhasha Dam in northern Pakistan is situated in an active tectonic zone with intensive seismicity,which makes it necessary for seismic hazard analysis(SHA).Deterministic and probabilisti... The proposed site of the Diamer Bhasha Dam in northern Pakistan is situated in an active tectonic zone with intensive seismicity,which makes it necessary for seismic hazard analysis(SHA).Deterministic and probabilistic approaches have been used for SHA of the dam site.The Main Mantle Thrust(MMT),Main Karakaram Thrust(MKT),Raikot-Sassi Fault(RKSF)and Kohistan Fault(KF)have been considered as major seismic sources,all of which can create maximum ground shaking with maximum potential earthquake(MPE).Deterministically estimated MPE for magnitudes of 7.8,7.7,7.6,and 7.1 can be produced from MMT,MKT,RKSF and KF,respectively.The corresponding peak ground accelerations(PGA)of 0.07,0.11,0.13 and 0.05 g can also be generated from these earthquakes,respectively.The deterministic analysis predicts a so-called floating earthquake as a MPE of magnitude=7.1 as close as 10 km away from the site.The corresponding PGA was computed as 0.38 g for a maximum design earthquake at the project site.However,the probabilistic analysis revealed that the PGA with 50%probability of exceedance in 100 years is 0.18 g.Thus,this PGA value related to the operational basis earthquake(OBE)is suggested for the design of this project with shear wave velocity(V_(s30))equal to 760 m/s under dense soil and soft rock conditions. 展开更多
关键词 seismic hazard analysis peak ground acceleration Gilgat-Biltastan diamer Bhasha Dam
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新型冠状病毒肺炎合并脑卒中患者的合理用药与药学监护 被引量:2
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作者 陈俊 张贝 +2 位作者 曾芳 张玉 刘易慧 《药物评价研究》 CAS 2020年第12期2557-2564,共8页
新型冠状病毒肺炎(COVID-19)患者尤其危重症患者,疾病后常伴有D-二聚体升高,易诱发或者加重缺血性脑卒中的发生。而两种疾病在病史初期均存在头痛、呕吐、发热、呼吸急促等相似症状,容易造成误诊、漏诊,且相互影响,导致病程延长。针对CO... 新型冠状病毒肺炎(COVID-19)患者尤其危重症患者,疾病后常伴有D-二聚体升高,易诱发或者加重缺血性脑卒中的发生。而两种疾病在病史初期均存在头痛、呕吐、发热、呼吸急促等相似症状,容易造成误诊、漏诊,且相互影响,导致病程延长。针对COVID-19患者,需积极尽早采取抗毒病治疗,合并脑卒中的患者,需密切监测D-二聚体的指标变化,根据其指标给予患者适宜的抗栓治疗,一旦D-二聚体升高,建议立即启动抗凝措施,同时需控制患者血压血脂等高危因素。结合脑卒中相关用药研究,探讨COVID-19合并脑卒中这类高危人群的合理用药策略与药学监护,为此类患者提供合理用药参考。 展开更多
关键词 新型冠状病毒肺炎(COVID-19) 脑卒中 抗病毒治疗 抗血栓治疗 药物相互作用 药学监护 D-二聚体
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