Sensory irritation of the upper respiratory tract was induced in mice by inhalation of vapors, generated under thermal stress of two tear gases viz. 1-chloroacetophenone (CN) and dibenz (b, f)-1, 4 oxazepine (CR) foll...Sensory irritation of the upper respiratory tract was induced in mice by inhalation of vapors, generated under thermal stress of two tear gases viz. 1-chloroacetophenone (CN) and dibenz (b, f)-1, 4 oxazepine (CR) following a simple exposure technique. A known quantity of the irritant was kept in an adapter fitted with glass exposure chamber, heated, and the vapor thus generated was purged into the chamber. The restrained mouse inhaled the vapor, and the resultant depression of respiratory rate was recorded on a polygraph. Fifty percent depression of the respiration rate and the corresponding air concentration of the irritant was determined by obtaining the linear curve fitting equation and putting the value of Y=50. It was concluded that inhalation of CR vapor was 2. 66 times more irritating than that of CN in mice. The employed exposure method also proved to be simple, sensitive, easy t0 operate,and may also prove useful in evaluating irritation of upper respiratory tract fOllowing the inhalation of vapors of various chemicals.展开更多
The basic characteristics of anthracene（AN） and dibenz[a,c]anthracene（D[a,c]A） derivatives, important semiconductors, were systematically studied. Differential scanning calorimetry（DSC） shows that D[a,c]A has th...The basic characteristics of anthracene（AN） and dibenz[a,c]anthracene（D[a,c]A） derivatives, important semiconductors, were systematically studied. Differential scanning calorimetry（DSC） shows that D[a,c]A has the reversibility of solid and liquid phases. Thermalgravimetric analysis（TGA） shows that D[a,c]A exhibits higher Td（decomposition temperature）, which indicates D[a,c]A, as active layers, should be more suitable to being made into stable devices. D[a,c]A shows blue-shifted UV-Vis absorption and emission despite increased conjugation compared to anthracene due to different symmetries. Both the compounds are planar and show weak blue fluorescence in the tetrahydrofuran（THF） solution and higher fluorescence in the solid-state, due to different energy levels in solution and solid-state, explained via Jablonski diagram.展开更多
A novel synthesis process of 5H-dibenz[b,f]azepine was studied.It is an important intermediate of 5H-dibenz[b,f]azepine-5-carboxamide,used in genetic engineering,materials science and so on.With 10,11-dihydro-5H-diben...A novel synthesis process of 5H-dibenz[b,f]azepine was studied.It is an important intermediate of 5H-dibenz[b,f]azepine-5-carboxamide,used in genetic engineering,materials science and so on.With 10,11-dihydro-5H-dibenz[b,f]azepine as raw material,5-chloroformyl-5H-dibenz[b,f]azepine was prepared by reflux with triphosgene in toluene,brominated with bromine in chlorobenzene,and dehydrobrominated at 130℃,finally,the title compound was obtained by removing chloroformyl group with NaOH in isopropanol with 80.4% overall yield.The optimal reaction conditions and yields (temperature,time,molar yield) were as follows: acyl chlorination,110℃,10 h,93.0%; bromination,dehydrobromination,100℃,2 h,130℃,5 h,88.0%; removal of chloroformyl group,40℃,3 h,98.2%. The melting point of the title compound was the same as literature reported,and its structure was confirmed by 1H NMR.The optimal technology condition to remove chloroformyl group as protection group and its application of protection for some amine compounds were also studied.展开更多
文摘Sensory irritation of the upper respiratory tract was induced in mice by inhalation of vapors, generated under thermal stress of two tear gases viz. 1-chloroacetophenone (CN) and dibenz (b, f)-1, 4 oxazepine (CR) following a simple exposure technique. A known quantity of the irritant was kept in an adapter fitted with glass exposure chamber, heated, and the vapor thus generated was purged into the chamber. The restrained mouse inhaled the vapor, and the resultant depression of respiratory rate was recorded on a polygraph. Fifty percent depression of the respiration rate and the corresponding air concentration of the irritant was determined by obtaining the linear curve fitting equation and putting the value of Y=50. It was concluded that inhalation of CR vapor was 2. 66 times more irritating than that of CN in mice. The employed exposure method also proved to be simple, sensitive, easy t0 operate,and may also prove useful in evaluating irritation of upper respiratory tract fOllowing the inhalation of vapors of various chemicals.
基金Supported by the National Natural Science Foundation of China（Nos.21107050, 51203091）.
文摘The basic characteristics of anthracene（AN） and dibenz[a,c]anthracene（D[a,c]A） derivatives, important semiconductors, were systematically studied. Differential scanning calorimetry（DSC） shows that D[a,c]A has the reversibility of solid and liquid phases. Thermalgravimetric analysis（TGA） shows that D[a,c]A exhibits higher Td（decomposition temperature）, which indicates D[a,c]A, as active layers, should be more suitable to being made into stable devices. D[a,c]A shows blue-shifted UV-Vis absorption and emission despite increased conjugation compared to anthracene due to different symmetries. Both the compounds are planar and show weak blue fluorescence in the tetrahydrofuran（THF） solution and higher fluorescence in the solid-state, due to different energy levels in solution and solid-state, explained via Jablonski diagram.
文摘A novel synthesis process of 5H-dibenz[b,f]azepine was studied.It is an important intermediate of 5H-dibenz[b,f]azepine-5-carboxamide,used in genetic engineering,materials science and so on.With 10,11-dihydro-5H-dibenz[b,f]azepine as raw material,5-chloroformyl-5H-dibenz[b,f]azepine was prepared by reflux with triphosgene in toluene,brominated with bromine in chlorobenzene,and dehydrobrominated at 130℃,finally,the title compound was obtained by removing chloroformyl group with NaOH in isopropanol with 80.4% overall yield.The optimal reaction conditions and yields (temperature,time,molar yield) were as follows: acyl chlorination,110℃,10 h,93.0%; bromination,dehydrobromination,100℃,2 h,130℃,5 h,88.0%; removal of chloroformyl group,40℃,3 h,98.2%. The melting point of the title compound was the same as literature reported,and its structure was confirmed by 1H NMR.The optimal technology condition to remove chloroformyl group as protection group and its application of protection for some amine compounds were also studied.
