Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of t...Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean population.Methods: We conducted a case–control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012. Each control was selected and individually matched to each patient based on sex, ethnicity, and age(±5 years). A total of 290 pairs of cases and controls were matched successfully. We examined lifestyle factors such as tobacco smoking, alcohol drinking, various salted and preserved food consumption, and weaning practices.Results: After adjusting for covariates, multivariate analysis showed that those participants who were current smokers and had ever smoked tobacco had a higher risk of NPC than participants who had never smoked, with odds ratios(ORs) of 4.50(95% confidence interval [CI] 2.58–7.86; P < 0.001) and 2.52(95% CI 1.54–4.12; P < 0.001), respectively. Those who consumed salted vegetables at least once a week also showed a significantly increased risk of NPC than those who never or rarely consumed salted vegetables, with an OR of 4.18(95% CI 1.69–10.38; P = 0.002).Conclusion: Smoking(currently and ever-smoked) and consuming salted vegetables once a week or more were lifestyle risk factors for NPC, and changes of these factors for the better may reduce the risk of NPC.展开更多
Aim： To investigate possible correlation factors for prostate cancer by a population-based case-control study in China. Methods： We carded out a mass screening of prostate cancer in Changchun, China, using a prostat...Aim： To investigate possible correlation factors for prostate cancer by a population-based case-control study in China. Methods： We carded out a mass screening of prostate cancer in Changchun, China, using a prostate-specific antigen assisted by Japan International Cooperation Agency. From June 1998 to December 2000, 3 940 men over 50 years old were screened. Of these, 29 men were diagnosed with prostate cancer. We selected 28 cases and matched them with controls of low prostate-specific antigen value （〈 4.1 ng/mL） by 1：10 according to age and place of employment. A case-control study of diet and prostate cancer was then carded out. Results： After adjustment for education, body mass index （BMI）, smoking, alcohol consumption, marriage and diet, intake of soybean product was discovered to be inversely related to prostate cancer. Men who consumed soybean product more than twice per week on different days had a multivariate odds ratio （OR） of 0.38 （95% confidence interval [CI], 0.13-1.12）. In addition, men who consumed soybean products more than once per day had a multivariate OR of 0.29 （95% CI, 0.11-0.79） compared with men who consumed soybean products less than once per week. The P for trend was 0.02, which showed significant difference. There was no significant difference in P trend for any dairy food. Even when we matched the cases and controls by other criteria, we found that soybean food was the only preventive factor associated with prostate cancer. Conclusion： Our study suggests that consumption of soybeans, one of the most popular foods in Asia, would decrease the risk of prostate cancer.展开更多
Objective： To investigate the efficacy of dietary therapy of qi-yin-reinforcing porridge for the alleviation of clinical symptoms during FOLFOX chemotherapy. Methods： A single-case randomized controlled study was ca...Objective： To investigate the efficacy of dietary therapy of qi-yin-reinforcing porridge for the alleviation of clinical symptoms during FOLFOX chemotherapy. Methods： A single-case randomized controlled study was carded out. Fourteen patients with gastrointestinal tumors accepting FOLFOX chemotherapy were enrolled using self-crossover control design. On days 1-7 of chemotherapy, the dietary therapy expedmental group and the placebo control group were given dietary therapy of qi-yin-reinforcing porridge and dextrin-prepared porridge which had the same appearance, smell, color and taste as the qi-yin-reinforcing porridge, respectively. Fourteen clinical symptoms, including debility, vomiting and nausea, etc. were observed. Restdts： Ten patients completed the study and were estimable. The qi-yin-reinforcing porridge demonstrated certain efficacy in alleviating clinical symptoms of patients with gastrointestinal tumors during the pedod of chemotherapy. Better effect of alleviating debility was found in the dietary therapy expedmantal group than in the placebo control group, and the difference was statistically significant （Z=2.27, P=0.02）. No statistically significant difference was found between the experimental group and the control group with respect to the effect of alleviating the other 13 clinical symptoms including anorexia, nausea, vomiting, dry stool, loose stool, etc. and body weight （P〉0.05）. Conclusion： Dietary therapy of qi-yin-reinforcing porridge shows an additional benefit in alleviating debility of patients during chemotherapy and deserves clinical use and popularization.展开更多
目的综合评价中国人群H型高血压与脑梗死的关系。方法计算机检索Pub Med、Web of Science、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)和万方数据库(Wanfang Database),收集有关中国人群...目的综合评价中国人群H型高血压与脑梗死的关系。方法计算机检索Pub Med、Web of Science、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)和万方数据库(Wanfang Database),收集有关中国人群H型高血压与脑梗死关系的病例对照研究,病例组为脑梗死患者,对照组为非脑梗死患者,检索时限为从各数据库建库至2015年1月。由2名研究人员独立提取资料并评价纳入文献的质量,采用Rev Man 5.2软件进行Meta分析。结果共纳入9篇文献进行Meta分析,均为中文文献。结果显示,病例组H型高血压发病率与对照组比较,差异有统计学意义〔OR=2.50,95%CI(1.59,3.91),P<0.05〕。H型高血压与急性脑梗死〔OR=2.65,95%CI(1.52,4.63),P<0.05〕和无症状脑梗死〔OR=2.10,95%CI(1.14,3.87),P<0.05〕的发生均相关。亚组分析结果表明,年龄>60岁的人群中,病例组H型高血压发病率与对照组间差异有统计学意义〔OR=2.27,95%CI(1.41,3.66),P<0.05〕。敏感性分析与发表偏倚分析表明本研究结果稳定、可靠。结论脑梗死患者与非脑梗死患者相比,H型高血压发病率更高,提示中国人群H型高血压与脑梗死关系密切,H型高血压患者可能更易患脑梗死。展开更多
基金This study was funded by a grant from the National Cancer Centre Singapore Research Fund(CEFIA 08113-25260790-CREF-IARC)(Grant No.CEFIA08136).
文摘Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean population.Methods: We conducted a case–control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012. Each control was selected and individually matched to each patient based on sex, ethnicity, and age(±5 years). A total of 290 pairs of cases and controls were matched successfully. We examined lifestyle factors such as tobacco smoking, alcohol drinking, various salted and preserved food consumption, and weaning practices.Results: After adjusting for covariates, multivariate analysis showed that those participants who were current smokers and had ever smoked tobacco had a higher risk of NPC than participants who had never smoked, with odds ratios(ORs) of 4.50(95% confidence interval [CI] 2.58–7.86; P < 0.001) and 2.52(95% CI 1.54–4.12; P < 0.001), respectively. Those who consumed salted vegetables at least once a week also showed a significantly increased risk of NPC than those who never or rarely consumed salted vegetables, with an OR of 4.18(95% CI 1.69–10.38; P = 0.002).Conclusion: Smoking(currently and ever-smoked) and consuming salted vegetables once a week or more were lifestyle risk factors for NPC, and changes of these factors for the better may reduce the risk of NPC.
基金We would appreciate the contribution of Prof. Kuwahara （Miyagi Prefecture Cancer Center, Japan） in this project. We would appreciate Mr. Robert Lister＇s critical reading and revision of our manuscript. This research was supported by the National Natural Science Foundation of China （Grant No. 30700827）, Changchun City Science and Technology Department （Grant No. 2007125）, and Northeast Normal University （Grant No. NENU-STC07005）.
文摘Aim： To investigate possible correlation factors for prostate cancer by a population-based case-control study in China. Methods： We carded out a mass screening of prostate cancer in Changchun, China, using a prostate-specific antigen assisted by Japan International Cooperation Agency. From June 1998 to December 2000, 3 940 men over 50 years old were screened. Of these, 29 men were diagnosed with prostate cancer. We selected 28 cases and matched them with controls of low prostate-specific antigen value （〈 4.1 ng/mL） by 1：10 according to age and place of employment. A case-control study of diet and prostate cancer was then carded out. Results： After adjustment for education, body mass index （BMI）, smoking, alcohol consumption, marriage and diet, intake of soybean product was discovered to be inversely related to prostate cancer. Men who consumed soybean product more than twice per week on different days had a multivariate odds ratio （OR） of 0.38 （95% confidence interval [CI], 0.13-1.12）. In addition, men who consumed soybean products more than once per day had a multivariate OR of 0.29 （95% CI, 0.11-0.79） compared with men who consumed soybean products less than once per week. The P for trend was 0.02, which showed significant difference. There was no significant difference in P trend for any dairy food. Even when we matched the cases and controls by other criteria, we found that soybean food was the only preventive factor associated with prostate cancer. Conclusion： Our study suggests that consumption of soybeans, one of the most popular foods in Asia, would decrease the risk of prostate cancer.
基金Supported by the Funding of Medical Capital Development Fund of Beijing Administration of Traditional Chinese Medicine (No.SF-2007-1-05)
文摘Objective： To investigate the efficacy of dietary therapy of qi-yin-reinforcing porridge for the alleviation of clinical symptoms during FOLFOX chemotherapy. Methods： A single-case randomized controlled study was carded out. Fourteen patients with gastrointestinal tumors accepting FOLFOX chemotherapy were enrolled using self-crossover control design. On days 1-7 of chemotherapy, the dietary therapy expedmental group and the placebo control group were given dietary therapy of qi-yin-reinforcing porridge and dextrin-prepared porridge which had the same appearance, smell, color and taste as the qi-yin-reinforcing porridge, respectively. Fourteen clinical symptoms, including debility, vomiting and nausea, etc. were observed. Restdts： Ten patients completed the study and were estimable. The qi-yin-reinforcing porridge demonstrated certain efficacy in alleviating clinical symptoms of patients with gastrointestinal tumors during the pedod of chemotherapy. Better effect of alleviating debility was found in the dietary therapy expedmantal group than in the placebo control group, and the difference was statistically significant （Z=2.27, P=0.02）. No statistically significant difference was found between the experimental group and the control group with respect to the effect of alleviating the other 13 clinical symptoms including anorexia, nausea, vomiting, dry stool, loose stool, etc. and body weight （P〉0.05）. Conclusion： Dietary therapy of qi-yin-reinforcing porridge shows an additional benefit in alleviating debility of patients during chemotherapy and deserves clinical use and popularization.
文摘目的综合评价中国人群H型高血压与脑梗死的关系。方法计算机检索Pub Med、Web of Science、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)和万方数据库(Wanfang Database),收集有关中国人群H型高血压与脑梗死关系的病例对照研究,病例组为脑梗死患者,对照组为非脑梗死患者,检索时限为从各数据库建库至2015年1月。由2名研究人员独立提取资料并评价纳入文献的质量,采用Rev Man 5.2软件进行Meta分析。结果共纳入9篇文献进行Meta分析,均为中文文献。结果显示,病例组H型高血压发病率与对照组比较,差异有统计学意义〔OR=2.50,95%CI(1.59,3.91),P<0.05〕。H型高血压与急性脑梗死〔OR=2.65,95%CI(1.52,4.63),P<0.05〕和无症状脑梗死〔OR=2.10,95%CI(1.14,3.87),P<0.05〕的发生均相关。亚组分析结果表明,年龄>60岁的人群中,病例组H型高血压发病率与对照组间差异有统计学意义〔OR=2.27,95%CI(1.41,3.66),P<0.05〕。敏感性分析与发表偏倚分析表明本研究结果稳定、可靠。结论脑梗死患者与非脑梗死患者相比,H型高血压发病率更高,提示中国人群H型高血压与脑梗死关系密切,H型高血压患者可能更易患脑梗死。
