DIAGONAL POINT BY POINT SURFACE DEVELOPMENT METHOD BASED ON NURBS SURFACE FOR BLANK SHAPE ESTIMATION OFCOVER PANEL

According to the characteristics of a complex cover panel, its geometry shape is described by the NURBS surface with great description capability. With the reference to the surface classification determined by Gauss curvature, the proportion of the mid-surface area between before and after being developed is derived from the displacement variation of the mid-surface in the normal vector direction of the sheet metal during the sheet metal forming process. Hereby, based on the curve development theory in differential geometry, a novel diagonal point by point surface development method is put forward to estimate a complex cover panel＇s blank contour efficiently. By comparing the sample＇s development result of diagonal point by point surface development method with that of available one-step method, the validity of the proposed surface development method is verified.

A computational model of the human glucose-insulin regulatory system

Objective：A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced.The proposed method for the estimation of parameters for a system of ordinary differential equations（ODEs）that represent the time course of plasma glucose and insulin concentrations during glucose tolerance test（GTT）in physiological studies is presented.The aim of this study was to explore how to interpret those laboratory glucose and insulin data as well as enhance the Ackerman mathematical model.Methods：Parameters estimation for a system of ODEs was performed by minimizing the sum of squared residuals（SSR）function,which quantifies the difference between theoretical model predictions and GTT＇s experimental observations.Our proposed perturbation search and multiple-shooting methods were applied during the estimating process.Results：Based on the Ackerman＇s published data,we estimated the key parameters by applying R-based iterative computer programs.As a result,the theoretically simulated curves perfectly matched the experimental data points.Our model showed that the estimated parameters,computed frequency and period values,were proven a good indicator of diabetes.Conclusion：The present paper introduces a computational algorithm to biomedical problems,particularly to endocrinology and metabolism fields,which involves two coupled differential equations with four parameters describing the glucose-insulin regulatory system that Ackerman proposed earlier.The enhanced approach may provide clinicians in endocrinology and metabolism field insight into the transition nature of human metabolic mechanism from normal to impaired glucose tolerance.

Robust Estimation of Parameters in Nonlinear Ordinary Differential Equation Models

Ordinary differential equation(ODE) models are widely used to model dynamic processes in many scientific fields.Parameter estimation is usually a challenging problem,especially in nonlinear ODE models.The most popular method,nonlinear least square estimation,is shown to be strongly sensitive to outliers.In this paper,robust estimation of parameters using M-estimators is proposed,and their asymptotic properties are obtained under some regular conditions.The authors also provide a method to adjust Huber parameter automatically according to the observations.Moreover,a method is presented to estimate the initial values of parameters and state variables.The efficiency and robustness are well balanced in Huber estimators,which is demonstrated via numerical simulations and chlorides data analysis.

BOUNDARY DIFFERENCE-INTEGRAL EQUATION METHOD AND ITS ERROR ESTIMATES FOR SECOND ORDER HYPERBOLIC PARTIAL DIFFERENTIAL EQUATION

Combining difference method and boundary integral equation method,we propose a new numerical method for solving initial-boundary value problem of second order hyperbolic partial differential equations defined on a bounded or unbounded domain in R~3 and obtain the error estimates of the approximate solution in energy norm and local maximum norm.