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Differential Effects of Butyric Acid on Mouse Skin Tumorigenesis 被引量:1
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作者 KRISHNAP·GUPTA N·K·MEHROTRA 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1997年第4期436-441,共6页
We studied the effects of butyric acid (BA) on mouse skin tumorigenesis using chronicanimal bioassays. Topical application of BA immediately after each treatment with 12-0-te-t radecanoyl phorbol-13-acetate (TPA) prom... We studied the effects of butyric acid (BA) on mouse skin tumorigenesis using chronicanimal bioassays. Topical application of BA immediately after each treatment with 12-0-te-t radecanoyl phorbol-13-acetate (TPA) promoter' inhi bi ted skint umors. The effect was depe n -dent on the dose of BA applied. BA showed no marked inhibitory effect on either skin tumorinitiation or complete tumorigenesis induced by dimet hyl benzant hracene (DMBA ). Si nce t u -mor promotion reportedly involves epigenetic events whereas tumor initiation or complete tu-morigenesis takes place through genetic pathways, it is Possible that BA exerts its antitumori-genic effects mainly by altering the epigenetic events responsible for tumor promotion. The re-sults of the study could further be used to study the mechanism of action and modification ofantitumorigenic effects of BA in combination with other substances 展开更多
关键词 DMBA differential effects of Butyric Acid on Mouse Skin Tumorigenesis
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Differential effects of d,l-sotalol and d-sotalol on isoproterenol increased delayed rectifier outward potassium current in guinea pig myocytes
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作者 X.Z. Yao, N.C. Yannoulis, J.Kiehn and J.Brachmann 《Chinese Medical Journal》 SCIE CAS CSCD 1997年第12期51-51,共1页
Objective Catecholamines antagonize the clinical efficacy of pure class Ⅲ antiarrhythmic agents in vivo. The antiarrhythmic agent d, l sotalol has β adrenergic blocking properties and class Ⅲ activity. However, ... Objective Catecholamines antagonize the clinical efficacy of pure class Ⅲ antiarrhythmic agents in vivo. The antiarrhythmic agent d, l sotalol has β adrenergic blocking properties and class Ⅲ activity. However, its d isomer without β blockade has been shown to exert significant proarrhythmia. To determine the role of β adrenergic blocking properties of d, l sotalol on its antiarrhythmic effect, we compared the effects of d, l sotalol and d sotalol on delayed rectifier K + outward current in the presence of isoproterenol at different concentrations. Methods Time dependent delayed rectifier K + outward currents, I K (I Kr and I Ks ) and tail current (I K tail ) were measured in isolated guinea pig myocytes using the whole cell configuration of the patch clamp technique. Currents were measured in response to 300 ms depolarizing pulses from a holding potential of Department of Cardiology, University Hospital Heidelberg, Germany (Yao XZ, Yannoulis NC, Kiehn J and Brachmann J) 40 mV in three experimental protocols [control, isoproterenol (10 9 -10 6 mol/L), and isoproterenol (10 9 -10 6 mol/L) plus either d, l sotalol (10 4 mol/L) or d sotalol (10 4 mol/L)]. I K tail currents were measured upon repolarization to 40 mV. Results Isoproterenol significantly inreased I K and I K tail in a concentration dependent manner. I K was significantly amplified in the presence of isoproterenol (10 9 -10 6 mol/L) plus d sotalol. At 10 8 mol/L isoproterenol, I K was increased by 92.3%±23.7% before and 54.3%±13.4% after d sotalol. In contrast, d, l sotalol strongly suppressed the effect of isoproterenol on I K, and compared to control, I K was decreased by 35.6%±8.1% at 10 8 mol/L isoproterenol. Conclusions The β adrenergic blocking property of d, l sotalol maintains delayed rectifier K + outward current block in the presence of isoproterenol in guinea pig myocytes. This may result in its supperior antiarrhythmic efficacy compared to d sotalol. 展开更多
关键词 differential effects of d l-sotalol and d-sotalol on isoproterenol increased delayed rectifier outward potassium current in guinea pig myocytes
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EFFECT OF LOW SELENIUM ON CHONDROCYTE DIFFERENTIATION AND DIFFERENTIAL EXPRESSION OF COLLAGEN TYPES Ⅰ,Ⅱ AND Ⅹ IN ARTICULAR CARTILAGE FROM MINI-PIGS 被引量:3
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作者 郭雄 于志道 熊咏民 《Academic Journal of Xi'an Jiaotong University》 2000年第2期108-112,172,共6页
关键词 KBD effect OF LOW SELENIUM ON CHONDROCYTE DIFFERENTIATION AND differential EXPRESSION OF COLLAGEN TYPES IN ARTICULAR CARTILAGE FROM MINI-PIGS AND
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Nucleus-Nucleus Effects in Fully Differential Cross Sections for Energetic C6++He Collisions with Small Momentum Transfer
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作者 陆晨文 安文芳 +1 位作者 孙世艳 贾祥富 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第9期35-38,共4页
The modified Coulomb-Born approximation with and without the internuclear interaction (MCB-NN and MCB) is used to calculate the fully differential cross sections (FDCS) for the single ionization of helium by lOO M... The modified Coulomb-Born approximation with and without the internuclear interaction (MCB-NN and MCB) is used to calculate the fully differential cross sections (FDCS) for the single ionization of helium by lOO MeV/amu C6+ impact. The effects of the internuclear interaction on the FDCS are examined in geometries. The results are compared with experimental data and theoretical predictions from a three-body distorted-wave (3DW) model and a time-dependent close-coupling model. It is shown that the present MCB-NN results are in good agreement with the experiments in the scattering plane and the MCB results qualitatively reproduce the experimental structure outside the scattering plane. In particular, the MCB theory predicts the 'double-peak' structure in the perpendicular plane. 展开更多
关键词 MCB NN Nucleus-Nucleus effects in Fully differential Cross Sections for Energetic C He Collisions with Small Momentum Transfer
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Dynamics of Quantum State and Effective Hamiltonian with Vector Differential Form of Motion Method
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作者 Long Xiong Wei-Feng Zhuang Ming Gong 《Chinese Physics Letters》 SCIE EI CAS CSCD 2022年第7期36-40,共5页
Effective Hamiltonians in periodically driven systems have received widespread attention for realization of novel quantum phases, non-equilibrium phase transition, and Majorana mode. Recently, the study of effective H... Effective Hamiltonians in periodically driven systems have received widespread attention for realization of novel quantum phases, non-equilibrium phase transition, and Majorana mode. Recently, the study of effective Hamiltonian using various methods has gained great interest. We consider a vector differential equation of motion to derive the effective Hamiltonian for any periodically driven two-level system, and the dynamics of the spin vector are an evolution under the Bloch sphere. Here, we investigate the properties of this equation and show that a sudden change of the effective Hamiltonian is expected. Furthermore, we present several exact relations, whose expressions are independent of the different starting points. Moreover, we deduce the effective Hamiltonian from the high-frequency limit, which approximately equals the results in previous studies. Our results show that the vector differential equation of motion is not affected by a convergence problem, and thus, can be used to numerically investigate the effective models in any periodic modulating system. Finally, we anticipate that the proposed method can be applied to experimental platforms that require time-periodic modulation, such as ultracold atoms and optical lattices. 展开更多
关键词 Dynamics of Quantum State and effective Hamiltonian with Vector differential Form of Motion Method HAMILTONIAN VECTOR QUANTUM
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A chaotic hierarchical encryption/watermark embedding scheme for multi-medical images based on row-column confusion and closed-loop bi-directional diffusion
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作者 张哲祎 牟俊 +1 位作者 Santo Banerjee 曹颖鸿 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期228-237,共10页
Security during remote transmission has been an important concern for researchers in recent years.In this paper,a hierarchical encryption multi-image encryption scheme for people with different security levels is desi... Security during remote transmission has been an important concern for researchers in recent years.In this paper,a hierarchical encryption multi-image encryption scheme for people with different security levels is designed,and a multiimage encryption(MIE)algorithm with row and column confusion and closed-loop bi-directional diffusion is adopted in the paper.While ensuring secure communication of medical image information,people with different security levels have different levels of decryption keys,and differentiated visual effects can be obtained by using the strong sensitivity of chaotic keys.The highest security level can obtain decrypted images without watermarks,and at the same time,patient information and copyright attribution can be verified by obtaining watermark images.The experimental results show that the scheme is sufficiently secure as an MIE scheme with visualized differences and the encryption and decryption efficiency is significantly improved compared to other works. 展开更多
关键词 chaotic hierarchical encryption multi-medical image encryption differentiated visual effects row-column confusion closed-loop bi-directional diffusion transform domain watermark embedding
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Electroacupuncture pretreatment exhibits antidepressive effects by regulating hippocampal proteomics in rats with chronic restraint stress 被引量:8
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作者 Zhuo Guo Ya Tu +7 位作者 Tian-wei Guo Yun-chu Wu Xue-qin Yang Lan Sun Xin-jing Yang Wen-yue Zhang Yu Wang Xu-hui Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第8期1298-1304,共7页
The clinical effect of electroacupuncture on depression is widely recognized. However, the signal transduction pathways and target proteins involved remain unclear. In the present study, rat models of chronic restrain... The clinical effect of electroacupuncture on depression is widely recognized. However, the signal transduction pathways and target proteins involved remain unclear. In the present study, rat models of chronic restraint stress were used to explore the mechanism by which electroacupuncture alleviates depression. Rats were randomly divided into control, model, and electroacupuncture groups. Chronic restraint stress was induced in the model and electroacupuncture groups by restraining rats for 28 days. In the electroacupuncture group, electroacupuncture pretreatment at Baihui(GV20) and Yintang(GV29) acupoints was performed daily(1 m A, 2 Hz, discontinuous wave, 20 minutes) prior to restraint for 28 days. Open field tests and body weight measurements were carried out to evaluate the depressive symptoms at specific time points. On day 28, the crossing number, rearing number, and body weights of the model group were significantly lower than those in the control group. Behavior test results indicated that rat models of depressive-like symptoms were successfully established by chronic restraint stress combined with solitary raising. On day 28, an isobaric tag for a relative and absolute quantitation-based quantitative proteomic approach was performed to identify differentially expressed proteins in hippocampal samples obtained from the model and electroacupuncture groups. The potential function of these differential proteins was predicted through the use of the Cluster of Orthologous Groups of proteins(COG) database. Twenty-seven differential proteins(uncharacteristic proteins expected) were selected from the model and electroacupuncture groups. In addition to unknown protein functions, COG are mainly concentrated in general prediction function, mechanism of signal transduction, amino acid transport and metabolism groups. This suggests that electroacupuncture improved depressive-like symptoms by regulating differential proteins, and most of these related proteins exist in nerve cells. 展开更多
关键词 nerve regeneration traditional Chinese medicine electroacupuncture depression chronic restraint stress i TRAQ differential protein proteomics multi-target effect neural regeneration
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Tunneling field effect transistors based on in-plane and vertical layered phosphorus heterostructures
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作者 冯申艳 张巧璇 +2 位作者 杨洁 雷鸣 屈贺如歌 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第9期421-427,共7页
Tunneling field effect transistors(TFETs) based on two-dimensional materials are promising contenders to the traditional metal oxide semiconductor field effect transistor, mainly due to potential applications in low... Tunneling field effect transistors(TFETs) based on two-dimensional materials are promising contenders to the traditional metal oxide semiconductor field effect transistor, mainly due to potential applications in low power devices. Here,we investigate the TFETs based on two different integration types: in-plane and vertical heterostructures composed of two kinds of layered phosphorous(β-P and δ-P) by ab initio quantum transport simulations. NDR effects have been observed in both in-plane and vertical heterostructures, and the effects become significant with the highest peak-to-valley ratio(PVR)when the intrinsic region length is near zero. Compared with the in-plane TFET based on β-P and δ-P, better performance with a higher on/off current ratio of - 10-6 and a steeper subthreshold swing(SS) of - 23 mV/dec is achieved in the vertical TFET. Such differences in the NDR effects, on/off current ratio and SS are attributed to the distinct interaction nature of theβ-P and δ-P layers in the in-plane and vertical heterostructures. 展开更多
关键词 tunneling field effect transistors negative differential resistance effect on/off current ratio subthreshold swing
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Identification of thermal effects involved in DSC experiment on Al-Cu-Mg-Ag alloys with high Cu:Mg ratio
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作者 Jian-bo Zhang Yong-an Zhang Bao-hong Zhu Feng Wang Zhi-hui Li Xi-wu Li Bai-qing Xiong 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2011年第6期671-675,共5页
Precipitation reactions in the differential scanning calorimetry (DSC) of an Al-Cu-Mg-Ag alloy were identified by analyzing the results from hardness test,electrical conductivity test,and transmission electron micro... Precipitation reactions in the differential scanning calorimetry (DSC) of an Al-Cu-Mg-Ag alloy were identified by analyzing the results from hardness test,electrical conductivity test,and transmission electron microscope (TEM) examination.It is discovered that thermal effects can be identified through selected area electron diffraction and bright-field images.The reaction peaks around 171,231,and 276℃ can be attributed to a structural rearrangement of coherent zones,to the precipitation of Ω phases,and to the precipitation of Ω and θ' and possible combination with the transition of θ'→θ,respectively.In addition,the hardness and electrical conductivity of the alloy change proportionately with the progression of reactions during the heating process.This phenomenon can be attributed to the evolution of the micro-structure. 展开更多
关键词 aluminum alloys thermal effects identification differential scanning calorimetry microstructure
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Gas-sensor property of single-molecule device:F_2 adsorbing effect
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作者 李宗良 毕俊杰 +5 位作者 刘然 衣晓华 傅焕俨 孙峰 魏明志 王传奎 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第9期536-541,共6页
The single thiolated arylethynylene molecule with 9,10-dihydroanthracene core(denoted as TADHA) possesses pronounced negative differential conductance(NDC) behavior at lower bias regime. The adsorption effects of ... The single thiolated arylethynylene molecule with 9,10-dihydroanthracene core(denoted as TADHA) possesses pronounced negative differential conductance(NDC) behavior at lower bias regime. The adsorption effects of F2 molecule on the current and NDC behavior of TADHA molecular junctions are studied by applying non-equilibrium Green's formalism combined with density functional theory. The numerical results show that the F2 molecule adsorbed on the benzene ring of TADHA molecule near the electrode can dramatically suppresses the current of TADHA molecular junction. When the F2 molecule adsorbed on the conjugated segment of 9,10-dihydroanthracene core of TADHA molecule, an obviously asymmetric effect on the current curves induces the molecular system showing apparent rectifier behavior. However, the current especially the NDC behavior have been significantly enlarged when F2 addition reacted with triple bond of TADHA molecule. 展开更多
关键词 molecular device negative differential conductance(NDC) F2 adsorption gas-sensor effect
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Cooling rate effects on the structure and transformation behavior of Cu-Zn-Al shape memory alloys
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作者 Nicoleta-Monica Lohan Marius-Gabriel Suru +1 位作者 Bogdan Pricop Leandru-Gheorghe Bujoreanu 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2014年第11期1109-1114,共6页
Different fragments of a hot-rolled and homogenized Cu–Zn–Al shape memory alloy(SMA) were subjected to thermal cycling by means of a differential scanning calorimetric(DSC) device. During thermal cycling, heatin... Different fragments of a hot-rolled and homogenized Cu–Zn–Al shape memory alloy(SMA) were subjected to thermal cycling by means of a differential scanning calorimetric(DSC) device. During thermal cycling, heating was performed at the same constant rate of increasing temperature while cooling was carried out at different rates of decreasing temperature. For each cooling rate, the temperature decreased in the same thermal interval. During each cooling stage, an exothermic peak(maximum) was observed on the DSC thermogram. This peak was associated with forward martensitic transformation. The DSC thermograms were analyzed with PROTEUS software: the critical martensitic transformation start(Ms) and finish(Mf) temperatures were determined by means of integral and tangent methods, and the dissipated heat was evaluated by the area between the corresponding maximum plot and a sigmoid baseline. The effects of the increase in cooling rate, assessed from a calorimetric viewpoint, consisted in the augmentation of the exothermic peak and the delay of direct martensitic transformation. The latter had the tendency to move to lower critical transformation temperatures. The martensite plates changed in morphology by becoming more oriented and by an augmenting in surface relief, which corresponded with the increase in cooling rate as observed by scanning electron microscopy(SEM) and atomic force microscopy(AFM). 展开更多
关键词 copper alloys shape memory effect microstructure phase transformations martensite cooling rate differential scanning calo-rimetry
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Two-dimensional tetragonal ZnB: A nodalline semimetal with good transport properties
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作者 赵永春 朱铭鑫 +1 位作者 李胜世 李萍 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第6期529-536,共8页
Nodal-line semimetals have become a research hot-spot due to their novel properties and great potential application in spin electronics. It is more challenging to find 2D nodal-line semimetals that can resist the spin... Nodal-line semimetals have become a research hot-spot due to their novel properties and great potential application in spin electronics. It is more challenging to find 2D nodal-line semimetals that can resist the spin–orbit coupling(SOC)effect. Here, we predict that 2D tetragonal Zn B is a nodal-line semimetal with great transport properties. There are two crossing bands centered on the S point at the Fermi surface without SOC, which are mainly composed of the pxy orbitals of Zn and B atoms and the pz orbitals of the B atom. Therefore, the system presents a nodal line centered on the S point in its Brillouin zone(BZ). And the nodal line is protected by the horizontal mirror symmetry M_(z). We further examine the robustness of a nodal line under biaxial strain by applying up to-4% in-plane compressive strain and 5% tensile strain on the Zn B monolayer, respectively. The transmission along the a direction is significantly stronger than that along the b direction in the conductive channel. The current in the a direction is as high as 26.63 μA at 0.8 V, and that in the b direction reaches 8.68 μA at 0.8 V. It is interesting that the transport characteristics of Zn B show the negative differential resistance(NDR) effect after 0.8 V along the a(b) direction. The results provide an ideal platform for research of fundamental physics of 2D nodal-line fermions and nanoscale spintronics, as well as the design of new quantum devices. 展开更多
关键词 nodal-line semimetals negative differential resistance(NDR)effect horizontal mirror symmetry
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Microstructure and thermal conductivity of copper matrix composites reinforced with mixtures of diamond and SiC particles 被引量:14
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作者 Han, Yuanyuan Guo, Hong +3 位作者 Yin, Fazhang Zhang, Ximin Chu, Ke Fan, Yeming 《Rare Metals》 SCIE EI CAS CSCD 2012年第1期58-63,共6页
The thermal conductivity of diamond hybrid SiC/Cu,diamond/Cu and SiC/Cu composite were calculated by using the extended differential effective medium (DEM) theoretical model in this paper.The effects of the particle v... The thermal conductivity of diamond hybrid SiC/Cu,diamond/Cu and SiC/Cu composite were calculated by using the extended differential effective medium (DEM) theoretical model in this paper.The effects of the particle volume fraction,the particle size and the volume ratio of the diamond particles to the total particles on the thermal conductivity of the composite were studied.The DEM theoretical calculation results show that,for the diamond hybrid SiC/Cu composite,when the particle volume fraction is above 46% and the volume ratio of the diamond particles to the SiC particles is above 13:12,the thermal conductivity of the composite can reach 500 W·m-1·K-1.The thermal conduc-tivity of the composite has little change when the particle size is above 200μm.The experimental results show that Ti can improve the wettability of the SiC and Cu.The thermal conductivity of the diamond hybrid SiCTi/Cu is almost two times better than that of the diamond hybrid SiC/Cu.It is feasible to predict the thermal conductivity of the composite by DEM theoretical model. 展开更多
关键词 diamond hybrid SiC/Cu composite MICROSTRUCTURE thermal conductivity differential effective medium
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Mathematical Study of A Memory Induced Biochemical System 被引量:1
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作者 Mithun Kumar Ghosh Tridip Sardar +1 位作者 Xianbing Cao Priti Kumar Roy 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2018年第6期1142-1149,共8页
In this work, to study the effect of memory on a bi-substrate enzyme kinetic reaction, we have introduced an approach to fractionalize the system, considering it as a threecompartmental model. Solutions of the fractio... In this work, to study the effect of memory on a bi-substrate enzyme kinetic reaction, we have introduced an approach to fractionalize the system, considering it as a threecompartmental model. Solutions of the fractionalized system are compared with the corresponding integer-order model. The equilibrium points of the fractionalized system are derived analytically. Their stability properties are discussed from numerical aspect. We determine the changes of the substances due to the changes of "memory effect". The effect is discussed critically from the perspective of product formation. We have also analyzed the memory induced system with a control measure in view of optimizing the product. Our numerical result reveals that the solutions of the fractionalized system, when it is free from memory, are in good agreement with the integer-order system.It is noticed that the effect of memory influences the reaction in the forward direction and assists in yielding the product more quickly. However, an extensive use of memory makes the system slower, but introduction of a control input makes the reaction faster. It is possible to overcome the slowness of the reaction due to the undue effect of memory by appropriate use of a control measure. 展开更多
关键词 Bi-substrate enzymatic reaction compartmental system control theoretic approach fractional-order differential equations memory effect
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Negative differential resistance effects induced by protonation in naphthalocyanine molecular junctions
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作者 CHEN Yiming ZHAO Wanzhu +3 位作者 ZHANG Baiyang WU Kangle BIAN Jiangyu CHANG Yingfei 《分子科学学报》 CAS 2024年第4期358-362,共5页
The electronic and transport characteristics of protonated derivatives of naphthalocyanine(Nc)were investigated using density functional theory and non-equilibrium Green's functions.The results indicate that the p... The electronic and transport characteristics of protonated derivatives of naphthalocyanine(Nc)were investigated using density functional theory and non-equilibrium Green's functions.The results indicate that the protonation of external meso-N atoms of Nc preserves its planar structure and is energetically more favorable than the protonation of internal isoindole-N atoms.The protonation shifts the energy levels of system's frontier molecular orbitals closer to the Fermi level,thus creating channels for electron transport.In contrast with the semiconductor transport properties of H2Nc,its protonation products respond more sensitively to bias and exhibit negative differential resistance phenomena at specific bias. 展开更多
关键词 protonation reaction electronic structure transport property naphthalocyanine negative differential resistance effect
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Large electrocaloric effect in BaTiO_3 based multilayer ceramic capacitors 被引量:3
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作者 LU Biao WEN XinHua +8 位作者 TANG ZhenHua LIANG Bo TAO Tao XIE ZhiWei ZHANG TianFu TANG XinGui XIANG Yong LIAO Jie LU ShengGuo 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2016年第7期1054-1058,共5页
The electrocaloric effect(ECE) of multilayer ceramic capacitor(MLCC) of Y5 V type was directly measured via a differential scanning calorimetry(DSC) method and a reference resistor was used to calibrate the heat flow ... The electrocaloric effect(ECE) of multilayer ceramic capacitor(MLCC) of Y5 V type was directly measured via a differential scanning calorimetry(DSC) method and a reference resistor was used to calibrate the heat flow due to the heat dissipation. The results are compared with those calculated from Maxwell relations by using the polarization data obtained from the polarization–electric field hysteresis loops. The direct method shows a larger ECE temperature change, which is accounted for the situation approaches an ideal condition. For the indirect method using Maxwell relations, only the polarization projection along the electric field was taken into account, which will be less than the randomly distributed real polarizations that contribute to the ECE. The MLCCs exhibit a broad peak of ECE around 80 C, which will be favorite for the practical ECE cooling devices. 展开更多
关键词 multilayer ceramic capacitors maxwell relations electrocaloric effect polarization–electric field hysteresis loop differential scanning calorimetry
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DIFFERENTIATION OF THE TRUE AND INTERVENTION INDUCED PSEUDO-MILKING EFFECT BY INTRAVASCULAR ULTRASOUND
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作者 Peter Kearney Lothar Koch +1 位作者 Gunter Gorge Ramund Erbel 《Chinese Medical Journal》 SCIE CAS CSCD 1995年第3期70-71,共2页
We have shown the value of intravascular ultrasound (IVUS) in the evaluation of myocardial bridging (MB). The purpose of the study was to elucidate the mechanism of inter-
关键词 IVUS DIFFERENTIATION OF THE TRUE AND INTERVENTION INDUCED PSEUDO-MILKING effect BY INTRAVASCULAR ULTRASOUND
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Effects of arotinoid acid on induction of apoptosis and differentiation and telomerase activity and cell cycle in the HL 60 cell line
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作者 刘小珊 娄陵生 +7 位作者 蒋纪恺 曾淑蓉 唐宗山 张彦 许湘儒 刘北忠 何渝军 康格非 《Chinese Medical Journal》 SCIE CAS CSCD 2000年第2期47-47,共1页
Objective To investigate the effects of arotinoid acid (Ro13 7410) on the morphological and functional alterations of leukemia HL 60 cell line and compared with those of RA Methods Differentiation of HL 60 ce... Objective To investigate the effects of arotinoid acid (Ro13 7410) on the morphological and functional alterations of leukemia HL 60 cell line and compared with those of RA Methods Differentiation of HL 60 cells was assessed by morphology and by NBT reduction Trypan blue exclusion was used to determine viability Apoptosis was assessed by changes in cell morphology and by measurement of fragmented DNA using the PCD assay kit Telomerase PCR ELISA kit tested telomerase activity The cell cycle was analyzed by flow cytometry Results Incubation of the HL 60 cells with 10 -6 10 -8 ?mol/L Ro13 7410 resulted in suppression of cell growth Apoptotic cells were detected following exposure to 10 -6 ?mol/LRo13 7410 for 3 hours by measurement of the “in situ” enzymatic labeling of DNA breaks with biotinylated dUTP Ultrastructural examination of Ro13 7410 treated samples showed cells with chromatin compaction and cytoplasm condensation and the presence of “apoptotic bodies” Cells induced into apoptosis were accompanied by Department of Hematology, the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China (Liu XS, Lou LS, Zeng SR and Tang ZH) Department of Clinical Biochemistry, Chongqing University of Medical Sciences, Chongqing 400046, China (Jiang JK, Zhang Y, Xu XG, Liu BZ, He YJ and Kang GF) increase of intracellular free Ca 2+ Percentage of HL 60 cells reduced NBT following incubation with Ro13 7410 was lower than with all trans retinoic acid (RA) (27% vas 85%) Telomerase PCR ELISA assay showed that HL 60 cells cultured in the absence of inducing agents had significant telomerase activity Telomerase activity declined gradually after 10 -6 ?mol/L Ro13 7410 treatment, and changes becoming evident at 1 day The inhibition of telomerase activity at day 5 of treatment with Ro13 7410 was less effective than with RA DNA flow cytofluorimetric analysis revealed that Ro13 7410 caused partial cell arrest in the G 2/M phase after a 2 day treatment and the percentage of cells arrested in the G 2/M phase increased after 4 days treatment With RA treated cells, a reduction in the percentage of cells in the G 2/M phase was observed after 2 day of treatment Conclusion Our study shows that Ro13 7410 suppresses HL 60 cells growth mainly via the induction of apoptosis and is less effective than RA in induction differentiation Ro13 7410 dramatically inhibits telomerase activity during the course of induction and results in G 2/M arrest within 2 days These findings suggest that Ro13 7410 is worthy of further study for its effects on leukemic cells 展开更多
关键词 cell line and telomerase activity and cell cycle in the HL effects of arotinoid acid on induction of apoptosis and differentiation
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Combined effects of fluoride and arsenic exposure on proliferation,differentiation and beta-catenin expression in rat osteoblasts
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作者 宋晓甜 《China Medical Abstracts(Internal Medicine)》 2016年第3期138-139,共2页
<正>Objective To investigate the combined effects of fluoride(Na F)and arsenate(Na As O2)exposure on proliferation,differentiation and bata-catenin expression in SD rat osteoblasts.Methods Osteoblasts were isola... <正>Objective To investigate the combined effects of fluoride(Na F)and arsenate(Na As O2)exposure on proliferation,differentiation and bata-catenin expression in SD rat osteoblasts.Methods Osteoblasts were isolated from calvarias of twelve SD rats born in 1~3 days and cul- 展开更多
关键词 As Combined effects of fluoride and arsenic exposure on proliferation differentiation and beta-catenin expression in rat osteoblasts
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Thermal Conduction and Insulation Modification in Asphalt-Based Composites 被引量:1
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作者 Xiaofeng Zhou Shengyue Wang Chao Zhou 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2012年第3期285-288,共4页
The relationship between thermal conductivity and properties of mixing particles is required for quantitative study of heat transfer processes in asphalt-based materials. In this paper, we measured the e?ective ther-... The relationship between thermal conductivity and properties of mixing particles is required for quantitative study of heat transfer processes in asphalt-based materials. In this paper, we measured the e?ective ther- mal conductivity of asphalt-based materials with thermal conduction (graphite) and insulation (cenosphere) powders modification. By taking account of the particle shape, volume fraction, the thermal conductivity of filling particles and base asphalt, we present a new differential effective medium formula to predict the thermal conductivity modification in asphalt-based composite. Our theoretical predications are in good agreement with the experiment data. The new model can be applied for predicting the thermal properties of asphalt-based mixture, which is available for most of thermal modification in two-phase composites. 展开更多
关键词 Thermal conductivity Asphalt-based composites Graphite CENOSPHERE differential effective medium formula
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