奥林巴斯μ-40 DIGITAL倾情发布

继推出μ-mini之后，奥林巴斯近日又推出一款μ系列新机μ-40 DIGITAL该机外型靓丽，小巧可人，颜色鲜明。很受追求时尚的年轻人的青睐。

单反式数码相机柯尼卡美能达α-7DIGITAL

柯尼卡美能达α-7 DIGITAL数码单反相机，坚固耐用的镁合金机身，外观时尚．做工精致。它采用APS-C尺寸CCD影像传感器，有效像素为610万像素，内置RGB三色滤镜和低通滤镜。

Add-on pegylated interferon augments hepatitis B surface antigen clearance vs continuous nucleos(t)ide analog monotherapy in Chinese patients with chronic hepatitis B and hepatitis B surface antigen≤1500 IU/mL:An observational study

BACKGROUND Nucleos(t)ide analog(NA)has shown limited effectiveness against hepatitis B surface antigen(HBsAg)clearance in chronic hepatitis B(CHB)patients.AIM To evaluate the efficacy and safety of add-on peginterferonα-2a(peg-IFNα-2a)to an ongoing NA regimen in CHB patients.METHODS In this observational study,195 CHB patients with HBsAg≤1500 IU/m L,hepatitis B e antigen(HBeAg)-negative(including HBeAg-negative patients or HBeAg-positive patients who achieved HBeAg-negative after antiviral treatment with NA)and hepatitis B virus-deoxyribonucleic acid<1.0×10^2 IU/mL after over 1 year of NA therapy were enrolled between November 2015 and December2018 at the Second Affiliated Hospital of Xi'an Jiaotong University,China.Patients were given the choice between receiving either peg-IFNα-2a add-on therapy to an ongoing NA regimen(add-on group,n=91)or continuous NA monotherapy(monotherapy group,n=104)after being informed of the benefits and risks of the peg-IFNα-2a therapy.Total therapy duration of peg-IFNα-2a was 48 wk.All patients were followed-up to week 72(24 wk after discontinuation of peg-IFNα-2a).The primary endpoint was the proportion of patients with HBsAg clearance at week 72.RESULTS Demographic and baseline characteristics were comparable between the two groups.Intention-to-treatment analysis showed that the HBsAg clearance rate in the add-on group and monotherapy group was 37.4%(34/91)and 1.9%(2/104)at week 72,respectively.The HBsAg seroconversion rate in the add-on group was 29.7%(27/91)at week 72,and no patient in the monotherapy group achieved HBsAg seroconversion at week 72.The HBsAg clearance and seroconversion rates in the add-on group were significantly higher than in the monotherapy group at week 72(P<0.001).Younger patients,lower baseline HBsAg concentration,lower HBsAg concentrations at weeks 12 and 24,greater HBsAg decline from baseline to weeks 12 and 24 and the alanine aminotransferase≥2×upper limit of normal during the first 12 wk of therapy were strong predictors of HBsAg clearance in patients with peg-IFNα-2a add-on treatment.Regarding the safety of the treatment,4.4%(4/91)of patients in the add-on group discontinued peg-IFNα-2a due to adverse events.No severe adverse events were noted.CONCLUSION Peg-IFNα-2a as an add-on therapy augments HBsAg clearance in HBeAg-negative CHB patients with HBsAg≤1500 IU/m L after over 1 year of NA therapy.

Integration and verification case of IP-core based system on chip design

In this paper, the design and verification process of an automobile-engine-fan control system on chip （SoC） are introduced. The SoC system, SHU-MV08, reuses four new intellectual property （IP） cores and the design flow is accomplished with 0.35 btm chartered CMOS technology. Some special functions of IP cores, the detailed integration scheme of four IP cores, and the verification method of the entire SoC are presented. To settle the verification problems brought by analog IP cores, NanoSim based chip-level mixed-signal verification method is introduced. The verification time is greatly reduced and the first tape-out achieves success which proves the validity of our design.

3-Dimensional Body Measurement Technology

3 - dimensional body measurement technology, the basis of developing high technology in industry, accelerates digital development of aplparel industry. This paper briefly introduces the history of 3 - dimensional body measurement technology, and recounts the principle and primary structure of some types of 3 - dimensional automatic body measurement system. With this understanding, it discusses prospect of 3- dimensional CAD and virtual technology used in apparel industry.

Replay Attack and Defense of Electric Vehicle Charging on GB/T 27930-2015 Communication Protocol

The GB/T 27930-2015 protocol is the communication protocol between the non-vehicle-mounted charger and the battery management system (BMS) stipulated by the state. However, as the protocol adopts the way of broadcast communication and plaintext to transmit data, the data frame does not contain the source address and the destination address, making the Electric Vehicle (EV) vulnerable to replay attack in the charging process. In order to verify the security problems of the protocol, this paper uses 27,655 message data in the complete charging process provided by Shanghai Thaisen electric company, and analyzes these actual data frames one by one with the program written by C++. In order to enhance the security of the protocol, Rivest-Shamir-Adleman (RSA) digital signature and adding random numbers are proposed to resist replay attack. Under the experimental environment of Eclipse, the normal charging of electric vehicles, RSA digital signature and random number defense are simulated. Experimental results show that RSA digital signature cannot resist replay attack, and adding random numbers can effectively enhance the ability of EV to resist replay attack during charging.

Design and Implementation of a Digital PID Temperature Controller for Neonatal Incubator ESVIN

The project has as its aim the design and implementation of the control of temperature in the cockpit of the prototype of neonatal life support equipment ESVIN based on the international standard IEC 60601-2-19 concerning the basic security and operation of the neonatal incubators. The prototype has been developed and is important because the cockpit is a new concept of medical equipment of neonatal life support. There was a modeling of the system of heating of the incubator using the concepts of system identification with the purpose of finding a mathematical model that describes the dynamic behavior of the system. Then, design and implement the strategy of feedback control with digital PID （proportional-integral-derivative） algorithm. The model allowed the design and implementation of a digital PID controller that meets in a satisfactory manner with the requirements, in accordance with the international standard. The control system implemented in the neonatal incubator ESVIN improved the effectiveness of the neonatal life support equipment in regard to temperature controller of the cockpit.

Micro-droplet Digital Polymerase Chain Reaction and Real-Time Quantitative Polymerase Chain Reaction Technologies Provide Highly Sensitive and Accurate Detection of Zika Virus

The establishment of highly sensitive diagnostic methods is critical in the early diagnosis and control of Zika virus(ZIKV)and in preventing serious neurological complications of ZIKV infection. In this study, we established micro-droplet digital polymerase chain reaction(ddPCR) and real-time quantitative PCR(RT-qPCR) protocols for the detection of ZIKV based on the amplification of the NS5 gene. For the ZIKV standard plasmid, the RT-qPCR results showed that the cycle threshold(Ct) value was linear from 10~1 to 10~8 copy/l L, with a standard curve R^2 of 0.999 and amplification efficiency of 92.203%;however, a concentration as low as 1 copy/l L could not be detected. In comparison with RT-qPCR, the dd PCR method resulted in a linear range of 10~1–10~4 copy/l L and was able to detect concentrations as low as 1 copy/l L. Thus, for detecting ZIKV from clinical samples, RT-qPCR is a better choice for high-concentration samples(above 10~1 copy/l L),while ddPCR has excellent accuracy and sensitivity for low-concentration samples. These results indicate that the ddPCR method should be of considerable use in the early diagnosis, laboratory study, and monitoring of ZIKV.

Construction of a mutant of Actinoplanes sp. N902-109 that produces a new rapamycin analog

In the present study, we introduced point mutations into Ac_rap A which encodes a polyketide synthase responsible for rapamycin biosynthesis in Actinoplanes sp. N902-109, in order to construct a mutant with an inactivated enoylreductase(ER) domain, which was able to synthesize a new rapamycin analog. Based on the homologous recombination induced by double-strand breaks in chromosome mediated by endonuclease I-SceI, the site-directed mutation in the first ER domain of Ac_rapA was introduced using non-replicating plasmid pL YERIA combined with an I-SceI expression plasmid. Three amino acid residues of the active center, Ala-Gly-Gly, were converted to Ala-Ser-Pro. The broth of the mutant strain SIPI-027 was analyzed by HPLC and a new peak with the similar UV spectrum to that of rapamycin was found. The sample of the new peak was prepared by solvent extraction, column chromatography, and crystallization methods. The structure of new compound, named as SIPI-rapxin, was elucidated by determining and analyzing its MS and NMR spectra and its biological activity was assessed using mixed lymphocyte reaction(MLR). An ER domain–deficient mutant of Actinoplanes sp. N902-109, named as SIPI-027, was constructed, which produced a novel rapamycin analog SIPI-rapxin and its structure was elucidated to be 35, 36-didehydro-27-O-demethylrapamycin. The biological activity of SIPI-rapxin was better than that of rapamycin. In conclusion, inactivation of the first ER domain of rap A, one of the modular polyketide synthase responsible for macro-lactone synthesis of rapamycin, gave rise to a mutant capable of producing a novel rapamycin analog, 35, 36-didehydro-27-O-demethylrapamycin, demonstrating that the enoylreductase domain was responsible for the reduction of the double bond between C-35 and C-36 during rapamycin synthesis.

改进型DIC技术在静压桩模型试验中的应用

目前数字图像匹配(digital image correlation, DIC)技术在岩土工程领域中的应用越来越广泛.在室内模型试验中采用DIC分析技术可实现对沉桩过程中桩周土体位移的测量,进而对桩周土体位移分布规律进行研究.但是位于桩-土界面处的薄层土厚度较小,其位移无法利用DIC技术进行测量,因此对DIC分析技术进行改进,可记录并计算桩-土界面土体位移场情况,从而研究沉桩过程中压桩速度和桩端深度对桩-土界面土体位移的影响规律.研究结果表明,桩体贯入时桩-土界面土体位移的规律可分为初始阶段和稳定阶段,初始阶段土体位移表现为急剧增大然后迅速减小,而稳定阶段土体位移在0 mm附近波动.总体来说,在砂土中压桩,桩-土界面土体随桩体贯入发生的位移较小.在同一桩端深度处,压桩速度越快,桩-土界面土体位移越大;当压桩速度相同时,桩体贯入深度越深,桩-土界面土体累计位移越大,稳定阶段反弹位移越小.研究结果对进一步揭示桩-土相互作用机理和桩-土界面受力变形机理具有一定的参考价值.

ADS40数码航摄影像在DTM立体测图中的应用

介绍了基于ADS40数码航摄影像,使用MAPMATR IX2006建立立体模型进行立体测量DTM的全过程,以及ADS40数码相机的有关参数,对建立立体模型的作用。应用MAPMATR IX2006软件的操作使用方法。

Surface roughness measurement and analysis of mechanical parts based on digital holography

We measure the surface roughness of the mechanical parts based on digital holography. A digital off- axis hologram recording setup for reflective samples is built. Firstly, the height reconstruction error 2.3% of the setup is calibrated by using the quartz step height standard （VLSI- SHS-880QC）. Then, the standard scribed-line model and the grinding roughness specimen are selected as the test samples and their surface roughness are 0.095 6 jam and 0.025 3 jam, with errors 6.3%, 0.9%, respectively. The results are in good agreement with the given roughness parameters. At last, we also analyze the window effect of the filter on the roughness measurement value based on digital holography. In conclu- sion, the paper demonstrated effectively that the digital holography could provide the surface feature for the rough- ness measurement with high accuracy.

Study on GNSS satellite signal simulator

Satellite signal simulator for global navigation satellite system(GNSS)can evaluate the accuracy of capturing,tracing and positioning of GNSS receiver.It has significant use-value in the military and civil fields.The system adopts the overall design scheme of digital signal processor(DSP)and field-programmable gate array(FPGA).It consists of four modules:industrial control computer simulation software,mid-frequency signal generator,digital-to-analog(D/A)module and radio frequency(RF)module.In this paper,we test the dynamic performance of simulator using the dynamic scenes testing method,and the signal generated by the designed simulator is primarily validated.

Study on denoising filter of underwater vehicle using DWT

In the step processing a digitalized signal,noises are generated by internal or external causes of the system.In order to eliminate these noises,various methods are researched.Among these noise elimination methods,Fourier fast transform(FFT)and short-time Fourier transform(STFT)are widely used.Because they are expressed as a fixed time-frequency domain,they have the disadvantage that the time information about the signal is unknown.In order to overcome these limitations,by using the wavelet transform that provides a variety of time-frequency resolution,multi-resolution analysis can be analysed and a varying noise depending on the time characteristics can be removed more efficiently.Therefore,in this paper,a denoising method of underwater vehicle using discrete wavelet transform(DWT)is proposed.

DSP在车辆系统中的应用

的趋势。DSP（Digital Signal Processor），具有较高的运算速度和精度，其在车辆行车安全、人-车交流及导航等方面有着宽广的应用。本文综述了其在车辆中的应用，对未来更深层次的应用进行了展望。

柯尼卡美能达重拳出击

入门级单反数字相机市场上的竞争日趋激烈，α-5 Digital的发布意味着柯尼卡美能达也加入了战局之中，这是继α-7 D之后第二款采用AS防抖技术的单反数字相机，它将成为佳能EOS 350D，尼康D50等产品的有力竞争对手。