PRVALENCE OF ARRHYTHMIAS IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY

A total of 105 patients with idiopathic dilated cardiomyopathy （IDCM） underwent Holter monitoring. The prevalence of arrhythmias was as follows: ventricular premature beats （VPB） 100%, including complex VPB 58.1%, short runs of ventricular tachycardia （VT） 25.7%, A-VB or BBB 46.7%, atrial arrhythmias 38.1%, sinus node dysfunction 6.6％, ST-T change 38.1%. The incidence of ventricular arrhythmia （VA） was not related to severity of cardiac dysfunction （NYHA）, duration of illness and sex. The most common arrhythmia was VA, the second one was heart block and atrial arrhythmia. Serum norepinephrine and epinephrine levels were 743.4± 252.5 and 688.0± 452.4 pg/ml, respectively, which were higher than those in control group （P<0.01）. Isoproterenol sensitivity test （ICD5） 8.43± 11.21 μg, was also much higher than that in control group （P<0.01）.Average H-V interval was 69.4±13.3 msec in HBE. Eight patients died.Two died of congestive heart failure （class Ⅱ-Ⅳ）,and six cases were diagnosed as sudden cardiac

Frequency of apoptosisin cardiac myocytes of patients with myocarditisand dilated cardiomyopathy

Background Programmed cell death has previously been observed in animal models of viral myocarditis and in patients with end stage dilated cardio myopathy (DCM). The purpose of the present study was to investigate if apoptosis is also detectable in endomyocardial biopsies of patients with clinical and immuno histological signs of myocarditis. Methods Right ventricular myocardial biopsies were obtained from 53 patients with clinically suspected myocarditis (left ventricular ejection fraction 30±14%). Cardiac tissues from 4 patients with end stage heart failure were obtained during heart transplantation. Diagnosis of myocarditis and DCM was based on clinical presentation and on histological and immunohistological findings. The presence of apoptosis was investigated in paraffin embedded tissue sections by in situ end labeling of nuclear DNA strand breaks. Results By histological and immunohistological analysis 19 patients (36%) were diagnosed as myocarditis and 34 patients (64%) as DCM. Apoptosis was detected in 9 out of 19 patients with myocarditis, in 12 out of 34 patients with DCM (47% versus 35%, p=NS), and in all patients with end stage heart failure. Conclusions A high frequency of apoptosis was detectable in endomyocardial biopsies of patients with immunohistologically documented myocarditis. The rate of apoptosis in patients with myocarditis, however, was not different to patients with DCM. These findings suggest that apoptosis may be one common pathway in the pathogenesis of cardiac contractile dysfunction in patients with myocarditis and DCM.

Effect of primary prevention of implantable cardioverter defibrillator on sudden cardiac death in 24 patients with dilated cardiomyopathy

Objective To study the effect of primary prevention of implantable cardioverter defibrillator(ICD)on sudden cardiac death(SCD)in patients with dilated cardiomyopathy.Methods A total of 36 patients with dilated cardiomyopathy treated in our hospital from 2013-12 to2014-12 were studied including 29(80.6%)male and 7(19.4%)female with the mean age of(63±11.8)