The title complexes, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO), and their diphenyltindichloride adduct, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO)?SnPh2Cl2, were synthesized and char-acterized by elemental analysis, IR, H and C NMR an...The title complexes, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO), and their diphenyltindichloride adduct, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO)?SnPh2Cl2, were synthesized and char-acterized by elemental analysis, IR, H and C NMR and X-ray single crystal diffraction. The 1 13structural features of the compounds were described.展开更多
Four new diorganotin complexes were synthesized and characterized by IR and 1H NMR.Their in vitro antitumor activities against a series of human tumor cell lines such as P 388 tumor cells were tested.The results showe...Four new diorganotin complexes were synthesized and characterized by IR and 1H NMR.Their in vitro antitumor activities against a series of human tumor cell lines such as P 388 tumor cells were tested.The results showed that the complexes mainly exhibited strong antitumor activities against P 388 ,but presented no activities against other tumor cell lines.The structure activity relationships were discussed.展开更多
Three diorganotin compounds containing silicon and their phenanthroline complexes have been synthesized.Their structures were characterized by elemental analsis,IR and NMR(1H,13C).The results indicated that in the com...Three diorganotin compounds containing silicon and their phenanthroline complexes have been synthesized.Their structures were characterized by elemental analsis,IR and NMR(1H,13C).The results indicated that in the complexes the two donor N atoms of the ligand coordinate to Sn atom,gave the struture of six-coordinated distorted octahedron.展开更多
目的对抗肿瘤药物二乙基二氯化锡配合物（Et2SnCl2L）（L=phen，Pphen，DMphen and TMphen）1-4的电子结构和分子性质进行理论研究。方法在B3LYP／6—31G的水平上，采用量子化学密度泛函法进行计算。结果配合物Et2SnCl2（phen）通过两...目的对抗肿瘤药物二乙基二氯化锡配合物（Et2SnCl2L）（L=phen，Pphen，DMphen and TMphen）1-4的电子结构和分子性质进行理论研究。方法在B3LYP／6—31G的水平上，采用量子化学密度泛函法进行计算。结果配合物Et2SnCl2（phen）通过两种方式与DNA结合，一是静电结合，可用静电作用能（Ee）表示氯原子和金属锡原子间的静电作用强度；二是插入结合，配合物的LUMO轨道的能量（εL）、插入配体的电荷（QL）以及插入配体的配位键长（Sn-N）等对配合物与DNA的作用有显著影响。结论对配合物的抗肿瘤活性进行了合理解释并设计了具有较高活性的新配合物5。展开更多
基金This work was supported by the National Natural Science Foundation of China(No.20173050).
文摘The title complexes, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO), and their diphenyltindichloride adduct, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO)?SnPh2Cl2, were synthesized and char-acterized by elemental analysis, IR, H and C NMR and X-ray single crystal diffraction. The 1 13structural features of the compounds were described.
文摘Four new diorganotin complexes were synthesized and characterized by IR and 1H NMR.Their in vitro antitumor activities against a series of human tumor cell lines such as P 388 tumor cells were tested.The results showed that the complexes mainly exhibited strong antitumor activities against P 388 ,but presented no activities against other tumor cell lines.The structure activity relationships were discussed.
文摘Three diorganotin compounds containing silicon and their phenanthroline complexes have been synthesized.Their structures were characterized by elemental analsis,IR and NMR(1H,13C).The results indicated that in the complexes the two donor N atoms of the ligand coordinate to Sn atom,gave the struture of six-coordinated distorted octahedron.
文摘目的对抗肿瘤药物二乙基二氯化锡配合物（Et2SnCl2L）（L=phen，Pphen，DMphen and TMphen）1-4的电子结构和分子性质进行理论研究。方法在B3LYP／6—31G的水平上，采用量子化学密度泛函法进行计算。结果配合物Et2SnCl2（phen）通过两种方式与DNA结合，一是静电结合，可用静电作用能（Ee）表示氯原子和金属锡原子间的静电作用强度；二是插入结合，配合物的LUMO轨道的能量（εL）、插入配体的电荷（QL）以及插入配体的配位键长（Sn-N）等对配合物与DNA的作用有显著影响。结论对配合物的抗肿瘤活性进行了合理解释并设计了具有较高活性的新配合物5。
