Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types...Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.展开更多
当前国家正大力推行按照疾病诊断相关分组付费(diagnosis related groups,DRG)和按照病种分值付费(diagnosis-intervention packet,DIP)的医疗服务付费改革。其根本是为了严格控制医保资源的支出,杜绝过度诊疗,最终达到提高医疗服务质...当前国家正大力推行按照疾病诊断相关分组付费(diagnosis related groups,DRG)和按照病种分值付费(diagnosis-intervention packet,DIP)的医疗服务付费改革。其根本是为了严格控制医保资源的支出,杜绝过度诊疗,最终达到提高医疗服务质量并降低医疗费用的目的。自身抗体检测在临床实践中,存在涉及疾病种类多、检测项目繁杂且各地医疗服务收费标准差异较大等现实问题。因此,选择最能适应DRG/DIP医疗付费大趋势的自身抗体检测方案,是目前临床检验领域必须面对和解答的现实问题。该文结合自身抗体检测技术发展和国内临床应用现状,探讨如何建立既符合临床实践规律,又兼顾不同临床应用场景的自身抗体检测方案,以求最大程度满足临床相关疾病诊断需求,同时确保有限医保资源的高效利用,并真正践行个体化医疗。展开更多
基金supported by the STI 2030—Major Projects 2021ZD0204000,No.2021ZD0204003 (to XZ)the National Natural Science Foundation of China,Nos.32170973 (to XZ),32071018 (to ZH)。
文摘Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.
文摘当前国家正大力推行按照疾病诊断相关分组付费(diagnosis related groups,DRG)和按照病种分值付费(diagnosis-intervention packet,DIP)的医疗服务付费改革。其根本是为了严格控制医保资源的支出,杜绝过度诊疗,最终达到提高医疗服务质量并降低医疗费用的目的。自身抗体检测在临床实践中,存在涉及疾病种类多、检测项目繁杂且各地医疗服务收费标准差异较大等现实问题。因此,选择最能适应DRG/DIP医疗付费大趋势的自身抗体检测方案,是目前临床检验领域必须面对和解答的现实问题。该文结合自身抗体检测技术发展和国内临床应用现状,探讨如何建立既符合临床实践规律,又兼顾不同临床应用场景的自身抗体检测方案,以求最大程度满足临床相关疾病诊断需求,同时确保有限医保资源的高效利用,并真正践行个体化医疗。
