An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K2CO3 as base at room temperature, giving a series of al...An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K2CO3 as base at room temperature, giving a series of aliphatic a-amino acid derivatives in moderate to high yields（up to 99%）. Preliminary study on this asymmetric process showed that cinchona-derived phase transfer catalyst was elTective, aflbrding the corresponding product in 13% e.e. and 40% yield.展开更多
基金Supported by the Natural Science Foundation of China（No.21402127）. Foundation of Liaoning Province Education Department（No.l,2013381）, PhD Research Startup Foundation of Liaoning Province（No.20131110）, and Career Dcvclopment Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University.
文摘An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K2CO3 as base at room temperature, giving a series of aliphatic a-amino acid derivatives in moderate to high yields（up to 99%）. Preliminary study on this asymmetric process showed that cinchona-derived phase transfer catalyst was elTective, aflbrding the corresponding product in 13% e.e. and 40% yield.
