BACKGROUND Patellar tendon rupture after total knee arthroplasty(TKA)is a catastrophic complication.Although the occurrence of this injury is rare,it can lead to significant dysfunction for the patient and is very tri...BACKGROUND Patellar tendon rupture after total knee arthroplasty(TKA)is a catastrophic complication.Although the occurrence of this injury is rare,it can lead to significant dysfunction for the patient and is very tricky to deal with.There has been no standard treatment for early patella tendon rupture after TKA,and long-term follow-up data are lacking.AIM To introduce a direct repair method for early patella tendon rupture following TKA and determine the clinical outcomes and complications of this method.METHODS During the period of 2008 to 2021,3265 consecutive TKAs were retrospectively reviewed.Twelve patients developed early patellar tendon rupture postoperatively and were treated by a direct repair method.Mean follow-up was 5.7 years.Demographic,operative,and clinical data were collected.The clinical outcomes were assessed using the Western Ontario and McMaster Universities(WOMAC)score,the Hospital for Special Surgery(HSS)score,knee range of motion,extensor lag,and surgical complications.Descriptive statistics and paired t test were employed to analyze the data.RESULTS For all 12 patients who underwent direct repair for early patellar tendon rupture,3 patients failed:One(8.3%)for infection and two(17.6%)for re-fracture.The two patients with re-fracture both underwent reoperation to reconstruct the extensor mechanism and the patient with infection underwent revision surgery.The range of motion was 109.2°±10.6°preoperatively to 87.9°±11°postoperatively,mean extensor lag was 21°at follow-up,and mean WOMAC and HSS scores were 65.8±30.9 and 60.3±21.7 points,respectively.CONCLUSION This direct repair method of early patellar tendon rupture is not an ideal therapy.It is actually ineffective for the recovery of knee joint function in patients,and is still associated with severe knee extension lag and high complication rates.Compared with the outcomes of other repair methods mentioned in the literature,this direct repair method shows poor clinical outcomes.展开更多
Direct coaptation of contralateral C7 to the upper trunk could avoid the interposition of nerve grafts. We have successfully shortened the gap and graft lengths, and even achieved direct coaptation. However, direct re...Direct coaptation of contralateral C7 to the upper trunk could avoid the interposition of nerve grafts. We have successfully shortened the gap and graft lengths, and even achieved direct coaptation. However, direct repair can only be performed in some selected cases, and partial procedures still require autografts, which are the gold standard for repairing neurologic defects. As symptoms often occur after autografting, human acellular nerve allografts have been used to avoid concomitant symptoms. This study investigated the quality of shoulder abduction and elbow flexion following direct repair and acellular allografting to evaluate issues requiring attention for brachial plexus injury repair. Fifty-one brachial plexus injury patients in the surgical database were eligible for this retrospective study. Patients were divided into two groups according to different surgical methods. Direct repair was performed in 27 patients, while acellular nerve allografts were used to bridge the gap between the contralateral C7 nerve root and upper trunk in 24 patients. The length of the harvested contralateral C7 nerve root was measured intraoperatively. Deltoid and biceps muscle strength, and degrees of shoulder abduction and elbow flexion were examined according to the British Medical Research Council scoring system;meaningful recovery was defined as M3–M5. Lengths of anterior and posterior divisions of the contralateral C7 in the direct repair group were 7.64 ± 0.69 mm and 7.55 ± 0.69 mm, respectively, and in the acellular nerve allografts group were 6.46 ± 0.58 mm and 6.43 ± 0.59 mm, respectively. After a minimum of 4-year follow-up, meaningful recoveries of deltoid and biceps muscles in the direct repair group were 88.89% and 85.19%, respectively, while they were 70.83% and 66.67% in the acellular nerve allografts group. Time to C5/C6 reinnervation was shorter in the direct repair group compared with the acellular nerve allografts group. Direct repair facilitated the restoration of shoulder abduction and elbow flexion. Thus, if direct coaptation is not possible, use of acellular nerve allografts is a suitable option. This study was approved by the Medical Ethical Committee of the First Affiliated Hospital of Sun Yat-sen University, China (Application ID:[2017] 290) on November 14, 2017.展开更多
Objective:Peripheral nerve repair is required after traumatic injury.This common condition represents a major public health problem worldwide.Recovery after nerve repair depends on several factors,including the severi...Objective:Peripheral nerve repair is required after traumatic injury.This common condition represents a major public health problem worldwide.Recovery after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical skills.Despite the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being studied.Pre-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRISMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair studies.Data sources:Original articles,published in English from 2000 to 2018,were collected using the Web of Science,Scopus,and PubMed databases.Data selection:Only preclinical trials on direct nerve repair were included in this review.The articles were evaluated by the first two authors,in accordance with predefined data fields.Outcome measures:The primary outcomes included functional motor abilities,daily activity and regeneration rate.Secondary outcomes included coaptation technique and animal model.Results:This review yielded 267 articles,of which,after completion of the screening,49 studies were analyzed.There were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical models.The nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).Conclusion:The most widely used animal model in the study of peripheral nerve repair is the rat.Other animal models are also used but the cost-benefit of the rat model provides several strengths over the others.Suture techniques are currently the first option for nerve repair,but the use of glues,lasers and bioengineering materials is increasing.Hence,further research in this field is required to improve clinical practice.展开更多
A two-stage directed Semi-Markov repairable network system is presented in this paper to model the performance of many transmission systems, such as power or oil transmission network, water or gas supply network, etc....A two-stage directed Semi-Markov repairable network system is presented in this paper to model the performance of many transmission systems, such as power or oil transmission network, water or gas supply network, etc. The availability of the system is discussed by using Markov renewal theory, Laplace transform and probability analysis methods. A numerical example is given to illustrate the results obtained in the paper.展开更多
目的回顾性分析直接修复(direct repair,DR)手术和非手术治疗对青年腰椎峡部裂患者的早期效果。方法选择2015年1月~2019年12月在该院就诊的151例青年腰椎峡部裂患者作为研究对象,根据患者治疗方法分为非手术组(79例,传统非手术治疗)和...目的回顾性分析直接修复(direct repair,DR)手术和非手术治疗对青年腰椎峡部裂患者的早期效果。方法选择2015年1月~2019年12月在该院就诊的151例青年腰椎峡部裂患者作为研究对象,根据患者治疗方法分为非手术组(79例,传统非手术治疗)和手术组(72例,螺钉固定直接修复),观察两组疼痛VAS评分、Oswestry功能障碍指数(Oswestry disability index,ODI)、12项简式健康调查量表(the 12-items short form health survey,SF-12)得分、缺损间隙距离和缺损愈合率。结果治疗后1个月、3个月、6个月、12个月时,两组患者VAS均较治疗前显著降低(P<0.05),但两组各时间段的VAS评分差异均无统计学意义(P>0.05)。治疗后1个月、3个月、6个月、12个月两组患者ODI指数呈降低趋势,SF-12评分呈升高趋势,差异均有统计学意义(P<0.05);两组患者各时间段的ODI指数和SF-12评分差异均无统计学意义(P>0.05)。治疗后12个月,非手术组腰椎滑脱发生率高于手术组(P<0.05);手术组患者峡部愈合率(75.00%)明显高于非手术组(P<0.05)。手术组并发症发生率高于非手术组(P<0.05)。结论DR手术和非手术治疗对患者腰部、功能障碍和生活质量的短期影响无显著差异,DR手术的并发症高于非手术治疗,但DR手术对抑制病变节段的前移具有积极作用。展开更多
目的 分析对于关节侧部分肩袖损伤患者分别采用关节镜下转全层修复和部分修复的效果。方法 随机选取莆田九十五医院骨科于2019年1月—2021年12月收治的50例关节侧部分肩袖损伤患者为研究对象,根据随机数表法分为对照组(关节镜下直接修复...目的 分析对于关节侧部分肩袖损伤患者分别采用关节镜下转全层修复和部分修复的效果。方法 随机选取莆田九十五医院骨科于2019年1月—2021年12月收治的50例关节侧部分肩袖损伤患者为研究对象,根据随机数表法分为对照组(关节镜下直接修复)和观察组(关节镜下转全层撕裂后修复),各25例。对比两组Constant-Murley肩关节功能评分(Constant-Murley Shoulder Function Score, CSS)、洛杉矶加利福尼亚大学评分(University of California Los Angeles Rating, UCLA)、临床效果。结果 观察组术后3、6个月的CSS评分为(57.09±6.11)、(79.32±5.23)分,高于对照组的(52.30±5.86)、(74.38±6.67)分,差异有统计学意义(t=2.829、2.914,P均<0.05)。观察组术后3、6个月的UCLA评分为(25.13±3.34)、(29.38±1.57)分,高于对照组的(22.84±3.04)、(27.94±1.64)分,差异有统计学意义(t=2.535、3.171,P均<0.05)。两组临床治疗总有效率对比,差异无统计学意义(P>0.05)。结论 对于关节侧部分肩袖损伤患者,分别采用关节镜下直接修复和关节镜下转全层撕裂后修复均可获得较为理想的效果,但关节镜下全层撕裂后修复术更有利于肩关节功能修复。展开更多
Directly repairing end-of-life lithium-ion battery cathodes poses significant chal-lenges due to the diverse compositions of the wastes.Here,we propose a water-facilitated targeted repair strategy applicable to variou...Directly repairing end-of-life lithium-ion battery cathodes poses significant chal-lenges due to the diverse compositions of the wastes.Here,we propose a water-facilitated targeted repair strategy applicable to various end-of-life batches and cathodes.The process involves initiating structural repair and reconstruct-ing particle morphology in degraded LiMn_(2)O_(4)(LMO)through an additional thermal drive post-ambient water remanganization,achieving elemental repair.Compared to solid-phase repair,the resulting LMO material exhibits superior electrochemical and kinetic characteristics.The theoretical analysis highlights the impact of Mn defects on the structural stability and electron transfer rate of degraded materials.The propensity of Mn ions to diffuse within the Mn layer,specifically occupying the Mn 16d site instead of the Li 8a site,theoretically sup-ports the feasibility of ambient water remanganization.Moreover,this method proves effective in the relithiation of degraded layered cathode materials,yielding single crystals.By combining low energy consumption,environmental friendli-ness,and recyclability,our study proposes a sustainable approach to utilizing spent batteries.This strategy holds the potential to enable the industrial direct repair of deteriorated cathode materials.展开更多
文摘BACKGROUND Patellar tendon rupture after total knee arthroplasty(TKA)is a catastrophic complication.Although the occurrence of this injury is rare,it can lead to significant dysfunction for the patient and is very tricky to deal with.There has been no standard treatment for early patella tendon rupture after TKA,and long-term follow-up data are lacking.AIM To introduce a direct repair method for early patella tendon rupture following TKA and determine the clinical outcomes and complications of this method.METHODS During the period of 2008 to 2021,3265 consecutive TKAs were retrospectively reviewed.Twelve patients developed early patellar tendon rupture postoperatively and were treated by a direct repair method.Mean follow-up was 5.7 years.Demographic,operative,and clinical data were collected.The clinical outcomes were assessed using the Western Ontario and McMaster Universities(WOMAC)score,the Hospital for Special Surgery(HSS)score,knee range of motion,extensor lag,and surgical complications.Descriptive statistics and paired t test were employed to analyze the data.RESULTS For all 12 patients who underwent direct repair for early patellar tendon rupture,3 patients failed:One(8.3%)for infection and two(17.6%)for re-fracture.The two patients with re-fracture both underwent reoperation to reconstruct the extensor mechanism and the patient with infection underwent revision surgery.The range of motion was 109.2°±10.6°preoperatively to 87.9°±11°postoperatively,mean extensor lag was 21°at follow-up,and mean WOMAC and HSS scores were 65.8±30.9 and 60.3±21.7 points,respectively.CONCLUSION This direct repair method of early patellar tendon rupture is not an ideal therapy.It is actually ineffective for the recovery of knee joint function in patients,and is still associated with severe knee extension lag and high complication rates.Compared with the outcomes of other repair methods mentioned in the literature,this direct repair method shows poor clinical outcomes.
基金supported by the National Natural Science Foundation of China,No.81572130(to LQG)and 81601057(to JTY)the National Key Research and Development Plan of China,No.2016YFC1101603(to XLL)the Natural Science Foundation of Guangdong Province of China,No.2015A030310350(to JTY)
文摘Direct coaptation of contralateral C7 to the upper trunk could avoid the interposition of nerve grafts. We have successfully shortened the gap and graft lengths, and even achieved direct coaptation. However, direct repair can only be performed in some selected cases, and partial procedures still require autografts, which are the gold standard for repairing neurologic defects. As symptoms often occur after autografting, human acellular nerve allografts have been used to avoid concomitant symptoms. This study investigated the quality of shoulder abduction and elbow flexion following direct repair and acellular allografting to evaluate issues requiring attention for brachial plexus injury repair. Fifty-one brachial plexus injury patients in the surgical database were eligible for this retrospective study. Patients were divided into two groups according to different surgical methods. Direct repair was performed in 27 patients, while acellular nerve allografts were used to bridge the gap between the contralateral C7 nerve root and upper trunk in 24 patients. The length of the harvested contralateral C7 nerve root was measured intraoperatively. Deltoid and biceps muscle strength, and degrees of shoulder abduction and elbow flexion were examined according to the British Medical Research Council scoring system;meaningful recovery was defined as M3–M5. Lengths of anterior and posterior divisions of the contralateral C7 in the direct repair group were 7.64 ± 0.69 mm and 7.55 ± 0.69 mm, respectively, and in the acellular nerve allografts group were 6.46 ± 0.58 mm and 6.43 ± 0.59 mm, respectively. After a minimum of 4-year follow-up, meaningful recoveries of deltoid and biceps muscles in the direct repair group were 88.89% and 85.19%, respectively, while they were 70.83% and 66.67% in the acellular nerve allografts group. Time to C5/C6 reinnervation was shorter in the direct repair group compared with the acellular nerve allografts group. Direct repair facilitated the restoration of shoulder abduction and elbow flexion. Thus, if direct coaptation is not possible, use of acellular nerve allografts is a suitable option. This study was approved by the Medical Ethical Committee of the First Affiliated Hospital of Sun Yat-sen University, China (Application ID:[2017] 290) on November 14, 2017.
文摘Objective:Peripheral nerve repair is required after traumatic injury.This common condition represents a major public health problem worldwide.Recovery after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical skills.Despite the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being studied.Pre-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRISMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair studies.Data sources:Original articles,published in English from 2000 to 2018,were collected using the Web of Science,Scopus,and PubMed databases.Data selection:Only preclinical trials on direct nerve repair were included in this review.The articles were evaluated by the first two authors,in accordance with predefined data fields.Outcome measures:The primary outcomes included functional motor abilities,daily activity and regeneration rate.Secondary outcomes included coaptation technique and animal model.Results:This review yielded 267 articles,of which,after completion of the screening,49 studies were analyzed.There were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical models.The nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).Conclusion:The most widely used animal model in the study of peripheral nerve repair is the rat.Other animal models are also used but the cost-benefit of the rat model provides several strengths over the others.Suture techniques are currently the first option for nerve repair,but the use of glues,lasers and bioengineering materials is increasing.Hence,further research in this field is required to improve clinical practice.
文摘A two-stage directed Semi-Markov repairable network system is presented in this paper to model the performance of many transmission systems, such as power or oil transmission network, water or gas supply network, etc. The availability of the system is discussed by using Markov renewal theory, Laplace transform and probability analysis methods. A numerical example is given to illustrate the results obtained in the paper.
文摘目的回顾性分析直接修复(direct repair,DR)手术和非手术治疗对青年腰椎峡部裂患者的早期效果。方法选择2015年1月~2019年12月在该院就诊的151例青年腰椎峡部裂患者作为研究对象,根据患者治疗方法分为非手术组(79例,传统非手术治疗)和手术组(72例,螺钉固定直接修复),观察两组疼痛VAS评分、Oswestry功能障碍指数(Oswestry disability index,ODI)、12项简式健康调查量表(the 12-items short form health survey,SF-12)得分、缺损间隙距离和缺损愈合率。结果治疗后1个月、3个月、6个月、12个月时,两组患者VAS均较治疗前显著降低(P<0.05),但两组各时间段的VAS评分差异均无统计学意义(P>0.05)。治疗后1个月、3个月、6个月、12个月两组患者ODI指数呈降低趋势,SF-12评分呈升高趋势,差异均有统计学意义(P<0.05);两组患者各时间段的ODI指数和SF-12评分差异均无统计学意义(P>0.05)。治疗后12个月,非手术组腰椎滑脱发生率高于手术组(P<0.05);手术组患者峡部愈合率(75.00%)明显高于非手术组(P<0.05)。手术组并发症发生率高于非手术组(P<0.05)。结论DR手术和非手术治疗对患者腰部、功能障碍和生活质量的短期影响无显著差异,DR手术的并发症高于非手术治疗,但DR手术对抑制病变节段的前移具有积极作用。
文摘目的 分析对于关节侧部分肩袖损伤患者分别采用关节镜下转全层修复和部分修复的效果。方法 随机选取莆田九十五医院骨科于2019年1月—2021年12月收治的50例关节侧部分肩袖损伤患者为研究对象,根据随机数表法分为对照组(关节镜下直接修复)和观察组(关节镜下转全层撕裂后修复),各25例。对比两组Constant-Murley肩关节功能评分(Constant-Murley Shoulder Function Score, CSS)、洛杉矶加利福尼亚大学评分(University of California Los Angeles Rating, UCLA)、临床效果。结果 观察组术后3、6个月的CSS评分为(57.09±6.11)、(79.32±5.23)分,高于对照组的(52.30±5.86)、(74.38±6.67)分,差异有统计学意义(t=2.829、2.914,P均<0.05)。观察组术后3、6个月的UCLA评分为(25.13±3.34)、(29.38±1.57)分,高于对照组的(22.84±3.04)、(27.94±1.64)分,差异有统计学意义(t=2.535、3.171,P均<0.05)。两组临床治疗总有效率对比,差异无统计学意义(P>0.05)。结论 对于关节侧部分肩袖损伤患者,分别采用关节镜下直接修复和关节镜下转全层撕裂后修复均可获得较为理想的效果,但关节镜下全层撕裂后修复术更有利于肩关节功能修复。
基金Beijing Natural Science Foundation,Grant/Award Number:Z220021National Key R&D Program of China,Grant/Award Number:2022YFB3305400+3 种基金National Natural Science Foundation of China,Grant/Award Numbers:22202011,52102207Joint Funds of the National Natural Science Foundation of China,Grant/Award Number:U2130204Beijing Outstanding Young Scientists Program,Grant/Award Number:BJJWZYJH01201910007023Shandong Provincial Natural Science Foundation,Grant/Award Number:ZR2022QB056。
文摘Directly repairing end-of-life lithium-ion battery cathodes poses significant chal-lenges due to the diverse compositions of the wastes.Here,we propose a water-facilitated targeted repair strategy applicable to various end-of-life batches and cathodes.The process involves initiating structural repair and reconstruct-ing particle morphology in degraded LiMn_(2)O_(4)(LMO)through an additional thermal drive post-ambient water remanganization,achieving elemental repair.Compared to solid-phase repair,the resulting LMO material exhibits superior electrochemical and kinetic characteristics.The theoretical analysis highlights the impact of Mn defects on the structural stability and electron transfer rate of degraded materials.The propensity of Mn ions to diffuse within the Mn layer,specifically occupying the Mn 16d site instead of the Li 8a site,theoretically sup-ports the feasibility of ambient water remanganization.Moreover,this method proves effective in the relithiation of degraded layered cathode materials,yielding single crystals.By combining low energy consumption,environmental friendli-ness,and recyclability,our study proposes a sustainable approach to utilizing spent batteries.This strategy holds the potential to enable the industrial direct repair of deteriorated cathode materials.