Background:Doctoral students have much higher risk of anxiety or depression than general population.Doctoral students worldwide are facing varying degrees of mental health risks.Method:Based on the survey data of 6,81...Background:Doctoral students have much higher risk of anxiety or depression than general population.Doctoral students worldwide are facing varying degrees of mental health risks.Method:Based on the survey data of 6,812 doctoral students worldwide in Nature in 2019,Probit and Logit models are used to explore the correlation between thefit of doctoral education and training process and the mental health of doctoral students.Results:(1)The training environmentfit of doctoral students has a significant positive impact on their mental health.(2)The academic professionfit of doctoral students has a significant positive impact on their mental health.(3)The orga-nizational culturefit of doctoral students has a significant positive impact on their mental health.(4)Thefinancial supportfit of doctoral students has a significant positive impact on their mental health.Conclusion:The higher the degree of doctoral students’training environmentfit,academic professionfit,organizational culturefit,andfinancial supportfit,the lower the possibility of anxiety or depression among doctoral students.The current research results can help reveal extensive factors that affect the mental health of doctoral students,facilitate the planning and development of effective intervention measures by universities,improve thefit of the doctoral education and training process,improve the mental health of doctoral students,and boost academic excellence.展开更多
This paper provides an overview of research into mental health problem and occupational stress among Chinese doctors in recent 10 years. It indicates that doctors in general hospitals have worse mental status. Occupat...This paper provides an overview of research into mental health problem and occupational stress among Chinese doctors in recent 10 years. It indicates that doctors in general hospitals have worse mental status. Occupational stress comes from over workload, high demanding from patients, occupational risk, effort-reward imbalance and fierce competition for job promotion. For medical staffs battling against severe acute respiratory syndrome (SARS), or working in catastrophic Wenchuan earthquake-affected areas, they have elevated stress and worrying levels of psychological distress. Post-traumatic stress disorder (PTSD) is a common mental health problem among them. The most common diseases the Chinese doctors usually suffered were cervical spondylosis, hyperlipidemia, hypertension, fatty liver and hyperglycemia. It could be important for health administrators to note that mental health appears to be an?increasing problem in Chinese doctors and corresponding helping measure should be made.展开更多
AIMTo study impact of baseline mental health disease on hepatitis C virus (HCV) treatment; and Beck’s Depression Inventory (BDI) changes with sofosbuvir- and interferon-based therapy. METHODSThis is a retros...AIMTo study impact of baseline mental health disease on hepatitis C virus (HCV) treatment; and Beck’s Depression Inventory (BDI) changes with sofosbuvir- and interferon-based therapy. METHODSThis is a retrospective cohort study of participants from 5 studies enrolled from single center trials conducted at the Clinical Research Center of the National Institutes of Health, Bethesda, MD, United States. All participants were adults with chronic HCV genotype 1 infection and naïve to HCV therapy. Two of the studies included HCV mono-infected participants only (SPARE, SYNERGY-A), and 3 included human immunodeficiency virus (HIV)/HCV co-infected participants only (ERADICATE, PFINPK, and ALBIN). Patients were treated for HCV with 3 different regimens: Sofosbuvir and ribavirin in the SPARE trial, ledipasvir and sofosbuvir in SYNERGY-A and ERADICATE trials, and pegylated interferon (IFN) and ribavirin for 48 wk in the PIFNPK and ALBIN trials. Participants with baseline mental health disease (MHD) were identified (defined as either a DSM IV diagnosis of major depression, bipolar disorder, schizophrenia, generalized anxiety, and post-traumatic stress disorder or requiring anti-depressants, antipsychotics, mood stabilizers or psychotropics prescribed by a psychiatrist). For our first aim, we compared sustained virologic response (SVR) and adherence (pill counts, study visits, and in 25 patients, blood levels of the sofosbuvir metabolite, GS-331007) within each study. For our second aim, only patients with HIV coinfection were evaluated. BDI scores were obtained pre-treatment, during treatment, and post-treatment among participants treated with sofosbuvir-based therapy, and compared to scores from participants treated with interferon-based therapy. Statistical differences for both aims were analyzed by Fisher’s Exact, and t-test with significance defined as a P value less than 0.05. RESULTSBaseline characteristics did not differ significantly between all participants with and without MHD groups treated with sofosbuvir-based therapy. Among patients treated with sofosbuvir-based therapy, the percentage of patients with MHD who achieved SVR was the same as those without (SPARE: 60.9% of those MHD compared to 67.6% in those without, P = 0.78; SYNERGY-A: 100% of both groups; ERADICATE: 100% compared to 97.1%). There was no statistically significant difference in pill counts, adherence to study visits between groups, nor mean serum concentrations of GS-331007 for each group at week 2 of treatment (P = 0.72). Among patients with HIV co-infection, pre-treatment BDI scores were similar among patients treated with sofosbuvir, and those treated with interferon (sofosbuvir-based 5.24, IFN-based 6.96; P = 0.14); however, a dichotomous effect on was observed during treatment. Among participants treated with directly acting antiviral (DAA)-based therapy, mean BDI scores decreased from 5.24 (pre-treatment) to 3.28 during treatment (1.96 decrease, P = 0.0034) and 2.82 post-treatment. The decrease in mean score from pre- to post-treatment was statistically significant (-2.42, P = 0.0012). Among participants treated with IFN-based therapy, mean BDI score increased from 6.96 at pre-treatment to 9.19 during treatment (an increase of 2.46 points, P = 0.1), and then decreased back to baseline post-treatment (mean BDI score 6.3, P = 0.54). Overall change in mean BDI scores from pre-treatment to during treatment among participants treated with DAA-based and IFN-therapy was statistically significant (-1.96 and +2.23, respectively; P = 0.0032). This change remained statistically significant when analysis was restricted to participants who achieved SVR (-2.0 and +4.36, respectively; P = 0.0004). CONCLUSIONSofosbuvir-based therapy is safe and well tolerated in patients with MHD. A decline in BDI associated with sofosbuvir-based HCV treatment suggests additional MHD benefits, although the duration of these effects is unknown.展开更多
NEWTON’s laws of motion predicted that light would travel faster from a moving source—it doesn’t.Einstein was convinced that unruly electrons had no place in an orderly,understandable universe.Both assumed that hum...NEWTON’s laws of motion predicted that light would travel faster from a moving source—it doesn’t.Einstein was convinced that unruly electrons had no place in an orderly,understandable universe.Both assumed that human knowledge could be perfected,mathematically,and that a coherent scientific account of the world we find ourselves in,not only exists,but is available and open to dedicated human enquiry.This paper argues that Hume,Kant and recent work on Hubble’s Constant render this idealistic position untenable.The remedy proposed is not to tighten scientific definitions ever further,but to reposition Science so as to prioritise the biosphere.This entails placing the process of living organisms centre stage,since they defy the Second Law of Thermodynamics,thereby reducing Uncertainty for all—an approach best exemplified in clinical medicine,where despite unbridgeable gaps in medical knowledge,healing can and does take place.Using Quaker insights developed in the 1650s,a non-theological pathway is offered which emphasises human creativity and social cohesion.Unhappily psychiatry today,under the guise of being 100%scientific in the Einstein way,discards three counts of millennial medical wisdom,with catastrophic consequences,as shown by scientifically valid data.A healthier approach to mental and social health,emphasising trust and consent,is described.展开更多
该文对B/S模式下心理预警系统的构建过程进行了分析。系统基于B/S模式,集在线测评、学习、宣传、管理于一体,实现了无纸化的心理学问卷调查,并能准确地计算测试结果。该系统运用了ASP.NET、SQL Server 2005数据库、网页设计等计算机技术...该文对B/S模式下心理预警系统的构建过程进行了分析。系统基于B/S模式,集在线测评、学习、宣传、管理于一体,实现了无纸化的心理学问卷调查,并能准确地计算测试结果。该系统运用了ASP.NET、SQL Server 2005数据库、网页设计等计算机技术,将心理学研究成果赋予实体,具有较强的先进性和可扩展性。展开更多
As the British colonized West Africa, Africans worked as medical officers. John Farrell Easmon practiced private medicine that in 1897 affected his work as the chief medical officer. The Secretary of State for the Col...As the British colonized West Africa, Africans worked as medical officers. John Farrell Easmon practiced private medicine that in 1897 affected his work as the chief medical officer. The Secretary of State for the Colonies Joseph Chamberlain investigated the complaints of medical officers and fashioned the policy of the West African Medical Staff in 1902. During the Great Depression, the West African Medical Staff and Staff Pay shaped how African medical officers and European women medical doctors earned salaries as colonial government workers. Percy Selwyn-Clarke the deputy director of health service employed European women medical doctors in preventive health at infant and child welfare clinics. In 1935, health visitor Christian challenged the government for paying European woman medical doctor Nora Vane-Percy £10 to treat destitute African women and children at the Christiansborg infant welfare clinic.展开更多
文摘Background:Doctoral students have much higher risk of anxiety or depression than general population.Doctoral students worldwide are facing varying degrees of mental health risks.Method:Based on the survey data of 6,812 doctoral students worldwide in Nature in 2019,Probit and Logit models are used to explore the correlation between thefit of doctoral education and training process and the mental health of doctoral students.Results:(1)The training environmentfit of doctoral students has a significant positive impact on their mental health.(2)The academic professionfit of doctoral students has a significant positive impact on their mental health.(3)The orga-nizational culturefit of doctoral students has a significant positive impact on their mental health.(4)Thefinancial supportfit of doctoral students has a significant positive impact on their mental health.Conclusion:The higher the degree of doctoral students’training environmentfit,academic professionfit,organizational culturefit,andfinancial supportfit,the lower the possibility of anxiety or depression among doctoral students.The current research results can help reveal extensive factors that affect the mental health of doctoral students,facilitate the planning and development of effective intervention measures by universities,improve thefit of the doctoral education and training process,improve the mental health of doctoral students,and boost academic excellence.
文摘This paper provides an overview of research into mental health problem and occupational stress among Chinese doctors in recent 10 years. It indicates that doctors in general hospitals have worse mental status. Occupational stress comes from over workload, high demanding from patients, occupational risk, effort-reward imbalance and fierce competition for job promotion. For medical staffs battling against severe acute respiratory syndrome (SARS), or working in catastrophic Wenchuan earthquake-affected areas, they have elevated stress and worrying levels of psychological distress. Post-traumatic stress disorder (PTSD) is a common mental health problem among them. The most common diseases the Chinese doctors usually suffered were cervical spondylosis, hyperlipidemia, hypertension, fatty liver and hyperglycemia. It could be important for health administrators to note that mental health appears to be an?increasing problem in Chinese doctors and corresponding helping measure should be made.
文摘AIMTo study impact of baseline mental health disease on hepatitis C virus (HCV) treatment; and Beck’s Depression Inventory (BDI) changes with sofosbuvir- and interferon-based therapy. METHODSThis is a retrospective cohort study of participants from 5 studies enrolled from single center trials conducted at the Clinical Research Center of the National Institutes of Health, Bethesda, MD, United States. All participants were adults with chronic HCV genotype 1 infection and naïve to HCV therapy. Two of the studies included HCV mono-infected participants only (SPARE, SYNERGY-A), and 3 included human immunodeficiency virus (HIV)/HCV co-infected participants only (ERADICATE, PFINPK, and ALBIN). Patients were treated for HCV with 3 different regimens: Sofosbuvir and ribavirin in the SPARE trial, ledipasvir and sofosbuvir in SYNERGY-A and ERADICATE trials, and pegylated interferon (IFN) and ribavirin for 48 wk in the PIFNPK and ALBIN trials. Participants with baseline mental health disease (MHD) were identified (defined as either a DSM IV diagnosis of major depression, bipolar disorder, schizophrenia, generalized anxiety, and post-traumatic stress disorder or requiring anti-depressants, antipsychotics, mood stabilizers or psychotropics prescribed by a psychiatrist). For our first aim, we compared sustained virologic response (SVR) and adherence (pill counts, study visits, and in 25 patients, blood levels of the sofosbuvir metabolite, GS-331007) within each study. For our second aim, only patients with HIV coinfection were evaluated. BDI scores were obtained pre-treatment, during treatment, and post-treatment among participants treated with sofosbuvir-based therapy, and compared to scores from participants treated with interferon-based therapy. Statistical differences for both aims were analyzed by Fisher’s Exact, and t-test with significance defined as a P value less than 0.05. RESULTSBaseline characteristics did not differ significantly between all participants with and without MHD groups treated with sofosbuvir-based therapy. Among patients treated with sofosbuvir-based therapy, the percentage of patients with MHD who achieved SVR was the same as those without (SPARE: 60.9% of those MHD compared to 67.6% in those without, P = 0.78; SYNERGY-A: 100% of both groups; ERADICATE: 100% compared to 97.1%). There was no statistically significant difference in pill counts, adherence to study visits between groups, nor mean serum concentrations of GS-331007 for each group at week 2 of treatment (P = 0.72). Among patients with HIV co-infection, pre-treatment BDI scores were similar among patients treated with sofosbuvir, and those treated with interferon (sofosbuvir-based 5.24, IFN-based 6.96; P = 0.14); however, a dichotomous effect on was observed during treatment. Among participants treated with directly acting antiviral (DAA)-based therapy, mean BDI scores decreased from 5.24 (pre-treatment) to 3.28 during treatment (1.96 decrease, P = 0.0034) and 2.82 post-treatment. The decrease in mean score from pre- to post-treatment was statistically significant (-2.42, P = 0.0012). Among participants treated with IFN-based therapy, mean BDI score increased from 6.96 at pre-treatment to 9.19 during treatment (an increase of 2.46 points, P = 0.1), and then decreased back to baseline post-treatment (mean BDI score 6.3, P = 0.54). Overall change in mean BDI scores from pre-treatment to during treatment among participants treated with DAA-based and IFN-therapy was statistically significant (-1.96 and +2.23, respectively; P = 0.0032). This change remained statistically significant when analysis was restricted to participants who achieved SVR (-2.0 and +4.36, respectively; P = 0.0004). CONCLUSIONSofosbuvir-based therapy is safe and well tolerated in patients with MHD. A decline in BDI associated with sofosbuvir-based HCV treatment suggests additional MHD benefits, although the duration of these effects is unknown.
文摘NEWTON’s laws of motion predicted that light would travel faster from a moving source—it doesn’t.Einstein was convinced that unruly electrons had no place in an orderly,understandable universe.Both assumed that human knowledge could be perfected,mathematically,and that a coherent scientific account of the world we find ourselves in,not only exists,but is available and open to dedicated human enquiry.This paper argues that Hume,Kant and recent work on Hubble’s Constant render this idealistic position untenable.The remedy proposed is not to tighten scientific definitions ever further,but to reposition Science so as to prioritise the biosphere.This entails placing the process of living organisms centre stage,since they defy the Second Law of Thermodynamics,thereby reducing Uncertainty for all—an approach best exemplified in clinical medicine,where despite unbridgeable gaps in medical knowledge,healing can and does take place.Using Quaker insights developed in the 1650s,a non-theological pathway is offered which emphasises human creativity and social cohesion.Unhappily psychiatry today,under the guise of being 100%scientific in the Einstein way,discards three counts of millennial medical wisdom,with catastrophic consequences,as shown by scientifically valid data.A healthier approach to mental and social health,emphasising trust and consent,is described.
文摘该文对B/S模式下心理预警系统的构建过程进行了分析。系统基于B/S模式,集在线测评、学习、宣传、管理于一体,实现了无纸化的心理学问卷调查,并能准确地计算测试结果。该系统运用了ASP.NET、SQL Server 2005数据库、网页设计等计算机技术,将心理学研究成果赋予实体,具有较强的先进性和可扩展性。
文摘As the British colonized West Africa, Africans worked as medical officers. John Farrell Easmon practiced private medicine that in 1897 affected his work as the chief medical officer. The Secretary of State for the Colonies Joseph Chamberlain investigated the complaints of medical officers and fashioned the policy of the West African Medical Staff in 1902. During the Great Depression, the West African Medical Staff and Staff Pay shaped how African medical officers and European women medical doctors earned salaries as colonial government workers. Percy Selwyn-Clarke the deputy director of health service employed European women medical doctors in preventive health at infant and child welfare clinics. In 1935, health visitor Christian challenged the government for paying European woman medical doctor Nora Vane-Percy £10 to treat destitute African women and children at the Christiansborg infant welfare clinic.