Predicting the stages of cancer accurately is crucial for effective treatment planning. In this study, we aimed to develop a model using gene expression data and XGBoost (eXtreme Gradient Boosting) that include clinic...Predicting the stages of cancer accurately is crucial for effective treatment planning. In this study, we aimed to develop a model using gene expression data and XGBoost (eXtreme Gradient Boosting) that include clinical and demographic variables to predict specific lung cancer stages in patients. By conducting the feature selection using the Wilcoxon Rank Test, we picked the most impactful genes associated with lung cancer stage prediction. Our model achieved an overall accuracy of 82% in classifying lung cancer stages according to patients’ gene expression data. These findings demonstrate the potential of gene expression analysis and machine learning techniques in improving the accuracy of lung cancer stage prediction, aiding in personalized treatment decisions.展开更多
Exercise is a potent force of nature with significant potential for extending longevity and boosting physical fitness. It is also be- ing increasingly used as a prophylactic and curative measure for various physical a...Exercise is a potent force of nature with significant potential for extending longevity and boosting physical fitness. It is also be- ing increasingly used as a prophylactic and curative measure for various physical ailments, such as cardiovascular diseases and diabetes.展开更多
Constant escalations in the number of diabetics worldwide and the failure of conventional therapy to restore normoglycemia without adverse effects,in spite of tremendous strides in modern medicine,calls for naturopath...Constant escalations in the number of diabetics worldwide and the failure of conventional therapy to restore normoglycemia without adverse effects,in spite of tremendous strides in modern medicine,calls for naturopathy and alternative medicine.Because diabetes is multi-factorial and has secondary complications,prevention of hyperglycemia is the central dogma for its management.To date,no oral hypoglycemic exists which can achieve tight glycemic control without side effects.Dietary adjuncts,lifestyle interventions and a resurgence of interest in phyto-therapy have consequently gained ground.Natural hypoglycemics have attracted attention due to ease of incorporation in everyday diet,affordability,less adverse effects,and long term safety.Ethno botanical literature reports more than 800 anti-diabetic plants species.Eucalyptus is well represented in the Aboriginal Pharmacopoeias for its various pharmacological activities.Its hot aqueous decoction has been used as a hypoglycemic in various regions of world.This editorial attempts to summarize the data on the hypoglycemic potential of the different eucalyptus species,highlight the value of its natural biomolecules for the prophylaxis and treatment of type2 diabetes,describe their mechanistic actions,shed light on the posology and safety aspects of eucalyptusand assess its applicability as a reinforcement to currently used therapy.展开更多
The normal development and optimal functioning of the brain requires a vigilant immune surveillance system to detect and remove potential risk factors and prevent infection and tissue damage. Microglia are the residen...The normal development and optimal functioning of the brain requires a vigilant immune surveillance system to detect and remove potential risk factors and prevent infection and tissue damage. Microglia are the resident immune cells and the frontline defenders responsible for the immune response of the brain. Resting microglia possess a ramified morphology with numerous thin processes that continuously sample the environment. In response to inflammatory signals, microglia become activated and transform their morphology into a thick, amoeboid-like shape. Activated microglia proliferate, tolerate to sites of iniurv,展开更多
Editor’s Note: In the early 1980s, some graduates of the prestigious Central Conservatory of Music began their musical careers. When one such graduate, Tan Dun, was awarded an Oscar in 1999 for his musical score to t...Editor’s Note: In the early 1980s, some graduates of the prestigious Central Conservatory of Music began their musical careers. When one such graduate, Tan Dun, was awarded an Oscar in 1999 for his musical score to the film Crouching Tiger, Hidden Dragon, well-known Chinese composer Chen Qigang, now resident in France, wrote a letter of congratulations to his former classmate. He said, "Ours was a class of student nonentities until we rocked China and then the world. We ’lit beacons’ in different parts of the world. Whether friends or rivals, our influence on each other is symbiotic. Now, when people call me ’master,’ I can’t help remembering being one of eight classmates, all sharing an hotel room in Amsterdam." At the end of his letter Chen Qigang wrote, "Our horizons are broadening."This article gives an insight into artists who were young during the "cultural revolution, " and the impressions of European and American music circles they gained from their experience abroad.展开更多
DNA-encoded chemical library(DEL)links the power of amplifiable genetics and the nonself-replicating chemical phenotypes,generating a diverse chemical world.In analogy with the biological world,the DEL world can evolv...DNA-encoded chemical library(DEL)links the power of amplifiable genetics and the nonself-replicating chemical phenotypes,generating a diverse chemical world.In analogy with the biological world,the DEL world can evolve by using a chemical central dogma,wherein DNA replicates using the PCR reactions to amplify the genetic codes,DNA sequencing transcripts the genetic information,and DNA-compatible synthesis translates into chemical phenotypes.Importantly,DNA-compatible synthesis is the key to expanding the DEL chemical space.Besides,the evolution-driven selection system pushes the chemicals to evolve under the selective pressure,i.e.,desired selection strategies.In this perspective,we summarized recent advances in expanding DEL synthetic toolbox and panning strategies,which will shed light on the drug discovery harnessing in vitro evolution of chemicals via DEL.展开更多
The central dogma(CD)of molecular biology is the transfer of genetic information from DNA to RNA to protein.Major CD processes governing genetic flow include the cell cycle,DNA replication,chromosome packaging,epigene...The central dogma(CD)of molecular biology is the transfer of genetic information from DNA to RNA to protein.Major CD processes governing genetic flow include the cell cycle,DNA replication,chromosome packaging,epigenetic changes,transcription,posttranscriptional alterations,translation,and posttranslational modifications.The CD processes are tightly regulated in plants to maintain genetic integrity throughout the life cycle and to pass genetic materials to next generation.Engineering of various CD processes involved in gene regulation will accelerate crop improvement to feed the growing world population.CRISPR technology enables programmable editing of CD processes to alter DNA,RNA,or protein,which would have been impossible in the past.Here,an overview of recent advancements in CRISPR tool development and CRISPR-based CD modulations that expedite basic and applied plant research is provided.Furthermore,CRISPR applications in major thriving areas of research,such as gene discovery(allele mining and cryptic gene activation),introgression(de novo domestication and haploid induction),and application of desired traits beneficial to farmers or consumers(biotic/abiotic stress-resilient crops,plant cell factories,and delayed senescence),are described.Finally,the global regulatory policies,challenges,and prospects for CRISPR-mediated crop improvement are discussed.展开更多
Background:The genetic central dogma(GCD)has been demonstrated its essential function in many biological processes and diseases.However,its roles in the process of osteogenic differentiation of mesenchymal stem cells(...Background:The genetic central dogma(GCD)has been demonstrated its essential function in many biological processes and diseases.However,its roles in the process of osteogenic differentiation of mesenchymal stem cells(MSCs)remain unclear.Methods:In this project,we analyzed an online database of osteogenic differentiation of MSCs after 14 days and 28 days by osteoinductive medium(GSE83770).The differentially expressed genes were screened by GEO2R,with further conducting of KEGG pathways using DAVID.In addition,protein-protein interactions of the enriched pathways were performed using STRING with marked hub genes measured by the CytoHubba.Hub genes were verified by quantitative reverse-transcription polymerase chain reaction.Results:Results showed that six pathways related to GCD,including DNA replication,Aminoacyl-tRNA biosynthesis,Mismatch repair,Ribosome,Spliceosome,and RNA degradation pathways enriched in the early stage(14 days vs.undifferentiated MSCs)of osteogenesis.The Lysosome pathway was highly enriched in the late stage(28 vs.14 days)of osteogenesis,and Ribosome pathway plays a key role throughout the entire process(28 days vs.undifferentiated MSCs)of osteogenesis.Conclusion:Both DNA replication and protein translation were functionally worked in the early stage of osteogenesis,whereas the Lysosome pathway was the only GCD-related one in the late stage of osteogenesis.The GCD-related Ribosome pathway occupied the entire process of osteogenesis.展开更多
文摘Predicting the stages of cancer accurately is crucial for effective treatment planning. In this study, we aimed to develop a model using gene expression data and XGBoost (eXtreme Gradient Boosting) that include clinical and demographic variables to predict specific lung cancer stages in patients. By conducting the feature selection using the Wilcoxon Rank Test, we picked the most impactful genes associated with lung cancer stage prediction. Our model achieved an overall accuracy of 82% in classifying lung cancer stages according to patients’ gene expression data. These findings demonstrate the potential of gene expression analysis and machine learning techniques in improving the accuracy of lung cancer stage prediction, aiding in personalized treatment decisions.
文摘Exercise is a potent force of nature with significant potential for extending longevity and boosting physical fitness. It is also be- ing increasingly used as a prophylactic and curative measure for various physical ailments, such as cardiovascular diseases and diabetes.
文摘Constant escalations in the number of diabetics worldwide and the failure of conventional therapy to restore normoglycemia without adverse effects,in spite of tremendous strides in modern medicine,calls for naturopathy and alternative medicine.Because diabetes is multi-factorial and has secondary complications,prevention of hyperglycemia is the central dogma for its management.To date,no oral hypoglycemic exists which can achieve tight glycemic control without side effects.Dietary adjuncts,lifestyle interventions and a resurgence of interest in phyto-therapy have consequently gained ground.Natural hypoglycemics have attracted attention due to ease of incorporation in everyday diet,affordability,less adverse effects,and long term safety.Ethno botanical literature reports more than 800 anti-diabetic plants species.Eucalyptus is well represented in the Aboriginal Pharmacopoeias for its various pharmacological activities.Its hot aqueous decoction has been used as a hypoglycemic in various regions of world.This editorial attempts to summarize the data on the hypoglycemic potential of the different eucalyptus species,highlight the value of its natural biomolecules for the prophylaxis and treatment of type2 diabetes,describe their mechanistic actions,shed light on the posology and safety aspects of eucalyptusand assess its applicability as a reinforcement to currently used therapy.
基金supported by the Bio&Medical Technology Development Program of the National Research Foundation of Korea(NRF)grant(No.2012M3A9C6049935)the DGIST Convergence Science Center Program(15-BD-04)of the Ministry of Science,ICT and Future Planning of Korea
文摘The normal development and optimal functioning of the brain requires a vigilant immune surveillance system to detect and remove potential risk factors and prevent infection and tissue damage. Microglia are the resident immune cells and the frontline defenders responsible for the immune response of the brain. Resting microglia possess a ramified morphology with numerous thin processes that continuously sample the environment. In response to inflammatory signals, microglia become activated and transform their morphology into a thick, amoeboid-like shape. Activated microglia proliferate, tolerate to sites of iniurv,
文摘Editor’s Note: In the early 1980s, some graduates of the prestigious Central Conservatory of Music began their musical careers. When one such graduate, Tan Dun, was awarded an Oscar in 1999 for his musical score to the film Crouching Tiger, Hidden Dragon, well-known Chinese composer Chen Qigang, now resident in France, wrote a letter of congratulations to his former classmate. He said, "Ours was a class of student nonentities until we rocked China and then the world. We ’lit beacons’ in different parts of the world. Whether friends or rivals, our influence on each other is symbiotic. Now, when people call me ’master,’ I can’t help remembering being one of eight classmates, all sharing an hotel room in Amsterdam." At the end of his letter Chen Qigang wrote, "Our horizons are broadening."This article gives an insight into artists who were young during the "cultural revolution, " and the impressions of European and American music circles they gained from their experience abroad.
基金Financial support was provided by the National Natural Science Foundation of China(grant numbers 22177073,21977070,21907085,and U19A2011)the Natural Science Foundation of Shanghai,China(grant numbers 21ZR1442900 and 23ZR1437600)+2 种基金the Natural Science Foundation of Zhejiang Province,China(grant number LY22H300001)Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal SystemShanghai Key Laboratory of Orthopedic Implants(grant number KFKT202207,China)for financial support.
文摘DNA-encoded chemical library(DEL)links the power of amplifiable genetics and the nonself-replicating chemical phenotypes,generating a diverse chemical world.In analogy with the biological world,the DEL world can evolve by using a chemical central dogma,wherein DNA replicates using the PCR reactions to amplify the genetic codes,DNA sequencing transcripts the genetic information,and DNA-compatible synthesis translates into chemical phenotypes.Importantly,DNA-compatible synthesis is the key to expanding the DEL chemical space.Besides,the evolution-driven selection system pushes the chemicals to evolve under the selective pressure,i.e.,desired selection strategies.In this perspective,we summarized recent advances in expanding DEL synthetic toolbox and panning strategies,which will shed light on the drug discovery harnessing in vitro evolution of chemicals via DEL.
基金This work was supported by the National Research Foundation of Korea(grants NRF 2020M3A9I4038352,2020R1A6A1A03044344)by the Next-Generation BioGreen 21 Program(SSAC,grant PJ01322601)the Program for New Plant Breeding Techniques(NBT,grant PJ01478401),Rural Development Administration,Korea.
文摘The central dogma(CD)of molecular biology is the transfer of genetic information from DNA to RNA to protein.Major CD processes governing genetic flow include the cell cycle,DNA replication,chromosome packaging,epigenetic changes,transcription,posttranscriptional alterations,translation,and posttranslational modifications.The CD processes are tightly regulated in plants to maintain genetic integrity throughout the life cycle and to pass genetic materials to next generation.Engineering of various CD processes involved in gene regulation will accelerate crop improvement to feed the growing world population.CRISPR technology enables programmable editing of CD processes to alter DNA,RNA,or protein,which would have been impossible in the past.Here,an overview of recent advancements in CRISPR tool development and CRISPR-based CD modulations that expedite basic and applied plant research is provided.Furthermore,CRISPR applications in major thriving areas of research,such as gene discovery(allele mining and cryptic gene activation),introgression(de novo domestication and haploid induction),and application of desired traits beneficial to farmers or consumers(biotic/abiotic stress-resilient crops,plant cell factories,and delayed senescence),are described.Finally,the global regulatory policies,challenges,and prospects for CRISPR-mediated crop improvement are discussed.
文摘Background:The genetic central dogma(GCD)has been demonstrated its essential function in many biological processes and diseases.However,its roles in the process of osteogenic differentiation of mesenchymal stem cells(MSCs)remain unclear.Methods:In this project,we analyzed an online database of osteogenic differentiation of MSCs after 14 days and 28 days by osteoinductive medium(GSE83770).The differentially expressed genes were screened by GEO2R,with further conducting of KEGG pathways using DAVID.In addition,protein-protein interactions of the enriched pathways were performed using STRING with marked hub genes measured by the CytoHubba.Hub genes were verified by quantitative reverse-transcription polymerase chain reaction.Results:Results showed that six pathways related to GCD,including DNA replication,Aminoacyl-tRNA biosynthesis,Mismatch repair,Ribosome,Spliceosome,and RNA degradation pathways enriched in the early stage(14 days vs.undifferentiated MSCs)of osteogenesis.The Lysosome pathway was highly enriched in the late stage(28 vs.14 days)of osteogenesis,and Ribosome pathway plays a key role throughout the entire process(28 days vs.undifferentiated MSCs)of osteogenesis.Conclusion:Both DNA replication and protein translation were functionally worked in the early stage of osteogenesis,whereas the Lysosome pathway was the only GCD-related one in the late stage of osteogenesis.The GCD-related Ribosome pathway occupied the entire process of osteogenesis.
