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Analysis of vegetation changes and dominant factors on the Qinghai-Tibet Plateau, China 被引量:6
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作者 HongWei Wang Yuan Qi +3 位作者 ChunLin Huang XiaoYing Li XiaoHong Deng JinLong Zhang 《Research in Cold and Arid Regions》 CSCD 2019年第2期150-158,共9页
This research was undertaken to clarify the characteristics of vegetation change and its main influencing factors on the Qinghai-Tibet Plateau. Using the greenness rate of change(GRC) and correlation factors, we analy... This research was undertaken to clarify the characteristics of vegetation change and its main influencing factors on the Qinghai-Tibet Plateau. Using the greenness rate of change(GRC) and correlation factors, we analyzed the trend of vegetation change and its dominant factors from 2000 to 2015. The results indicate that the vegetation tended to improve from 2000 to 2015 on the Qinghai-Tibet Plateau, with the improved area accounting for 39.93% of the total; and the degraded area accounting for 19.32%. The areas of degraded vegetation are mainly concentrated in the low-relief and intermediate-relief mountains of the high-altitude and extremely high-altitude areas on the Qinghai-Tibet Plateau, as the vegetation characteristics are impacted by the terrain. Temperature and precipitation have obvious response mechanisms to vegetation growth, but the effects of precipitation and temperature on vegetation degradation are not significant over a short time frame. Overgrazing and population growth are the dominant factors of vegetation degradation on the Qinghai-Tibet Plateau. 展开更多
关键词 Qinghai-Tibet PLATEAU REMOTE sensing VEGETATION activity degraded dominant factorS
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Dominant Factors on the Early Hydration of Metakaolin-Cement Paste 被引量:2
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作者 水中和 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2010年第5期849-852,共4页
The dominant factors during early hydration process of cement paste containing 10% metakaolin replacement (MK10) and 10% kaolin replacement (K10) are investigated in comparison to neat cement paste (NCP), and X-... The dominant factors during early hydration process of cement paste containing 10% metakaolin replacement (MK10) and 10% kaolin replacement (K10) are investigated in comparison to neat cement paste (NCP), and X-ray Diffraction (XRD) analysis is employed to identify the crystalline phases of all specimens. Thermogravimetric (TG) and Differential Scanning Calorimetry (DSC) are used to identify the phase constituents. The amount of acid-insoluble residue (AIR) of all specimens is used to evaluate the unreacted materials. The results indicate that, after the first day, MK act as nuclei for the formation of C-S-H during hydration of C3S and C2S, densifying the microstructure of cement paste. Its contribution is mainly due to the fine nature of the MK. From 3 days to 7 days, more and more MK reacts with CH to form C-S-H, making the microstructure denser. The strength contribution is mainly due to the chemical activity of MK. 展开更多
关键词 metakaolin (MK) HYDRATION dominant factor cement paste
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Dominant factors in MiniCone, CPT and pile correlations: A data‐based approach
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作者 Seyed Sajad Shirani Abolfazl Eslami +1 位作者 Amirhossein Ebrahimipour Moses Karakouzian 《Deep Underground Science and Engineering》 2023年第4期346-358,共13页
The cone penetration test(CPT)contributes to the design and analysis of piles regarding geometry,installation effect,and pile capacity(shaft and toe resistance).MiniCone,as an alternative to CPT sounding,has been used... The cone penetration test(CPT)contributes to the design and analysis of piles regarding geometry,installation effect,and pile capacity(shaft and toe resistance).MiniCone,as an alternative to CPT sounding,has been used to carry outfield and laboratory investigations by physical modeling.More tests can be practically carried out through light equipment and small soil mass,involving fewer errors caused by boundary conditions.Furthermore,it can be used for in situ testing,such as quality control,assessment of ground improvement,and subgrade characterization.A database comprising MiniCone and CPT records infield and physical modeling is proposed with a variety of cone diameters.The case study records in the database have been obtained from 140 tests compiled from data from 26 sources.The sources include the results of 20 physical modelings andfield data from six sites in 10 countries.The data comprise MiniCone and CPT cone tip resistance(qc),and sleeve friction(fs).The different cones are used in sandy,silty sand,and clayey soils via simple chambers(1 g),calibration chambers,and frustum confining vessels.In addition,correlations were found in penetration records in terms of physical modeling types,cone diameters,penetration rates,and soil densities.Moreover,qc and fs are related to capacities of pile toes and shafts using proper correlation coefficients less than unity,respectively.Correlations and dominant factors in geotechnical practice between MiniCone,CPT,and pile have been reviewed and discussed. 展开更多
关键词 CORRELATIONS CPT DATABASE dominant factors MiniCone PILE
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Recognition of two dominant modes of EASM and its thermal driving factors based on 25 monsoon indexes
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作者 YE Mao CHEN Haishan 《Atmospheric and Oceanic Science Letters》 CSCD 2019年第4期278-285,共8页
Based on three reanalysis datasets—ERA-Interim,NCAR–NCEP and JRA-55—the classification of25 commonly used indexes of the East Asian summer monsoon(EASM)was investigated.The physical nature of two categories of mons... Based on three reanalysis datasets—ERA-Interim,NCAR–NCEP and JRA-55—the classification of25 commonly used indexes of the East Asian summer monsoon(EASM)was investigated.The physical nature of two categories of monsoon index,together with their circulation pattern,climate anomalies,and driving factors,were investigated.Results suggest that the selected 25 monsoon indexes can be classified into two typical categories(CategoryⅠandⅡ),which are dominated by interannual and decadal variabilities of the EASM,respectively.The anomalous circulation patterns and summer rainfall patterns related to the two categories of index also exhibit evident differences.CategoryⅠis closely linked to the low-latitude circulation system and the anomalous circulation pattern is a typical East Asia–Pacific teleconnection pattern.The summer rainfall anomaly exhibits a typical tripole pattern.However,CategoryⅡmainly reflects the impacts of the middle–high latitude circulation system on the summer monsoon and is closely linked to a typical Eurasian teleconnection pattern,which corresponds to a dipole of summer rainfall anomalies.Further analysis suggests that the underlying thermal driving factors of the two categories of monsoon are distinct.The main driving factors of CategoryⅠare the tropical sea surface temperature anomalies(SSTAs),especially ENSO-related SSTAs in the preceding winter and summer SSTAs in the tropical Indian Ocean.The winter signal of Category II summer monsoon anomalous activity mainly originates from the polar region and the middle and high latitudes of the Eurasian continent.CategoryⅡmonsoon activity is also associated with summer SSTAs in the equatorial central Pacific. 展开更多
关键词 East Asian summer monsoon dominant modes summer rainfall anomaly anomalous atmospheric general circulation pattern thermal driving factors
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Dominant early heading without yield drag in a sister-line BC breeding progeny DEH_229 is controlled by multiple genetic factors with maineffect loci
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作者 Muhiuddin Faruquee Qiang Zhang +7 位作者 Lubiao Zhang Linyun Xu Wensheng Wang Jiansan Chen Jianlong Xu Zhikang Li Binying Fu Tianqing Zheng 《The Crop Journal》 SCIE CSCD 2021年第2期400-411,共12页
Dominant early heading(DEH)in rice(Oryza sativa L.)is of interest in both breeding and genetics.The genetic mechanisms underlying DEH have remained largely unclear.We have developed a near-isogenic DEH line without yi... Dominant early heading(DEH)in rice(Oryza sativa L.)is of interest in both breeding and genetics.The genetic mechanisms underlying DEH have remained largely unclear.We have developed a near-isogenic DEH line without yield drag named DEH_229 by sister-line backcross(BC)breeding with MH63,a restorer,as the genetic background.We conducted a pilot genetic investigation under both short-day(SD)and long-day(LD)conditions.The DEH line harbored only 1.06%variation in the genome sequence relative to MH63.The variants were distributed throughout the genome.Using QTL mapping by sequencing(QTL-seq)on an F_(2) population derived from a cross of MH63×DEH_229,57 loci were detected under the SD condition.Joint mapping employing a genome-wide association study with accessions from the 3000 rice genome sequencing project(3K-RG),reduced the number of QTL by 43.9%.Using Rice Functional Genomics&Breeding(RFGB)database,the number of SNP cluster regions within the QTL regions reduced by 27.3%.Further comparison of the genome variation between DEH_229 and MH63 in addition to gene annotation information revealed a new DEH allele of DTH3 with multiple variable sites as a possible major factor underlying the early-heading phenotype of DEH_229.An InDel marker,ZMEH_1,was designed based on the variation between DEH_229 and MH63 within this region.It accounted for 86.0%of heading date variation under both SD and LD conditions in 109 randomly chosen progeny derived from extreme lines of the MH63×DEH_229 population.This study reveals the genetic complexity of DEH in the near-isogenic line and may provide useful material and marker information for plant molecular breeding. 展开更多
关键词 dominant early heading Yield drag Sister-line BC breeding Multiple genetic factors Cryptic genetic variation(CGV) Rice(Oryza sativa L.)
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Geological Characteristics and Ore-controlling Factors of the Beiya Gold–Polymetallic Ore Deposit, Northwestern Yunnan Province 被引量:9
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作者 ZHOU Yunman ZHANG Changqing +4 位作者 HE Zhonghua LIU Huan ZHOU Guiwu SUN Jia LIU Bo 《Acta Geologica Sinica(English Edition)》 CAS CSCD 2018年第5期1841-1861,共21页
Based on comprehensive petrological, geochronological, and geochemical studies, this study analyzed the relationships between the Beiya gold-polymetallic skarn deposit and quartz syenite porphyries, and discussed the ... Based on comprehensive petrological, geochronological, and geochemical studies, this study analyzed the relationships between the Beiya gold-polymetallic skarn deposit and quartz syenite porphyries, and discussed the source(s) and evolution of magmas. Our results suggest that syenite porphyries(i.e. the Wandongshan, the Dashadi, and the Hongnitang porphyries), which formed between the Eocene and the early Oligocene epochs, are the sources for the gold-polymetallic ores at the Beiya deposit. Carbonate rocks(T2 b) of the Triassic Beiya Formation in the ore district provide favorable host space for deposit formation. Fold and fault structures collectively play an important role in ore formation. The contact zone between the porphyries and carbonates, the structurally fractured zone of carbonate and clastic rocks, and the zone with well-developed fractures are the ideal locations for ore bodies. Four types of mineralization have been recognized: 1) porphyry-style stockwork gold–iron(copper) ore, 2) skarn-style gold-iron(copper and lead) ore in the near contact zone, 3) strata-bound, lense-type lead–silver–gold ore in the outer contact zone, and 4) distal vein-type gold–lead–silver ore. Supergene processes led to the formation of oxide ore, such as the weathered and accumulated gold–iron ore, the strata-bound fracture oxide ore, and the structure-controlled vein-type ore. Most of these ore deposits are distributed along the axis of the depressed basin, with the hypogene ore controlling the shape and characteristics of the oxide ore. This study provides critical geology understanding for mineral prospecting scenarios. 展开更多
关键词 porphyry-skarn type quartz syenite porphyries ore-controlling factors Beiya goldpolymetallic deposit northwestern Yunnan province
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Quantitative analysis of geological ore-controlling factors and stereoscopic quantitative prediction of concealed ore bodies 被引量:5
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作者 毛先成 邹艳红 +2 位作者 卢晓琴 吴湘滨 戴塔根 《Journal of Central South University》 SCIE EI CAS 2009年第6期987-993,共7页
To address the issues for assessing and prospecting the replaceable resource of crisis mines, a geological ore-controlling field model and a mineralization distribution field model were proposed from the viewpoint of ... To address the issues for assessing and prospecting the replaceable resource of crisis mines, a geological ore-controlling field model and a mineralization distribution field model were proposed from the viewpoint of field analysis. By dint of solving the field models through transferring the continuous models into the discrete ones, the relationship between the geological ore-controlling effect field and the mineralization distribution field was analyzed, and the quantitative and located parameters were extracted for describing the geological factors controlling mineralization enrichment. The method was applied to the 3-dimensional localization and quantitative prediction for concealed ore bodies in the depths and margins of the Daehang mine in Guangxi, China, and the 3-dimensional distribution models of mineralization indexes and ore-controlling factors such as magmatic rocks, strata, faults, lithology and folds were built. With the methods of statistical analysis and the non-linear programming, the quantitative index set of the geological ore-controlling factors was obtained. In addition, the stereoscopic located and quantitative prediction models were set up by exploring the relationship between the mineralization indexes and the geological ore-controlling factors. So far, some concealed ore bodies with the resource volume of a medium-sized mineral deposit are found in the deep parts of the Dachang Mine by means of the deep prospecting drills following the prediction results, from which the effectiveness of the predication models and results is proved. 展开更多
关键词 geological ore-controlling factor concealed ore body stereoscopic prediction
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Dominating factors on well productivity and development strategies optimization in Weiyuan shale gas play, Sichuan Basin, SW China 被引量:6
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作者 MA Xinhua LI Xizhe +7 位作者 LIANG Feng WAN Yujin SHI Qiang WANG Yonghui ZHANG Xiaowei CHE Mingguang GUO Wei GUO Wei 《Petroleum Exploration and Development》 2020年第3期594-602,共9页
Weiyuan shale gas play is characterized by thin high-quality reservoir thickness,big horizontal stress difference,and big productivity differences between wells.Based on integrated evaluation of shale gas reservoir ge... Weiyuan shale gas play is characterized by thin high-quality reservoir thickness,big horizontal stress difference,and big productivity differences between wells.Based on integrated evaluation of shale gas reservoir geology and well logging interpretation of more than 20 appraisal wells,a correlation was built between the single well test production rate and the high-quality reservoir length drilled in the horizontal wells,high-quality reservoir thickness and the stimulation treatment parameters in over 100 horizontal wells,the dominating factors on horizontal well productivity were found out,and optimized development strategies were proposed.The results show that the deployed reserves of high-quality reservoir are the dominating factors on horizontal well productivity.In other words,the shale gas well productivity is controlled by the thickness of the high-quality reservoir,the high-quality reservoir drilling length and the effectiveness of stimulation.Based on the above understanding,the development strategies in Weiyuan shale gas play are optimized as follows:(1)The target of horizontal wells is located in the middle and lower parts of Longyi 11(Wei202 area)and Longyi 11(Wei204 area).(2)Producing wells are drilled in priority in the surrounding areas of Weiyuan county with thick high-quality reservoir.(3)A medium to high intensity stimulation is adopted.After the implementation of these strategies,both the production rate and the estimated ultimate recovery(EUR)of individual shale gas wells have increased substantially. 展开更多
关键词 Weiyuan shale gas play dominating factors of well productivity deployed reserves of high-quality reservoir thickness of high-quality reservoir high-quality reservoir drilling length effectiveness of stimulation development strategies optimization
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Identification of Dominant Climate Variables on Spatiotemporal Variation in Reference Evapotranspiration on the Loess Plateau,China
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作者 LI Xiaofei LIANG Wei +6 位作者 JIAO Lei YAN Jianwu ZHANG Weibin WANG Fengjiao GOU Fen WANG Chengxi SHAO Quanqin 《Chinese Geographical Science》 SCIE CSCD 2022年第4期620-642,共23页
Reference evapotranspiration(ET_(0))is a vital component in hydrometeorological research and is widely applied to various aspects,such as water resource management,hydrological modeling,irrigation deployment,and under... Reference evapotranspiration(ET_(0))is a vital component in hydrometeorological research and is widely applied to various aspects,such as water resource management,hydrological modeling,irrigation deployment,and understanding and predicting the influence of hydrologic cycle variations on future climate and land use changes.Quantifying the influence of various meteorological variables on ET_(0) is not only helpful for predicting actual evapotranspiration but also has important implications for understanding the impact of global climate change on regional water resources.Based on daily data from 69 meteorological stations,the present study analyzed the spatiotemporal pattern of ET_(0) and major contributing meteorological variables to ET_(0) from 1960 to 2017 by the segmented re-gression model,Mann-Kendall test,wavelet analysis,generalized linear model,and detrending method.The results showed that the annual ET_(0) declined slightly because of the combined effects of the reduction in solar radiation and wind speed and the increase in vapor pressure deficit(VPD)and average air temperature in the Loess Plateau(LP)during the past 58 yr.Four change points were detected in 1972,1990,1999,and 2010,and the annual ET_(0) showed a zigzag change trend of‘increasing-decreasing-increasing-decreasing-increasing’.Wind speed and VPD played a leading role in the ET_(0) changes from 1960 to 1990 and from 1991 to 2017,respectively.This study confirms that the dominant meteorological factors affecting ET_(0) had undergone significant changes due to global climate change and vegetation greening in the past 58 years,and VPD had become the major factor controlling the ET_(0) changes on the LP.The data presented herein will contribute to increasing the accuracy of predictions on future changes in ET_(0). 展开更多
关键词 reference evapotranspiration(ET0) change points generalized linear model dominant factors vapor pressure deficit(VPD) Loess Plateau(LP)
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Variations in evaporation from water surfaces along the margins of the Badain Jaran Desert over nearly 60 years and influencing factors 被引量:1
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作者 Li-juan Wang Zhe Wang +3 位作者 Gao-lei Jiang Zhen-long Nie Jian-mei Shen Sheng-hua Song 《Journal of Groundwater Science and Engineering》 2024年第3期253-263,共11页
Based on meteorological data collected over nearly 60 years(1960-2017)from four national meteorological stations along the margins of the Badain Jaran Desert,this study analyzed the spatiotemporal variations in evapor... Based on meteorological data collected over nearly 60 years(1960-2017)from four national meteorological stations along the margins of the Badain Jaran Desert,this study analyzed the spatiotemporal variations in evaporation from water surfaces and identified the dominant controlling factors.Methods used included linear trend analysis,linear tendency estimation,the departure method,the rank correlation coefficient-based method,and Multiple Linear Regression(MLR).Results indicate notable spatiotemporal differences in evaporation distribution and evolution.Spatially,average annual evaporation exhibited a pronounced altitude effect,decreasing at a rate of about 8.23 mm/m from east to west with increasing altitude.Temporally,annual evaporation showed significant upward trends after 1996 at the northeastern(Guaizi Lake)and western(Dingxin)margins,with rates of 132 mm/10a and 105 mm/10a,respectively.Conversely,along the northwestern(Ejina Banner)and southern(Alxa Right Banner)margins of the desert,an evaporation paradox was observed,with annual evaporation trending downward at rates of 162 mm/10a and 187 mm/10a,respectively,especially after 1987.The dominant factors controlling evaporation varied spatially:Average annual temperature and relative humidity influended the western margin(Dingxin),average annual temperature was the key factor for the northeastern margin(Guaizi Lake),and average wind speed was crucial for the northern(Ejina Banner)and southern(Alxa Right Banner)margins. 展开更多
关键词 Evaporation from water surface Evaporation paradox dominant controlling factor Variation trend
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ORE-CONTROLLING FACTORS AND PROSPECTS OF GEODEPRESSION (DIWA) BASIN SANDSTONE TYPE COPPER DEPOSITS IN CHINA
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《Geotectonica et Metallogenia》 1994年第Z2期48-49,共2页
关键词 ore-controlLING factorS AND PROSPECTS OF GEODEPRESSION BASIN SANDSTONE TYPE COPPER DEPOSITS IN CHINA DIWA
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Responding of zooplankton to environmental factor changes in the Changjiang River estuarine regions in spring-summer from 2016 to 2020
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作者 Jieqing YANG Dongrong ZHANG +4 位作者 Yuange CHEN Longling OUYANG Yangyang YANG Jin ZHOU Yunrong SHI 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第2期544-559,共16页
The estuarine areas are under frequent influence from freshwater intrusion and ocean currents,in which zooplankton species are diversified and variable as they are sensitive to physio-chemical variations in water.Ther... The estuarine areas are under frequent influence from freshwater intrusion and ocean currents,in which zooplankton species are diversified and variable as they are sensitive to physio-chemical variations in water.Therefore,understanding the relationships between zooplankton and environmental factors help us know the water quality.To achieve co-existence with species in similar ecological group or habit,they could inevitably alter themselves to fit the ecology and adjust the function according to the competitive exclusion in ecological theory.However,information of the co-existence of dominant species in the Changjiang(Yangtze)River estuary(CRE)and adjacent waters remains scarce.We explored the relationships between dominant zooplankton and environmental factors in the study region in spring-summer from 2016 to 2020,involving particularly the composition of dominant species,ecological groups,their relationships with environmental factors,and co-existence of important species,using the non-multidimensional scale analysis(nMDS)method and redundancy analysis.Results show that Labidocera euchaeta and Tortanus vermiculus were dominant species in the study scope.The turnover rate of dominant zooplankton was greater(>50%)in spring while the species number was higher in summer.The dominant species were estuarine,offshore,and eurytopic based on the adaptation to salinity.In spring,the ecological groups were dominated by estuarine species,while in summer by estuarine and offshore species.In addition,the nMDS showed that the dominant species in the same ecological group were more dispersed and not prominently clustered;the dominant species were staggered among different ecological groups.The temperature,salinity,pH,dissolved oxygen,and chlorophyll a were the main environmental factors on the distribution of the dominant species in spring,while in summer were dissolved oxygen,temperature,salinity,and pH.The domination of medusae of Nemopsis bachei and Pleurobrachia globosa in zooplankton community in spring,and the continuous decrease in abundance of L.euchaeta reflected the effects of local climate change.The temperature and salinity changes in different years and the subsequent response of zooplankton reflected the influence of freshwater intrusion and/or ocean currents.Zooplankton in similar ecological habits exhibited the competitive exclusion in terms of co-existence. 展开更多
关键词 Changjiang River estuary(CRE) ZOOPLANKTON dominant species ecological group environmental factor CO-EXISTENCE
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Spatial-temporal heterogeneity of ecological quality changes across the Qinghai-Tibet Plateau under the influence of climate factors and human activities
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作者 ZiPing Zhang YuWei Cui +1 位作者 WenJia Tang Sen Li 《Research in Cold and Arid Regions》 CSCD 2024年第3期129-140,共12页
Over the last few decades,the ecological quality of the Qinghai–Tibet Plateau(QTP)has significantly changed due to climate warming,humidification,and increasing human activities.Thus,evaluating this region's ecol... Over the last few decades,the ecological quality of the Qinghai–Tibet Plateau(QTP)has significantly changed due to climate warming,humidification,and increasing human activities.Thus,evaluating this region's ecological quality and dominant factors is crucial for sustainable development.In this study,the changes in the ecological quality on the QTP from 2000 to 2020 were evaluated based on aggregated indices and Sen–MK trend analyses,and the dominant factors affecting the ecological quality of the QTP were quantitatively analyzed using decision tree classification.The results revealed that(1)the ecological quality of the QTP exhibited an overall high trend in the east and a low pattern in the west;(2)the ecological quality of the QTP significantly increased from 2000 to 2020,and human activities were the dominant factors causing this change;and(3)the changes in the ecological quality and dominant factors exhibited obvious spatiotemporal heterogeneity.The area with an improved ecological quality occurred mainly in the northern QTP region.It was governed by human activities and precipitation.In contrast,the area with a deteriorated ecological quality occurred largely in the southern QTP region and was dominated by human activities and temperature.The 2000–2010 period was the most significant period of heterogeneity regarding of ecological quality and its driving factors.(4)The change in the ecological quality was mainly affected by the synergistic relationship between human activities and climate change in this region,which encompassed multiple dominant factors.This study provides important information on the spatiotemporal heterogeneity of ecological quality change and its dominant factors on the QTP and offers systematic guidance for the planning and implementation of ecological protection projects. 展开更多
关键词 Remote sensing-based ecological index(RSEI) dominant factors Synergies and trade-offs Qinghai‒Tibet Plateau
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Hepatocyte nuclear factor 1B mutation in a Chinese family with renal cysts and diabetes syndrome:A case report 被引量:1
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作者 Tang-Li Xiao Jun Zhang +1 位作者 Li Liu Bo Zhang 《World Journal of Clinical Cases》 SCIE 2021年第28期8461-8469,共9页
BACKGROUND Renal cysts and diabetes(RCAD)syndrome is an autosomal dominant diabetic renal disease.Precise molecular diagnosis of RCAD syndrome has proven valuable for understanding its mechanism and personalized thera... BACKGROUND Renal cysts and diabetes(RCAD)syndrome is an autosomal dominant diabetic renal disease.Precise molecular diagnosis of RCAD syndrome has proven valuable for understanding its mechanism and personalized therapy.CASE SUMMARY A RCAD patient and her family were studied to investigate potential responsible genes by the whole exome sequencing(WES).Candidate pathogenic variants were validated by Sanger sequencing.The clinical characteristics of RCAD patient were collected from medical records.Unlike those typical RCAD patients,we observed renal manifestation and prediabetes phenotype,but not reproductive organ phenotype and hypomagnesaemia.A novel 7-bp deletion mutation in exon 4 of the hepatocyte nuclear factor 1B,NM_000458:c.882_888del(p.V294fs),was identified by WES and confirmed by Sanger sequencing.CONCLUSION This novel mutation identified in a Chinese family with RCAD syndrome might be the molecular pathogenic basis of this disorder. 展开更多
关键词 Renal cysts and diabetes Hepatocyte nuclear factor 1B Exome sequencing Novel mutation Autosomal dominant disorder Case report
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A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers 被引量:14
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作者 Yasushi Adachi Hiroyuki Yamamoto +4 位作者 Hirokazu Ohashi Takao Endo David P Carbone Kohzoh Imai Yasuhisa Shinomura 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第46期5779-5789,共11页
Advances in molecular research in cancer have brought new therapeutic strategies into clinical usage.One new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small mol... Advances in molecular research in cancer have brought new therapeutic strategies into clinical usage.One new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) carcinomas.The concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new drugs.Type I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human malignancies.In this review,we focus on this promising therapeutic target,IGF-IR.The IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI cancers.Preclinical studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer treatments.These results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and pancreas.We also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical experiences.Several mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single agents.We summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug combinations.Thus,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcinomas. 展开更多
关键词 dominant negative GASTROINTESTINAL cancer Insulin like growth factor-I RECEPTOR MONOCLONAL anti-body TYROSINE kinase inhibitor
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An effective connected dominating set based mobility management algorithm in MANETs
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作者 Xin-yu WANG Xiao-hu YANG +3 位作者 Jian-ling SUN Wei LI Wei SHI Shan-ping LI 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2008年第10期1318-1325,共8页
This paper proposes a connected dominating set (CDS) based mobility management algorithm, CMMA, to solve the problems of node entering, exiting and movement in mobile ad hoc networks (MANETs), which ensures the connec... This paper proposes a connected dominating set (CDS) based mobility management algorithm, CMMA, to solve the problems of node entering, exiting and movement in mobile ad hoc networks (MANETs), which ensures the connectivity and efficiency of the CDS. Compared with Wu's algorithm, the proposed algorithm can make full use of present network conditions and involves fewer nodes. Also it has better performance with regard to the approximation factor, message complexity, and time complexity. 展开更多
关键词 Mobile ad hoc network (MANET) Connected dominating set (CDS) MOBILITY dominator No-key dominator Approximation factor
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Changes in Climate Factors and Their Impacts on Wind Erosion Climatic Erosivity in Farming-pastoral Zone of Northern China
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作者 YUE Shuping YAN Yechao +1 位作者 ZHANG Shuwen YANG Jiuchun 《Chinese Geographical Science》 SCIE CSCD 2022年第4期665-675,共11页
Climate change can affect wind erosion power and hence induce changes in wind erosion rates.In this study,the wind erosion climate factor(C-factor),proposed by the Food and Agriculture Organization of the United Natio... Climate change can affect wind erosion power and hence induce changes in wind erosion rates.In this study,the wind erosion climate factor(C-factor),proposed by the Food and Agriculture Organization of the United Nations,was used to assess the impact of changes in climate on wind erosion climatic erosivity.The Mann-Kendall test was employed to detect trends in the C-factor during the period of 1961–2017 in the farming-pastoral zone of northern China.Sensitivity analysis was used to determine the sensitivity of the C-factor to changes in key climate factors.Furthermore,a comparison of the contributions of different climate factors was carried out to understand their impact on changes in the C-factor.The results indicated that most of the surveyed region exhibited decreasing trends in wind speed at a confidence level of 90%,while maximum and minimum temperatures showed increasing trends throughout the study area.As a consequence of decreasing wind speed,the annual C-factor exhibited significant decreasing trends,with a mean slope of–0.58/yr.Seasonal analysis revealed that in most regions,the changes in the C-factor had significant decreasing trends in spring,winter,and autumn,while in more than two-thirds of the study area,no significant change trends in the C-factor were detected in summer at a confidence level of 90%.Sensitivity analysis showed that the C-factor was most sensitive to wind speed,and that the sensitivity coefficients from July to September were much higher than those in other months.Contribution analysis revealed that,for most stations,wind speed(with greater values of sensitivity coefficients)was the dominant factor in the change of C-factor,while for some stations,the minimum temperature made the most contribution to the C-factor’s change due to its dramatic changes during the study period.Although the minimum temperature sensitivity coefficient was the lowest of all the sensitivity coefficients,it is urgent to evaluate the expected impact of minimum temperature due to its possible changes in the future. 展开更多
关键词 climate factors wind erosion climatic erosivity sensitivity analysis dominant factor climate change
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鄂尔多斯盆地石盒子组-山西组致密储层形成主控因素与发育模式:以彬长地区为例 被引量:4
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作者 李松 马立元 +4 位作者 王濡岳 邓杰 李昱东 全晓园 蒋融 《地质科技通报》 CAS CSCD 北大核心 2024年第2期28-40,共13页
明确致密储层“甜点”的分布是致密储层油气勘探的重点。通过岩心观察、薄片鉴定、X射线衍射、包裹体均一温度测定、常规物性分析等手段,对鄂尔多斯盆地南部彬长地区上古生界致密砂岩沉积特征、储层特征、成岩作用进行了详细研究,明确... 明确致密储层“甜点”的分布是致密储层油气勘探的重点。通过岩心观察、薄片鉴定、X射线衍射、包裹体均一温度测定、常规物性分析等手段,对鄂尔多斯盆地南部彬长地区上古生界致密砂岩沉积特征、储层特征、成岩作用进行了详细研究,明确了储层形成的主要控制因素并建立了优质储层的发育模式。结果表明:沉积相是储层形成的基础,辫状河三角洲平原分流河道心滩微相岩石粒度粗,孔隙结构为小孔-中细喉型,储层物性相对较好;曲流河三角洲前缘水下分流河道及河口坝微相岩石粒度细,孔喉结构为微孔-微喉型,储层物性相对较差。成岩作用对优质储层的发育与分布具有重要控制作用。间歇性火山凝灰质在酸性地层蚀变为高岭石,而在碱性地层蚀变为绿泥石套膜,抑制了石英次生加大和方解石胶结,保护了储集空间。石英次生加大主要为泥岩转化形成的SiO_(2)渗滤到砂岩中形成的,中晚期方解石充填长石、岩屑溶孔为方解石顶底板胶结的主要原因。晚期构造改造形成的微裂缝无方解石胶结,改善了储层物性,对气藏起调整作用。彬长地区在3 750 m和3 900 m埋深段附近为2个溶蚀孔发育带。最优储层为溶蚀孔发育带内火山凝灰质转化形成的富含绿泥石套膜的中-粗砂岩;次优储层主要分布在溶蚀孔发育带内单砂体厚度较大、有旋回且无泥岩隔档的砂体的中下部,主要为缺少绿泥石套膜的中-粗砂岩,方解石胶结与石英次生加大作用最低。研究成果进一步深化了鄂尔多斯盆地南部地区上古生界致密砂岩优质储层发育的成因,对该地区天然气勘探开发具有重要指导意义。 展开更多
关键词 沉积相 成岩作用 致密储层 主控因素 储层发育模式 上古生界 鄂尔多斯盆地
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锦州市规划区地质环境安全评价研究 被引量:1
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作者 代雅建 崔健 郭常来 《地质与勘探》 CAS CSCD 北大核心 2024年第1期76-87,共12页
地质环境问题是影响城市国土空间安全开发利用的重要因素,在城市规划开发阶段开展地质环境综合评价可有效控制地质灾害风险。锦州市规划区尚处于开发前期,本文基于该规划区的地质条件和开发需求,构建了地质环境安全评价指标和评价方法体... 地质环境问题是影响城市国土空间安全开发利用的重要因素,在城市规划开发阶段开展地质环境综合评价可有效控制地质灾害风险。锦州市规划区尚处于开发前期,本文基于该规划区的地质条件和开发需求,构建了地质环境安全评价指标和评价方法体系,基于主导因素综合法开展了地质环境安全综合评价。根据评价结果,锦州市规划区地质环境安全程度可划分为3级,空间分布上以相对安全区为主,其次为次不安全区和安全区。按照空间位置和区域构造稳定性、地质灾害易发性等不同成因划分为23个亚区,并指出了每个亚区安全程度主要影响因素。该评价结果反映了锦州市规划区的地质环境安全程度,确定了影响地质环境安全问题的关键因素,有助于规避该区国土空间规划开发可能面临的地质灾害风险。 展开更多
关键词 地质环境 主导因素综合法 区域构造稳定性 地质灾害易发性 安全评价 规划区 锦州市
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基于装置运行平稳性的石油化工安全管理策略研究 被引量:1
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作者 姜国刚 王海超 黄文萍 《石油炼制与化工》 CAS CSCD 北大核心 2024年第4期40-46,共7页
为了找出并评价石化装置支配性风险因素,实现安全生产风险源头控制和管理,满足石化装置安全生产风险控制的高效性要求,通过建立石化装置事故风险影响模型,运用决策试验与评估实验室方法(DEMATEL)从“现代事故因果连锁理论”视角分析发... 为了找出并评价石化装置支配性风险因素,实现安全生产风险源头控制和管理,满足石化装置安全生产风险控制的高效性要求,通过建立石化装置事故风险影响模型,运用决策试验与评估实验室方法(DEMATEL)从“现代事故因果连锁理论”视角分析发现人、机(物)等风险因素都受管理因素支配。进而,基于工艺稳定性、工艺稳定性修正、非计划停工3个指标建立石化装置平稳性模型,对装置运行平稳率进行追踪统计,并通过实例对该模型进行了分析和验证。结果表明:该石化装置运行平稳性模型可以量化追踪事故风险支配性因素的控制效果,可展示石化装置不同阶段下的风险特点,可作为装置事故风险预警指标和安全管理绩效指标,可提高装置的安全管理水平。 展开更多
关键词 DEMATEL 支配性事故风险 石化装置 安全管理 装置平稳性
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