Probes are the interface between microsystems and bio-cells.The ideal interface is one-to-one interface.Though various research groups have been able to establish some sort of interfaces after many years of research,t...Probes are the interface between microsystems and bio-cells.The ideal interface is one-to-one interface.Though various research groups have been able to establish some sort of interfaces after many years of research,they are very crude.Neurons are millions in numbers,whereas the prostheses successfully built so far have only a few hundred probes at best.Creating an ef- fective interface is still far away.Though we have micro-and nano-technologies,we couldn't build a prosthesis with an effective resolution.Main reasons behind it are the type of probe being used and the poor design of the probe.To address this problem,we developed a methodology to design a probe and an array of probes with better resolution and less resistive donut probe.This methodology helps us to design a probe optimizing all the parameters.We presented our methodology through a design that is capable of 70 μm penetration inside the tissue.The tissue heating by our designed probe is only 0.411 °C.We also characterized the donut probe,which could be used by any research group to design a donut probe of their specific need.展开更多
In this paper, we demonstrate the variation of donut-shaped depletion pattern which influenced by multiple primary aberrations. The simulation is base on a common stimulation emission of depletion (STED) system compos...In this paper, we demonstrate the variation of donut-shaped depletion pattern which influenced by multiple primary aberrations. The simulation is base on a common stimulation emission of depletion (STED) system composed by Gaussian laser and vortex phase plate. The simulation results are helpful guidelines for analyzing the aberration of depletion patterns in real situations.展开更多
基金supported by the Royal National Institute for Deaf people (RNID)
文摘Probes are the interface between microsystems and bio-cells.The ideal interface is one-to-one interface.Though various research groups have been able to establish some sort of interfaces after many years of research,they are very crude.Neurons are millions in numbers,whereas the prostheses successfully built so far have only a few hundred probes at best.Creating an ef- fective interface is still far away.Though we have micro-and nano-technologies,we couldn't build a prosthesis with an effective resolution.Main reasons behind it are the type of probe being used and the poor design of the probe.To address this problem,we developed a methodology to design a probe and an array of probes with better resolution and less resistive donut probe.This methodology helps us to design a probe optimizing all the parameters.We presented our methodology through a design that is capable of 70 μm penetration inside the tissue.The tissue heating by our designed probe is only 0.411 °C.We also characterized the donut probe,which could be used by any research group to design a donut probe of their specific need.
文摘In this paper, we demonstrate the variation of donut-shaped depletion pattern which influenced by multiple primary aberrations. The simulation is base on a common stimulation emission of depletion (STED) system composed by Gaussian laser and vortex phase plate. The simulation results are helpful guidelines for analyzing the aberration of depletion patterns in real situations.
